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Items: 27

1.

Global translation inhibition yields condition-dependent de-repression of ribosome biogenesis mRNAs.

Cheng Z, Brar GA.

Nucleic Acids Res. 2019 Jun 4;47(10):5061-5073. doi: 10.1093/nar/gkz231.

2.

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells.

Hollerer I, Barker JC, Jorgensen V, Tresenrider A, Dugast-Darzacq C, Chan LY, Darzacq X, Tjian R, Ünal E, Brar GA.

G3 (Bethesda). 2019 Apr 9;9(4):1045-1053. doi: 10.1534/g3.118.200802.

3.

Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis.

Eisenberg AR, Higdon A, Keskin A, Hodapp S, Jovanovic M, Brar GA.

Cell Rep. 2018 Dec 26;25(13):3603-3617.e2. doi: 10.1016/j.celrep.2018.12.008.

4.

Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate.

Cheng Z, Mugler CF, Keskin A, Hodapp S, Chan LY, Weis K, Mertins P, Regev A, Jovanovic M, Brar GA.

Mol Cell. 2019 Jan 3;73(1):36-47.e10. doi: 10.1016/j.molcel.2018.10.032. Epub 2018 Nov 29.

PMID:
30503772
5.

Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms.

Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA.

Dev Cell. 2018 Jul 16;46(2):219-235.e8. doi: 10.1016/j.devcel.2018.06.016.

6.

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.

Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E.

Nature. 2018 Jul;559(7712):130-134. doi: 10.1038/s41586-018-0258-0. Epub 2018 Jun 27.

7.

Seq-ing answers: uncovering the unexpected in global gene regulation.

Otto GM, Brar GA.

Curr Genet. 2018 Dec;64(6):1183-1188. doi: 10.1007/s00294-018-0839-3. Epub 2018 Apr 19. Review.

8.

Pervasive, Coordinated Protein-Level Changes Driven by Transcript Isoform Switching during Meiosis.

Cheng Z, Otto GM, Powers EN, Keskin A, Mertins P, Carr SA, Jovanovic M, Brar GA.

Cell. 2018 Feb 22;172(5):910-923.e16. doi: 10.1016/j.cell.2018.01.035.

9.

m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress.

Powers EN, Brar GA.

Mol Cell. 2018 Feb 15;69(4):537-538. doi: 10.1016/j.molcel.2018.01.036.

10.

Strategies and Challenges in Identifying Function for Thousands of sORF-Encoded Peptides in Meiosis.

Hollerer I, Higdon A, Brar GA.

Proteomics. 2018 May;18(10):e1700274. doi: 10.1002/pmic.201700274. Epub 2017 Oct 26.

11.

Beyond the Triplet Code: Context Cues Transform Translation.

Brar GA.

Cell. 2016 Dec 15;167(7):1681-1692. doi: 10.1016/j.cell.2016.09.022. Review.

12.

Ribosome profiling reveals the what, when, where and how of protein synthesis.

Brar GA, Weissman JS.

Nat Rev Mol Cell Biol. 2015 Nov;16(11):651-64. doi: 10.1038/nrm4069. Epub 2015 Oct 14. Review.

13.

Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.

Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS.

Cell Rep. 2014 Sep 11;8(5):1365-79. doi: 10.1016/j.celrep.2014.07.045. Epub 2014 Aug 21.

14.

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.

Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A.

Genes Dev. 2013 Oct 1;27(19):2147-63. doi: 10.1101/gad.224253.113.

15.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS.

Cell. 2013 Jul 18;154(2):442-51. doi: 10.1016/j.cell.2013.06.044. Epub 2013 Jul 11.

16.

Genome-wide annotation and quantitation of translation by ribosome profiling.

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS.

Curr Protoc Mol Biol. 2013 Jul;Chapter 4:Unit 4.18. doi: 10.1002/0471142727.mb0418s103.

17.

Aneuploid yeast strains exhibit defects in cell growth and passage through START.

Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman JS, Amon A.

Mol Biol Cell. 2013 May;24(9):1274-89. doi: 10.1091/mbc.E12-07-0520. Epub 2013 Mar 6.

18.

Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions.

Miller MP, Unal E, Brar GA, Amon A.

Elife. 2012 Dec 18;1:e00117. doi: 10.7554/eLife.00117.

19.

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments.

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS.

Nat Protoc. 2012 Jul 26;7(8):1534-50. doi: 10.1038/nprot.2012.086.

20.

Proto-genes and de novo gene birth.

Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M.

Nature. 2012 Jul 19;487(7407):370-4. doi: 10.1038/nature11184.

21.

High-resolution view of the yeast meiotic program revealed by ribosome profiling.

Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman JS.

Science. 2012 Feb 3;335(6068):552-7. doi: 10.1126/science.1215110. Epub 2011 Dec 22.

22.

The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing.

Brar GA, Hochwagen A, Ee LS, Amon A.

Mol Biol Cell. 2009 Feb;20(3):1030-47. doi: 10.1091/mbc.E08-06-0637. Epub 2008 Dec 10.

23.

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Nguyen HH, Aronchik I, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19750-5. doi: 10.1073/pnas.0806581105. Epub 2008 Dec 8.

24.

Emerging roles for centromeres in meiosis I chromosome segregation.

Brar GA, Amon A.

Nat Rev Genet. 2008 Dec;9(12):899-910. doi: 10.1038/nrg2454. Review.

25.

Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis.

Brar GA, Kiburz BM, Zhang Y, Kim JE, White F, Amon A.

Nature. 2006 May 25;441(7092):532-6. Epub 2006 May 3.

PMID:
16672979
26.

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