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Items: 42

1.

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN.

Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30.

PMID:
30173955
2.

CRISPR genetic screens to discover host-virus interactions.

McDougall WM, Perreira JM, Reynolds EC, Brass AL.

Curr Opin Virol. 2018 Apr;29:87-100. doi: 10.1016/j.coviro.2018.03.007. Review.

PMID:
29684735
3.

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G.

PLoS Comput Biol. 2018 Apr 20;14(4):e1006093. doi: 10.1371/journal.pcbi.1006093. eCollection 2018 Apr.

4.

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M.

Nature. 2016 Oct 20;538(7625):350-355. doi: 10.1038/nature19799. Epub 2016 Sep 28.

5.

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL.

Cell Rep. 2016 Jun 28;16(1):232-246. doi: 10.1016/j.celrep.2016.06.028. Epub 2016 Jun 21.

6.

The IFITMs Inhibit Zika Virus Replication.

Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL.

Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3.

7.

Functional Genomic Strategies for Elucidating Human-Virus Interactions: Will CRISPR Knockout RNAi and Haploid Cells?

Perreira JM, Meraner P, Brass AL.

Adv Virus Res. 2016;94:1-51. doi: 10.1016/bs.aivir.2015.11.001. Epub 2016 Mar 2. Review.

PMID:
26997589
8.

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration.

Chin CR, Perreira JM, Savidis G, Portmann JM, Aker AM, Feeley EM, Smith MC, Brass AL.

Cell Rep. 2015 Nov 24;13(8):1717-31. doi: 10.1016/j.celrep.2015.10.036. Epub 2015 Nov 12.

9.

RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus.

Perreira JM, Aker AM, Savidis G, Chin CR, McDougall WM, Portmann JM, Meraner P, Smith MC, Rahman M, Baker RE, Gauthier A, Franti M, Brass AL.

Cell Rep. 2015 Aug 4;12(5):850-63. doi: 10.1016/j.celrep.2015.06.076. Epub 2015 Jul 23.

10.

Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.

Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, Kaufmann DE, Lichterfeld M, Brass AL, Walker BD.

Immunity. 2014 Dec 18;41(6):1001-12. doi: 10.1016/j.immuni.2014.12.011. Epub 2014 Dec 8.

11.

Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL.

Cell Rep. 2014 Oct 23;9(2):752-66. doi: 10.1016/j.celrep.2014.09.031. Epub 2014 Oct 16.

12.

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.

Desai TM, Marin M, Chin CR, Savidis G, Brass AL, Melikyan GB.

PLoS Pathog. 2014 Apr 3;10(4):e1004048. doi: 10.1371/journal.ppat.1004048. eCollection 2014 Apr.

13.

Immunology. The fiery side of HIV-induced T cell death.

Gaiha GD, Brass AL.

Science. 2014 Jan 24;343(6169):383-4. doi: 10.1126/science.1250175. No abstract available.

PMID:
24458634
14.

A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.

E X, Savidis G, Chin CR, Wang S, Lu S, Brass AL, Kowalik TF.

J Virol. 2014 Feb;88(4):2279-90. doi: 10.1128/JVI.03423-13. Epub 2013 Dec 11.

15.

Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction.

Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL.

Cell Rep. 2013 Nov 27;5(4):895-908. doi: 10.1016/j.celrep.2013.10.033. Epub 2013 Nov 21.

16.

IFITMs restrict the replication of multiple pathogenic viruses.

Perreira JM, Chin CR, Feeley EM, Brass AL.

J Mol Biol. 2013 Dec 13;425(24):4937-55. doi: 10.1016/j.jmb.2013.09.024. Epub 2013 Sep 25. Review.

17.

Host genetic determinants of influenza pathogenicity.

Lin TY, Brass AL.

Curr Opin Virol. 2013 Oct;3(5):531-6. doi: 10.1016/j.coviro.2013.07.005. Epub 2013 Aug 8. Review.

18.

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.

John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL.

J Virol. 2013 Jul;87(14):7837-52. doi: 10.1128/JVI.00481-13. Epub 2013 May 8.

19.

Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry.

Anafu AA, Bowen CH, Chin CR, Brass AL, Holm GH.

J Biol Chem. 2013 Jun 14;288(24):17261-71. doi: 10.1074/jbc.M112.438515. Epub 2013 May 6.

20.

A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication.

Fusco DN, Brisac C, John SP, Huang YW, Chin CR, Xie T, Zhao H, Jilg N, Zhang L, Chevaliez S, Wambua D, Lin W, Peng L, Chung RT, Brass AL.

Gastroenterology. 2013 Jun;144(7):1438-49, 1449.e1-9. doi: 10.1053/j.gastro.2013.02.026. Epub 2013 Feb 24.

21.

Host-pathogen interactions of retroviruses.

Waheed AA, Brass AL, Gummuluru S, Tachedjian G.

Mol Biol Int. 2012;2012:648512. doi: 10.1155/2012/648512. Epub 2012 Oct 24. No abstract available.

22.

Reactivation of latent HIV-1 by inhibition of BRD4.

Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL.

Cell Rep. 2012 Oct 25;2(4):807-16. doi: 10.1016/j.celrep.2012.09.008. Epub 2012 Oct 4.

23.

A genome wide RNA interference screening method to identify host factors that modulate influenza A virus replication.

Chin CR, Brass AL.

Methods. 2013 Feb;59(2):217-24. doi: 10.1016/j.ymeth.2012.09.009. Epub 2012 Oct 2.

24.

Enhanced Tim3 activity improves survival after influenza infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD.

J Immunol. 2012 Sep 15;189(6):2879-89. doi: 10.4049/jimmunol.1102483. Epub 2012 Aug 8.

25.

IFITM3 restricts the morbidity and mortality associated with influenza.

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P.

Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921.

26.

TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.

Valle-Casuso JC, Di Nunzio F, Yang Y, Reszka N, Lienlaf M, Arhel N, Perez P, Brass AL, Diaz-Griffero F.

J Virol. 2012 May;86(10):5931-6. doi: 10.1128/JVI.00451-12. Epub 2012 Mar 7.

27.

HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.

Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, Ranasinghe S, Lindqvist M, Davis I, Lane K, Rychert J, Rosenberg ES, Piechocka-Trocha A, Brass AL, Brenchley JM, Walker BD, Streeck H.

Sci Transl Med. 2012 Feb 29;4(123):123ra25. doi: 10.1126/scitranslmed.3003165.

28.

IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.

Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL.

PLoS Pathog. 2011 Oct;7(10):e1002337. doi: 10.1371/journal.ppat.1002337. Epub 2011 Oct 27.

29.

Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers.

Buzon MJ, Seiss K, Weiss R, Brass AL, Rosenberg ES, Pereyra F, Yu XG, Lichterfeld M.

J Virol. 2011 Sep;85(18):9646-50. doi: 10.1128/JVI.05327-11. Epub 2011 Jul 6.

30.

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21.

Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.

J Clin Invest. 2011 Apr;121(4):1549-60. doi: 10.1172/JCI44539. Epub 2011 Mar 14.

31.

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M.

PLoS Pathog. 2011 Jan 6;7(1):e1001258. doi: 10.1371/journal.ppat.1001258.

32.

Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.

Singh R, Gaiha G, Werner L, McKim K, Mlisana K, Luban J, Walker BD, Karim SS, Brass AL, Ndung'u T; CAPRISA Acute Infection Study Team.

J Virol. 2011 Jan;85(1):208-16. doi: 10.1128/JVI.01810-10. Epub 2010 Oct 27.

33.

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ.

Cell. 2009 Dec 24;139(7):1243-54. doi: 10.1016/j.cell.2009.12.017.

34.

A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16410-5. doi: 10.1073/pnas.0907439106. Epub 2009 Aug 27.

35.

A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.

Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):163-8. doi: 10.1073/pnas.0811631106. Epub 2008 Dec 24.

36.

RNA interference screen for human genes associated with West Nile virus infection.

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E.

Nature. 2008 Sep 11;455(7210):242-5. doi: 10.1038/nature07207.

37.

Identification of host proteins required for HIV infection through a functional genomic screen.

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ.

Science. 2008 Feb 15;319(5865):921-6. doi: 10.1126/science.1152725. Epub 2008 Jan 10.

38.

Crystal structure of PU.1/IRF-4/DNA ternary complex.

Escalante CR, Brass AL, Pongubala JM, Shatova E, Shen L, Singh H, Aggarwal AK.

Mol Cell. 2002 Nov;10(5):1097-105.

39.

Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.

Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK.

J Struct Biol. 2002 Jul;139(1):55-9.

PMID:
12372320
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