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Items: 29

1.

Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.

Eberle-Singh JA, Sagalovskiy I, Maurer HC, Sastra SA, Palermo CF, Decker AR, Kim MJ, Sheedy J, Mollin A, Cao L, Hu J, Branstrom A, Weetall M, Olive KP.

Clin Cancer Res. 2019 Sep 15;25(18):5548-5560. doi: 10.1158/1078-0432.CCR-18-3281. Epub 2019 Jun 7.

PMID:
31175095
2.

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.

Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW.

PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018.

3.

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.

Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim MJ, Furia B, Romfo C, Graci JD, Li W, Du J, Sheedy J, Hedrick J, Risher N, Yeh S, Qi H, Arasu T, Hwang S, Lennox W, Kong R, Petruska J, Moon YC, Babiak J, Davis TW, Jacobson A, Almstead NG, Branstrom A, Colacino JM, Peltz SW.

Mol Cancer Ther. 2019 Jan;18(1):3-16. doi: 10.1158/1535-7163.MCT-18-0863. Epub 2018 Oct 23.

PMID:
30352802
4.

Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria.

Gerasyuto AI, Arnold MA, Wang J, Chen G, Zhang X, Smith S, Woll MG, Baird J, Zhang N, Almstead NG, Narasimhan J, Peddi S, Dumble M, Sheedy J, Weetall M, Branstrom AA, Prasad JVN, Karp GM.

J Med Chem. 2018 Oct 25;61(20):9394. doi: 10.1021/acs.jmedchem.8b01538. Epub 2018 Oct 16. No abstract available.

5.

Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer.

Buechel M, Dey A, Dwivedi SKD, Crim A, Ding K, Zhang R, Mukherjee P, Moore KN, Cao L, Branstrom A, Weetall M, Baird J, Bhattacharya R.

Mol Cancer Ther. 2018 Oct;17(10):2136-2143. doi: 10.1158/1535-7163.MCT-17-1192. Epub 2018 Jul 19.

PMID:
30026381
6.

Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma.

Maeda A, Nishida Y, Weetall M, Cao L, Branstrom A, Ishizawa J, Nii T, Schober WD, Abe Y, Matsue K, Yoshimura M, Kimura S, Kojima K.

Oncotarget. 2018 Jun 19;9(47):28547-28560. doi: 10.18632/oncotarget.25558. eCollection 2018 Jun 19.

7.

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.

Gerasyuto AI, Arnold MA, Wang J, Chen G, Zhang X, Smith S, Woll MG, Baird J, Zhang N, Almstead NG, Narasimhan J, Peddi S, Dumble M, Sheedy J, Weetall M, Branstrom AA, Prasad JVN, Karp GM.

J Med Chem. 2018 May 24;61(10):4456-4475. doi: 10.1021/acs.jmedchem.8b00114. Epub 2018 May 14. Erratum in: J Med Chem. 2018 Oct 25;61(20):9394.

8.

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.

Arnold MA, Gerasyuto AI, Wang J, Du W, Gorske YJK, Arasu T, Baird J, Almstead NG, Narasimhan J, Peddi S, Ginzburg O, Lue SW, Hedrick J, Sheedy J, Lagaud G, Branstrom AA, Weetall M, Prasad JVNV, Karp GM.

Bioorg Med Chem Lett. 2017 Nov 15;27(22):5014-5021. doi: 10.1016/j.bmcl.2017.10.006. Epub 2017 Oct 5.

PMID:
29032026
9.

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

Nishida Y, Maeda A, Kim MJ, Cao L, Kubota Y, Ishizawa J, AlRawi A, Kato Y, Iwama A, Fujisawa M, Matsue K, Weetall M, Dumble M, Andreeff M, Davis TW, Branstrom A, Kimura S, Kojima K.

Blood Cancer J. 2017 Feb 17;7(2):e527. doi: 10.1038/bcj.2017.8.

10.

Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.

Veselkov DA, Laponogov I, Pan XS, Selvarajah J, Skamrova GB, Branstrom A, Narasimhan J, Prasad JV, Fisher LM, Sanderson MR.

Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):488-96. doi: 10.1107/S2059798316001212. Epub 2016 Mar 24.

11.

Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial.

Kerem E, Konstan MW, De Boeck K, Accurso FJ, Sermet-Gaudelus I, Wilschanski M, Elborn JS, Melotti P, Bronsveld I, Fajac I, Malfroot A, Rosenbluth DB, Walker PA, McColley SA, Knoop C, Quattrucci S, Rietschel E, Zeitlin PL, Barth J, Elfring GL, Welch EM, Branstrom A, Spiegel RJ, Peltz SW, Ajayi T, Rowe SM; Cystic Fibrosis Ataluren Study Group.

Lancet Respir Med. 2014 Jul;2(7):539-47. doi: 10.1016/S2213-2600(14)70100-6. Epub 2014 May 15.

12.

Structure of Francisella tularensis peptidyl-tRNA hydrolase.

Clarke TE, Romanov V, Lam R, Gothe SA, Peddi SR, Razumova EB, Lipman RS, Branstrom AA, Chirgadze NY.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):446-9. doi: 10.1107/S174430911100515X. Epub 2011 Mar 26.

13.

PTC124 targets genetic disorders caused by nonsense mutations.

Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, Ren H, Moon YC, Corson D, Turpoff AA, Campbell JA, Conn MM, Khan A, Almstead NG, Hedrick J, Mollin A, Risher N, Weetall M, Yeh S, Branstrom AA, Colacino JM, Babiak J, Ju WD, Hirawat S, Northcutt VJ, Miller LL, Spatrick P, He F, Kawana M, Feng H, Jacobson A, Peltz SW, Sweeney HL.

Nature. 2007 May 3;447(7140):87-91. Epub 2007 Apr 22.

PMID:
17450125
14.

Synthesis and mode of action of hydrophobic derivatives of the glycopeptide antibiotic eremomycin and des-(N-methyl-D-leucyl)eremomycin against glycopeptide-sensitive and -resistant bacteria.

Printsevskaya SS, Pavlov AY, Olsufyeva EN, Mirchink EP, Isakova EB, Reznikova MI, Goldman RC, Branstrom AA, Baizman ER, Longley CB, Sztaricskai F, Batta G, Preobrazhenskaya MN.

J Med Chem. 2002 Mar 14;45(6):1340-7.

PMID:
11882003
15.

Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.

Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D.

Science. 2001 Oct 12;294(5541):361-4. Epub 2001 Aug 23.

16.

Synthesis of hydrophobic N'-mono and N',N"-double alkylated eremomycins inhibiting the transglycosylation stage of bacterial cell wall biosynthesis.

Pavlov AY, Miroshnikova OV, Printsevskaya SS, Olsufyeva EN, Preobrazhenskaya MN, Goldman RC, Branstrom AA, Baizman ER, Longley CB.

J Antibiot (Tokyo). 2001 May;54(5):455-9.

17.

Synthesis and biological evaluation of analogues of bacterial lipid I.

Silva DJ, Bowe CL, Branstrom AA, Baizman ER, Sofia MJ.

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2811-3.

PMID:
11133098
18.

Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase.

Baizman ER, Branstrom AA, Longley CB, Allanson N, Sofia MJ, Gange D, Goldman RC.

Microbiology. 2000 Dec;146 Pt 12:3129-40.

PMID:
11101671
19.

Differential antibacterial activity of moenomycin analogues on gram-positive bacteria.

Goldman RC, Baizman ER, Branstrom AA, Longley CB.

Bioorg Med Chem Lett. 2000 Oct 16;10(20):2251-4.

PMID:
11055331
20.

In situ assay for identifying inhibitors of bacterial transglycosylase.

Branstrom AA, Midha S, Goldman RC.

FEMS Microbiol Lett. 2000 Oct 15;191(2):187-90.

21.

Assay for identification of inhibitors for bacterial MraY translocase or MurG transferase.

Branstrom AA, Midha S, Longley CB, Han K, Baizman ER, Axelrod HR.

Anal Biochem. 2000 May 1;280(2):315-9.

PMID:
10790316
22.
23.

Discovery of novel disaccharide antibacterial agents using a combinatorial library approach.

Sofia MJ, Allanson N, Hatzenbuhler NT, Jain R, Kakarla R, Kogan N, Liang R, Liu D, Silva DJ, Wang H, Gange D, Anderson J, Chen A, Chi F, Dulina R, Huang B, Kamau M, Wang C, Baizman E, Branstrom A, Bristol N, Goldman R, Han K, Longley C, Axelrod HR, et al.

J Med Chem. 1999 Aug 26;42(17):3193-8. No abstract available.

PMID:
10464005
24.

Targeting cell wall synthesis and assembly in microbes: similarities and contrasts between bacteria and fungi.

Goldman RC, Branstrom A.

Curr Pharm Des. 1999 Jul;5(7):473-501. Review.

PMID:
10438893
25.

Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization.

Sizemore DR, Branstrom AA, Sadoff JC.

Vaccine. 1997 Jun;15(8):804-7.

PMID:
9234519
26.

Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages.

Sizemore DR, Elsinghorst EA, Eck LC, Branstrom AA, Hoover DL, Warren RL, Rubin FA.

Infect Immun. 1997 Jan;65(1):309-12.

27.

Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization.

Sizemore DR, Branstrom AA, Sadoff JC.

Science. 1995 Oct 13;270(5234):299-302.

PMID:
7569980
28.
29.

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