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Items: 1 to 50 of 142

1.

Strategies to improve the oxygen supply to microencapsulated islets.

Brandhorst D, Brandhorst H, Johnson PRV.

Transplantation. 2019 Jul 25. doi: 10.1097/TP.0000000000002897. [Epub ahead of print] No abstract available.

PMID:
31356576
2.

Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation.

Brandhorst H, Johnson PR, Mönch J, Kurfürst M, Korsgren O, Brandhorst D.

Cell Transplant. 2019 Feb;28(2):176-184. doi: 10.1177/0963689718811614. Epub 2018 Nov 13.

3.

Does Islet Size Really Influence Graft Function After Clinical Islet Transplantation?

Hughes SJ, Bateman PA, Cross SE, Brandhorst D, Brandhorst H, Spiliotis I, Ballav C, Rosenthal M, Rutter MK, Shaw J, Gough S, Johnson PRV.

Transplantation. 2018 Nov;102(11):1857-1863. doi: 10.1097/TP.0000000000002392.

PMID:
30063695
4.

Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity.

Brandhorst H, Johnson PRV, Korsgren O, Brandhorst D.

Cell Transplant. 2017 Nov;26(11):1733-1741. doi: 10.1177/0963689717727544. Erratum in: Cell Transplant. 2018 Jan 1;:963689718764949.

5.

Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation.

Brandhorst D, Parnaud G, Friberg A, Lavallard V, Demuylder-Mischler S, Hughes S, Saphörster J, Kurfürst M, Korsgren O, Berney T, Johnson PRV.

Cell Transplant. 2017 Oct;26(10):1688-1693. doi: 10.1177/0963689717731574.

6.

Hypoxia-Induced Damage in Human Islets Is Reduced With the Use of Mesenchymal Stem Cell-Preconditioned Medium.

Brandhorst D, Brandhorst H, Acreman S, Schive SW, Bjørnson Scholz H, Johnson PRV.

Transplant Proc. 2017 Dec;49(10):2330-2332. doi: 10.1016/j.transproceed.2017.11.003.

PMID:
29198672
7.

Effect of Etanercept Concentration on Human Islet Integrity.

Acreman S, Brandhorst H, Abraham A, Johnson PRV, Brandhorst D.

Transplant Proc. 2017 Dec;49(10):2327-2329. doi: 10.1016/j.transproceed.2017.11.002.

PMID:
29198671
8.

Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.

Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AMJ.

Diabetes. 2017 Sep;66(9):2531. doi: 10.2337/db17-er09a. Epub 2017 Jun 29. No abstract available.

9.

Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation?

Brandhorst D, Brandhorst H, Johnson PRV.

Rev Diabet Stud. 2017 Spring;14(1):22-38. doi: 10.1900/RDS.2017.14.22. Epub 2017 Jun 12. Review.

10.

Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.

NIH CIT Consortium Chemistry Manufacturing Controls Monitoring Committee, Ansite J, Balamurugan AN, Barbaro B, Battle J, Brandhorst D, Cano J, Chen X, Deng S, Feddersen D, Friberg A, Gilmore T, Goldstein JS, Holbrook E, Khan A, Kin T, Lei J, Linetsky E, Liu C, Luo X, McElvaney K, Min Z, Moreno J, O'Gorman D, Papas KK, Putz G, Ricordi C, Szot G, Templeton T, Wang L, Wilhelm JJ, Willits J, Wilson T, Zhang X; NIH CIT Consortium, Avila J, Begley B, Cano J, Carpentier S, Holbrook E, Hutchinson J, Larsen CP, Moreno J, Sears M, Turgeon NA, Webster D, Deng S, Lei J, Markmann JF, Bridges ND, Czarniecki CW, Goldstein JS, Putz G, Templeton T, Wilson T, Eggerman TL, Al-Saden P, Battle J, Chen X, Hecyk A, Kissler H, Luo X, Molitch M, Monson N, Stuart E, Wallia A, Wang L, Wang S, Zhang X, Bigam D, Campbell P, Dinyari P, Kin T, Kneteman N, Lyon J, Malcolm A, O'Gorman D, Onderka C, Owen R, Pawlick R, Richer B, Rosichuk S, Sarman D, Schroeder A, Senior PA, Shapiro AMJ, Toth L, Toth V, Zhai W, Johnson K, McElroy J, Posselt AM, Ramos M, Rojas T, Stock PG, Szot G, Barbaro B, Martellotto J, Oberholzer J, Qi M, Wang Y, Bayman L, Chaloner K, Clarke W, Dillon JS, Diltz C, Doelle GC, Ecklund D, Feddersen D, Foster E, Hunsicker LG, Jasperson C, Lafontant DE, McElvaney K, Neill-Hudson T, Nollen D, Qidwai J, Riss H, Schwieger T, Willits J, Yankey J, Alejandro R, Corrales AC, Faradji R, Froud T, Garcia AA, Herrada E, Ichii H, Inverardi L, Kenyon N, Khan A, Linetsky E, Montelongo J, Peixoto E, Peterson K, Ricordi C, Szust J, Wang X, Abdulla MH, Ansite J, Balamurugan AN, Bellin MD, Brandenburg M, Gilmore T, Harmon JV, Hering BJ, Kandaswamy R, Loganathan G, Mueller K, Papas KK, Pedersen J, Wilhelm JJ, Witson J, Dalton-Bakes C, Fu H, Kamoun M, Kearns J, Li Y, Liu C, Luning-Prak E, Luo Y, Markmann E, Min Z, Naji A, Palanjian M, Rickels M, Shlansky-Goldberg R, Vivek K, Ziaie AS, Fernandez L, Kaufman DB, Zitur L, Brandhorst D, Friberg A, Korsgren O.

CellR4 Repair Replace Regen Reprogram. 2017;5(3). pii: e2377. Epub 2017 May 26. No abstract available.

11.

Pancreatic Islets: Methods for Isolation and Purification of Juvenile and Adult Pig Islets.

Brandhorst H, Johnson PR, Brandhorst D.

Adv Exp Med Biol. 2016;938:35-55. doi: 10.1007/978-3-319-39824-2_4.

PMID:
27586421
12.

Comparison of Neutral Proteases and Collagenase Class I as Essential Enzymes for Human Islet Isolation.

Brandhorst H, Kurfürst M, Johnson PR, Korsgren O, Brandhorst D.

Transplant Direct. 2015 Dec 15;2(1):e47. doi: 10.1097/TXD.0000000000000552. eCollection 2016 Jan.

13.

National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.

Ricordi C, Goldstein JS, Balamurugan AN, Szot GL, Kin T, Liu C, Czarniecki CW, Barbaro B, Bridges ND, Cano J, Clarke WR, Eggerman TL, Hunsicker LG, Kaufman DB, Khan A, Lafontant DE, Linetsky E, Luo X, Markmann JF, Naji A, Korsgren O, Oberholzer J, Turgeon NA, Brandhorst D, Chen X, Friberg AS, Lei J, Wang LJ, Wilhelm JJ, Willits J, Zhang X, Hering BJ, Posselt AM, Stock PG, Shapiro AM, Chen X.

Diabetes. 2016 Nov;65(11):3418-3428. Epub 2016 Jul 27. Erratum in: Diabetes. 2017 Sep;66(9):2531.

14.

Evaluation of Perfluorohexyloctane/Polydimethylsiloxane for Pancreas Preservation for Clinical Islet Isolation and Transplantation.

Sthle M, Foss A, Gustafsson B, Lempinen M, Lundgren T, Rafael E, Tufveson G, Theisinger B, Brandhorst D, Korsgren O, Friberg A.

Cell Transplant. 2016 Dec 13;25(12):2269-2276. doi: 10.3727/096368916X691709. Epub 2016 May 27.

PMID:
27301705
15.

High Seeding Density Induces Local Hypoxia and Triggers a Proinflammatory Response in Isolated Human Islets.

Brandhorst D, Brandhorst H, Mullooly N, Acreman S, Johnson PR.

Cell Transplant. 2016;25(8):1539-46. doi: 10.3727/096368915X689929. Epub 2015 Nov 20.

PMID:
26628048
16.

Pancreatic L-Glutamine Administration Protects Pig Islets From Cold Ischemic Injury and Increases Resistance Toward Inflammatory Mediators.

Brandhorst H, Theisinger B, Guenther B, Johnson PR, Brandhorst D.

Cell Transplant. 2016;25(3):531-8. doi: 10.3727/096368915X688623. Epub 2015 Jul 8.

PMID:
26177261
17.

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.

Brandhorst D, Brandhorst H, Maataoui V, Maataoui A, Johnson PR.

Apoptosis. 2013 Jun;18(6):681-8. doi: 10.1007/s10495-013-0834-6.

PMID:
23536200
18.

Liver-directed chemotherapy of cetuximab and bevacizumab in combination with oxaliplatin is more effective to inhibit tumor growth of CC531 colorectal rat liver metastases than systemic chemotherapy.

Sperling J, Brandhorst D, Schäfer T, Ziemann C, Benz-Weißer A, Scheuer C, Kollmar O, Schilling MK, Menger MD.

Clin Exp Metastasis. 2013 Apr;30(4):447-55. doi: 10.1007/s10585-012-9550-9. Epub 2012 Nov 27.

19.

Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

Brandhorst H, Iken M, Scott WE 3rd, Papas KK, Theisinger B, Johnson PR, Korsgren O, Brandhorst D.

Cell Transplant. 2013;22(8):1477-83. doi: 10.3727/096368912X657639. Epub 2012 Oct 4.

PMID:
23044229
20.

Oxygen-charged HTK-F6H8 emulsion reduces ischemia-reperfusion injury in kidneys from brain-dead pigs.

Asif S, Sedigh A, Nordström J, Brandhorst H, Jorns C, Lorant T, Larsson E, Magnusson PU, Nowak G, Theisinger S, Hoeger S, Wennberg L, Korsgren O, Brandhorst D.

J Surg Res. 2012 Dec;178(2):959-67. doi: 10.1016/j.jss.2012.06.031. Epub 2012 Jul 6.

PMID:
22795349
21.

Using HTK for prolonged pancreas preservation prior to human islet isolation.

Caballero-Corbalán J, Brandhorst H, Malm H, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

J Surg Res. 2012 Jun 1;175(1):163-8. doi: 10.1016/j.jss.2011.03.012. Epub 2011 Mar 31.

PMID:
21550052
22.

Quantification of the islet product: presentation of a standardized current good manufacturing practices compliant system with minimal variability.

Friberg AS, Brandhorst H, Buchwald P, Goto M, Ricordi C, Brandhorst D, Korsgren O.

Transplantation. 2011 Mar 27;91(6):677-83. doi: 10.1097/TP.0b013e31820ae48e.

PMID:
21248660
23.

Large-scale bioreactor expansion of tumor-infiltrating lymphocytes.

Sadeghi A, Pauler L, Annerén C, Friberg A, Brandhorst D, Korsgren O, Tötterman TH.

J Immunol Methods. 2011 Feb 1;364(1-2):94-100. doi: 10.1016/j.jim.2010.11.007. Epub 2010 Nov 25.

PMID:
21111743
24.

Pathogen inactivation of human serum facilitates its clinical use for islet cell culture and subsequent transplantation.

Ståhle MU, Brandhorst D, Korsgren O, Knutson F.

Cell Transplant. 2011;20(5):775-81. doi: 10.3727/096368910X539056. Epub 2010 Nov 5.

PMID:
21054939
25.

Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine.

Kakabadze Z, Gupta S, Brandhorst D, Korsgren O, Berishvili E.

Transpl Int. 2011 Feb;24(2):175-83. doi: 10.1111/j.1432-2277.2010.01160.x. Epub 2010 Sep 6.

26.

The effect of truncated collagenase class I isomers on human islet isolation outcome.

Brandhorst H, Asif S, Andersson K, Mönch J, Friedrich O, Rämsch-Günther N, Rämsch C, Steffens M, Lambrecht J, Schräder T, Kurfürst M, Andersson HH, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Transplantation. 2010 Aug 15;90(3):334-5. doi: 10.1097/TP.0b013e3181e49bd7. No abstract available.

PMID:
20683429
27.

Mammalian tissue-free liberase: a new GMP-graded enzyme blend for human islet isolation.

Caballero-Corbalán J, Brandhorst H, Asif S, Korsgren O, Engelse M, de Koning E, Pattou F, Kerr-Conte J, Brandhorst D.

Transplantation. 2010 Aug 15;90(3):332-3. doi: 10.1097/TP.0b013e3181e117e3. No abstract available.

PMID:
20683428
28.

A new oxygen carrier for improved long-term storage of human pancreata before islet isolation.

Brandhorst H, Asif S, Andersson K, Theisinger B, Andersson HH, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Transplantation. 2010 Jan 27;89(2):155-60. doi: 10.1097/TP.0b013e3181c9266c.

PMID:
20098277
29.

Vitacyte collagenase HA: a novel enzyme blend for efficient human islet isolation.

Caballero-Corbalán J, Friberg AS, Brandhorst H, Nilsson B, Andersson HH, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Transplantation. 2009 Dec 27;88(12):1400-2. doi: 10.1097/TP.0b013e3181bd1441. No abstract available. Erratum in: Transplantation. 2010 Apr 15;89(7):907.

PMID:
20029339
30.

Large-scale comparison of Liberase HI and collagenase NB1 utilized for human islet isolation.

Brandhorst H, Friberg A, Nilsson B, Andersson HH, Felldin M, Foss A, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Cell Transplant. 2010;19(1):3-8. doi: 10.3727/096368909X477507. Epub 2009 Oct 9.

PMID:
19818208
31.

Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.

Brandhorst H, Theisinger B, Yamaya H, Henriksnäs J, Carlsson PO, Korsgren O, Brandhorst D.

Transpl Int. 2009 Oct;22(10):1017-22. doi: 10.1111/j.1432-2277.2009.00905.x. Epub 2009 Jul 10.

32.

Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.

Iken M, Brandhorst H, Korsgren O, Brandhorst D.

Cell Transplant. 2009;18(7):745-51. doi: 10.3727/096368909X470838. Epub 2009 Apr 23.

PMID:
19520045
33.

The importance of tryptic-like activity in purified enzyme blends for efficient islet isolation.

Brandhorst H, Friberg A, Andersson HH, Felldin M, Foss A, Salmela K, Lundgren T, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Transplantation. 2009 Feb 15;87(3):370-5. doi: 10.1097/TP.0b013e31819499f0.

PMID:
19202441
34.

Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.

Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl KN, Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B.

Xenotransplantation. 2008 Jul-Aug;15(4):225-34. doi: 10.1111/j.1399-3089.2008.00482.x. Erratum in: Xenotransplantation. 2008 Sep;15(5):352.

35.

New class of oxygen carriers improves islet isolation from long-term stored rat pancreata.

Brandhorst H, Muehling B, Yamaya H, Henriksnaes J, Carlsson PO, Korsgren O, Brandhorst D.

Transplant Proc. 2008 Mar;40(2):393-4. doi: 10.1016/j.transproceed.2008.01.012.

PMID:
18374079
36.

Degraded collagenase deteriorates islet viability.

Brandhorst H, Raemsch-Guenther N, Raemsch C, Friedrich O, Kurfuerst M, Korsgren O, Brandhorst D.

Transplant Proc. 2008 Mar;40(2):370-1. doi: 10.1016/j.transproceed.2008.01.013.

PMID:
18374071
37.

The clinical significance of soluble human leukocyte antigen class-I, ICTP, and RANKL molecules in multiple myeloma patients.

Schütt P, Rebmann V, Brandhorst D, Wiefelspütz J, Ebeling P, Opalka B, Seeber S, Nowrousian MR, Moritz T, Grosse-Wilde H.

Hum Immunol. 2008 Feb;69(2):79-87. doi: 10.1016/j.humimm.2008.01.006. Epub 2008 Feb 7.

PMID:
18361931
38.

The ratio between collagenase class I and class II influences the efficient islet release from the rat pancreas.

Brandhorst H, Raemsch-Guenther N, Raemsch C, Friedrich O, Huettler S, Kurfuerst M, Korsgren O, Brandhorst D.

Transplantation. 2008 Feb 15;85(3):456-61. doi: 10.1097/TP.0b013e31816050c8.

PMID:
18301337
39.

Human islet separation utilizing a closed automated purification system.

Friberg AS, Ståhle M, Brandhorst H, Korsgren O, Brandhorst D.

Cell Transplant. 2008;17(12):1305-13.

PMID:
19364068
40.

Effect of pretransplant preconditioning by whole body hyperthermia on islet graft survival.

Brandhorst H, Olbrich M, Neumann A, Jahr H, Brandhorst D.

Cell Transplant. 2007;16(7):707-15.

PMID:
18019360
41.

Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model.

Eich T, Eriksson O, Sundin A, Estrada S, Brandhorst D, Brandhorst H, Langstrom B, Nilsson B, Korsgren O, Lundgren T.

Transplantation. 2007 Oct 15;84(7):893-8.

PMID:
17984843
42.

No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation.

Caballero-Corbalán J, Eich T, Lundgren T, Foss A, Felldin M, Källen R, Salmela K, Tibell A, Tufveson G, Korsgren O, Brandhorst D.

Transplantation. 2007 Oct 15;84(7):864-9.

PMID:
17984839
43.

Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients.

Rebmann V, Schütt P, Brandhorst D, Opalka B, Moritz T, Nowrousian MR, Grosse-Wilde H.

Clin Immunol. 2007 Apr;123(1):114-20. Epub 2007 Jan 10.

PMID:
17218152
44.

Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles.

Rizzoli SO, Bethani I, Zwilling D, Wenzel D, Siddiqui TJ, Brandhorst D, Jahn R.

Traffic. 2006 Sep;7(9):1163-76.

45.

Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections.

Schütt P, Brandhorst D, Stellberg W, Poser M, Ebeling P, Müller S, Buttkereit U, Opalka B, Lindemann M, Grosse-Wilde H, Seeber S, Moritz T, Nowrousian MR.

Leuk Lymphoma. 2006 Aug;47(8):1570-82.

PMID:
16966269
46.

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.

Brandhorst D, Iken M, Bretzel RG, Brandhorst H.

Xenotransplantation. 2006 Sep;13(5):465-70.

PMID:
16925671
47.

Porcine islet graft function is affected by pretreatment with a caspase-3 inhibitor.

Brandhorst D, Kumarasamy V, Maatoui A, Alt A, Bretzel RG, Brandhorst H.

Cell Transplant. 2006;15(4):311-7.

PMID:
16898224
48.

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.

Linn T, Schmitz J, Hauck-Schmalenberger I, Lai Y, Bretzel RG, Brandhorst H, Brandhorst D.

Clin Exp Immunol. 2006 May;144(2):179-87. Review.

49.

Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity.

Brandhorst D, Zwilling D, Rizzoli SO, Lippert U, Lang T, Jahn R.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2701-6. Epub 2006 Feb 9.

50.

Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma.

Nowrousian MR, Brandhorst D, Sammet C, Kellert M, Daniels R, Schuett P, Poser M, Mueller S, Ebeling P, Welt A, Bradwell AR, Buttkereit U, Opalka B, Flasshove M, Moritz T, Seeber S.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8706-14.

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