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Items: 1 to 50 of 179


Correction: Increased Levels of Plasma Soluble Sema4D in Patients with Heart Failure.

Lu Q, Dong N, Wang Q, Yi W, Wang Y, Zhang S, Gu H, Zhao X, Tang X, Jin B, Wu Q, Brass LF, Zhu L.

PLoS One. 2019 Mar 28;14(3):e0214894. doi: 10.1371/journal.pone.0214894. eCollection 2019.


Interrelationships between structure and function during the hemostatic response to injury.

Tomaiuolo M, Matzko CN, Poventud-Fuentes I, Weisel JW, Brass LF, Stalker TJ.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2243-2252. doi: 10.1073/pnas.1813642116. Epub 2019 Jan 23.


Training the physician-scientist: views from program directors and aspiring young investigators.

Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M.

JCI Insight. 2018 Dec 6;3(23). pii: 125651. doi: 10.1172/jci.insight.125651.


RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists.

Ma P, Gupta S, Sampietro S, DeHelian D, Tutwiler V, Tang A, Stalker TJ, Brass LF.

Blood Adv. 2018 Aug 28;2(16):2145-2155. doi: 10.1182/bloodadvances.2017008508.


Joining forces to understand hemostasis and thrombosis: A call to communicate: Comment on "Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones" by A.V. Belyaev et al.

Tomaiuolo M, Brass LF.

Phys Life Rev. 2018 Nov;26-27:110-112. doi: 10.1016/j.plrev.2018.06.019. Epub 2018 Jul 2. No abstract available.


Is an MD/PhD program right for me? Advice on becoming a physician-scientist.

Brass LF.

Mol Biol Cell. 2018 Apr 15;29(8):881-885. doi: 10.1091/mbc.E17-12-0721.


Platelet packing density is an independent regulator of the hemostatic response to injury.

Mirramezani M, Herbig BA, Stalker TJ, Nettey L, Cooper M, Weisel JW, Diamond SL, Sinno T, Brass LF, Shadden SC, Tomaiuolo M.

J Thromb Haemost. 2018 May;16(5):973-983. doi: 10.1111/jth.13986. Epub 2018 Apr 2.


Coordination of platelet agonist signaling during the hemostatic response in vivo.

Shen J, Sampietro S, Wu J, Tang J, Gupta S, Matzko CN, Tang C, Yu Y, Brass LF, Zhu L, Stalker TJ.

Blood Adv. 2017 Dec 21;1(27):2767-2775. doi: 10.1182/bloodadvances.2017009498. eCollection 2017 Dec 26.


The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.

Branchford BR, Stalker TJ, Law L, Acevedo G, Sather S, Brzezinski C, Wilson KM, Minson K, Lee-Sherick AB, Davizon-Castillo P, Ng C, Zhang W, Neeves KB, Lentz SR, Wang X, Frye SV, Shelton Earp H 3rd, DeRyckere D, Brass LF, Graham DK, Di Paola JA.

J Thromb Haemost. 2018 Feb;16(2):352-363. doi: 10.1111/jth.13875. Epub 2018 Jan 12.


Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.

Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H.

Sci Rep. 2017 Jun 27;7(1):4275. doi: 10.1038/s41598-017-04494-y.


Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature.

Welsh JD, Poventud-Fuentes I, Sampietro S, Diamond SL, Stalker TJ, Brass LF.

J Thromb Haemost. 2017 Mar;15(3):526-537. doi: 10.1111/jth.13600. Epub 2017 Feb 6.


Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis.

Tomaiuolo M, Brass LF, Stalker TJ.

Interv Cardiol Clin. 2017 Jan;6(1):1-12. doi: 10.1016/j.iccl.2016.08.001. Review.


Platelets and hemostasis: a new perspective on an old subject.

Brass LF, Diamond SL, Stalker TJ.

Blood Adv. 2016 Nov 22;1(1):5-9. doi: 10.1182/bloodadvances.2016000059. eCollection 2016 Nov 29.


The regulation of Sema4D exodomain shedding by protein kinase A in platelets.

Chen T, Xu DZ, Li Q, Mou P, Zeng Z, Brass LF, Zhu L.

Platelets. 2016 Nov;27(7):673-679. Epub 2016 Apr 11.


Transport physics and biorheology in the setting of hemostasis and thrombosis.

Brass LF, Diamond SL.

J Thromb Haemost. 2016 May;14(5):906-17. doi: 10.1111/jth.13280. Epub 2016 Mar 30. Review.


A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.

Welsh JD, Muthard RW, Stalker TJ, Taliaferro JP, Diamond SL, Brass LF.

Blood. 2016 Mar 24;127(12):1598-605. doi: 10.1182/blood-2015-09-672188. Epub 2016 Jan 6.


Platelet-targeting thiol reduction sensor detects thiol isomerase activity on activated platelets in mouse and human blood under flow.

Zhu S, Welsh JD, Brass LF, Diamond SL.

J Thromb Haemost. 2016 May;14(5):1070-81. doi: 10.1111/jth.13245. Epub 2016 Mar 7.


Rescuing the physician-scientist workforce: the time for action is now.

Milewicz DM, Lorenz RG, Dermody TS, Brass LF; National Association of MD-PhD Programs Executive Committee.

J Clin Invest. 2015 Oct 1;125(10):3742-7. doi: 10.1172/JCI84170. Epub 2015 Oct 1.


Modulating platelet reactivity through control of RGS18 availability.

Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF.

Blood. 2015 Dec 10;126(24):2611-20. doi: 10.1182/blood-2015-04-640037. Epub 2015 Sep 25.


Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).

Ma P, Foote DC, Sinnamon AJ, Brass LF.

PLoS One. 2015 Mar 18;10(3):e0119496. doi: 10.1371/journal.pone.0119496. eCollection 2015.


Fibrin, γ'-fibrinogen, and transclot pressure gradient control hemostatic clot growth during human blood flow over a collagen/tissue factor wound.

Muthard RW, Welsh JD, Brass LF, Diamond SL.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):645-54. doi: 10.1161/ATVBAHA.114.305054. Epub 2015 Jan 22.


Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.

Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS.

Blood. 2015 Mar 5;125(10):1623-32. doi: 10.1182/blood-2014-07-586727. Epub 2014 Dec 4.


Shaping the platelet response to vascular injury.

Stalker TJ, Welsh JD, Brass LF.

Curr Opin Hematol. 2014 Sep;21(5):410-7. doi: 10.1097/MOH.0000000000000070. Review.


A closer look at attrition in MD-PhD programs.

Akabas MH, Brass LF.

Acad Med. 2014 Jul;89(7):958. doi: 10.1097/ACM.0000000000000299. No abstract available.


A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity.

Stalker TJ, Welsh JD, Tomaiuolo M, Wu J, Colace TV, Diamond SL, Brass LF.

Blood. 2014 Sep 11;124(11):1824-31. doi: 10.1182/blood-2014-01-550319. Epub 2014 Jun 20.


A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.

Tomaiuolo M, Stalker TJ, Welsh JD, Diamond SL, Sinno T, Brass LF.

Blood. 2014 Sep 11;124(11):1816-23. doi: 10.1182/blood-2014-01-550343. Epub 2014 Jun 20.


A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.

Welsh JD, Stalker TJ, Voronov R, Muthard RW, Tomaiuolo M, Diamond SL, Brass LF.

Blood. 2014 Sep 11;124(11):1808-15. doi: 10.1182/blood-2014-01-550335. Epub 2014 Jun 20.


An expanded role for semaphorin 4D in platelets includes contact-dependent amplification of Clec-2 signaling.

Wannemacher KM, Jiang H, Hess PR, Shin Y, Suzuki-Inoue K, Brass LF.

J Thromb Haemost. 2013 Dec;11(12):2190-3. doi: 10.1111/jth.12428. No abstract available.


Increased levels of plasma soluble Sema4D in patients with heart failure.

Lu Q, Dong N, Wang Q, Yi W, Wang Y, Zhang S, Gu H, Zhao X, Tang X, Jin B, Wu Q, Brass LF, Zhu L.

PLoS One. 2013 May 31;8(5):e64265. doi: 10.1371/journal.pone.0064265. Print 2013. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214894.


Harnessing the platelet signaling network to produce an optimal hemostatic response.

Brass LF, Tomaiuolo M, Stalker TJ.

Hematol Oncol Clin North Am. 2013 Jun;27(3):381-409. doi: 10.1016/j.hoc.2013.02.002. Epub 2013 Apr 11. Review.


Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.

Mou P, Zeng Z, Li Q, Liu X, Xin X, Wannemacher KM, Ruan C, Li R, Brass LF, Zhu L.

Blood. 2013 May 16;121(20):4221-30. doi: 10.1182/blood-2012-11-470609. Epub 2013 Apr 5.


Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.

Voronov RS, Stalker TJ, Brass LF, Diamond SL.

Ann Biomed Eng. 2013 Jun;41(6):1297-307. doi: 10.1007/s10439-013-0764-z. Epub 2013 Feb 20.


Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network.

Stalker TJ, Traxler EA, Wu J, Wannemacher KM, Cermignano SL, Voronov R, Diamond SL, Brass LF.

Blood. 2013 Mar 7;121(10):1875-85. doi: 10.1182/blood-2012-09-457739. Epub 2013 Jan 9.


Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse.

Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL.

J Thromb Haemost. 2012 Nov;10(11):2344-53. doi: 10.1111/j.1538-7836.2012.04928.x.


Platelet signaling.

Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LF.

Handb Exp Pharmacol. 2012;(210):59-85. doi: 10.1007/978-3-642-29423-5_3. Review.


Minding the gaps--and the junctions, too.

Brass LF, Stalker TJ.

Circulation. 2012 May 22;125(20):2414-6. doi: 10.1161/CIRCULATIONAHA.112.106377. Epub 2012 Apr 23. No abstract available.


Multiscale prediction of patient-specific platelet function under flow.

Flamm MH, Colace TV, Chatterjee MS, Jing H, Zhou S, Jaeger D, Brass LF, Sinno T, Diamond SL.

Blood. 2012 Jul 5;120(1):190-8. doi: 10.1182/blood-2011-10-388140. Epub 2012 Apr 18.


Applying the brakes to platelet activation.

Brass LF, Ma P.

Blood. 2012 Apr 19;119(16):3651-2. doi: 10.1182/blood-2012-02-406629. No abstract available.


Differential dynamics of platelet contact and spreading.

Lee D, Fong KP, King MR, Brass LF, Hammer DA.

Biophys J. 2012 Feb 8;102(3):472-82. doi: 10.1016/j.bpj.2011.10.056. Epub 2012 Feb 7.


JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

Naik MU, Stalker TJ, Brass LF, Naik UP.

Blood. 2012 Apr 5;119(14):3352-60. doi: 10.1182/blood-2011-12-397398. Epub 2012 Jan 23.


A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF.

Blood. 2012 Feb 23;119(8):1935-45. doi: 10.1182/blood-2011-10-387910. Epub 2011 Dec 30.


Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease.

Schmaier AA, Stalker TJ, Runge JJ, Lee D, Nagaswami C, Mericko P, Chen M, Cliché S, Gariépy C, Brass LF, Hammer DA, Weisel JW, Rosenthal K, Kahn ML.

Blood. 2011 Sep 29;118(13):3661-9. doi: 10.1182/blood-2011-02-338244. Epub 2011 Aug 3.


Regulating thrombus growth and stability to achieve an optimal response to injury.

Brass LF, Wannemacher KM, Ma P, Stalker TJ.

J Thromb Haemost. 2011 Jul;9 Suppl 1:66-75. doi: 10.1111/j.1538-7836.2011.04364.x. Review.


The role of semaphorins and their receptors in platelets: Lessons learned from neuronal and immune synapses.

Wannemacher KM, Wang L, Zhu L, Brass LF.

Platelets. 2011;22(6):461-5. doi: 10.3109/09537104.2011.561891. Epub 2011 Jun 13. Review.


Collagen surfaces to measure thrombus formation under flow: possibilities for standardization.

Heemskerk JW, Sakariassen KS, Zwaginga JJ, Brass LF, Jackson SP, Farndale RW; Biorheology Subcommittee of the SSC of the ISTH.

J Thromb Haemost. 2011 Apr;9(4):856-8. No abstract available.


Towards standardization of in vivo thrombosis studies in mice.

Denis CV, Dubois C, Brass LF, Heemskerk JW, Lenting PJ; Biorheology Subcommittee of the SSC of the ISTH.

J Thromb Haemost. 2011 Aug;9(8):1641-4. doi: 10.1111/j.1538-7836.2011.04350.x. No abstract available.


Deciphering the human platelet sheddome.

Fong KP, Barry C, Tran AN, Traxler EA, Wannemacher KM, Tang HY, Speicher KD, Blair IA, Speicher DW, Grosser T, Brass LF.

Blood. 2011 Jan 6;117(1):e15-26. doi: 10.1182/blood-2010-05-283838. Epub 2010 Oct 20.


Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

Wannemacher KM, Zhu L, Jiang H, Fong KP, Stalker TJ, Lee D, Tran AN, Neeves KB, Maloney S, Kumanogoh A, Kikutani H, Hammer DA, Diamond SL, Brass LF.

Blood. 2010 Dec 16;116(25):5707-15. doi: 10.1182/blood-2010-04-279943. Epub 2010 Sep 20.


RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury.

Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF.

Blood. 2010 Dec 23;116(26):6092-100. doi: 10.1182/blood-2010-05-283846. Epub 2010 Sep 17.


Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli.

Chatterjee MS, Purvis JE, Brass LF, Diamond SL.

Nat Biotechnol. 2010 Jul;28(7):727-32. doi: 10.1038/nbt.1642. Epub 2010 Jun 20.

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