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Cells deficient for Krüppel-like factor 4 exhibit mitochondrial dysfunction and impaired mitophagy.

Rosencrans WM, Walsh ZH, Houerbi N, Blum A, Belew M, Liu C, Chernak B, Brauer PR, Trazo A, Olson A, Hagos E.

Eur J Cell Biol. 2019 Dec 5:151061. doi: 10.1016/j.ejcb.2019.151061. [Epub ahead of print]


Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.

Hildebrandt MR, Reuter MS, Wei W, Tayebi N, Liu J, Sharmin S, Mulder J, Lesperance LS, Brauer PM, Mok RSF, Kinnear C, Piekna A, Romm A, Howe J, Pasceri P, Meng G, Rozycki M, Rodrigues DC, Martinez EC, Szego MJ, Zúñiga-Pflücker JC, Anderson MK, Prescott SA, Rosenblum ND, Kamath BM, Mital S, Scherer SW, Ellis J.

Stem Cell Reports. 2019 Dec 10;13(6):1126-1141. doi: 10.1016/j.stemcr.2019.11.003.


Prediction modelling of 1-year outcomes to a personalized lifestyle intervention for Canadians with Metabolic Syndrome.

Lowry DE, Feng Z, Jeejeebhoy K, Dhaliwal R, Brauer P, Royall D, Tremblay A, Klein D, Mutch DM.

Appl Physiol Nutr Metab. 2019 Nov 18. doi: 10.1139/apnm-2019-0375. [Epub ahead of print]


Patterns of Red and Processed Meat Consumption and Risk for Cardiometabolic and Cancer Outcomes: A Systematic Review and Meta-analysis of Cohort Studies.

Vernooij RWM, Zeraatkar D, Han MA, El Dib R, Zworth M, Milio K, Sit D, Lee Y, Gomaa H, Valli C, Swierz MJ, Chang Y, Hanna SE, Brauer PM, Sievenpiper J, de Souza R, Alonso-Coello P, Bala MM, Guyatt GH, Johnston BC.

Ann Intern Med. 2019 Oct 1. doi: 10.7326/M19-1583. [Epub ahead of print]


Margins in Laryngeal Squamous Cell Carcinoma Treated with Transoral Laser Microsurgery: A National Database Study.

Hanna J, Brauer PR, Morse E, Mehra S.

Otolaryngol Head Neck Surg. 2019 Dec;161(6):986-992. doi: 10.1177/0194599819874315. Epub 2019 Sep 3.


Epidemiological analysis of croup in the emergency department using two national datasets.

Hanna J, Brauer PR, Morse E, Berson E, Mehra S.

Int J Pediatr Otorhinolaryngol. 2019 Nov;126:109641. doi: 10.1016/j.ijporl.2019.109641. Epub 2019 Aug 13.


A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness.

Hanna J, Malhotra A, Brauer PR, Luryi A, Michaelides E.

Am J Otolaryngol. 2019 Nov - Dec;40(6):102263. doi: 10.1016/j.amjoto.2019.07.007. Epub 2019 Jul 8.


Understanding the Use of Dietary Supplements among Athlete and Non-Athlete University Students: Development and Validation of a Questionnaire.

El Khoury D, Dwyer JJM, Fein L, Brauer P, Brennan S, Alfaro I.

Sports (Basel). 2019 Jul 6;7(7). pii: E166. doi: 10.3390/sports7070166.


Is robotic surgery an option for early T-stage laryngeal cancer? Early nationwide results.

Hanna J, Brauer PR, Morse E, Judson B, Mehra S.

Laryngoscope. 2019 Jun 24. doi: 10.1002/lary.28144. [Epub ahead of print]


Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.

Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casadesús M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T.

Neoplasia. 2019 Jul;21(7):721-729. doi: 10.1016/j.neo.2019.04.009. Epub 2019 Jun 4.


Correction: Maxwell-Stefan diffusion coefficient estimation for ternary systems: an ideal ternary alcohol system.

Allie-Ebrahim T, Zhu Q, Bräuer P, Moggridge GD, D'Agostino C.

Phys Chem Chem Phys. 2019 Jun 21;21(23):12704-12705. doi: 10.1039/c9cp90142f. Epub 2019 Jun 3.


Adherence to Dietary Approaches to Stop Hypertension (DASH)-Style Diet and the Risk of Cancer: A Systematic Review and Meta-Analysis of Cohort Studies.

Ali Mohsenpour M, Fallah-Moshkani R, Ghiasvand R, Khosravi-Boroujeni H, Mehdi Ahmadi S, Brauer P, Salehi-Abargouei A.

J Am Coll Nutr. 2019 Aug;38(6):513-525. doi: 10.1080/07315724.2018.1554460. Epub 2019 May 29.


Industry Payments for Otolaryngology Research: A Four-Year Analysis of the Open Payments Database.

Brauer PR, Morse E, Mehra S.

Laryngoscope. 2019 May 6. doi: 10.1002/lary.27896. [Epub ahead of print]


Positive margin rates and predictors in transoral robotic surgery after federal approval: A national quality study.

Hanna J, Morse E, Brauer PR, Judson B, Mehra S.

Head Neck. 2019 Sep;41(9):3064-3072. doi: 10.1002/hed.25792. Epub 2019 May 6.


Nutrient intake and dietary quality changes within a personalized lifestyle intervention program for metabolic syndrome in primary care.

Brauer P, Royall D, Li A, Rodrigues A, Green J, Macklin S, Craig A, Pasanen J, Brunelle L, Maitland S, Dhaliwal R, Klein D, Tremblay A, Rheaume C, Mutch DM, Jeejeebhoy K.

Appl Physiol Nutr Metab. 2019 Dec;44(12):1297-1304. doi: 10.1139/apnm-2019-0070. Epub 2019 Apr 30.


Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.

Bräuer P, Parker JL, Gerondopoulos A, Zimmermann I, Seeger MA, Barr FA, Newstead S.

Science. 2019 Mar 8;363(6431):1103-1107. doi: 10.1126/science.aaw2859.


Prenatal Nutrition in Team-Based Care: Current Practices and Opportunities for Optimization of Care.

Town M, Smoliak O, Brauer P, Forbes L.

Can J Diet Pract Res. 2019 Sep 1;80(3):96-103. doi: 10.3148/cjdpr-2018-043. Epub 2019 Feb 7.


Adult epiglottitis: Trends and predictors of mortality in over 30 thousand cases from 2007 to 2014.

Hanna J, Brauer PR, Berson E, Mehra S.

Laryngoscope. 2019 May;129(5):1107-1112. doi: 10.1002/lary.27741. Epub 2018 Dec 24.


Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention.

Lowry DE, Fenwick PH, Roke K, Jeejeebhoy K, Dhaliwal R, Brauer P, Royall D, Tremblay A, Klein D, Mutch DM.

Lifestyle Genom. 2018;11(2):80-89. doi: 10.1159/000494331. Epub 2018 Nov 23.


Base adsorption mechanism over zeolite catalysts at different Al contents probed by the tapered element oscillating microbalance (TEOM).

Bräuer P, D'Agostino C.

Phys Chem Chem Phys. 2018 Oct 10;20(39):25357-25364. doi: 10.1039/c8cp05001e.


Patient experiences of a lifestyle program for metabolic syndrome offered in family medicine clinics: a mixed methods study.

Klein J, Brauer P, Royall D, Israeloff-Smith M, Klein D, Tremblay A, Dhaliwal R, Rheaume C, Mutch DM, Jeejeebhoy K.

BMC Fam Pract. 2018 Aug 31;19(1):148. doi: 10.1186/s12875-018-0837-z.


Improving Documentation of Pediatric Height, Weight, and Body Mass Index by Primary Care Providers.

Wray CV, Brauer PM, Heuberger RA, Logomarsino JV.

Can J Diet Pract Res. 2018 Nov 1;79(4):186-190. doi: 10.3148/cjdpr-2018-019. Epub 2018 Jul 16.


Guelph Family Health Study: pilot study of a home-based obesity prevention intervention.

Haines J, Douglas S, Mirotta JA, O'Kane C, Breau R, Walton K, Krystia O, Chamoun E, Annis A, Darlington GA, Buchholz AC, Duncan AM, Vallis LA, Spriet LL, Mutch DM, Brauer P, Allen-Vercoe E, Taveras EM, Ma DWL; Guelph Family Health Study.

Can J Public Health. 2018 Aug;109(4):549-560. doi: 10.17269/s41997-018-0072-3. Epub 2018 Apr 25.


In vitro metabolism of selected bioactive compounds of Eurycoma longifolia root extract to identify suitable markers in doping control.

Bräuer P, Anielski P, Schwaiger S, Stuppner H, Tran TVA, Vollmer G, Zierau O, Thieme D, Keiler AM.

Drug Test Anal. 2019 Jan;11(1):86-94. doi: 10.1002/dta.2449. Epub 2018 Aug 9.


The ion channel TRPM7 is required for B cell lymphopoiesis.

Krishnamoorthy M, Buhari FHM, Zhao T, Brauer PM, Burrows K, Cao EY, Moxley-Paquette V, Mortha A, Zúñiga-Pflücker JC, Treanor B.

Sci Signal. 2018 Jun 5;11(533). pii: eaan2693. doi: 10.1126/scisignal.aan2693.


Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins.

Wu CM, Roth TL, Baglaenko Y, Ferri DM, Brauer P, Zuniga-Pflucker JC, Rosbe KW, Wither JE, Marson A, Allen CDC.

J Immunol Methods. 2018 Jun;457:33-40. doi: 10.1016/j.jim.2018.03.009. Epub 2018 Mar 31.


Awareness of Omega-3 Fatty Acids and Possible Health Effects among Young Adults.

Roke K, Rattner J, Brauer P, Mutch DM.

Can J Diet Pract Res. 2018 Sep 1;79(3):106-112. doi: 10.3148/cjdpr-2018-005. Epub 2018 Mar 16.


Krüppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity.

Brauer PR, Kim JH, Ochoa HJ, Stratton ER, Black KM, Rosencrans W, Stacey E, Hagos EG.

Cell Commun Adhes. 2018 Dec;24(1):1-10. doi: 10.1080/15419061.2018.1444034.


Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions.

Fenwick PH, Jeejeebhoy K, Dhaliwal R, Royall D, Brauer P, Tremblay A, Klein D, Mutch DM.

Crit Rev Food Sci Nutr. 2019;59(13):2028-2039. doi: 10.1080/10408398.2018.1437022. Epub 2018 Mar 1. Review.


A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.

Gallery M, Zhang J, Bradley DP, Brauer P, Cvet D, Estevam J, Danaee H, Greenfield E, Li P, Manfredi M, Loke HK, Rabino C, Stringer B, Williamson M, Wyant T, Yang J, Zhu Q, Abu-Yousif A, Veiby OP.

PLoS One. 2018 Jan 25;13(1):e0191046. doi: 10.1371/journal.pone.0191046. eCollection 2018.


Effect of Al content on the strength of terminal silanol species in ZSM-5 zeolite catalysts: a quantitative DRIFTS study without the use of molar extinction coefficients.

Bräuer P, Situmorang O, Ng PL, D'Agostino C.

Phys Chem Chem Phys. 2018 Feb 7;20(6):4250-4262. doi: 10.1039/c7cp07826a.


Development of a patient experience questionnaire to improve lifestyle services in primary care.

Brauer P, Royall D, Kaethler A, Mayhew A, Israeloff-Smith M.

Prim Health Care Res Dev. 2018 Nov;19(6):542-552. doi: 10.1017/S1463423617000937. Epub 2018 Jan 15.


Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Li Y, Brauer PM, Singh J, Xhiku S, Yoganathan K, Zúñiga-Pflücker JC, Anderson MK.

Stem Cell Reports. 2017 Sep 12;9(3):779-795. doi: 10.1016/j.stemcr.2017.07.011. Epub 2017 Aug 10.


The CHANGE program: Exercise intervention in primary care.

Klein D, Jeejeebhoy K, Tremblay A, Kallio M, Rheaume C, Humphries S, Royall D, Brauer P, Heyland D, Dhaliwal R, Mutch DM.

Can Fam Physician. 2017 Jul;63(7):546-552.


Maxwell-Stefan diffusion coefficient estimation for ternary systems: an ideal ternary alcohol system.

Allie-Ebrahim T, Zhu Q, Bräuer P, Moggridge GD, D'Agostino C.

Phys Chem Chem Phys. 2017 Jun 21;19(24):16071-16077. doi: 10.1039/c7cp02582c. Erratum in: Phys Chem Chem Phys. 2019 Jun 21;21(23):12704-12705.


Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence.

Rahman N, Brauer PM, Ho L, Usenko T, Tewary M, Zúñiga-Pflücker JC, Zandstra PW.

Nat Commun. 2017 May 25;8:15380. doi: 10.1038/ncomms15380.


Family physician-led, team-based, lifestyle intervention in patients with metabolic syndrome: results of a multicentre feasibility project.

Jeejeebhoy K, Dhaliwal R, Heyland DK, Leung R, Day AG, Brauer P, Royall D, Tremblay A, Mutch DM, Pliamm L, Rhéaume C, Klein D.

CMAJ Open. 2017 Mar 14;5(1):E229-E236. doi: 10.9778/cmajo.20160101. eCollection 2017 Jan-Mar. Erratum in: CMAJ Open. 2017 May 1;5(2):E337.


Eliciting Provider and Patient Perspectives on New Obesity Management Services in a Team-Based Primary Care Organization.

Royall D, Brauer P, Atta-Konadu E, Dwyer JJM, Edwards AM, Hussey T, Kates N.

Can J Diet Pract Res. 2017 Sep 1;78(3):109-116. doi: 10.3148/cjdpr-2017-005. Epub 2017 Mar 23.


Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.

Fuller FD, Gul S, Chatterjee R, Burgie ES, Young ID, Lebrette H, Srinivas V, Brewster AS, Michels-Clark T, Clinger JA, Andi B, Ibrahim M, Pastor E, de Lichtenberg C, Hussein R, Pollock CJ, Zhang M, Stan CA, Kroll T, Fransson T, Weninger C, Kubin M, Aller P, Lassalle L, Bräuer P, Miller MD, Amin M, Koroidov S, Roessler CG, Allaire M, Sierra RG, Docker PT, Glownia JM, Nelson S, Koglin JE, Zhu D, Chollet M, Song S, Lemke H, Liang M, Sokaras D, Alonso-Mori R, Zouni A, Messinger J, Bergmann U, Boal AK, Bollinger JM Jr, Krebs C, Högbom M, Phillips GN Jr, Vierstra RD, Sauter NK, Orville AM, Kern J, Yachandra VK, Yano J.

Nat Methods. 2017 Apr;14(4):443-449. doi: 10.1038/nmeth.4195. Epub 2017 Feb 27.


EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.

Volpi S, Yamazaki Y, Brauer PM, van Rooijen E, Hayashida A, Slavotinek A, Sun Kuehn H, Di Rocco M, Rivolta C, Bortolomai I, Du L, Felgentreff K, Ott de Bruin L, Hayashida K, Freedman G, Marcovecchio GE, Capuder K, Rath P, Luche N, Hagedorn EJ, Buoncompagni A, Royer-Bertrand B, Giliani S, Poliani PL, Imberti L, Dobbs K, Poulain FE, Martini A, Manis J, Linhardt RJ, Bosticardo M, Rosenzweig SD, Lee H, Puck JM, Zúñiga-Pflücker JC, Zon L, Park PW, Superti-Furga A, Notarangelo LD.

J Exp Med. 2017 Mar 6;214(3):623-637. doi: 10.1084/jem.20161525. Epub 2017 Feb 1.


Structure of photosystem II and substrate binding at room temperature.

Young ID, Ibrahim M, Chatterjee R, Gul S, Fuller F, Koroidov S, Brewster AS, Tran R, Alonso-Mori R, Kroll T, Michels-Clark T, Laksmono H, Sierra RG, Stan CA, Hussein R, Zhang M, Douthit L, Kubin M, de Lichtenberg C, Long Vo P, Nilsson H, Cheah MH, Shevela D, Saracini C, Bean MA, Seuffert I, Sokaras D, Weng TC, Pastor E, Weninger C, Fransson T, Lassalle L, Bräuer P, Aller P, Docker PT, Andi B, Orville AM, Glownia JM, Nelson S, Sikorski M, Zhu D, Hunter MS, Lane TJ, Aquila A, Koglin JE, Robinson J, Liang M, Boutet S, Lyubimov AY, Uervirojnangkoorn M, Moriarty NW, Liebschner D, Afonine PV, Waterman DG, Evans G, Wernet P, Dobbek H, Weis WI, Brunger AT, Zwart PH, Adams PD, Zouni A, Messinger J, Bergmann U, Sauter NK, Kern J, Yachandra VK, Yano J.

Nature. 2016 Dec 15;540(7633):453-457. doi: 10.1038/nature20161. Epub 2016 Nov 21.


Obesity services planning framework for interprofessional primary care organizations - ERRATUM.

Brauer P, Royall D, Dwyer J, Edwards AM, Hussey T, Kates N, Smith H, Kirkconnell R.

Prim Health Care Res Dev. 2017 Mar;18(2):148. doi: 10.1017/S1463423616000402. Epub 2016 Nov 7. No abstract available.


T Cell Genesis: In Vitro Veritas Est?

Brauer PM, Singh J, Xhiku S, Zúñiga-Pflücker JC.

Trends Immunol. 2016 Dec;37(12):889-901. doi: 10.1016/ Epub 2016 Oct 24. Review.


An advanced modeling study on the impacts and atmospheric implications of multiphase dimethyl sulfide chemistry.

Hoffmann EH, Tilgner A, Schrödner R, Bräuer P, Wolke R, Herrmann H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11776-11781. Epub 2016 Sep 29.


Obesity services planning framework for interprofessional primary care organizations.

Brauer P, Royall D, Dwyer J, Edwards AM, Hussey T, Kates N, Smith H, Kirkconnell R.

Prim Health Care Res Dev. 2017 Mar;18(2):135-147. doi: 10.1017/S1463423616000372. Epub 2016 Oct 3. Erratum in: Prim Health Care Res Dev. 2017 Mar;18(2):148.


Interventions for prevention of childhood obesity in primary care: a qualitative study.

Bourgeois N, Brauer P, Simpson JR, Kim S, Haines J.

CMAJ Open. 2016 Apr 28;4(2):E194-9. doi: 10.9778/cmajo.20150081. eCollection 2016 Apr-Jun.


An ultrasensitive assay format for detecting ULK1 inhibition by monitoring the phosphorylation status of Atg13.

Yan ZH, Zhang W, Rollins N, Tayber O, Chen J, Wu D, Brauer P, Chouitar J, Bosse R, Yu J, Bembenek ME.

Anal Biochem. 2016 Sep 15;509:73-78. doi: 10.1016/j.ab.2016.06.023. Epub 2016 Jul 4.


Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies.

Brauer PM, Pessach IM, Clarke E, Rowe JH, Ott de Bruin L, Lee YN, Dominguez-Brauer C, Comeau AM, Awong G, Felgentreff K, Zhang YH, Bredemeyer A, Al-Herz W, Du L, Ververs F, Kennedy M, Giliani S, Keller G, Sleckman BP, Schatz DG, Bushman FD, Notarangelo LD, Zúñiga-Pflücker JC.

Blood. 2016 Aug 11;128(6):783-93. doi: 10.1182/blood-2015-10-676304. Epub 2016 Jun 14.


High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.

Oppermann S, Ylanko J, Shi Y, Hariharan S, Oakes CC, Brauer PM, Zúñiga-Pflücker JC, Leber B, Spaner DE, Andrews DW.

Blood. 2016 Aug 18;128(7):934-47. doi: 10.1182/blood-2015-12-687814. Epub 2016 Jun 13.


Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.

Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12.

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