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Items: 17


Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.

Hosseinzade A, Sadeghi O, Naghdipour Biregani A, Soukhtehzari S, Brandt GS, Esmaillzadeh A.

Front Immunol. 2019 Jan 31;10:51. doi: 10.3389/fimmu.2019.00051. eCollection 2019. Review.


Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target.

Novak WRP, West KHJ, Kirkman LMD, Brandt GS.

Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):664-668. doi: 10.1107/S2053230X18010610. Epub 2018 Sep 21.


FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors.

Lin BC, Harris DR, Kirkman LMD, Perez AM, Qian Y, Schermerhorn JT, Hong MY, Winston DS, Xu L, Brandt GS.

ACS Omega. 2017 Oct 31;2(10):6605-6612. doi: 10.1021/acsomega.7b00997. Epub 2017 Oct 11.


The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum.

Lin BC, Harris DR, Kirkman LMD, Perez AM, Qian Y, Schermerhorn JT, Hong MY, Winston DS, Xu L, Lieber AM, Hamilton M, Brandt GS.

Bioorg Chem. 2017 Dec;75:217-223. doi: 10.1016/j.bioorg.2017.09.011. Epub 2017 Sep 18.


Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu CF, Brandt GS, Hoang QQ, Naumova N, Lazarevic V, Hwang ES, Dekker J, Glimcher LH, Ringe D, Petsko GA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6572-E6581. Epub 2016 Oct 10.


Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J.

PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132. eCollection 2014 May.


Dematin, a human erythrocyte cytoskeletal protein, is a substrate for a recombinant FIKK kinase from Plasmodium falciparum.

Brandt GS, Bailey S.

Mol Biochem Parasitol. 2013 Sep;191(1):20-3. doi: 10.1016/j.molbiopara.2013.08.003. Epub 2013 Aug 21.


Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.

Brandt GS, Kneen MM, Petsko GA, Ringe D, McLeish MJ.

J Am Chem Soc. 2010 Jan 20;132(2):438-9. doi: 10.1021/ja907064w.


Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.

Brandt GS, Kneen MM, Chakraborty S, Baykal AT, Nemeria N, Yep A, Ruby DI, Petsko GA, Kenyon GL, McLeish MJ, Jordan F, Ringe D.

Biochemistry. 2009 Apr 21;48(15):3247-57. doi: 10.1021/bi801950k.


Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.

Chakraborty S, Nemeria NS, Balakrishnan A, Brandt GS, Kneen MM, Yep A, McLeish MJ, Kenyon GL, Petsko GA, Ringe D, Jordan F.

Biochemistry. 2009 Feb 10;48(5):981-94. doi: 10.1021/bi801810h.


Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.

Brandt GS, Nemeria N, Chakraborty S, McLeish MJ, Yep A, Kenyon GL, Petsko GA, Jordan F, Ringe D.

Biochemistry. 2008 Jul 22;47(29):7734-43. doi: 10.1021/bi8004413. Epub 2008 Jun 21.


Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.

Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ.

Science. 2006 Apr 28;312(5773):572-6.


Caged phosphoproteins.

Rothman DM, Petersson EJ, Vázquez ME, Brandt GS, Dougherty DA, Imperiali B.

J Am Chem Soc. 2005 Jan 26;127(3):846-7.


Caging proteins through unnatural amino acid mutagenesis.

Petersson EJ, Brandt GS, Zacharias NM, Dougherty DA, Lester HA.

Methods Enzymol. 2003;360:258-73.


Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine.

Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, Dougherty DA.

Biochemistry. 2002 Aug 13;41(32):10262-9.


Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor.

Philipson KD, Gallivan JP, Brandt GS, Dougherty DA, Lester HA.

Am J Physiol Cell Physiol. 2001 Jul;281(1):C195-206.


Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel.

Tong Y, Brandt GS, Li M, Shapovalov G, Slimko E, Karschin A, Dougherty DA, Lester HA.

J Gen Physiol. 2001 Feb;117(2):103-18.

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