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Update: Mepolizumab treatment in patients with severe eosinophilic asthma and prior omalizumab use.

Albers FC, Hozawa S, Bratton DJ, Yancey SW, Prazma CM, Humbert M, Liu MC.

Allergy. 2019 Sep 14. doi: 10.1111/all.14048. [Epub ahead of print] No abstract available.


Mepolizumab reduces exacerbations in patients with severe eosinophilic asthma, irrespective of body weight/body mass index: meta-analysis of MENSA and MUSCA.

Albers FC, Papi A, Taillé C, Bratton DJ, Bradford ES, Yancey SW, Kwon N.

Respir Res. 2019 Jul 30;20(1):169. doi: 10.1186/s12931-019-1134-7.


Effect of mepolizumab in severe eosinophilic asthma according to omalizumab eligibility.

Humbert M, Albers FC, Bratton DJ, Yancey SW, Liu MC, Hozawa S, Llanos JP, Kwon N.

Respir Med. 2019 Jul - Aug;154:69-75. doi: 10.1016/j.rmed.2019.06.004. Epub 2019 Jun 8.



Gunsoy NB, Bratton DJ, Albers FC, Busse W.

J Allergy Clin Immunol. 2019 Mar;143(3):1267-1268. doi: 10.1016/j.jaci.2018.11.023. Epub 2019 Jan 11. No abstract available.


Methodological Concerns of a Recent Network Meta-analysis Assessing Biologics for Eosinophilic Asthma.

Gunsoy NB, Bratton DJ, Alfonso-Cristancho R.

Lung. 2019 Feb;197(1):105-106. doi: 10.1007/s00408-018-0183-x. Epub 2018 Nov 30. No abstract available.


Treatment policy estimands for recurrent event data using data collected after cessation of randomised treatment.

Roger JH, Bratton DJ, Mayer B, Abellan JJ, Keene ON.

Pharm Stat. 2019 Jan;18(1):85-95. doi: 10.1002/pst.1910. Epub 2018 Nov 8.


Effect of continuous positive airway pressure therapy on circadian patterns of cardiac repolarization in patients with obstructive sleep apnoea: data from a randomized trial.

Schlatzer C, Bratton DJ, Schwarz EI, Gaisl T, Pepperell JCT, Stradling JR, Kohler M.

J Thorac Dis. 2018 Aug;10(8):4940-4948. doi: 10.21037/jtd.2018.07.17.


Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison.

Busse W, Chupp G, Nagase H, Albers FC, Doyle S, Shen Q, Bratton DJ, Gunsoy NB.

J Allergy Clin Immunol. 2019 Jan;143(1):190-200.e20. doi: 10.1016/j.jaci.2018.08.031. Epub 2018 Sep 8. Erratum in: J Allergy Clin Immunol. 2019 Jun;143(6):2336.


Help for Future Research: Lessons Learned in Trial Design, Recruitment, and Delivery From the "hELP" Study.

Simpson RC, Murphy R, Bratton DJ, Sydes MR, Wilkes S, Nankervis H, Dowey S, Bell H, Cruickshank M, Gibbon K, Green CM, Wong C, Owen CM, London K, Haque S, Thomas KS.

J Low Genit Tract Dis. 2018 Oct;22(4):405-408. doi: 10.1097/LGT.0000000000000407. No abstract available.


Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms.

Malcolm KC, Caceres SM, Pohl K, Poch KR, Bernut A, Kremer L, Bratton DL, Herrmann JL, Nick JA.

PLoS One. 2018 Apr 19;13(4):e0196120. doi: 10.1371/journal.pone.0196120. eCollection 2018.


Role of gp91phox in hepatic macrophage programming and alcoholic liver disease.

Wang M, Frasch SC, Li G, Feng D, Gao B, Xu L, Ir D, Frank DN, Bratton DL, Ju C.

Hepatol Commun. 2017 Aug 11;1(8):765-779. doi: 10.1002/hep4.1078. eCollection 2017 Oct.


Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK.

Mohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L69-L82. doi: 10.1152/ajplung.00058.2017. Epub 2017 Sep 21.


Reappraisal of the clinical effect of mepolizumab - Authors' reply.

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A.

Lancet Respir Med. 2017 Jun;5(6):e21. doi: 10.1016/S2213-2600(17)30184-4. Epub 2017 May 26. No abstract available.


A case of recurrent facial angioedema associated with elevated tree pollen counts.

Jayaraman D, Bratton DL, Harbeck RJ, Wolf M, Rabinovitch N.

J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1771-1772. doi: 10.1016/j.jaip.2017.04.012. Epub 2017 May 11. No abstract available.


Risk of Sleepiness-Related Accidents in Switzerland: Results of an Online Sleep Apnea Risk Questionnaire and Awareness Campaigns.

Lichtblau M, Bratton D, Giroud P, Weiler T, Bloch KE, Brack T.

Front Med (Lausanne). 2017 Apr 12;4:34. doi: 10.3389/fmed.2017.00034. eCollection 2017.


Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):294-306. doi: 10.1165/rcmb.2017-0061OC.


Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A.

Lancet Respir Med. 2017 May;5(5):390-400. doi: 10.1016/S2213-2600(17)30125-X. Epub 2017 Apr 5.


Three Unique Interstitial Macrophages in the Murine Lung at Steady State.

Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):66-76. doi: 10.1165/rcmb.2016-0361OC.


Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA: A Systematic Review and Meta-analysis.

Kuhn E, Schwarz EI, Bratton DJ, Rossi VA, Kohler M.

Chest. 2017 Apr;151(4):786-794. doi: 10.1016/j.chest.2017.01.020. Epub 2017 Jan 24. Review.


Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study.

Gaisl T, Giunta C, Bratton DJ, Sutherland K, Schlatzer C, Sievi N, Franzen D, Cistulli PA, Rohrbach M, Kohler M.

Thorax. 2017 Aug;72(8):729-735. doi: 10.1136/thoraxjnl-2016-209560. Epub 2017 Jan 10.


Myeloid Cell Turnover and Clearance.

Janssen WJ, Bratton DL, Jakubzick CV, Henson PM.

Microbiol Spectr. 2016 Nov;4(6). doi: 10.1128/microbiolspec.MCHD-0005-2015. Review.


Defining the sham environment for post-myocardial infarction studies in mice.

Iyer RP, de Castro Brás LE, Cannon PL, Ma Y, DeLeon-Pennell KY, Jung M, Flynn ER, Henry JB, Bratton DR, White JA, Fulton LK, Grady AW, Lindsey ML.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H822-36. doi: 10.1152/ajpheart.00067.2016. Epub 2016 Aug 12.


Sedation during bronchoscopy: data from a nationwide sedation and monitoring survey.

Gaisl T, Bratton DJ, Heuss LT, Kohler M, Schlatzer C, Zalunardo MP, Frey M, Franzen D.

BMC Pulm Med. 2016 Aug 5;16(1):113. doi: 10.1186/s12890-016-0275-4.


The Roles of the Charlson Comorbidity Index and Time to First Antibiotic Dose as Predictors of Outcome in Pneumococcal Community-Acquired Pneumonia.

Franzen D, Lim M, Bratton DJ, Kuster SP, Kohler M.

Lung. 2016 Oct;194(5):769-75. doi: 10.1007/s00408-016-9922-z. Epub 2016 Jul 12.


G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.

Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL.

J Immunol. 2016 Aug 15;197(4):1425-34. doi: 10.4049/jimmunol.1600264. Epub 2016 Jul 8.


Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes.

Bratton DJ, Parmar MK, Phillips PP, Choodari-Oskooei B.

Trials. 2016 Jul 2;17(1):309. doi: 10.1186/s13063-016-1382-5.


Target-controlled versus fractionated propofol sedation in flexible bronchoscopy: A randomized noninferiority trial.

Franzen D, Bratton DJ, Clarenbach CF, Freitag L, Kohler M.

Respirology. 2016 Nov;21(8):1445-1451. doi: 10.1111/resp.12830. Epub 2016 Jun 15.


Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion.

Gaisl T, Wons AM, Rossi V, Bratton DJ, Schlatzer C, Schwarz EI, Camen G, Kohler M.

PLoS One. 2016 Apr 12;11(4):e0152994. doi: 10.1371/journal.pone.0152994. eCollection 2016.


ECG risk markers for atrial fibrillation and sudden cardiac death in minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised trial.

Schlatzer C, Bratton DJ, Craig SE, Kohler M, Stradling JR.

BMJ Open. 2016 Mar 16;6(3):e010150. doi: 10.1136/bmjopen-2015-010150.


In patients with minimally symptomatic OSA can baseline characteristics and early patterns of CPAP usage predict those who are likely to be longer-term users of CPAP.

Turnbull CD, Bratton DJ, Craig SE, Kohler M, Stradling JR.

J Thorac Dis. 2016 Feb;8(2):276-81. doi: 10.3978/j.issn.2072-1439.2016.01.54.


Effect of rituximab on pulmonary function in patients with rheumatoid arthritis.

Franzen D, Ciurea A, Bratton DJ, Clarenbach CF, Latshang TD, Russi EW, Kyburz D, Kohler M.

Pulm Pharmacol Ther. 2016 Apr;37:24-9. doi: 10.1016/j.pupt.2016.02.002. Epub 2016 Feb 8.


Systemic therapy for vulval Erosive Lichen Planus (the 'hELP' trial): study protocol for a randomised controlled trial.

Simpson RC, Murphy R, Bratton DJ, Sydes MR, Wilkes S, Nankervis H, Dowey S, Thomas KS.

Trials. 2016 Jan 4;17:2. doi: 10.1186/s13063-015-1133-z.


Prevalence and Risk Factors of Sleep Disordered Breathing in Fabry disease: A Prospective Cohort Study.

Franzen D, Gerard N, Bratton DJ, Wons A, Gaisl T, Sievi NA, Clarenbach CF, Kohler M, Krayenbühl PA.

Medicine (Baltimore). 2015 Dec;94(52):e2413. doi: 10.1097/MD.0000000000002413.


CPAP vs Mandibular Advancement Devices and Blood Pressure in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.

Bratton DJ, Gaisl T, Wons AM, Kohler M.

JAMA. 2015 Dec 1;314(21):2280-93. doi: 10.1001/jama.2015.16303. Review.


Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26. doi: 10.1164/rccm.201507-1376OC.


Comparison of the effects of continuous positive airway pressure and mandibular advancement devices on sleepiness in patients with obstructive sleep apnoea: a network meta-analysis.

Bratton DJ, Gaisl T, Schlatzer C, Kohler M.

Lancet Respir Med. 2015 Nov;3(11):869-78. doi: 10.1016/S2213-2600(15)00416-6. Epub 2015 Oct 20. Erratum in: Lancet Respir Med. 2015 Dec;3(12):e44.


Comments on "Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea" by Sharples et al.

Bratton DJ, Kohler M.

Sleep Med Rev. 2016 Jun;27:39-40. doi: 10.1016/j.smrv.2015.07.007. Epub 2015 Aug 13. No abstract available.


Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment.

Fernandez-Boyanapalli RF, Falcone EL, Zerbe CS, Marciano BE, Frasch SC, Henson PM, Holland SM, Bratton DL.

J Allergy Clin Immunol. 2015 Nov;136(5):1399-1401.e3. doi: 10.1016/j.jaci.2015.07.034. Epub 2015 Sep 18. No abstract available.


A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis.

Lindsey ML, Iyer RP, Zamilpa R, Yabluchanskiy A, DeLeon-Pennell KY, Hall ME, Kaplan A, Zouein FA, Bratton D, Flynn ER, Cannon PL, Tian Y, Jin YF, Lange RA, Tokmina-Roszyk D, Fields GB, de Castro Brás LE.

J Am Coll Cardiol. 2015 Sep 22;66(12):1364-74. doi: 10.1016/j.jacc.2015.07.035.


Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.

Gibbings SL, Goyal R, Desch AN, Leach SM, Prabagar M, Atif SM, Bratton DL, Janssen W, Jakubzick CV.

Blood. 2015 Sep 10;126(11):1357-66. doi: 10.1182/blood-2015-01-624809. Epub 2015 Jul 31.


Comments on 'A modest proposal for dropping poor arms in clinical trials' by Proschan and Dodd.

Bratton DJ, Choodari-Oskooei B, Phillips PP, Sydes MR, Parmar MK.

Stat Med. 2015 Aug 15;34(18):2678-9. doi: 10.1002/sim.6337. No abstract available.


The impact of obstructive sleep apnoea on the aorta.

Gaisl T, Bratton DJ, Kohler M.

Eur Respir J. 2015 Aug;46(2):532-44. doi: 10.1183/09031936.00029315. Epub 2015 Jun 25. Review.


A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT.

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Davies RJ, Nunn AJ, Stradling JR, Riha RL, Morrell MJ.

Health Technol Assess. 2015 Jun;19(40):1-188. doi: 10.3310/hta19400.


Effect of CPAP on Cardiac Function in Minimally Symptomatic Patients with OSA: Results from a Subset of the MOSAIC Randomized Trial.

Craig S, Kylintireas I, Kohler M, Nicoll D, Bratton DJ, Nunn AJ, Leeson P, Neubauer S, Stradling JR.

J Clin Sleep Med. 2015 Sep 15;11(9):967-73. doi: 10.5664/jcsm.5004.


A randomized controlled trial to compare the safety and effectiveness of doxycycline (200 mg daily) with oral prednisolone (0.5 mg kg(-1) daily) for initial treatment of bullous pemphigoid: a protocol for the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) Trial.

Chalmers JR, Wojnarowska F, Kirtschig G, Nunn AJ, Bratton DJ, Mason J, Foster KA, Whitham D, Williams HC; BLISTER study group.

Br J Dermatol. 2015 Jul;173(1):227-34. doi: 10.1111/bjd.13729. Epub 2015 May 26.


Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease.

Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL.

J Allergy Clin Immunol. 2015 Feb;135(2):517-527.e12. doi: 10.1016/j.jaci.2014.10.034. Epub 2014 Dec 10.


Sleep apnoea in the elderly - authors' reply.

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Nunn AJ, Stradling JR, Riha RL, Morrell MJ.

Lancet Respir Med. 2014 Nov;2(11):e21-e22. doi: 10.1016/S2213-2600(14)70240-1. Epub 2014 Nov 3. No abstract available.


Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials.

Kahan BC, Cro S, Doré CJ, Bratton DJ, Rehal S, Maskell NA, Rahman N, Jairath V.

Trials. 2014 Nov 21;15:456. doi: 10.1186/1745-6215-15-456.


Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases.

Eltzschig HK, Bratton DL, Colgan SP.

Nat Rev Drug Discov. 2014 Nov;13(11):852-69. doi: 10.1038/nrd4422. Review.


P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9.

DeLeon-Pennell KY, de Castro Brás LE, Iyer RP, Bratton DR, Jin YF, Ripplinger CM, Lindsey ML.

J Mol Cell Cardiol. 2014 Nov;76:218-26. doi: 10.1016/j.yjmcc.2014.09.007. Epub 2014 Sep 18.

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