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Items: 1 to 50 of 228

1.

cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas.

Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C, Holland EC, Jenkins RB, Kleinschmidt-DeMasters B, Komori T, Kros JM, Louis DN, McLean C, Perry A, Reifenberger G, Sarkar C, Stupp R, van den Bent MJ, von Deimling A, Weller M.

Acta Neuropathol. 2020 Jan 29. doi: 10.1007/s00401-020-02127-9. [Epub ahead of print] No abstract available.

PMID:
31996992
2.

Longitudinal molecular trajectories of diffuse glioma in adults.

Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW; GLASS Consortium.

Nature. 2019 Dec;576(7785):112-120. doi: 10.1038/s41586-019-1775-1. Epub 2019 Nov 20.

PMID:
31748746
3.

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors.

Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D.

Oncoimmunology. 2019 Aug 22;8(11):e1655360. doi: 10.1080/2162402X.2019.1655360. eCollection 2019.

4.

Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion.

Logun MT, Wynens KE, Simchick G, Zhao W, Mao L, Zhao Q, Mukherjee S, Brat DJ, Karumbaiah L.

FASEB J. 2019 Nov;33(11):11973-11992. doi: 10.1096/fj.201802610RR. Epub 2019 Aug 9.

PMID:
31398290
5.

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients.

Horbinski C, Ligon KL, Brastianos P, Huse JT, Venere M, Chang S, Buckner J, Cloughesy T, Jenkins RB, Giannini C, Stupp R, Nabors LB, Wen PY, Aldape KJ, Lukas RV, Galanis E, Eberhart CG, Brat DJ, Sarkaria JN.

Neuro Oncol. 2019 Dec 17;21(12):1498-1508. doi: 10.1093/neuonc/noz119.

PMID:
31276167
6.

Data Sets for the Reporting of Tumors of the Central Nervous System: Recommendations From The International Collaboration on Cancer Reporting.

Louis DN, Wesseling P, Brandner S, Brat DJ, Ellison DW, Giangaspero F, Hattab EM, Hawkins C, Judge MJ, Kleinschmidt-DeMasters B, Komori T, McLean C, Paulus W, Perry A, Reifenberger G, Weller M, Rous B.

Arch Pathol Lab Med. 2020 Feb;144(2):196-206. doi: 10.5858/arpa.2018-0565-OA. Epub 2019 Jun 20.

PMID:
31219344
7.

cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.

Louis DN, Ellison DW, Brat DJ, Aldape K, Capper D, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, von Deimling A, Wesseling P.

Brain Pathol. 2019 Jul;29(4):469-472. doi: 10.1111/bpa.12732. Epub 2019 May 22.

PMID:
31038238
8.

What Every Neuropathologist Needs to Know: Update on cIMPACT-NOW.

Yeaney GA, Brat DJ.

J Neuropathol Exp Neurol. 2019 Apr 1;78(4):294-296. doi: 10.1093/jnen/nlz012.

PMID:
30830209
9.

Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease.

Voorhees JR, Remy MT, Erickson CM, Dutca LM, Brat DJ, Pieper AA.

NPJ Aging Mech Dis. 2019 Jan 22;5:3. doi: 10.1038/s41514-018-0033-3. eCollection 2019.

10.

Inhibition of breast cancer metastasis to the lungs with UBS109.

Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC.

Oncotarget. 2018 Nov 16;9(90):36102-36109. doi: 10.18632/oncotarget.26302. eCollection 2018 Nov 16.

11.

Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.

Chen AS, Wardwell-Ozgo J, Shah NN, Wright D, Appin CL, Vigneswaran K, Brat DJ, Kornblum HI, Read RD.

Cancer Res. 2019 Mar 15;79(6):1085-1097. doi: 10.1158/0008-5472.CAN-18-0482. Epub 2018 Dec 10.

PMID:
30530503
12.

Chordoma of the corpus callosum: case report.

Rinaldo L, Priemer DS, Vortmeyer AO, Cohen-Gadol AA, Brat DJ, Mahajan A, Giannini C, Burns TC.

J Neurosurg. 2018 Nov 1:1-7. doi: 10.3171/2018.6.JNS181028. [Epub ahead of print]

PMID:
30497142
13.

Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways.

Halani SH, Yousefi S, Velazquez Vega J, Rossi MR, Zhao Z, Amrollahi F, Holder CA, Baxter-Stoltzfus A, Eschbacher J, Griffith B, Olson JJ, Jiang T, Yates JR, Eberhart CG, Poisson LM, Cooper LAD, Brat DJ.

NPJ Precis Oncol. 2018 Nov 6;2:24. doi: 10.1038/s41698-018-0067-9. eCollection 2018.

14.

cIMPACT-NOW update 3: recommended diagnostic criteria for "Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV".

Brat DJ, Aldape K, Colman H, Holland EC, Louis DN, Jenkins RB, Kleinschmidt-DeMasters BK, Perry A, Reifenberger G, Stupp R, von Deimling A, Weller M.

Acta Neuropathol. 2018 Nov;136(5):805-810. doi: 10.1007/s00401-018-1913-0. Epub 2018 Sep 26. No abstract available.

15.

[18F]Fluciclovine PET discrimination between high- and low-grade gliomas.

Parent EE, Benayoun M, Ibeanu I, Olson JJ, Hadjipanayis CG, Brat DJ, Adhikarla V, Nye J, Schuster DM, Goodman MM.

EJNMMI Res. 2018 Jul 25;8(1):67. doi: 10.1186/s13550-018-0415-3.

16.

CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.

Mukherjee S, Tucker-Burden C, Kaissi E, Newsam A, Duggireddy H, Chau M, Zhang C, Diwedi B, Rupji M, Seby S, Kowalski J, Kong J, Read R, Brat DJ.

Cell Rep. 2018 May 8;23(6):1651-1664. doi: 10.1016/j.celrep.2018.04.016.

17.

TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.

Hou Y, Konen J, Brat DJ, Marcus AI, Cooper LAD.

Sci Rep. 2018 May 8;8(1):7248. doi: 10.1038/s41598-018-25337-4.

18.

Predicting cancer outcomes from histology and genomics using convolutional networks.

Mobadersany P, Yousefi S, Amgad M, Gutman DA, Barnholtz-Sloan JS, Velázquez Vega JE, Brat DJ, Cooper LAD.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2970-E2979. doi: 10.1073/pnas.1717139115. Epub 2018 Mar 12.

19.

Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.

Velázquez Vega JE, Brat DJ.

Adv Anat Pathol. 2018 May;25(3):143-171. doi: 10.1097/PAP.0000000000000186. Review.

PMID:
29521646
20.

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23;9(1):810. doi: 10.1038/s41467-018-02826-8.

21.

Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.

Chavez JA, Brat DJ, Hunter SB, Velazquez Vega J, Guarner J.

Am J Clin Pathol. 2018 Jan 29;149(2):98-104. doi: 10.1093/ajcp/aqx144. Review.

PMID:
29365030
22.

(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.

Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA.

Biol Psychiatry. 2018 Oct 1;84(7):488-498. doi: 10.1016/j.biopsych.2017.10.023. Epub 2017 Nov 6.

23.

5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins.

Ross JL, Cooper LAD, Kong J, Gutman D, Williams M, Tucker-Burden C, McCrary MR, Bouras A, Kaluzova M, Dunn WD Jr, Duong D, Hadjipanayis CG, Brat DJ.

Sci Rep. 2017 Nov 15;7(1):15593. doi: 10.1038/s41598-017-15849-w.

24.

Interactive phenotyping of large-scale histology imaging data with HistomicsML.

Nalisnik M, Amgad M, Lee S, Halani SH, Velazquez Vega JE, Brat DJ, Gutman DA, Cooper LAD.

Sci Rep. 2017 Nov 6;7(1):14588. doi: 10.1038/s41598-017-15092-3.

25.

Predicting clinical outcomes from large scale cancer genomic profiles with deep survival models.

Yousefi S, Amrollahi F, Amgad M, Dong C, Lewis JE, Song C, Gutman DA, Halani SH, Velazquez Vega JE, Brat DJ, Cooper LAD.

Sci Rep. 2017 Sep 15;7(1):11707. doi: 10.1038/s41598-017-11817-6.

26.

Progesterone improves neurocognitive outcomes following therapeutic cranial irradiation in mice.

Yousuf S, Brat DJ, Shu HK, Wang Y, Stein DG, Atif F.

Horm Behav. 2017 Nov;96:21-30. doi: 10.1016/j.yhbeh.2017.08.004. Epub 2017 Sep 18.

PMID:
28866326
27.

Meningioma With Tyrosine-Rich Crystalloids: A Case Report and Review of the Literature.

Reinertsen E, Neill SG, Nael K, Brat DJ, Hadjipanayis CG.

Int J Surg Pathol. 2018 Apr;26(2):157-160. doi: 10.1177/1066896917727100. Epub 2017 Aug 17. Review.

28.

Development of a Framework for Large Scale Three-Dimensional Pathology and Biomarker Imaging and Spatial Analytics.

Liang Y, Wang F, Zhang P, Saltz JH, Brat DJ, Kong J.

AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:75-84. eCollection 2017.

29.

DYNAMIC REGISTRATION FOR GIGAPIXEL SERIAL WHOLE SLIDE IMAGES.

Rossetti BJ, Wang F, Zhang P, Teodoro G, Brat DJ, Kong J.

Proc IEEE Int Symp Biomed Imaging. 2017 Apr;2017:424-428. doi: 10.1109/ISBI.2017.7950552. Epub 2017 Jun 19.

30.

T2-FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project.

Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, Thomas C, Franceschi AM, Griffith B, Flanders AE, Golfinos JG, Chi AS, Jain R.

Clin Cancer Res. 2017 Oct 15;23(20):6078-6085. doi: 10.1158/1078-0432.CCR-17-0560. Epub 2017 Jul 27.

31.

Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy.

Mukherjee S, Brat DJ.

Results Probl Cell Differ. 2017;61:401-421. doi: 10.1007/978-3-319-53150-2_18. Review.

PMID:
28409315
32.

Robust Cell Segmentation for Histological Images of Glioblastoma.

Kong J, Zhang P, Liang Y, Teodoro G, Brat DJ, Wang F.

Proc IEEE Int Symp Biomed Imaging. 2016 Apr;2016:1041-1045. doi: 10.1109/ISBI.2016.7493444. Epub 2016 Jun 16.

33.

Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.

Qi Q, Kang SS, Zhang S, Pham C, Fu H, Brat DJ, Ye K.

Oncogene. 2017 Aug 10;36(32):4562-4572. doi: 10.1038/onc.2017.67. Epub 2017 Apr 3.

34.

Chordoid glioma of the third ventricle: report of a rapidly progressive case.

Erwood AA, Velazquez-Vega JE, Neill S, Solomon DA, Butowski N, Nowlan A, Dunbar E, Brat DJ.

J Neurooncol. 2017 May;132(3):487-495. doi: 10.1007/s11060-017-2399-7. Epub 2017 Mar 18.

PMID:
28315998
35.

Genomic Analysis in the Practice of Surgical Neuropathology: The Emory Experience.

Neill SG, Saxe DF, Rossi MR, Schniederjan MJ, Brat DJ.

Arch Pathol Lab Med. 2017 Mar;141(3):355-365. doi: 10.5858/arpa.2016-0276-SAI. Review.

PMID:
28234572
36.

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.

Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ.

Mol Oncol. 2017 Mar;11(3):280-294. doi: 10.1002/1878-0261.12034. Epub 2017 Feb 15.

37.

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification.

Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Gregory Cairncross J, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A.

Brain Pathol. 2017 Nov;27(6):851-852. doi: 10.1111/bpa.12457. Epub 2016 Dec 20. No abstract available.

PMID:
27997995
38.

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy.

Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Cairncross JG, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A.

Acta Neuropathol. 2017 Jan;133(1):1-3. doi: 10.1007/s00401-016-1646-x. No abstract available.

39.

Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying).

Ostrom QT, Gittleman H, Kruchko C, Louis DN, Brat DJ, Gilbert MR, Petkov VI, Barnholtz-Sloan JS.

J Neurooncol. 2016 Oct;130(1):31-42. Epub 2016 Jul 14.

40.

EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.

Selagea L, Mishra A, Anand M, Ross J, Tucker-Burden C, Kong J, Brat DJ.

FASEB J. 2016 Dec;30(12):4098-4108. Epub 2016 Aug 29.

41.

Defining neoplastic diseases differently: An emerging paradigm from The Cancer Genome Atlas lower-grade gliomas project.

Halani SH, Brat DJ.

Mol Cell Oncol. 2015 Jul 29;3(2):e1074333. doi: 10.1080/23723556.2015.1074333. eCollection 2016 Mar.

42.

TNFRSF10C copy number variation is associated with metastatic colorectal cancer.

Tanenbaum DG, Hall WA, Colbert LE, Bastien AJ, Brat DJ, Kong J, Kim S, Dwivedi B, Kowalski J, Landry JC, Yu DS.

J Gastrointest Oncol. 2016 Jun;7(3):306-14. doi: 10.21037/jgo.2015.11.04.

43.

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

Lee AS, De Jesús-Cortés H, Kabir ZD, Knobbe W, Orr M, Burgdorf C, Huntington P, McDaniel L, Britt JK, Hoffmann F, Brat DJ, Rajadhyaksha AM, Pieper AA.

eNeuro. 2016 Mar 31;3(2). pii: ENEURO.0006-16.2016. doi: 10.1523/ENEURO.0006-16.2016. eCollection 2016 Mar-Apr.

44.

Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study.

Jakacki RI, Cohen KJ, Buxton A, Krailo MD, Burger PC, Rosenblum MK, Brat DJ, Hamilton RL, Eckel SP, Zhou T, Lavey RS, Pollack IF.

Neuro Oncol. 2016 Oct;18(10):1442-50. doi: 10.1093/neuonc/now038. Epub 2016 Mar 22.

45.

Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.

Mukherjee S, Tucker-Burden C, Zhang C, Moberg K, Read R, Hadjipanayis C, Brat DJ.

Cancer Res. 2016 Apr 15;76(8):2443-52. doi: 10.1158/0008-5472.CAN-15-2299. Epub 2016 Feb 18.

46.

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG.

Cell. 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028.

47.

Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment.

Zhang CM, Brat DJ.

Chin J Cancer. 2016 Jan 12;35:12. doi: 10.1186/s40880-015-0071-1.

48.

Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups.

Hinrichs BH, Newman S, Appin CL, Dunn W, Cooper L, Pauly R, Kowalski J, Rossi MR, Brat DJ.

Acta Neuropathol Commun. 2016 Jan 13;4:4. doi: 10.1186/s40478-015-0270-7.

49.

Assessing the Effects of Software Platforms on Volumetric Segmentation of Glioblastoma.

Dunn WD Jr, Aerts HJWL, Cooper LA, Holder CA, Hwang SN, Jaffe CC, Brat DJ, Jain R, Flanders AE, Zinn PO, Colen RR, Gutman DA.

J Neuroimaging Psychiatry Neurol. 2016;1(2):64-72. doi: 10.17756/jnpn.2016-008. Epub 2016 Jul 20.

50.

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.

Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ.

J Neurooncol. 2015 Dec;125(3):609-30. doi: 10.1007/s11060-015-1910-2. Epub 2015 Nov 3. Review.

PMID:
26530264

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