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Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms.

Malcolm KC, Caceres SM, Pohl K, Poch KR, Bernut A, Kremer L, Bratton DL, Herrmann JL, Nick JA.

PLoS One. 2018 Apr 19;13(4):e0196120. doi: 10.1371/journal.pone.0196120. eCollection 2018.


Role of gp91phox in hepatic macrophage programming and alcoholic liver disease.

Wang M, Frasch SC, Li G, Feng D, Gao B, Xu L, Ir D, Frank DN, Bratton DL, Ju C.

Hepatol Commun. 2017 Aug 11;1(8):765-779. doi: 10.1002/hep4.1078. eCollection 2017 Oct.


Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK.

Mohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L69-L82. doi: 10.1152/ajplung.00058.2017. Epub 2017 Sep 21.


A case of recurrent facial angioedema associated with elevated tree pollen counts.

Jayaraman D, Bratton DL, Harbeck RJ, Wolf M, Rabinovitch N.

J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1771-1772. doi: 10.1016/j.jaip.2017.04.012. Epub 2017 May 11. No abstract available.


Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):294-306. doi: 10.1165/rcmb.2017-0061OC.


Three Unique Interstitial Macrophages in the Murine Lung at Steady State.

Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):66-76. doi: 10.1165/rcmb.2016-0361OC.


Myeloid Cell Turnover and Clearance.

Janssen WJ, Bratton DL, Jakubzick CV, Henson PM.

Microbiol Spectr. 2016 Nov;4(6). doi: 10.1128/microbiolspec.MCHD-0005-2015. Review.


G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.

Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL.

J Immunol. 2016 Aug 15;197(4):1425-34. doi: 10.4049/jimmunol.1600264. Epub 2016 Jul 8.


Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26. doi: 10.1164/rccm.201507-1376OC.


Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment.

Fernandez-Boyanapalli RF, Falcone EL, Zerbe CS, Marciano BE, Frasch SC, Henson PM, Holland SM, Bratton DL.

J Allergy Clin Immunol. 2015 Nov;136(5):1399-1401.e3. doi: 10.1016/j.jaci.2015.07.034. Epub 2015 Sep 18. No abstract available.


Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.

Gibbings SL, Goyal R, Desch AN, Leach SM, Prabagar M, Atif SM, Bratton DL, Janssen W, Jakubzick CV.

Blood. 2015 Sep 10;126(11):1357-66. doi: 10.1182/blood-2015-01-624809. Epub 2015 Jul 31.


Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease.

Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL.

J Allergy Clin Immunol. 2015 Feb;135(2):517-527.e12. doi: 10.1016/j.jaci.2014.10.034. Epub 2014 Dec 10.


Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases.

Eltzschig HK, Bratton DL, Colgan SP.

Nat Rev Drug Discov. 2014 Nov;13(11):852-69. doi: 10.1038/nrd4422. Review.


Enhanced in vitro formation and antibiotic resistance of nonattached Pseudomonas aeruginosa aggregates through incorporation of neutrophil products.

Caceres SM, Malcolm KC, Taylor-Cousar JL, Nichols DP, Saavedra MT, Bratton DL, Moskowitz SM, Burns JL, Nick JA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6851-60. doi: 10.1128/AAC.03514-14. Epub 2014 Sep 2.


Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.

Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):825-37. doi: 10.1165/rcmb.2013-0386OC.


Circulating hematopoietic progenitor cells are decreased in COPD.

Janssen WJ, Yunt ZX, Muldrow A, Kearns MT, Kloepfer A, Barthel L, Bratton DL, Bowler RP, Henson PM.

COPD. 2014 Jun;11(3):277-89. doi: 10.3109/15412555.2013.841668. Epub 2013 Nov 1.


Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation.

Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NA, Bratton DL, Murphy RC, Leslie CC.

PLoS One. 2013 Jul 25;8(7):e69002. doi: 10.1371/journal.pone.0069002. eCollection 2013.


Induction of TGF-β1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36.

Xiong W, Frasch SC, Thomas SM, Bratton DL, Henson PM.

PLoS One. 2013 Aug 2;8(8):e72772. doi: 10.1371/journal.pone.0072772. Print 2013.


Antiinflammatory effects of apoptotic cells.

Henson PM, Bratton DL.

J Clin Invest. 2013 Jul;123(7):2773-4. doi: 10.1172/JCI69344. Epub 2013 Jul 1.


Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival.

Malcolm KC, Nichols EM, Caceres SM, Kret JE, Martiniano SL, Sagel SD, Chan ED, Caverly L, Solomon GM, Reynolds P, Bratton DL, Taylor-Cousar JL, Nichols DP, Saavedra MT, Nick JA.

PLoS One. 2013;8(2):e57402. doi: 10.1371/journal.pone.0057402. Epub 2013 Feb 25.


Allergy: airway epithelial Rac1 suppresses allergic inflammation.

Henson PM, Bratton DL.

Curr Biol. 2013 Feb 4;23(3):R104-6. doi: 10.1016/j.cub.2012.12.008.


Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine.

Frasch SC, Fernandez-Boyanapalli RF, Berry KA, Murphy RC, Leslie CC, Nick JA, Henson PM, Bratton DL.

J Biol Chem. 2013 Feb 15;288(7):4583-93. doi: 10.1074/jbc.M112.438507. Epub 2013 Jan 5.


Obesity impairs apoptotic cell clearance in asthma.

Fernandez-Boyanapalli R, Goleva E, Kolakowski C, Min E, Day B, Leung DY, Riches DW, Bratton DL, Sutherland ER.

J Allergy Clin Immunol. 2013 Apr;131(4):1041-7, 1047.e1-3. doi: 10.1016/j.jaci.2012.09.028. Epub 2012 Nov 13.


Emerging roles for lysophosphatidylserine in resolution of inflammation.

Frasch SC, Bratton DL.

Prog Lipid Res. 2012 Jul;51(3):199-207. doi: 10.1016/j.plipres.2012.03.001. Epub 2012 Mar 29. Review.


IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity.

Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM.

J Immunol. 2011 Sep 1;187(5):2101-11. doi: 10.4049/jimmunol.1003468. Epub 2011 Aug 3.


Neutrophil clearance: when the party is over, clean-up begins.

Bratton DL, Henson PM.

Trends Immunol. 2011 Aug;32(8):350-7. doi: 10.1016/ Epub 2011 Jul 23. Review.


SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice.

Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW.

Am J Pathol. 2011 May;178(5):2159-67. doi: 10.1016/j.ajpath.2011.01.026.


Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity.

Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL.

J Biol Chem. 2011 Apr 8;286(14):12108-22. doi: 10.1074/jbc.M110.181800. Epub 2011 Feb 4.


Modulation of macrophage efferocytosis in inflammation.

Korns D, Frasch SC, Fernandez-Boyanapalli R, Henson PM, Bratton DL.

Front Immunol. 2011 Nov 8;2:57. doi: 10.3389/fimmu.2011.00057. eCollection 2011.


Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress.

Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, Decsesznak J, Chu HW, Bratton DL, Riches DW, Bowler RP.

Free Radic Biol Med. 2010 Dec 15;49(12):1937-46. doi: 10.1016/j.freeradbiomed.2010.09.022. Epub 2010 Sep 29.


Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner.

Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL.

J Immunol. 2010 Oct 1;185(7):4030-41. doi: 10.4049/jimmunol.1001778. Epub 2010 Aug 30.


PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.

Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL.

Blood. 2010 Nov 25;116(22):4512-22. doi: 10.1182/blood-2010-02-272005. Epub 2010 Aug 6.


The Atopic Dermatitis Quickscore (ADQ): validation of a new parent-administered atopic dermatitis scoring tool.

Carel K, Bratton DL, Miyazawa N, Gyorkos E, Kelsay K, Bender B, Strand M, Atkins D, Gelfand EW, Klinnert MD.

Ann Allergy Asthma Immunol. 2008 Nov;101(5):500-7. doi: 10.1016/S1081-1206(10)60289-X.


Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL.

Blood. 2009 Feb 26;113(9):2047-55. doi: 10.1182/blood-2008-05-160564. Epub 2008 Oct 24.


NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A.

Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL.

J Biol Chem. 2008 Nov 28;283(48):33736-49. doi: 10.1074/jbc.M807047200. Epub 2008 Sep 29.


Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells.

Xiao YQ, Freire-de-Lima CG, Schiemann WP, Bratton DL, Vandivier RW, Henson PM.

J Immunol. 2008 Sep 1;181(5):3575-85.


Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?

Bratton DL, Henson PM.

Curr Biol. 2008 Jan 22;18(2):R76-9. doi: 10.1016/j.cub.2007.11.024.


TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms.

McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai S, Remigio L, Bratton DL, Kang JL, Henson P.

J Immunol. 2007 Jun 15;178(12):8117-26.


Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.

Frasch SC, Zemski-Berry K, Murphy RC, Borregaard N, Henson PM, Bratton DL.

J Immunol. 2007 May 15;178(10):6540-8.


Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages.

Freire-de-Lima CG, Xiao YQ, Gardai SJ, Bratton DL, Schiemann WP, Henson PM.

J Biol Chem. 2006 Dec 15;281(50):38376-84. Epub 2006 Oct 20.


Recognition ligands on apoptotic cells: a perspective.

Gardai SJ, Bratton DL, Ogden CA, Henson PM.

J Leukoc Biol. 2006 May;79(5):896-903. Review.


Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production.

Xiao YQ, Freire-de-Lima CG, Janssen WJ, Morimoto K, Lyu D, Bratton DL, Henson PM.

J Immunol. 2006 Jan 15;176(2):1209-17.


Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM.

Cell. 2005 Oct 21;123(2):321-34.


The effect of montelukast versus usual care on health care resource utilization in children aged 2 to 5 years with asthma.

Davies GM, Dasbach EJ, Santanello NC, Knorr BA, Bratton DL.

Clin Ther. 2004 Nov;26(11):1895-904.


Autoimmunity and apoptosis: refusing to go quietly.

Bratton DL, Henson PM.

Nat Med. 2005 Jan;11(1):26-7. No abstract available.


Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge.

Duez C, Dakhama A, Tomkinson A, Marquillies P, Balhorn A, Tonnel AB, Bratton DL, Gelfand EW.

J Allergy Clin Immunol. 2004 Oct;114(4):820-5.


Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil.

Fessler MB, Arndt PG, Frasch SC, Lieber JG, Johnson CA, Murphy RC, Nick JA, Bratton DL, Malcolm KC, Worthen GS.

J Biol Chem. 2004 Sep 17;279(38):39989-98. Epub 2004 Jul 15.


Single-breath exhaled nitric oxide in preschool children facilitated by a servo-controlled device maintaining constant flow.

Silkoff PE, Bates CA, Meiser JB, Bratton DL.

Pediatr Pulmonol. 2004 Jun;37(6):554-8.


Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils.

Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL.

J Biol Chem. 2004 Apr 23;279(17):17625-33. Epub 2004 Feb 6.


Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils.

Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, Henson PM.

J Biol Chem. 2004 May 14;279(20):21085-95. Epub 2004 Feb 6.

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