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Items: 1 to 50 of 275

1.

Complexome analysis of the nitrite-dependent methanotroph Methylomirabilis lanthanidiphila.

Versantvoort W, Guerrero-Castillo S, Wessels HJCT, van Niftrik L, Jetten MSM, Brandt U, Reimann J, Kartal B.

Biochim Biophys Acta Bioenerg. 2019 Jul 31;1860(9):734-744. doi: 10.1016/j.bbabio.2019.07.011. [Epub ahead of print]

PMID:
31376363
2.

Plasma Membrane Integrity During Cell-Cell Fusion and in Response to Pore-Forming Drugs Is Promoted by the Penta-EF-Hand Protein PEF1 in Neurospora crassa.

René Schumann M, Brandt U, Adis C, Hartung L, Fleißner A.

Genetics. 2019 Jul 3. pii: genetics.302363.2019. doi: 10.1534/genetics.119.302363. [Epub ahead of print]

3.

Adaptations of an ancient modular machine.

Brandt U.

Science. 2019 Jan 18;363(6424):230-231. doi: 10.1126/science.aaw0493. No abstract available.

PMID:
30655430
4.

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome.

Van Strien J, Guerrero-Castillo S, Chatzispyrou IA, Houtkooper RH, Brandt U, Huynen MA.

Bioinformatics. 2019 Jan 14. doi: 10.1093/bioinformatics/btz025. [Epub ahead of print]

PMID:
30649188
5.

Functional analysis of active amino acid residues of the mercaptosuccinate dioxygenase of Variovorax paradoxus B4.

Brandt U, Galant G, Meinert-Berning C, Steinbüchel A.

Enzyme Microb Technol. 2019 Jan;120:61-68. doi: 10.1016/j.enzmictec.2018.09.007. Epub 2018 Sep 21.

PMID:
30396400
6.

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.

Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U.

Nat Commun. 2018 Oct 29;9(1):4500. doi: 10.1038/s41467-018-06955-y.

7.

Cryo-EM structure of respiratory complex I at work.

Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V.

Elife. 2018 Oct 2;7. pii: e39213. doi: 10.7554/eLife.39213.

8.

Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution.

Chatzispyrou IA, Guerrero-Castillo S, Held NM, Ruiter JPN, Denis SW, IJlst L, Wanders RJ, van Weeghel M, Ferdinandusse S, Vaz FM, Brandt U, Houtkooper RH.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3650-3658. doi: 10.1016/j.bbadis.2018.08.041. Epub 2018 Sep 1.

9.

Spatio-temporal MAPK dynamics mediate cell behavior coordination during fungal somatic cell fusion.

Serrano A, Illgen J, Brandt U, Thieme N, Letz A, Lichius A, Read ND, Fleißner A.

J Cell Sci. 2018 May 4;131(9). pii: jcs213462. doi: 10.1242/jcs.213462.

10.

Bi-allelic Mutations in the Mitochondrial Ribosomal Protein MRPS2 Cause Sensorineural Hearing Loss, Hypoglycemia, and Multiple OXPHOS Complex Deficiencies.

Gardeitchik T, Mohamed M, Ruzzenente B, Karall D, Guerrero-Castillo S, Dalloyaux D, van den Brand M, van Kraaij S, van Asbeck E, Assouline Z, Rio M, de Lonlay P, Scholl-Buergi S, Wolthuis DFGJ, Hoischen A, Rodenburg RJ, Sperl W, Urban Z, Brandt U, Mayr JA, Wong S, de Brouwer APM, Nijtmans L, Munnich A, Rötig A, Wevers RA, Metodiev MD, Morava E.

Am J Hum Genet. 2018 Apr 5;102(4):685-695. doi: 10.1016/j.ajhg.2018.02.012. Epub 2018 Mar 22.

11.

Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy.

Wortmann SB, Timal S, Venselaar H, Wintjes LT, Kopajtich R, Feichtinger RG, Onnekink C, Mühlmeister M, Brandt U, Smeitink JA, Veltman JA, Sperl W, Lefeber D, Pruijn G, Stojanovic V, Freisinger P, V Spronsen F, Derks TG, Veenstra-Knol HE, Mayr JA, Rötig A, Tarnopolsky M, Prokisch H, Rodenburg RJ.

Hum Mutat. 2017 Dec;38(12):1786-1795. doi: 10.1002/humu.23340. Epub 2017 Oct 6.

PMID:
28905505
12.

Establishment of Neurospora crassa as a host for heterologous protein production using a human antibody fragment as a model product.

Havlik D, Brandt U, Bohle K, Fleißner A.

Microb Cell Fact. 2017 Jul 25;16(1):128. doi: 10.1186/s12934-017-0734-5.

13.

Proteomic analysis of organic sulfur compound utilisation in Advenella mimigardefordensis strain DPN7T.

Meinert C, Brandt U, Heine V, Beyert J, Schmidl S, Wübbeler JH, Voigt B, Riedel K, Steinbüchel A.

PLoS One. 2017 Mar 30;12(3):e0174256. doi: 10.1371/journal.pone.0174256. eCollection 2017.

14.

Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa.

Van Damme T, Gardeitchik T, Mohamed M, Guerrero-Castillo S, Freisinger P, Guillemyn B, Kariminejad A, Dalloyaux D, van Kraaij S, Lefeber DJ, Syx D, Steyaert W, De Rycke R, Hoischen A, Kamsteeg EJ, Wong SY, van Scherpenzeel M, Jamali P, Brandt U, Nijtmans L, Korenke GC, Chung BHY, Mak CCY, Hausser I, Kornak U, Fischer-Zirnsak B, Strom TM, Meitinger T, Alanay Y, Utine GE, Leung PKC, Ghaderi-Sohi S, Coucke P, Symoens S, De Paepe A, Thiel C, Haack TB, Malfait F, Morava E, Callewaert B, Wevers RA.

Am J Hum Genet. 2017 Feb 2;100(2):216-227. doi: 10.1016/j.ajhg.2016.12.010. Epub 2017 Jan 5.

15.

Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy.

Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM.

J Med Genet. 2017 May;54(5):346-356. doi: 10.1136/jmedgenet-2016-104212. Epub 2016 Dec 28.

PMID:
28031252
16.

Accumulation of specific sterol precursors targets a MAP kinase cascade mediating cell-cell recognition and fusion.

Weichert M, Lichius A, Priegnitz BE, Brandt U, Gottschalk J, Nawrath T, Groenhagen U, Read ND, Schulz S, Fleißner A.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11877-11882. Epub 2016 Oct 5.

17.

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.

D'Imprima E, Mills DJ, Parey K, Brandt U, Kühlbrandt W, Zickermann V, Vonck J.

Biochim Biophys Acta. 2016 Dec;1857(12):1935-1942. doi: 10.1016/j.bbabio.2016.09.014. Epub 2016 Sep 30.

18.

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T.

EMBO Rep. 2016 Dec;17(12):1844-1856. Epub 2016 Oct 13.

19.

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.

Guerrero-Castillo S, Baertling F, Kownatzki D, Wessels HJ, Arnold S, Brandt U, Nijtmans L.

Cell Metab. 2017 Jan 10;25(1):128-139. doi: 10.1016/j.cmet.2016.09.002. Epub 2016 Oct 6.

20.

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.

König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T.

Mol Cell. 2016 Oct 6;64(1):148-162. doi: 10.1016/j.molcel.2016.08.020. Epub 2016 Sep 15.

21.

When can a green entrepreneur manage the local environment?

Brandt US, Svendsen GT.

J Environ Manage. 2016 Dec 1;183(Pt 3):622-629. doi: 10.1016/j.jenvman.2016.09.007. Epub 2016 Sep 13.

PMID:
27637810
22.

Everolimus for the Treatment of Advanced Pancreatic Neuroendocrine Tumors: Overall Survival and Circulating Biomarkers From the Randomized, Phase III RADIANT-3 Study.

Yao JC, Pavel M, Lombard-Bohas C, Van Cutsem E, Voi M, Brandt U, He W, Chen D, Capdevila J, de Vries EGE, Tomassetti P, Hobday T, Pommier R, Öberg K.

J Clin Oncol. 2016 Nov 10;34(32):3906-3913. doi: 10.1200/JCO.2016.68.0702. Epub 2016 Sep 30.

23.

Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency.

Sánchez-Caballero L, Ruzzenente B, Bianchi L, Assouline Z, Barcia G, Metodiev MD, Rio M, Funalot B, van den Brand MA, Guerrero-Castillo S, Molenaar JP, Koolen D, Brandt U, Rodenburg RJ, Nijtmans LG, Rötig A.

Am J Hum Genet. 2016 Jul 7;99(1):208-16. doi: 10.1016/j.ajhg.2016.05.022. Epub 2016 Jun 30.

24.

Preface to complex I special issue.

Brandt UU, Zickermann V.

Biochim Biophys Acta. 2016 Jul;1857(7):861-2. doi: 10.1016/j.bbabio.2016.04.006. Epub 2016 Apr 21. No abstract available.

25.

Structure and function of mitochondrial complex I.

Wirth C, Brandt U, Hunte C, Zickermann V.

Biochim Biophys Acta. 2016 Jul;1857(7):902-14. doi: 10.1016/j.bbabio.2016.02.013. Epub 2016 Feb 24. Review.

26.

The tetraspanin TSP3 of Neurospora crassa is a vacuolar membrane protein and shares characteristics with IDI proteins.

Heine D, Petereit L, Schumann MR, Patzelt D, Rachid L, Brandt U, Werner A, Pöggeler S, Fleißner A.

Mycologia. 2016 May-Jun;108(3):581-9. doi: 10.3852/15-225. Epub 2016 Feb 23.

PMID:
26908649
27.

Effect of smoking cessation counseling within a randomised study on early detection of lung cancer in Germany.

Bade M, Bähr V, Brandt U, Eigentopf A, Brüchert T, Gross ML, Motsch E, Becker N.

J Cancer Res Clin Oncol. 2016 May;142(5):959-68. doi: 10.1007/s00432-015-2105-0. Epub 2016 Jan 27.

PMID:
26814889
28.

Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation.

Birkenmeier K, Dröse S, Wittig I, Winkelmann R, Käfer V, Döring C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML.

Int J Cancer. 2016 May 1;138(9):2231-46. doi: 10.1002/ijc.29934. Epub 2016 Jan 18.

29.

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.

Huynen MA, Mühlmeister M, Gotthardt K, Guerrero-Castillo S, Brandt U.

Biochim Biophys Acta. 2016 Jan;1863(1):91-101. doi: 10.1016/j.bbamcr.2015.10.009. Epub 2015 Oct 23.

30.

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG.

Cell Metab. 2015 Sep 1;22(3):399-407. doi: 10.1016/j.cmet.2015.08.002.

31.

A jack-of-all-trades: 2-mercaptosuccinic acid.

Brandt U, Deters A, Steinbüchel A.

Appl Microbiol Biotechnol. 2015 Jun;99(11):4545-57. doi: 10.1007/s00253-015-6605-2. Epub 2015 May 5. Review.

PMID:
25936377
32.

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5685-90. doi: 10.1073/pnas.1424353112. Epub 2015 Apr 20.

33.

The AngFus3 Mitogen-Activated Protein Kinase Controls Hyphal Differentiation and Secondary Metabolism in Aspergillus niger.

Priegnitz BE, Brandt U, Pahirulzaman KA, Dickschat JS, Fleißner A.

Eukaryot Cell. 2015 Jun;14(6):602-15. doi: 10.1128/EC.00018-15. Epub 2015 Apr 17.

34.

Phase I study of everolimus, cetuximab and irinotecan as second-line therapy in metastatic colorectal cancer.

Hecht JR, Reid TR, Garrett CR, Beck JT, Davidson SJ, Mackenzie MJ, Brandt U, Rizvi S, Sharma S.

Anticancer Res. 2015 Mar;35(3):1567-73.

PMID:
25750312
35.

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.

Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U.

Science. 2015 Jan 2;347(6217):44-9. doi: 10.1126/science.1259859.

36.

Generator-specific targets of mitochondrial reactive oxygen species.

Bleier L, Wittig I, Heide H, Steger M, Brandt U, Dröse S.

Free Radic Biol Med. 2015 Jan;78:1-10. doi: 10.1016/j.freeradbiomed.2014.10.511. Epub 2014 Oct 29.

PMID:
25451644
37.

NOVA: a software to analyze complexome profiling data.

Giese H, Ackermann J, Heide H, Bleier L, Dröse S, Wittig I, Brandt U, Koch I.

Bioinformatics. 2015 Feb 1;31(3):440-1. doi: 10.1093/bioinformatics/btu623. Epub 2014 Oct 9.

PMID:
25301849
38.

Mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, from Variovorax paradoxus strain B4 is the key enzyme of mercaptosuccinate degradation.

Brandt U, Schürmann M, Steinbüchel A.

J Biol Chem. 2014 Oct 31;289(44):30800-9. doi: 10.1074/jbc.M114.579730. Epub 2014 Sep 16.

39.

Superoxide production by cytochrome bc1 complex: a mathematical model.

Guillaud F, Dröse S, Kowald A, Brandt U, Klipp E.

Biochim Biophys Acta. 2014 Oct;1837(10):1643-52. doi: 10.1016/j.bbabio.2014.05.358. Epub 2014 Jun 7.

40.

Mercaptosuccinate metabolism in Variovorax paradoxus strain B4--a proteomic approach.

Brandt U, Waletzko C, Voigt B, Hecker M, Steinbüchel A.

Appl Microbiol Biotechnol. 2014 Jul;98(13):6039-50. doi: 10.1007/s00253-014-5811-7. Epub 2014 May 17.

PMID:
24839213
41.

Loss of PINK1 impairs stress-induced autophagy and cell survival.

Parganlija D, Klinkenberg M, Domínguez-Bautista J, Hetzel M, Gispert S, Chimi MA, Dröse S, Mai S, Brandt U, Auburger G, Jendrach M.

PLoS One. 2014 Apr 21;9(4):e95288. doi: 10.1371/journal.pone.0095288. eCollection 2014.

42.

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity.

Angerer H, Radermacher M, Mańkowska M, Steger M, Zwicker K, Heide H, Wittig I, Brandt U, Zickermann V.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5207-12. doi: 10.1073/pnas.1322438111. Epub 2014 Mar 24.

43.

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.

Dröse S, Brandt U, Wittig I.

Biochim Biophys Acta. 2014 Aug;1844(8):1344-54. doi: 10.1016/j.bbapap.2014.02.006. Epub 2014 Feb 19. Review.

PMID:
24561273
44.

A sensing role of the glutamine synthetase in the nitrogen regulation network in Fusarium fujikuroi.

Wagner D, Wiemann P, Huß K, Brandt U, Fleißner A, Tudzynski B.

PLoS One. 2013 Nov 15;8(11):e80740. doi: 10.1371/journal.pone.0080740. eCollection 2013.

45.

Genome-guided insights into the versatile metabolic capabilities of the mercaptosuccinate-utilizing β-proteobacterium Variovorax paradoxus strain B4.

Brandt U, Hiessl S, Schuldes J, Thürmer A, Wübbeler JH, Daniel R, Steinbüchel A.

Environ Microbiol. 2014 Nov;16(11):3370-86. doi: 10.1111/1462-2920.12340. Epub 2013 Dec 18.

PMID:
24245581
46.

Is local participation always optimal for sustainable action? The costs of consensus-building in Local Agenda 21.

Brandt US, Svendsen GT.

J Environ Manage. 2013 Nov 15;129:266-73. doi: 10.1016/j.jenvman.2013.07.020. Epub 2013 Aug 22.

PMID:
23974351
47.

Phase I study investigating everolimus combined with sorafenib in patients with advanced hepatocellular carcinoma.

Finn RS, Poon RT, Yau T, Klümpen HJ, Chen LT, Kang YK, Kim TY, Gomez-Martin C, Rodriguez-Lope C, Kunz T, Paquet T, Brandt U, Sellami D, Bruix J.

J Hepatol. 2013 Dec;59(6):1271-7. doi: 10.1016/j.jhep.2013.07.029. Epub 2013 Aug 6.

PMID:
23928403
48.

Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS.

Chimi MA, Dröse S, Wittig I, Heide H, Steger M, Werner A, Hamann A, Osiewacz HD, Brandt U.

J Proteomics. 2013 Oct 8;91:358-74. doi: 10.1016/j.jprot.2013.07.008. Epub 2013 Jul 19.

PMID:
23872087
49.

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.

Gispert S, Parganlija D, Klinkenberg M, Dröse S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Büchel F, Adler T, Hrabé de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G.

Hum Mol Genet. 2013 Dec 15;22(24):4871-87. doi: 10.1093/hmg/ddt338. Epub 2013 Jul 12.

PMID:
23851121
50.

APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria.

Weber TA, Koob S, Heide H, Wittig I, Head B, van der Bliek A, Brandt U, Mittelbronn M, Reichert AS.

PLoS One. 2013 May 21;8(5):e63683. doi: 10.1371/journal.pone.0063683. Print 2013.

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