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Items: 30

1.

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

Fujino N, Brand OJ, Morgan DJ, Fujimori T, Grabiec AM, Jagger CP, Maciewicz RA, Yamada M, Itakura K, Sugiura H, Ichinose M, Hussell T.

J Exp Med. 2019 Sep 2;216(9):2184-2201. doi: 10.1084/jem.20171978. Epub 2019 Jul 9.

PMID:
31289116
2.

Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia.

Morgan DJ, Casulli J, Chew C, Connolly E, Lui S, Brand OJ, Rahman R, Jagger C, Hussell T.

Front Immunol. 2018 Dec 14;9:2943. doi: 10.3389/fimmu.2018.02943. eCollection 2018. Review.

3.

Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.

Bell TJ, Brand OJ, Morgan DJ, Salek-Ardakani S, Jagger C, Fujimori T, Cholewa L, Tilakaratna V, Östling J, Thomas M, Day AJ, Snelgrove RJ, Hussell T.

Matrix Biol. 2019 Jul;80:14-28. doi: 10.1016/j.matbio.2018.06.006. Epub 2018 Jun 20.

4.

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.

Pasini A, Brand OJ, Jenkins G, Knox AJ, Pang L.

Biochim Biophys Acta Gene Regul Mech. 2018 May;1861(5):463-472. doi: 10.1016/j.bbagrm.2018.03.007. Epub 2018 Mar 17.

5.

Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis.

Coward WR, Brand OJ, Pasini A, Jenkins G, Knox AJ, Pang L.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):449-460. doi: 10.1165/rcmb.2017-0286OC.

6.

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL.

J Biol Chem. 2015 Jun 5;290(23):14717-28. doi: 10.1074/jbc.M114.630368. Epub 2015 Apr 27.

7.

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL.

Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074.

8.

Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.

Simmonds MJ, Kavvoura FK, Brand OJ, Newby PR, Jackson LE, Hargreaves CE, Franklyn JA, Gough SC.

J Clin Endocrinol Metab. 2014 Jan;99(1):E127-31. doi: 10.1210/jc.2013-2667. Epub 2013 Dec 20.

PMID:
24187400
9.

Skewing of female X-chromosome inactivation: an epigenetic risk factor for kidney transplantation outcome.

Simmonds MJ, Benavente D, Brand OJ, Moore J, Ball S, Ferro CJ, Briggs D, Gough SC, Borrows RJ.

Transplantation. 2013 Mar 15;95(5):e25-8. doi: 10.1097/TP.0b013e318282256f. No abstract available.

PMID:
23503508
10.

Donor ABCB1 variant associates with increased risk for kidney allograft failure.

Moore J, McKnight AJ, Döhler B, Simmonds MJ, Courtney AE, Brand OJ, Briggs D, Ball S, Cockwell P, Patterson CC, Maxwell AP, Gough SC, Opelz G, Borrows R.

J Am Soc Nephrol. 2012 Nov;23(11):1891-9. doi: 10.1681/ASN.2012030260. Epub 2012 Oct 11.

11.

Seven newly identified loci for autoimmune thyroid disease.

Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H, Coleman G; Wellcome Trust Case Control Consortium, Franklyn JA, Todd JA, Gough SC.

Hum Mol Genet. 2012 Dec 1;21(23):5202-8. doi: 10.1093/hmg/dds357. Epub 2012 Aug 24.

12.

Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.

Brand OJ, Gough SC.

Curr Genomics. 2011 Dec;12(8):526-41. doi: 10.2174/138920211798120790.

13.

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.

Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium; UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA.

Nat Genet. 2011 Dec 27;44(1):3-5. doi: 10.1038/ng.1037. No abstract available.

14.

Copy number variation in common disease.

Brand OJ, Gough SC.

Thyroid. 2011 Jan;21(1):1-4. doi: 10.1089/thy.2010.2101.ed. No abstract available.

PMID:
21219114
15.

Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts.

Płoski R, Brand OJ, Jurecka-Lubieniecka B, Franaszczyk M, Kula D, Krajewski P, Karamat MA, Simmonds MJ, Franklyn JA, Gough SC, Jarząb B, Bednarczuk T.

PLoS One. 2010 Nov 25;5(11):e15512. doi: 10.1371/journal.pone.0015512.

16.

Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3.

Simmonds MJ, Brand OJ, Barrett JC, Newby PR, Franklyn JA, Gough SC.

Clin Endocrinol (Oxf). 2010 Nov;73(5):654-60. doi: 10.1111/j.1365-2265.2010.03843.x.

17.

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.

Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, Gül A.

Nat Genet. 2010 Aug;42(8):698-702. doi: 10.1038/ng.625. Epub 2010 Jul 11.

18.

Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.

Newby PR, Pickles OJ, Mazumdar S, Brand OJ, Carr-Smith JD, Pearce SH, Franklyn JA; Wellcome Trust Case-Control Consortium (WTCCC), Evans DM, Simmonds MJ, Gough SC.

Eur J Hum Genet. 2010 Sep;18(9):1021-6. doi: 10.1038/ejhg.2010.55. Epub 2010 May 5.

19.

Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure.

Moore J, McKnight AJ, Simmonds MJ, Courtney AE, Hanvesakul R, Brand OJ, Briggs D, Ball S, Cockwell P, Patterson CC, Maxwell AP, Gough SC, Borrows R.

JAMA. 2010 Apr 7;303(13):1282-7. doi: 10.1001/jama.2010.356.

PMID:
20371787
20.

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Wellcome Trust Case Control Consortium, Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K, Bowes J, Brand OJ, Braund PS, Bredin F, Breen G, Brown MJ, Bruce IN, Bull J, Burren OS, Burton J, Byrnes J, Caesar S, Clee CM, Coffey AJ, Connell JM, Cooper JD, Dominiczak AF, Downes K, Drummond HE, Dudakia D, Dunham A, Ebbs B, Eccles D, Edkins S, Edwards C, Elliot A, Emery P, Evans DM, Evans G, Eyre S, Farmer A, Ferrier IN, Feuk L, Fitzgerald T, Flynn E, Forbes A, Forty L, Franklyn JA, Freathy RM, Gibbs P, Gilbert P, Gokumen O, Gordon-Smith K, Gray E, Green E, Groves CJ, Grozeva D, Gwilliam R, Hall A, Hammond N, Hardy M, Harrison P, Hassanali N, Hebaishi H, Hines S, Hinks A, Hitman GA, Hocking L, Howard E, Howard P, Howson JM, Hughes D, Hunt S, Isaacs JD, Jain M, Jewell DP, Johnson T, Jolley JD, Jones IR, Jones LA, Kirov G, Langford CF, Lango-Allen H, Lathrop GM, Lee J, Lee KL, Lees C, Lewis K, Lindgren CM, Maisuria-Armer M, Maller J, Mansfield J, Martin P, Massey DC, McArdle WL, McGuffin P, McLay KE, Mentzer A, Mimmack ML, Morgan AE, Morris AP, Mowat C, Myers S, Newman W, Nimmo ER, O'Donovan MC, Onipinla A, Onyiah I, Ovington NR, Owen MJ, Palin K, Parnell K, Pernet D, Perry JR, Phillips A, Pinto D, Prescott NJ, Prokopenko I, Quail MA, Rafelt S, Rayner NW, Redon R, Reid DM, Renwick, Ring SM, Robertson N, Russell E, St Clair D, Sambrook JG, Sanderson JD, Schuilenburg H, Scott CE, Scott R, Seal S, Shaw-Hawkins S, Shields BM, Simmonds MJ, Smyth DJ, Somaskantharajah E, Spanova K, Steer S, Stephens J, Stevens HE, Stone MA, Su Z, Symmons DP, Thompson JR, Thomson W, Travers ME, Turnbull C, Valsesia A, Walker M, Walker NM, Wallace C, Warren-Perry M, Watkins NA, Webster J, Weedon MN, Wilson AG, Woodburn M, Wordsworth BP, Young AH, Zeggini E, Carter NP, Frayling TM, Lee C, McVean G, Munroe PB, Palotie A, Sawcer SJ, Scherer SW, Strachan DP, Tyler-Smith C, Brown MA, Burton PR, Caulfield MJ, Compston A, Farrall M, Gough SC, Hall AS, Hattersley AT, Hill AV, Mathew CG, Pembrey M, Satsangi J, Stratton MR, Worthington J, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand W, Parkes M, Rahman N, Todd JA, Samani NJ, Donnelly P.

Nature. 2010 Apr 1;464(7289):713-20. doi: 10.1038/nature08979.

21.

Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease.

Simmonds MJ, Yesmin K, Newby PR, Brand OJ, Franklyn JA, Gough SC.

Thyroid. 2010 Apr;20(4):413-7. doi: 10.1089/thy.2009.0375.

PMID:
20210668
22.

Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.

Yesmin K, Hargreaves C, Newby PR, Brand OJ, Heward JM, Franklyn JA, Gough SC, Simmonds MJ.

Clin Endocrinol (Oxf). 2010 Jul;73(1):119-25. doi: 10.1111/j.1365-2265.2010.03780.x. Epub 2010 Feb 10.

PMID:
20148910
23.

Genetics of thyroid autoimmunity and the role of the TSHR.

Brand OJ, Gough SC.

Mol Cell Endocrinol. 2010 Jun 30;322(1-2):135-43. doi: 10.1016/j.mce.2010.01.013. Epub 2010 Jan 18. Review.

PMID:
20083159
24.

Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease.

Brand OJ, Barrett JC, Simmonds MJ, Newby PR, McCabe CJ, Bruce CK, Kysela B, Carr-Smith JD, Brix T, Hunt PJ, Wiersinga WM, Hegedüs L, Connell J, Wass JA, Franklyn JA, Weetman AP, Heward JM, Gough SC.

Hum Mol Genet. 2009 May 1;18(9):1704-13. doi: 10.1093/hmg/ddp087. Epub 2009 Feb 25.

PMID:
19244275
25.

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Matthew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop MG, Connell J, Dominiczak A, Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A; Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hilder SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Frayling TM, Freathy RM, Lango H, Perry JR, Shields BM, Weedon MN, Hattersley AT, Hitman GA, Walker M, Elliott KS, Groves CJ, Lindgren CM, Rayner NW, Timpson NJ, Zeggini E, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S; Breast Cancer Susceptibility Collaboration (UK), Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Davison D, Ferreira T, Pereira-Gale J, Hallgrimsdo'ttir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Brown MA, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Parkes M, Pembrey M, Stratton MR, Mitchell SL, Newby PR, Brand OJ, Carr-Smith J, Pearce SH, McGinnis R, Keniry A, Deloukas P, Reveille JD, Zhou X, Sims AM, Dowling A, Taylor J, Doan T, Davis JC, Savage L, Ward MM, Learch TL, Weisman MH, Brown M.

Nat Genet. 2007 Nov;39(11):1329-37. Epub 2007 Oct 21.

26.

Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy.

Syed AA, Simmonds MJ, Brand OJ, Franklyn JA, Gough SC, Heward JM.

Clin Endocrinol (Oxf). 2007 Nov;67(5):663-7. Epub 2007 Jul 3.

PMID:
17608818
27.

Tag SNP screening of the PDCD1 gene for association with Graves' disease.

Newby PR, Roberts-Davies EL, Brand OJ, Heward JM, Franklyn JA, Gough SC, Simmonds MJ.

Clin Endocrinol (Oxf). 2007 Jul;67(1):125-8. Epub 2007 May 9.

PMID:
17490403
28.

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC.

Clin Endocrinol (Oxf). 2007 Apr;66(4):508-12.

PMID:
17371467
29.

Association of PTPN22 haplotypes with Graves' disease.

Heward JM, Brand OJ, Barrett JC, Carr-Smith JD, Franklyn JA, Gough SC.

J Clin Endocrinol Metab. 2007 Feb;92(2):685-90. Epub 2006 Dec 5.

PMID:
17148556
30.

Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.

Zeitlin AA, Heward JM, Brand OJ, Newby PR, Franklyn JA, Gough SC, Simmonds MJ.

Clin Endocrinol (Oxf). 2006 Sep;65(3):380-4.

PMID:
16918960

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