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Items: 9


Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis.

Burstein AH, Brantley SJ, Dunn I, Altstiel LD, Schmith V.

Clin Pharmacol Drug Dev. 2019 May;8(4):426-435. doi: 10.1002/cpdd.689. Epub 2019 Apr 1.


Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening.

Brantley SJ, Cotten SW, Lamson DR, Smith GR, Liu R, Williams KP.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):773-779. doi: 10.1016/j.bbrc.2017.07.100. Epub 2017 Jul 18.


Physiologically based pharmacokinetic modeling framework for quantitative prediction of an herb-drug interaction.

Brantley SJ, Gufford BT, Dua R, Fediuk DJ, Graf TN, Scarlett YV, Frederick KS, Fisher MB, Oberlies NH, Paine MF.

CPT Pharmacometrics Syst Pharmacol. 2014 Mar 26;3:e107. doi: 10.1038/psp.2013.69.


Herb-drug interactions: challenges and opportunities for improved predictions.

Brantley SJ, Argikar AA, Lin YS, Nagar S, Paine MF.

Drug Metab Dispos. 2014 Mar;42(3):301-17. doi: 10.1124/dmd.113.055236. Epub 2013 Dec 11.


A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.

Brantley SJ, Graf TN, Oberlies NH, Paine MF.

Drug Metab Dispos. 2013 Sep;41(9):1662-70. doi: 10.1124/dmd.113.052563. Epub 2013 Jun 25.


Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.


The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation.

Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF.

J Exp Pharmacol. 2010 Jul;2010(2):83-91.


Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.

Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF, Oberlies NH.

Planta Med. 2011 Feb;77(3):265-70. doi: 10.1055/s-0030-1250259. Epub 2010 Aug 17.


Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

Brantley SJ, Oberlies NH, Kroll DJ, Paine MF.

J Pharmacol Exp Ther. 2010 Mar;332(3):1081-7. doi: 10.1124/jpet.109.161927. Epub 2009 Nov 24.

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