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Items: 1 to 50 of 242

1.

Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.

Zhao Y, Fang R, Zhang J, Zhang Y, Bechelli J, Smalley C, Valbuena G, Walker DH, Oteo JA, Brasier AR.

Am J Pathol. 2020 Feb;190(2):306-322. doi: 10.1016/j.ajpath.2019.10.007. Epub 2020 Jan 16.

PMID:
31955791
2.

Uronic acid pathway metabolites regulate mesenchymal transition and invasiveness in lung adenocarcinoma.

Zhao Y, Brasier AR.

Biotarget. 2019 Oct;3. pii: 19. doi: 10.21037/biotarget.2019.09.01. Epub 2019 Oct 12. No abstract available.

3.

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling.

Brasier AR, Zhou J.

Drug Discov Today. 2020 Jan;25(1):126-132. doi: 10.1016/j.drudis.2019.11.002. Epub 2019 Nov 13. Review.

PMID:
31733396
4.

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling.

Brasier AR, Boldogh I.

Drugs Context. 2019 Oct 23;8. pii: 2019-8-3. doi: 10.7573/dic.2019-8-3. eCollection 2019. Review.

5.

Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production.

Zhang J, Jamaluddin M, Zhang Y, Widen SG, Sun H, Brasier AR, Zhao Y.

J Proteome Res. 2019 Sep 6;18(9):3447-3460. doi: 10.1021/acs.jproteome.9b00342. Epub 2019 Aug 28.

PMID:
31424945
6.

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.

Zhao Y, Tian B, Sun H, Zhang J, Zhang Y, Ivannikov M, Motamedi M, Liu Z, Zhou J, Kaphalia L, Calhoun WJ, Maroto R, Brasier AR.

J Proteomics. 2019 Aug 15;205:103415. doi: 10.1016/j.jprot.2019.103415. Epub 2019 Jun 10.

PMID:
31195152
7.

Mechanisms how mucosal innate immunity affects progression of allergic airway disease.

Brasier AR.

Expert Rev Respir Med. 2019 Apr;13(4):349-356. doi: 10.1080/17476348.2019.1578211. Epub 2019 Feb 13.

PMID:
30712413
8.

PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome.

McDonnell TCR, Willis R, Pericleous C, Ripoll VM, Giles IP, Isenberg DA, Brasier AR, Gonzalez EB, Papalardo E, Romay-Penabad Z, Jamaluddin M, Ioannou Y, Rahman A.

Front Immunol. 2018 Oct 22;9:2413. doi: 10.3389/fimmu.2018.02413. eCollection 2018.

9.

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling.

Tian B, Hosoki K, Liu Z, Yang J, Zhao Y, Sun H, Zhou J, Rytting E, Kaphalia L, Calhoun WJ, Sur S, Brasier AR.

J Allergy Clin Immunol. 2019 Apr;143(4):1380-1394.e9. doi: 10.1016/j.jaci.2018.09.029. Epub 2018 Oct 13.

PMID:
30321559
10.

Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation.

Rayavara K, Kurosky A, Stafford SJ, Garg NJ, Brasier AR, Garofalo RP, Hosakote YM.

J Immunol. 2018 Nov 1;201(9):2753-2766. doi: 10.4049/jimmunol.1800558. Epub 2018 Oct 1.

11.

Therapeutic targets for inflammation-mediated airway remodeling in chronic lung disease.

Brasier AR.

Expert Rev Respir Med. 2018 Nov;12(11):931-939. doi: 10.1080/17476348.2018.1526677. Epub 2018 Oct 3. Review.

12.

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing.

Ochoa LF, Kholodnykh A, Villarreal P, Tian B, Pal R, Freiberg AN, Brasier AR, Motamedi M, Vargas G.

Sci Rep. 2018 Sep 6;8(1):13348. doi: 10.1038/s41598-018-31182-2.

13.

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells.

Tian B, Widen SG, Yang J, Wood TG, Kudlicki A, Zhao Y, Brasier AR.

J Biol Chem. 2018 Oct 19;293(42):16528-16545. doi: 10.1074/jbc.RA118.003662. Epub 2018 Aug 30.

14.

Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling.

Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, Patrikeev I, Ochoa L, Vargas G, Motamedi M, Ameredes BT, Zhou J, Brasier AR.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):68-83. doi: 10.1165/rcmb.2017-0445OC.

15.

Insights Into the Role of Regional Proteoglycan Metabolism in Thoracic Aortic Aneurysms.

Brasier AR.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1425-1426. doi: 10.1161/ATVBAHA.118.311120. No abstract available.

16.

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA.

Hao W, Qi T, Pan L, Wang R, Zhu B, Aguilera-Aguirre L, Radak Z, Hazra TK, Vlahopoulos SA, Bacsi A, Brasier AR, Ba X, Boldogh I.

Redox Biol. 2018 Sep;18:43-53. doi: 10.1016/j.redox.2018.06.002. Epub 2018 Jun 12.

17.

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation.

Tian B, Liu Z, Yang J, Sun H, Zhao Y, Wakamiya M, Chen H, Rytting E, Zhou J, Brasier AR.

Cell Rep. 2018 Apr 24;23(4):1138-1151. doi: 10.1016/j.celrep.2018.03.106.

18.

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

Liu Z, Tian B, Chen H, Wang P, Brasier AR, Zhou J.

Eur J Med Chem. 2018 May 10;151:450-461. doi: 10.1016/j.ejmech.2018.04.006. Epub 2018 Apr 3.

19.

Central Role of the NF-κB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation.

Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Wakamiya M, Garofalo RP, Brasier AR.

J Virol. 2018 May 14;92(11). pii: e00441-18. doi: 10.1128/JVI.00441-18. Print 2018 Jun 1.

20.

Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia.

Graber TG, Rawls BL, Tian B, Durham WJ, Brightwell CR, Brasier AR, Rasmussen BB, Fry CS.

Exp Gerontol. 2018 Jun;106:88-100. doi: 10.1016/j.exger.2018.02.002. Epub 2018 Feb 13.

21.

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways.

Czerkies M, Korwek Z, Prus W, Kochańczyk M, Jaruszewicz-Błońska J, Tudelska K, Błoński S, Kimmel M, Brasier AR, Lipniacki T.

Nat Commun. 2018 Feb 5;9(1):493. doi: 10.1038/s41467-017-02640-8.

22.

Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways.

Zhang K, Xu P, Sowers JL, Machuca DF, Mirfattah B, Herring J, Tang H, Chen Y, Tian B, Brasier AR, Sowers LC.

Mol Cell Proteomics. 2017 Nov;16(11):1906-1921. doi: 10.1074/mcp.RA117.000154. Epub 2017 Sep 5.

23.

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.

Maroto R, Zhao Y, Jamaluddin M, Popov VL, Wang H, Kalubowilage M, Zhang Y, Luisi J, Sun H, Culbertson CT, Bossmann SH, Motamedi M, Brasier AR.

J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.

24.

Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation.

Ijaz T, Sun H, Pinchuk IV, Milewicz DM, Tilton RG, Brasier AR.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1881-1890. doi: 10.1161/ATVBAHA.117.309863. Epub 2017 Aug 17.

25.

Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation.

Aguilera-Aguirre L, Hao W, Pan L, Li X, Saavedra-Molina A, Bacsi A, Radak Z, Sur S, Brasier AR, Ba X, Boldogh I.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1058-L1068. doi: 10.1152/ajplung.00141.2017. Epub 2017 Aug 10.

26.

Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification-Mass Spectrometry-based Protein-Protein Interaction Analysis.

Zhang Y, Sun H, Zhang J, Brasier AR, Zhao Y.

J Proteome Res. 2017 Aug 4;16(8):3068-3082. doi: 10.1021/acs.jproteome.7b00432. Epub 2017 Jul 20.

27.

Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples.

Zhao Y, Zhang Y, Sun H, Maroto R, Brasier AR.

J Proteome Res. 2017 Aug 4;16(8):2983-2992. doi: 10.1021/acs.jproteome.7b00275. Epub 2017 Jul 17.

28.

Major Histocompatibility Complex Class II Alleles Influence Induction of Pathogenic Antiphospholipid Antibodies in a Mouse Model of Thrombosis.

Papalardo E, Romay-Penabad Z, Willis R, Christadoss P, Carrera-Marin AL, Reyes-Maldonado E, Rudrangi R, Alfieri-Papalardo S, Garcia-Latorre E, Blank M, Pierangeli S, Brasier AR, Gonzalez EB.

Arthritis Rheumatol. 2017 Oct;69(10):2052-2061. doi: 10.1002/art.40195. Epub 2017 Sep 12.

29.

Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways.

Hosoki K, Redding D, Itazawa T, Chakraborty A, Tapryal N, Qian S, Qi H, Aguilera-Aguirre L, Brasier AR, Phani VS, Hazra TK, Boldogh I, Sur S.

J Allergy Clin Immunol. 2017 Nov;140(5):1436-1439.e5. doi: 10.1016/j.jaci.2017.04.044. Epub 2017 Jun 2. No abstract available.

PMID:
28583369
30.

Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition.

Yang J, Tian B, Sun H, Garofalo RP, Brasier AR.

Nat Microbiol. 2017 Jun 5;2:17086. doi: 10.1038/nmicrobiol.2017.86.

31.

Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.

Chen J, Peters A, Papke CL, Villamizar C, Ringuette LJ, Cao J, Wang S, Ma S, Gong L, Byanova KL, Xiong J, Zhu MX, Madonna R, Kee P, Geng YJ, Brasier AR, Davis EC, Prakash S, Kwartler CS, Milewicz DM.

Circ Res. 2017 Jun 9;120(12):1903-1915. doi: 10.1161/CIRCRESAHA.117.310563. Epub 2017 May 1.

32.

Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections.

Zhao Y, Jamaluddin M, Zhang Y, Sun H, Ivanciuc T, Garofalo RP, Brasier AR.

J Immunol. 2017 Apr 15;198(8):3345-3364. doi: 10.4049/jimmunol.1601291. Epub 2017 Mar 3.

33.

Targeting Chromatin Remodeling in Inflammation and Fibrosis.

Yang J, Tian B, Brasier AR.

Adv Protein Chem Struct Biol. 2017;107:1-36. doi: 10.1016/bs.apcsb.2016.11.001. Epub 2016 Dec 1. Review.

PMID:
28215221
34.

Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.

J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. Review.

35.

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.

Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, Herndon DN, Tilton RG, Brasier AR.

Cell Death Dis. 2017 Feb 9;8(2):e2606. doi: 10.1038/cddis.2016.434.

36.

Reply: Protease Plays a Role in Ragweed Pollen-Induced Neutrophil Recruitment and Epithelial Barrier Disruption.

Hosoki K, Brasier AR, Kurosky A, Boldogh I, Sur S.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):272-273. doi: 10.1165/rcmb.2016-0281LE. No abstract available.

37.

BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.

Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Garofalo RP, Brasier AR.

J Virol. 2017 Feb 28;91(6). pii: e00007-17. doi: 10.1128/JVI.00007-17. Print 2017 Mar 15.

38.

Qualification and Verification of Protein Biomarker Candidates.

Zhao Y, Brasier AR.

Adv Exp Med Biol. 2016;919:493-514. Review.

PMID:
27975232
39.

Introduction to Clinical Proteomics.

Wiktorowicz JE, Brasier AR.

Adv Exp Med Biol. 2016;919:435-441. Review.

PMID:
27975229
40.

NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns.

Tian B, Patrikeev I, Ochoa L, Vargas G, Belanger KK, Litvinov J, Boldogh I, Ameredes BT, Motamedi M, Brasier AR.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):506-520. doi: 10.1165/rcmb.2016-0259OC.

41.

BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation.

Tian B, Zhao Y, Sun H, Zhang Y, Yang J, Brasier AR.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1183-L1201. doi: 10.1152/ajplung.00224.2016. Epub 2016 Oct 28.

42.

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos SA, Hazra TK, Hegde ML, Radak Z, Bacsi A, Brasier AR, Ba X, Boldogh I.

J Biol Chem. 2016 Dec 2;291(49):25553-25566. Epub 2016 Oct 18.

43.

Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles.

Ijaz T, Wakamiya M, Sun H, Recinos A 3rd, Tilton RG, Brasier AR.

BMC Dev Biol. 2016 Sep 23;16(1):32.

44.

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.

Koo SJ, Spratt HM, Soman KV, Stafford S, Gupta S, Petersen JR, Zago MP, Kuyumcu-Martinez MN, Brasier AR, Wiktorowicz JE, Garg NJ.

Int J Proteomics. 2016;2016:1384523. doi: 10.1155/2016/1384523. Epub 2016 Aug 18.

45.

Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women.

Chondronikola M, Asghar R, Zhang X, Dillon EL, Durham WJ, Wu Z, Porter C, Camacho-Hughes M, Zhao Y, Brasier AR, Volpi E, Sheffield-Moore M, Abate N, Sidossis L, Tuvdendorj D.

Clin Nutr. 2017 Oct;36(5):1310-1319. doi: 10.1016/j.clnu.2016.08.019. Epub 2016 Sep 6.

46.

Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation.

Ijaz T, Tilton RG, Brasier AR.

J Thorac Dis. 2016 Aug;8(8):E746-54. doi: 10.21037/jtd.2016.06.37.

47.

Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response.

Hosakote YM, Brasier AR, Casola A, Garofalo RP, Kurosky A.

J Virol. 2016 Oct 14;90(21):9618-9631. doi: 10.1128/JVI.01279-16. Print 2016 Nov 1.

48.
49.

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition.

Zhao Y, Tian B, Sadygov RG, Zhang Y, Brasier AR.

J Proteomics. 2016 Oct 4;148:126-38. doi: 10.1016/j.jprot.2016.07.014. Epub 2016 Jul 25.

50.

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.

Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN.

Cell Rep. 2016 Jun 7;15(10):2200-2213. doi: 10.1016/j.celrep.2016.05.002. Epub 2016 May 26.

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