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The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity.

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P.

mSphere. 2015 Nov 11;1(1). pii: e00015-15. doi: 10.1128/mSphere.00015-15. eCollection 2016 Jan-Feb.


The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F.

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P.

mSphere. 2015 Nov 11;1(1). pii: e00014-15. doi: 10.1128/mSphere.00014-15. eCollection 2016 Jan-Feb.


Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses.

Gilson T, Blanchette P, Ballmann MZ, Papp T, Pénzes JJ, Benkő M, Harrach B, Branton PE.

J Virol. 2016 Jul 27;90(16):7350-7367. doi: 10.1128/JVI.00420-16. Print 2016 Aug 15.


The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway.

Mui MZ, Zhou Y, Blanchette P, Chughtai N, Knight JF, Gruosso T, Papadakis AI, Huang S, Park M, Gingras AC, Branton PE.

J Virol. 2015 Sep;89(17):8855-70. doi: 10.1128/JVI.03710-14. Epub 2015 Jun 17.


PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S.

Oncogene. 2016 Jan 7;35(1):69-82. doi: 10.1038/onc.2015.63. Epub 2015 Mar 16.


Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.

Sriskandarajah N, Blanchette P, Kucharski TJ, Teodoro JG, Branton PE.

J Virol. 2015 Apr;89(8):4685-9. doi: 10.1128/JVI.03437-14. Epub 2015 Feb 4.


Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.

Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG.

J Virol. 2014 Nov;88(22):13249-59. doi: 10.1128/JVI.00933-14. Epub 2014 Sep 10.


Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.

Gilson T, Cheng CY, Hur WS, Blanchette P, Branton PE.

J Virol. 2014 Apr;88(7):3885-97. doi: 10.1128/JVI.03579-13. Epub 2014 Jan 22.


Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.

Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, Branton PE.

PLoS Pathog. 2013;9(11):e1003742. doi: 10.1371/journal.ppat.1003742. Epub 2013 Nov 14.


Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.

Cabon L, Sriskandarajah N, Mui MZ, Teodoro JG, Blanchette P, Branton PE.

J Virol. 2013 Dec;87(24):13168-78. doi: 10.1128/JVI.01242-13. Epub 2013 Sep 25.


Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.

Cheng CY, Gilson T, Wimmer P, Schreiner S, Ketner G, Dobner T, Branton PE, Blanchette P.

J Virol. 2013 Jun;87(11):6232-45. doi: 10.1128/JVI.00384-13. Epub 2013 Mar 27.


Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substrates.

Blanchette P, Wimmer P, Dallaire F, Cheng CY, Branton PE.

J Virol. 2013 May;87(9):4872-81. doi: 10.1128/JVI.03272-12. Epub 2013 Feb 13.


CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.

Borozan I, Wilson S, Blanchette P, Laflamme P, Watt SN, Krzyzanowski PM, Sircoulomb F, Rottapel R, Branton PE, Ferretti V.

BMC Bioinformatics. 2012 Aug 17;13:206. doi: 10.1186/1471-2105-13-206.


Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.

Wimmer P, Blanchette P, Schreiner S, Ching W, Groitl P, Berscheminski J, Branton PE, Will H, Dobner T.

Oncogene. 2013 Mar 28;32(13):1626-37. doi: 10.1038/onc.2012.187. Epub 2012 May 21.


Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.

Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T.

J Virol. 2011 Sep;85(17):8752-65. doi: 10.1128/JVI.00440-11. Epub 2011 Jun 22.


The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.

Cheng CY, Gilson T, Dallaire F, Ketner G, Branton PE, Blanchette P.

J Virol. 2011 Jan;85(2):765-75. doi: 10.1128/JVI.01890-10. Epub 2010 Nov 10. Erratum in: J Virol. 2011 May;85(9):4632.


Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.

Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, Li S, Berghuis AM, Branton PE.

J Virol. 2011 Jan;85(1):286-95. doi: 10.1128/JVI.01381-10. Epub 2010 Nov 3.


Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism.

Mui MZ, Roopchand DE, Gentry MS, Hallberg RL, Vogel J, Branton PE.

J Virol. 2010 May;84(9):4798-809. doi: 10.1128/JVI.02434-09. Epub 2010 Feb 17.


A proteomic approach to identify candidate substrates of human adenovirus E4orf6-E1B55K and other viral cullin-based E3 ubiquitin ligases.

Dallaire F, Blanchette P, Branton PE.

J Virol. 2009 Dec;83(23):12172-84. doi: 10.1128/JVI.01169-09. Epub 2009 Sep 16.


The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

Li S, Brignole C, Marcellus R, Thirlwell S, Binda O, McQuoid MJ, Ashby D, Chan H, Zhang Z, Miron MJ, Pallas DC, Branton PE.

J Virol. 2009 Sep;83(17):8340-52. doi: 10.1128/JVI.00711-09. Epub 2009 Jun 17.


Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complex.

Dallaire F, Blanchette P, Groitl P, Dobner T, Branton PE.

J Virol. 2009 Jun;83(11):5329-38. doi: 10.1128/JVI.00089-09. Epub 2009 Mar 18.


Localization and importance of the adenovirus E4orf4 protein during lytic infection.

Miron MJ, Blanchette P, Groitl P, Dallaire F, Teodoro JG, Li S, Dobner T, Branton PE.

J Virol. 2009 Feb;83(4):1689-99. doi: 10.1128/JVI.01703-08. Epub 2008 Dec 10.


Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses.

Blanchette P, Branton PE.

Virology. 2009 Feb 20;384(2):317-23. doi: 10.1016/j.virol.2008.10.005. Epub 2008 Nov 14. Review.


The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells.

Li S, Szymborski A, Miron MJ, Marcellus R, Binda O, Lavoie JN, Branton PE.

Oncogene. 2009 Jan 22;28(3):390-400. doi: 10.1038/onc.2008.393. Epub 2008 Oct 27.


JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4.

Smadja-Lamère N, Boulanger MC, Champagne C, Branton PE, Lavoie JN.

J Biol Chem. 2008 Dec 5;283(49):34352-64. doi: 10.1074/jbc.M803364200. Epub 2008 Sep 25.


Does Canadian research investment relate to cancer burden?

Branton PE.

Lancet Oncol. 2008 Feb;9(2):82-3. doi: 10.1016/S1470-2045(08)70007-X. No abstract available.


SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.

Binda O, Nassif C, Branton PE.

Oncogene. 2008 May 29;27(24):3384-92. doi: 10.1038/sj.onc.1211014. Epub 2008 Jan 14.


Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity.

Blanchette P, Kindsmüller K, Groitl P, Dallaire F, Speiseder T, Branton PE, Dobner T.

J Virol. 2008 Mar;82(6):2642-51. doi: 10.1128/JVI.02309-07. Epub 2008 Jan 9.


The adenovirus E4orf6 E3 ubiquitin ligase complex assembles in a novel fashion.

Cheng CY, Blanchette P, Branton PE.

Virology. 2007 Jul 20;364(1):36-44. Epub 2007 Mar 23.


Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.

Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE.

Mol Cell Biol. 2004 Nov;24(21):9619-29.


Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death.

Miron MJ, Gallouzi IE, Lavoie JN, Branton PE.

Oncogene. 2004 Sep 30;23(45):7458-68. Erratum in: Oncogene. 2005 Jun 9;24(25):4162.


Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.

Robert A, Miron MJ, Champagne C, Gingras MC, Branton PE, Lavoie JN.

J Cell Biol. 2002 Aug 5;158(3):519-28. Epub 2002 Aug 5.


The role of adenovirus E4orf4 protein in viral replication and cell killing.

Branton PE, Roopchand DE.

Oncogene. 2001 Nov 26;20(54):7855-65. Review.


Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.

Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE.

Genes Dev. 2001 Dec 1;15(23):3104-17.


Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A.

Roopchand DE, Lee JM, Shahinian S, Paquette D, Bussey H, Branton PE.

Oncogene. 2001 Aug 30;20(38):5279-90.


Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW.

J Biol Chem. 2001 Aug 10;276(32):29748-53. Epub 2001 May 30.


RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.

Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE.

Mol Cell Biol. 2001 Apr;21(8):2918-32.


Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.

Querido E, Morrison MR, Chu-Pham-Dang H, Thirlwell SW, Boivin D, Branton PE.

J Virol. 2001 Jan;75(2):699-709. Erratum in: J Virol 2001 Mar;75(5):2508. Morisson MR [corrected to Morrison MR].


Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.

Marcellus RC, Chan H, Paquette D, Thirlwell S, Boivin D, Branton PE.

J Virol. 2000 Sep;74(17):7869-77.


Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase.

Kim J, Lee JM, Branton PE, Pelletier J.

FEBS Lett. 2000 Jun 2;474(2-3):121-8.


Modification of EWS/WT1 functional properties by phosphorylation.

Kim J, Lee JM, Branton PE, Pelletier J.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14300-5.


Viruses and apoptosis.

Roulston A, Marcellus RC, Branton PE.

Annu Rev Microbiol. 1999;53:577-628. Review.


Promoter analysis of the murine T-cell protein tyrosine phosphatase gene.

Wee C, Muise ES, Coquelet O, Ennis M, Wagner J, Lemieux N, Branton PE, Nepveu A, Tremblay ML.

Gene. 1999 Sep 17;237(2):351-60.


RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins.

Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG Jr, Seto E, Branton PE.

Mol Cell Biol. 1999 Oct;19(10):6632-41.


RBP1 induces growth arrest by repression of E2F-dependent transcription.

Lai A, Marcellus RC, Corbeil HB, Branton PE.

Oncogene. 1999 Mar 25;18(12):2091-100.

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