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Modulating Mistranslation Potential of tRNASer in Saccharomyces cerevisiae.

Berg MD, Zhu Y, Genereaux J, Ruiz BY, Rodriguez-Mias RA, Allan T, Bahcheli A, Villén J, Brandl CJ.

Genetics. 2019 Sep 4. pii: genetics.302525.2019. doi: 10.1534/genetics.119.302525. [Epub ahead of print]


Targeted sequencing reveals expanded genetic diversity of human transfer RNAs.

Berg MD, Giguere DJ, Dron JS, Lant JT, Genereaux J, Liao C, Wang J, Robinson JF, Gloor GB, Hegele RA, O'Donoghue P, Brandl CJ.

RNA Biol. 2019 Nov;16(11):1574-1585. doi: 10.1080/15476286.2019.1646079. Epub 2019 Aug 13.


Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity.

Jiang Y, Berg MD, Genereaux J, Ahmed K, Duennwald ML, Brandl CJ, Lajoie P.

Traffic. 2019 Apr;20(4):267-283. doi: 10.1111/tra.12637.


Pathways to disease from natural variations in human cytoplasmic tRNAs.

Lant JT, Berg MD, Heinemann IU, Brandl CJ, O'Donoghue P.

J Biol Chem. 2019 Apr 5;294(14):5294-5308. doi: 10.1074/jbc.REV118.002982. Epub 2019 Jan 14. Review.


Acceptor Stem Differences Contribute to Species-Specific Use of Yeast and Human tRNASer.

Berg MD, Genereaux J, Zhu Y, Mian S, Gloor GB, Brandl CJ.

Genes (Basel). 2018 Dec 7;9(12). pii: E612. doi: 10.3390/genes9120612.


Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté J.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10028-10033. doi: 10.1073/pnas.1806513115. Epub 2018 Sep 17.


The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes.

Berg MD, Genereaux J, Karagiannis J, Brandl CJ.

G3 (Bethesda). 2018 May 31;8(6):1943-1957. doi: 10.1534/g3.118.200288.


Visualizing tRNA-dependent mistranslation in human cells.

Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P.

RNA Biol. 2018;15(4-5):567-575. doi: 10.1080/15476286.2017.1379645. Epub 2017 Nov 9.


Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae.

Berg MD, Hoffman KS, Genereaux J, Mian S, Trussler RS, Haniford DB, O'Donoghue P, Brandl CJ.

Genetics. 2017 Aug;206(4):1865-1879. doi: 10.1534/genetics.117.203232. Epub 2017 Jun 2.


Mistranslation: from adaptations to applications.

Hoffman KS, O'Donoghue P, Brandl CJ.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3070-3080. doi: 10.1016/j.bbagen.2017.01.031. Epub 2017 Jan 30. Review.


Genetic selection for mistranslation rescues a defective co-chaperone in yeast.

Hoffman KS, Berg MD, Shilton BH, Brandl CJ, O'Donoghue P.

Nucleic Acids Res. 2017 Apr 7;45(6):3407-3421. doi: 10.1093/nar/gkw1021.


Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

Hoffman KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ.

G3 (Bethesda). 2016 Jun 1;6(6):1649-59. doi: 10.1534/g3.116.029520.


Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape.

Litchfield DW, Shilton BH, Brandl CJ, Gyenis L.

Biochim Biophys Acta. 2015 Oct;1850(10):2077-86. doi: 10.1016/j.bbagen.2015.02.018. Epub 2015 Mar 10. Review.


Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.

Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH.

Biochim Biophys Acta. 2015 May;1852(5):905-12. doi: 10.1016/j.bbadis.2014.12.025. Epub 2015 Jan 13.


The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

Lam SK, Ma X, Sing TL, Shilton BH, Brandl CJ, Davey MJ.

PLoS One. 2013 Dec 11;8(12):e82177. doi: 10.1371/journal.pone.0082177. eCollection 2013.


The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.

DaSilva LF, Pillon S, Genereaux J, Davey MJ, Gloor GB, Karagiannis J, Brandl CJ.

G3 (Bethesda). 2013 Oct 3;3(10):1661-74. doi: 10.1534/g3.113.006841.


Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding.

Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW.

Front Physiol. 2013 Feb 13;4:18. doi: 10.3389/fphys.2013.00018. eCollection 2013.


Mcm2 phosphorylation and the response to replicative stress.

Stead BE, Brandl CJ, Sandre MK, Davey MJ.

BMC Genet. 2012 May 7;13:36. doi: 10.1186/1471-2156-13-36.


Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.

Genereaux J, Kvas S, Dobransky D, Karagiannis J, Gloor GB, Brandl CJ.

Genetics. 2012 Jul;191(3):765-80. doi: 10.1534/genetics.112.140459. Epub 2012 Apr 13.


Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1.

Kvas S, Gloor GB, Brandl CJ.

BMC Genet. 2012 Mar 22;13:19. doi: 10.1186/1471-2156-13-19.


A synthetic human kinase can control cell cycle progression in budding yeast.

Davey MJ, Andrighetti HJ, Ma X, Brandl CJ.

G3 (Bethesda). 2011 Sep;1(4):317-25. doi: 10.1534/g3.111.000430. Epub 2011 Sep 1.


Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage.

Stead BE, Brandl CJ, Davey MJ.

Nucleic Acids Res. 2011 Sep 1;39(16):6998-7008. doi: 10.1093/nar/gkr371. Epub 2011 May 19.


Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1.

Duncan KE, Dempsey BR, Killip LE, Adams J, Bailey ML, Lajoie GA, Litchfield DW, Brandl CJ, Shaw GS, Shilton BH.

J Med Chem. 2011 Jun 9;54(11):3854-65. doi: 10.1021/jm200156c. Epub 2011 May 5.


Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.

Hoke SM, Irina Mutiu A, Genereaux J, Kvas S, Buck M, Yu M, Gloor GB, Brandl CJ.

Curr Genet. 2010 Oct;56(5):447-65. doi: 10.1007/s00294-010-0313-3. Epub 2010 Jul 16.


Functionally compensating coevolving positions are neither homoplasic nor conserved in clades.

Gloor GB, Tyagi G, Abrassart DM, Kingston AJ, Fernandes AD, Dunn SD, Brandl CJ.

Mol Biol Evol. 2010 May;27(5):1181-91. doi: 10.1093/molbev/msq004. Epub 2010 Jan 11.


ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.

Stead BE, Sorbara CD, Brandl CJ, Davey MJ.

J Mol Biol. 2009 Aug 14;391(2):301-13. doi: 10.1016/j.jmb.2009.06.038. Epub 2009 Jun 21.


Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.

Yousef AF, Brandl CJ, Mymryk JS.

BMC Mol Biol. 2009 Apr 17;10:32. doi: 10.1186/1471-2199-10-32.


A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids.

Hoke SM, Genereaux J, Liang G, Brandl CJ.

J Mol Biol. 2008 Dec 26;384(4):743-55. doi: 10.1016/j.jmb.2008.09.088. Epub 2008 Oct 11.


The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role.

Bailey ML, Shilton BH, Brandl CJ, Litchfield DW.

Biochemistry. 2008 Nov 4;47(44):11481-9. doi: 10.1021/bi800964q. Epub 2008 Oct 10.


Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.

Hoke SM, Guzzo J, Andrews B, Brandl CJ.

BMC Genet. 2008 Jul 10;9:46. doi: 10.1186/1471-2156-9-46.


Coactivator requirements for p53-dependent transcription in the yeast Saccharomyces cerevisiae.

Yousef AF, Xu GW, Mendez M, Brandl CJ, Mymryk JS.

Int J Cancer. 2008 Feb 15;122(4):942-6.


C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex.

Hoke SM, Liang G, Mutiu AI, Genereaux J, Brandl CJ.

BMC Biochem. 2007 Aug 8;8:16.


Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1.

Mutiu AI, Hoke SM, Genereaux J, Hannam C, MacKenzie K, Jobin-Robitaille O, Guzzo J, Côté J, Andrews B, Haniford DB, Brandl CJ.

Genetics. 2007 Sep;177(1):151-66. Epub 2007 Jul 29.


The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain.

Mutiu AI, Hoke SM, Genereaux J, Liang G, Brandl CJ.

Mol Genet Genomics. 2007 May;277(5):491-506. Epub 2007 Feb 15.


Functionally important residues in the peptidyl-prolyl isomerase Pin1 revealed by unigenic evolution.

Behrsin CD, Bailey ML, Bateman KS, Hamilton KS, Wahl LM, Brandl CJ, Shilton BH, Litchfield DW.

J Mol Biol. 2007 Jan 26;365(4):1143-62. Epub 2006 Oct 28.


Development of an unbiased statistical method for the analysis of unigenic evolution.

Behrsin CD, Brandl CJ, Litchfield DW, Shilton BH, Wahl LM.

BMC Bioinformatics. 2006 Mar 17;7:150.


RNA isolation from yeast using silica matrices.

Mutiu AI, Brandl CJ.

J Biomol Tech. 2005 Dec;16(4):316-7.


Molecular cloning using the interrupted recognition sequence of BplI to select for recombinant molecules.

Mastrodicasa MA, Brandl CJ.

Biotechniques. 2002 Nov;33(5):992, 994, 996. No abstract available.


The adenovirus E1A protein targets the SAGA but not the ADA transcriptional regulatory complex through multiple independent domains.

Shuen M, Avvakumov N, Walfish PG, Brandl CJ, Mymryk JS.

J Biol Chem. 2002 Aug 23;277(34):30844-51. Epub 2002 Jun 17.


The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcription.

Turner SD, Ricci AR, Petropoulos H, Genereaux J, Skerjanc IS, Brandl CJ.

Mol Cell Biol. 2002 Jun;22(12):4011-9.


NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, Pillus L, Workman JL, Côté J.

EMBO J. 1999 Sep 15;18(18):5108-19.


Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.

Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates JR 3rd, Lees-Miller SP, Cole MD, Brandl CJ.

J Biol Chem. 1998 Oct 9;273(41):26559-65.


TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.

Saleh A, Collart M, Martens JA, Genereaux J, Allard S, Cote J, Brandl CJ.

J Mol Biol. 1998 Oct 9;282(5):933-46.


Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p.

Martens JA, Genereaux J, Saleh A, Brandl CJ.

J Biol Chem. 1996 Jul 5;271(27):15884-90.


Structure/functional properties of the yeast dual regulator protein NGG1 that are required for glucose repression.

Brandl CJ, Martens JA, Margaliot A, Stenning D, Furlanetto AM, Saleh A, Hamilton KS, Genereaux J.

J Biol Chem. 1996 Apr 19;271(16):9298-306.


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