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Items: 1 to 50 of 257

1.

Surfen-mediated blockade of extratumoral chondroitin sulfate glycosaminoglycans inhibits glioblastoma invasion.

Logun MT, Wynens KE, Simchick G, Zhao W, Mao L, Zhao Q, Mukherjee S, Brat DJ, Karumbaiah L.

FASEB J. 2019 Aug 9:fj201802610RR. doi: 10.1096/fj.201802610RR. [Epub ahead of print]

PMID:
31398290
2.

The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients.

Horbinski C, Ligon KL, Brastianos P, Huse JT, Venere M, Chang S, Buckner J, Cloughesy T, Jenkins RB, Giannini C, Nabors LB, Wen PY, Aldape KJ, Lukas RV, Galanis E, Eberhart CG, Brat DJ, Sarkaria JN.

Neuro Oncol. 2019 Jul 4. pii: noz119. doi: 10.1093/neuonc/noz119. [Epub ahead of print]

PMID:
31276167
3.

Data Sets for the Reporting of Tumors of the Central Nervous System.

Louis DN, Wesseling P, Brandner S, Brat DJ, Ellison DW, Giangaspero F, Hattab EM, Hawkins C, Judge MJ, Kleinschmidt-DeMasters B, Komori T, McLean C, Paulus W, Perry A, Reifenberger G, Weller M, Rous B.

Arch Pathol Lab Med. 2019 Jun 20. doi: 10.5858/arpa.2018-0565-OA. [Epub ahead of print]

PMID:
31219344
4.

cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.

Louis DN, Ellison DW, Brat DJ, Aldape K, Capper D, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, von Deimling A, Wesseling P.

Brain Pathol. 2019 Jul;29(4):469-472. doi: 10.1111/bpa.12732. Epub 2019 May 22. Review.

PMID:
31038238
5.

Effective nuclei segmentation with sparse shape prior and dynamic occlusion constraint for glioblastoma pathology images.

Zhang P, Wang F, Teodoro G, Liang Y, Roy M, Brat D, Kong J.

J Med Imaging (Bellingham). 2019 Jan;6(1):017502. doi: 10.1117/1.JMI.6.1.017502. Epub 2019 Mar 14.

PMID:
30891467
6.

What Every Neuropathologist Needs to Know: Update on cIMPACT-NOW.

Yeaney GA, Brat DJ.

J Neuropathol Exp Neurol. 2019 Apr 1;78(4):294-296. doi: 10.1093/jnen/nlz012.

PMID:
30830209
7.

Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease.

Voorhees JR, Remy MT, Erickson CM, Dutca LM, Brat DJ, Pieper AA.

NPJ Aging Mech Dis. 2019 Jan 22;5:3. doi: 10.1038/s41514-018-0033-3. eCollection 2019.

8.

The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.

Fritchie K, Jensch K, Moskalev EA, Caron A, Jenkins S, Link M, Brown PD, Rodriguez FJ, Guajardo A, Brat D, Velázquez Vega JE, Perry A, Wu A, Raleigh DR, Santagata S, Louis DN, Brastianos PK, Kaplan A, Alexander BM, Rossi S, Ferrarese F, Haller F, Giannini C.

Acta Neuropathol. 2019 Feb;137(2):307-319. doi: 10.1007/s00401-018-1952-6. Epub 2018 Dec 24.

9.

Inhibition of breast cancer metastasis to the lungs with UBS109.

Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC.

Oncotarget. 2018 Nov 16;9(90):36102-36109. doi: 10.18632/oncotarget.26302. eCollection 2018 Nov 16.

10.

Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.

Chen AS, Wardwell-Ozgo J, Shah NN, Wright D, Appin CL, Vigneswaran K, Brat DJ, Kornblum HI, Read RD.

Cancer Res. 2019 Mar 15;79(6):1085-1097. doi: 10.1158/0008-5472.CAN-18-0482. Epub 2018 Dec 10.

PMID:
30530503
11.

Chordoma of the corpus callosum: case report.

Rinaldo L, Priemer DS, Vortmeyer AO, Cohen-Gadol AA, Brat DJ, Mahajan A, Giannini C, Burns TC.

J Neurosurg. 2018 Nov 1:1-7. doi: 10.3171/2018.6.JNS181028. [Epub ahead of print]

PMID:
30497142
12.

Analysis of Cellular Feature Differences of Astrocytomas with Distinct Mutational Profiles Using Digitized Histopathology Images.

Roy M, Wang F, Teodoro G, Vega JV, Brat D, Kong J.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4644-4647. doi: 10.1109/EMBC.2018.8513157.

PMID:
30441386
13.

Clumped Nuclei Segmentation with Adjacent Point Match and Local Shape-Based Intensity Analysis in Fluorescence Microscopy Images.

Guo X, Yu H, Rossetti B, Teodoro G, Brat D, Kong J.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:3410-3413. doi: 10.1109/EMBC.2018.8512961.

PMID:
30441120
14.

Multi-faceted computational assessment of risk and progression in oligodendroglioma implicates NOTCH and PI3K pathways.

Halani SH, Yousefi S, Velazquez Vega J, Rossi MR, Zhao Z, Amrollahi F, Holder CA, Baxter-Stoltzfus A, Eschbacher J, Griffith B, Olson JJ, Jiang T, Yates JR, Eberhart CG, Poisson LM, Cooper LAD, Brat DJ.

NPJ Precis Oncol. 2018 Nov 6;2:24. doi: 10.1038/s41698-018-0067-9. eCollection 2018.

15.

cIMPACT-NOW update 3: recommended diagnostic criteria for "Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV".

Brat DJ, Aldape K, Colman H, Holland EC, Louis DN, Jenkins RB, Kleinschmidt-DeMasters BK, Perry A, Reifenberger G, Stupp R, von Deimling A, Weller M.

Acta Neuropathol. 2018 Nov;136(5):805-810. doi: 10.1007/s00401-018-1913-0. Epub 2018 Sep 26. No abstract available.

PMID:
30259105
16.

A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.

Koehler JW, Miller AD, Miller CR, Porter B, Aldape K, Beck J, Brat D, Cornax I, Corps K, Frank C, Giannini C, Horbinski C, Huse JT, O'Sullivan MG, Rissi DR, Mark Simpson R, Woolard K, Shih JH, Mazcko C, Gilbert MR, LeBlanc AK.

J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1039-1054. doi: 10.1093/jnen/nly085.

17.

[18F]Fluciclovine PET discrimination between high- and low-grade gliomas.

Parent EE, Benayoun M, Ibeanu I, Olson JJ, Hadjipanayis CG, Brat DJ, Adhikarla V, Nye J, Schuster DM, Goodman MM.

EJNMMI Res. 2018 Jul 25;8(1):67. doi: 10.1186/s13550-018-0415-3.

18.

CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.

Mukherjee S, Tucker-Burden C, Kaissi E, Newsam A, Duggireddy H, Chau M, Zhang C, Diwedi B, Rupji M, Seby S, Kowalski J, Kong J, Read R, Brat DJ.

Cell Rep. 2018 May 8;23(6):1651-1664. doi: 10.1016/j.celrep.2018.04.016.

19.

TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.

Hou Y, Konen J, Brat DJ, Marcus AI, Cooper LAD.

Sci Rep. 2018 May 8;8(1):7248. doi: 10.1038/s41598-018-25337-4.

20.

Predicting cancer outcomes from histology and genomics using convolutional networks.

Mobadersany P, Yousefi S, Amgad M, Gutman DA, Barnholtz-Sloan JS, Velázquez Vega JE, Brat DJ, Cooper LAD.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2970-E2979. doi: 10.1073/pnas.1717139115. Epub 2018 Mar 12.

21.

Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics.

Velázquez Vega JE, Brat DJ.

Adv Anat Pathol. 2018 May;25(3):143-171. doi: 10.1097/PAP.0000000000000186. Review.

PMID:
29521646
22.

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23;9(1):810. doi: 10.1038/s41467-018-02826-8.

23.

Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.

Chavez JA, Brat DJ, Hunter SB, Velazquez Vega J, Guarner J.

Am J Clin Pathol. 2018 Jan 29;149(2):98-104. doi: 10.1093/ajcp/aqx144. Review.

PMID:
29365030
24.

(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.

Voorhees JR, Remy MT, Cintrón-Pérez CJ, El Rassi E, Khan MZ, Dutca LM, Yin TC, McDaniel LN, Williams NS, Brat DJ, Pieper AA.

Biol Psychiatry. 2018 Oct 1;84(7):488-498. doi: 10.1016/j.biopsych.2017.10.023. Epub 2017 Nov 6.

25.

5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins.

Ross JL, Cooper LAD, Kong J, Gutman D, Williams M, Tucker-Burden C, McCrary MR, Bouras A, Kaluzova M, Dunn WD Jr, Duong D, Hadjipanayis CG, Brat DJ.

Sci Rep. 2017 Nov 15;7(1):15593. doi: 10.1038/s41598-017-15849-w.

26.

Interactive phenotyping of large-scale histology imaging data with HistomicsML.

Nalisnik M, Amgad M, Lee S, Halani SH, Velazquez Vega JE, Brat DJ, Gutman DA, Cooper LAD.

Sci Rep. 2017 Nov 6;7(1):14588. doi: 10.1038/s41598-017-15092-3.

27.

Predicting clinical outcomes from large scale cancer genomic profiles with deep survival models.

Yousefi S, Amrollahi F, Amgad M, Dong C, Lewis JE, Song C, Gutman DA, Halani SH, Velazquez Vega JE, Brat DJ, Cooper LAD.

Sci Rep. 2017 Sep 15;7(1):11707. doi: 10.1038/s41598-017-11817-6.

28.

Progesterone improves neurocognitive outcomes following therapeutic cranial irradiation in mice.

Yousuf S, Brat DJ, Shu HK, Wang Y, Stein DG, Atif F.

Horm Behav. 2017 Nov;96:21-30. doi: 10.1016/j.yhbeh.2017.08.004. Epub 2017 Sep 18.

PMID:
28866326
29.

Meningioma With Tyrosine-Rich Crystalloids: A Case Report and Review of the Literature.

Reinertsen E, Neill SG, Nael K, Brat DJ, Hadjipanayis CG.

Int J Surg Pathol. 2018 Apr;26(2):157-160. doi: 10.1177/1066896917727100. Epub 2017 Aug 17. Review.

30.

Development of a Framework for Large Scale Three-Dimensional Pathology and Biomarker Imaging and Spatial Analytics.

Liang Y, Wang F, Zhang P, Saltz JH, Brat DJ, Kong J.

AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:75-84. eCollection 2017.

31.

DYNAMIC REGISTRATION FOR GIGAPIXEL SERIAL WHOLE SLIDE IMAGES.

Rossetti BJ, Wang F, Zhang P, Teodoro G, Brat DJ, Kong J.

Proc IEEE Int Symp Biomed Imaging. 2017 Apr;2017:424-428. doi: 10.1109/ISBI.2017.7950552. Epub 2017 Jun 19.

32.

AUTOMATED LEVEL SET SEGMENTATION OF HISTOPATHOLOGIC CELLS WITH SPARSE SHAPE PRIOR SUPPORT AND DYNAMIC OCCLUSION CONSTRAINT.

Zhang P, Wang F, Teodoro G, Liang Y, Brat D, Kong J.

Proc IEEE Int Symp Biomed Imaging. 2017 Apr;2017:718-722. doi: 10.1109/ISBI.2017.7950620. Epub 2017 Jun 19.

33.

T2-FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-grade Gliomas: A TCGA/TCIA Project.

Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, Thomas C, Franceschi AM, Griffith B, Flanders AE, Golfinos JG, Chi AS, Jain R.

Clin Cancer Res. 2017 Oct 15;23(20):6078-6085. doi: 10.1158/1078-0432.CCR-17-0560. Epub 2017 Jul 27.

34.

Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy.

Mukherjee S, Brat DJ.

Results Probl Cell Differ. 2017;61:401-421. doi: 10.1007/978-3-319-53150-2_18. Review.

PMID:
28409315
35.

Robust Cell Segmentation for Histological Images of Glioblastoma.

Kong J, Zhang P, Liang Y, Teodoro G, Brat DJ, Wang F.

Proc IEEE Int Symp Biomed Imaging. 2016 Apr;2016:1041-1045. doi: 10.1109/ISBI.2016.7493444. Epub 2016 Jun 16.

36.

Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.

Qi Q, Kang SS, Zhang S, Pham C, Fu H, Brat DJ, Ye K.

Oncogene. 2017 Aug 10;36(32):4562-4572. doi: 10.1038/onc.2017.67. Epub 2017 Apr 3.

37.

Chordoid glioma of the third ventricle: report of a rapidly progressive case.

Erwood AA, Velazquez-Vega JE, Neill S, Solomon DA, Butowski N, Nowlan A, Dunbar E, Brat DJ.

J Neurooncol. 2017 May;132(3):487-495. doi: 10.1007/s11060-017-2399-7. Epub 2017 Mar 18.

PMID:
28315998
38.

Genomic Analysis in the Practice of Surgical Neuropathology: The Emory Experience.

Neill SG, Saxe DF, Rossi MR, Schniederjan MJ, Brat DJ.

Arch Pathol Lab Med. 2017 Mar;141(3):355-365. doi: 10.5858/arpa.2016-0276-SAI. Review.

PMID:
28234572
39.

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.

Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ.

Mol Oncol. 2017 Mar;11(3):280-294. doi: 10.1002/1878-0261.12034. Epub 2017 Feb 15.

40.

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification.

Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Gregory Cairncross J, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A.

Brain Pathol. 2017 Nov;27(6):851-852. doi: 10.1111/bpa.12457. Epub 2016 Dec 20. No abstract available.

PMID:
27997995
41.

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy.

Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor TT, Cairncross JG, Pfister SM, Rutkowski S, Weller M, Wick W, von Deimling A.

Acta Neuropathol. 2017 Jan;133(1):1-3. doi: 10.1007/s00401-016-1646-x. No abstract available.

42.

Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying).

Ostrom QT, Gittleman H, Kruchko C, Louis DN, Brat DJ, Gilbert MR, Petkov VI, Barnholtz-Sloan JS.

J Neurooncol. 2016 Oct;130(1):31-42. Epub 2016 Jul 14.

43.

EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.

Selagea L, Mishra A, Anand M, Ross J, Tucker-Burden C, Kong J, Brat DJ.

FASEB J. 2016 Dec;30(12):4098-4108. Epub 2016 Aug 29.

44.

Defining neoplastic diseases differently: An emerging paradigm from The Cancer Genome Atlas lower-grade gliomas project.

Halani SH, Brat DJ.

Mol Cell Oncol. 2015 Jul 29;3(2):e1074333. doi: 10.1080/23723556.2015.1074333. eCollection 2016 Mar.

45.

TNFRSF10C copy number variation is associated with metastatic colorectal cancer.

Tanenbaum DG, Hall WA, Colbert LE, Bastien AJ, Brat DJ, Kong J, Kim S, Dwivedi B, Kowalski J, Landry JC, Yu DS.

J Gastrointest Oncol. 2016 Jun;7(3):306-14. doi: 10.21037/jgo.2015.11.04.

46.

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

Lee AS, De Jesús-Cortés H, Kabir ZD, Knobbe W, Orr M, Burgdorf C, Huntington P, McDaniel L, Britt JK, Hoffmann F, Brat DJ, Rajadhyaksha AM, Pieper AA.

eNeuro. 2016 Mar 31;3(2). pii: ENEURO.0006-16.2016. doi: 10.1523/ENEURO.0006-16.2016. eCollection 2016 Mar-Apr.

47.

Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227.

Glass J, Won M, Schultz CJ, Brat D, Bartlett NL, Suh JH, Werner-Wasik M, Fisher BJ, Liepman MK, Augspurger M, Bokstein F, Bovi JA, Solhjem MC, Mehta MP.

J Clin Oncol. 2016 May 10;34(14):1620-5. doi: 10.1200/JCO.2015.64.8634. Epub 2016 Mar 28.

48.

Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study.

Jakacki RI, Cohen KJ, Buxton A, Krailo MD, Burger PC, Rosenblum MK, Brat DJ, Hamilton RL, Eckel SP, Zhou T, Lavey RS, Pollack IF.

Neuro Oncol. 2016 Oct;18(10):1442-50. doi: 10.1093/neuonc/now038. Epub 2016 Mar 22.

49.

Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.

Mukherjee S, Tucker-Burden C, Zhang C, Moberg K, Read R, Hadjipanayis C, Brat DJ.

Cancer Res. 2016 Apr 15;76(8):2443-52. doi: 10.1158/0008-5472.CAN-15-2299. Epub 2016 Feb 18.

50.

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network, Noushmehr H, Iavarone A, Verhaak RG.

Cell. 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028.

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