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Surface loops of trypsin-like serine proteases as determinants of function.

Goettig P, Brandstetter H, Magdolen V.

Biochimie. 2019 Sep 7. pii: S0300-9084(19)30262-7. doi: 10.1016/j.biochi.2019.09.004. [Epub ahead of print] Review.


Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.

Pereira GAN, da Silva EB, Braga SFP, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FMR, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS.

Eur J Med Chem. 2019 Oct 1;179:765-778. doi: 10.1016/j.ejmech.2019.06.062. Epub 2019 Jun 22.


Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity.

Soh WT, Aglas L, Mueller GA, Gilles S, Weiss R, Scheiblhofer S, Huber S, Scheidt T, Thompson PM, Briza P, London RE, Traidl-Hoffmann C, Cabrele C, Brandstetter H, Ferreira F.

Allergy. 2019 Jun 22. doi: 10.1111/all.13948. [Epub ahead of print]


Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design.

Barbosa da Silva E, Dall E, Briza P, Brandstetter H, Ferreira RS.

Acta Crystallogr F Struct Biol Commun. 2019 Jun 1;75(Pt 6):419-427. doi: 10.1107/S2053230X19006320. Epub 2019 May 13.


Maturation of coagulation factor IX during Xase formation as deduced using factor VIII-derived peptides.

Fang H, Zögg T, Brandstetter H.

FEBS Open Bio. 2019 Aug;9(8):1370-1378. doi: 10.1002/2211-5463.12653. Epub 2019 Jul 2.


Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

Dahms SO, Demir F, Huesgen PF, Thorn K, Brandstetter H.

J Thromb Haemost. 2019 Mar;17(3):470-481. doi: 10.1111/jth.14384. Epub 2019 Feb 13.


Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P.

Sci Rep. 2018 Jul 16;8(1):10705. doi: 10.1038/s41598-018-29058-6.


Activation and activity of glycosylated KLKs 3, 4 and 11.

Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P.

Biol Chem. 2018 Sep 25;399(9):1009-1022. doi: 10.1515/hsz-2018-0148.


Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states.

Dall E, Hollerweger JC, Dahms SO, Cui H, Häussermann K, Brandstetter H.

J Biol Chem. 2018 Aug 24;293(34):13151-13165. doi: 10.1074/jbc.RA118.002154. Epub 2018 Jul 2.


Specificity profiling of human trypsin-isoenzymes.

Schilling O, Biniossek ML, Mayer B, Elsässer B, Brandstetter H, Goettig P, Stenman UH, Koistinen H.

Biol Chem. 2018 Sep 25;399(9):997-1007. doi: 10.1515/hsz-2018-0107.


Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates.

Zauner FB, Elsässer B, Dall E, Cabrele C, Brandstetter H.

J Biol Chem. 2018 Jun 8;293(23):8934-8946. doi: 10.1074/jbc.M117.817031. Epub 2018 Apr 8.


Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples.

Hollerweger JC, Hoppe IJ, Regl C, Stock LG, Huber CG, Lohrig U, Stutz H, Brandstetter H.

Anal Chem. 2018 Apr 17;90(8):5055-5065. doi: 10.1021/acs.analchem.7b04874. Epub 2018 Apr 5.


Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation.

Zauner FB, Dall E, Regl C, Grassi L, Huber CG, Cabrele C, Brandstetter H.

Plant Cell. 2018 Mar;30(3):686-699. doi: 10.1105/tpc.17.00963. Epub 2018 Feb 16.


Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch.

Schinagl A, Kerschbaumer RJ, Sabarth N, Douillard P, Scholz P, Voelkel D, Hollerweger JC, Goettig P, Brandstetter H, Scheiflinger F, Thiele M.

Biochemistry. 2018 Mar 6;57(9):1523-1532. doi: 10.1021/acs.biochem.7b01156. Epub 2018 Feb 15.


Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.

Soh WT, Briza P, Dall E, Asam C, Schubert M, Huber S, Aglas L, Bohle B, Ferreira F, Brandstetter H.

Int J Mol Sci. 2017 Oct 16;18(10). pii: E2156. doi: 10.3390/ijms18102156.


Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations.

Elsässer B, Zauner FB, Messner J, Soh WT, Dall E, Brandstetter H.

ACS Catal. 2017 Sep 1;7(9):5585-5593. doi: 10.1021/acscatal.7b01505. Epub 2017 Jul 14.


Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.

Schönauer E, Kany AM, Haupenthal J, Hüsecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsässer B, Ducho C, Brandstetter H, Hartmann RW.

J Am Chem Soc. 2017 Sep 13;139(36):12696-12703. doi: 10.1021/jacs.7b06935. Epub 2017 Aug 31.


Endolysosomal Degradation of Allergenic Ole e 1-Like Proteins: Analysis of Proteolytic Cleavage Sites Revealing T Cell Epitope-Containing Peptides.

Wildner S, Elsässer B, Stemeseder T, Briza P, Soh WT, Villalba M, Lidholm J, Brandstetter H, Gadermaier G.

Int J Mol Sci. 2017 Aug 16;18(8). pii: E1780. doi: 10.3390/ijms18081780.


Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K.

Nat Commun. 2017 Mar 27;8:14740. doi: 10.1038/ncomms14740.


Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

Braga SF, Martins LC, da Silva EB, Sales Júnior PA, Murta SM, Romanha AJ, Soh WT, Brandstetter H, Ferreira RS, de Oliveira RB.

Bioorg Med Chem. 2017 Mar 15;25(6):1889-1900. doi: 10.1016/j.bmc.2017.02.009. Epub 2017 Feb 9.


Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family.

Stemeseder T, Freier R, Wildner S, Fuchs JE, Briza P, Lang R, Batanero E, Lidholm J, Liedl KR, Campo P, Hawranek T, Villalba M, Brandstetter H, Ferreira F, Gadermaier G.

J Allergy Clin Immunol. 2017 Jul;140(1):277-280. doi: 10.1016/j.jaci.2016.10.035. Epub 2016 Dec 10. No abstract available.


The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME.

Sci Rep. 2016 Sep 27;6:34303. doi: 10.1038/srep34303.


Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.

Debela M, Magdolen V, Bode W, Brandstetter H, Goettig P.

Biol Chem. 2016 Dec 1;397(12):1251-1264. doi: 10.1515/hsz-2016-0205.


Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579.

Abfalter CM, Schönauer E, Ponnuraj K, Huemer M, Gadermaier G, Regl C, Briza P, Ferreira F, Huber CG, Brandstetter H, Posselt G, Wessler S.

PLoS One. 2016 Sep 2;11(9):e0162433. doi: 10.1371/journal.pone.0162433. eCollection 2016.


The FELASA Award 2016 - A major award for laboratory animal science within Europe.

Brandstetter H.

Lab Anim. 2016 Aug;50(4):317-8. doi: 10.1177/0023677216660658. No abstract available.


Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.

Kristensen LH, Olsen OH, Blouse GE, Brandstetter H.

Biochem J. 2016 Aug 1;473(15):2395-411. doi: 10.1042/BCJ20160336. Epub 2016 May 19.


A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.

Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P.

J Biol Chem. 2016 Jan 8;291(2):593-604. doi: 10.1074/jbc.M115.691097. Epub 2015 Nov 18.


Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.

Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R.

J Allergy Clin Immunol. 2016 May;137(5):1525-34. doi: 10.1016/j.jaci.2015.09.026. Epub 2015 Nov 11.


Structure and function of legumain in health and disease.

Dall E, Brandstetter H.

Biochimie. 2016 Mar;122:126-50. doi: 10.1016/j.biochi.2015.09.022. Epub 2015 Sep 25. Review.


Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity.

Freier R, Dall E, Brandstetter H.

Sci Rep. 2015 Aug 3;5:12707. doi: 10.1038/srep12707.


HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis.

Wolkerstorfer S, Schwaiger E, Rinnerthaler M, Karina Gratz I, Zoegg T, Brandstetter H, Achatz-Straussberger G.

Cell Mol Immunol. 2016 Jul;13(4):451-61. doi: 10.1038/cmi.2015.18. Epub 2015 Apr 13.


Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain.

Dall E, Fegg JC, Briza P, Brandstetter H.

Angew Chem Int Ed Engl. 2015 Mar 2;54(10):2917-21. doi: 10.1002/anie.201409135. Epub 2015 Jan 28.


Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.

Grutsch S, Fuchs JE, Freier R, Kofler S, Bibi M, Asam C, Wallner M, Ferreira F, Brandstetter H, Liedl KR, Tollinger M.

Biophys J. 2014 Dec 16;107(12):2972-2981. doi: 10.1016/j.bpj.2014.10.062.


Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.

Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P.

J Biol Chem. 2014 Dec 5;289(49):34267-83. doi: 10.1074/jbc.M114.598201. Epub 2014 Oct 16.


Sweetened kallikrein-related peptidases (KLKs): glycan trees as potential regulators of activation and activity.

Guo S, Skala W, Magdolen V, Brandstetter H, Goettig P.

Biol Chem. 2014 Sep;395(9):959-76. doi: 10.1515/hsz-2014-0140. Review.


The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.

Ackaert C, Kofler S, Horejs-Hoeck J, Zulehner N, Asam C, von Grafenstein S, Fuchs JE, Briza P, Liedl KR, Bohle B, Ferreira F, Brandstetter H, Oostingh GJ, Duschl A.

PLoS One. 2014 Aug 15;9(8):e104520. doi: 10.1371/journal.pone.0104520. eCollection 2014.


Structural integrity of the antigen is a determinant for the induction of T-helper type-1 immunity in mice by gene gun vaccines against E. coli beta-galactosidase.

Deressa T, Stoecklinger A, Wallner M, Himly M, Kofler S, Hainz K, Brandstetter H, Thalhamer J, Hammerl P.

PLoS One. 2014 Jul 15;9(7):e102280. doi: 10.1371/journal.pone.0102280. eCollection 2014.


Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.

Eibl C, Hessenberger M, Wenger J, Brandstetter H.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):2007-18. doi: 10.1107/S1399004714010311. Epub 2014 Jun 29.


X-ray structures of human furin in complex with competitive inhibitors.

Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME.

ACS Chem Biol. 2014 May 16;9(5):1113-8. doi: 10.1021/cb500087x. Epub 2014 Apr 1.


Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.

Reinmuth-Selzle K, Ackaert C, Kampf CJ, Samonig M, Shiraiwa M, Kofler S, Yang H, Gadermaier G, Brandstetter H, Huber CG, Duschl A, Oostingh GJ, Pöschl U.

J Proteome Res. 2014 Mar 7;13(3):1570-7. doi: 10.1021/pr401078h. Epub 2014 Feb 19.


Small peptides blocking inhibition of factor Xa and tissue factor-factor VIIa by tissue factor pathway inhibitor (TFPI).

Dockal M, Hartmann R, Fries M, Thomassen MC, Heinzmann A, Ehrlich H, Rosing J, Osterkamp F, Polakowski T, Reineke U, Griessner A, Brandstetter H, Scheiflinger F.

J Biol Chem. 2014 Jan 17;289(3):1732-41. doi: 10.1074/jbc.M113.533836. Epub 2013 Nov 25.


Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties.

Kofler S, Ackaert C, Samonig M, Asam C, Briza P, Horejs-Hoeck J, Cabrele C, Ferreira F, Duschl A, Huber C, Brandstetter H.

J Biol Chem. 2014 Jan 3;289(1):540-51. doi: 10.1074/jbc.M113.518795. Epub 2013 Nov 19.


Do-it-yourself histidine-tagged bovine enterokinase: a handy member of the protein engineer's toolbox.

Skala W, Goettig P, Brandstetter H.

J Biotechnol. 2013 Dec;168(4):421-5. doi: 10.1016/j.jbiotec.2013.10.022. Epub 2013 Oct 30.


Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.

Eckhard U, Huesgen PF, Brandstetter H, Overall CM.

J Proteomics. 2014 Apr 4;100:102-14. doi: 10.1016/j.jprot.2013.10.004. Epub 2013 Oct 11.


Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.

Dall E, Brandstetter H.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10940-5. doi: 10.1073/pnas.1300686110. Epub 2013 Jun 17.


Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T.

Eckhard U, Schönauer E, Brandstetter H.

J Biol Chem. 2013 Jul 12;288(28):20184-94. doi: 10.1074/jbc.M112.448548. Epub 2013 May 23.


Crystal structures of the viral protease Npro imply distinct roles for the catalytic water in catalysis.

Zögg T, Sponring M, Schindler S, Koll M, Schneider R, Brandstetter H, Auer B.

Structure. 2013 Jun 4;21(6):929-38. doi: 10.1016/j.str.2013.04.003. Epub 2013 May 2.


The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions.

Hoy B, Brandstetter H, Wessler S.

J Basic Microbiol. 2013 May;53(5):402-9. doi: 10.1002/jobm.201200074. Epub 2012 Jun 26.


Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen bet v 1.

Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H.

J Mol Biol. 2012 Sep 7;422(1):109-23. doi: 10.1016/j.jmb.2012.05.016. Epub 2012 May 23.


Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.

Dall E, Brandstetter H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):24-31. doi: 10.1107/S1744309111048020. Epub 2011 Dec 24.

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