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The Whys and Hows of Calculating Total Cellular ATP Production Rate.

Handel ME, Brand MD, Mookerjee SA.

Trends Endocrinol Metab. 2019 Jul;30(7):412-416. doi: 10.1016/j.tem.2019.04.007. Epub 2019 May 27.


Mitochondrial and cytosolic sources of hydrogen peroxide in resting C2C12 myoblasts.

Wong HS, Benoit B, Brand MD.

Free Radic Biol Med. 2019 Jan;130:140-150. doi: 10.1016/j.freeradbiomed.2018.10.448. Epub 2018 Oct 31.


Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements.

Mookerjee SA, Gerencser AA, Nicholls DG, Brand MD.

J Biol Chem. 2018 Aug 10;293(32):12649-12652. doi: 10.1074/jbc.AAC118.004855. No abstract available.


Plate-Based Measurement of Respiration by Isolated Mitochondria.

Mookerjee SA, Quinlan CL, Wong HS, Dighe P, Brand MD.

Methods Mol Biol. 2018;1782:301-313. doi: 10.1007/978-1-4939-7831-1_17.


Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.

Wong HS, Monternier PA, Orr AL, Brand MD.

Methods Mol Biol. 2018;1782:287-299. doi: 10.1007/978-1-4939-7831-1_16.


Measurement of Proton Leak in Isolated Mitochondria.

Affourtit C, Wong HS, Brand MD.

Methods Mol Biol. 2018;1782:157-170. doi: 10.1007/978-1-4939-7831-1_9.


Osteoblast-like MC3T3-E1 Cells Prefer Glycolysis for ATP Production but Adipocyte-like 3T3-L1 Cells Prefer Oxidative Phosphorylation.

Guntur AR, Gerencser AA, Le PT, DeMambro VE, Bornstein SA, Mookerjee SA, Maridas DE, Clemmons DE, Brand MD, Rosen CJ.

J Bone Miner Res. 2018 Jun;33(6):1052-1065. doi: 10.1002/jbmr.3390. Epub 2018 Mar 30.


Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells.

Bunik VI, Brand MD.

Biol Chem. 2018 Apr 25;399(5):407-420. doi: 10.1515/hsz-2017-0284. Review.


Comparison of Mitochondrial Reactive Oxygen Species Production of Ectothermic and Endothermic Fish Muscle.

Wiens L, Banh S, Sotiri E, Jastroch M, Block BA, Brand MD, Treberg JR.

Front Physiol. 2017 Sep 15;8:704. doi: 10.3389/fphys.2017.00704. eCollection 2017.


Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions.

Wong HS, Dighe PA, Mezera V, Monternier PA, Brand MD.

J Biol Chem. 2017 Oct 13;292(41):16804-16809. doi: 10.1074/jbc.R117.789271. Epub 2017 Aug 24. Review.


Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements.

Mookerjee SA, Gerencser AA, Nicholls DG, Brand MD.

J Biol Chem. 2017 Apr 28;292(17):7189-7207. doi: 10.1074/jbc.M116.774471. Epub 2017 Mar 7. Erratum in: J Biol Chem. 2018 Aug 10;293(32):12649-12652.


Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant.

Boominathan A, Vanhoozer S, Basisty N, Powers K, Crampton AL, Wang X, Friedricks N, Schilling B, Brand MD, O'Connor MS.

Nucleic Acids Res. 2016 Nov 2;44(19):9342-9357. Epub 2016 Sep 4.


Positive Feedback Amplifies the Response of Mitochondrial Membrane Potential to Glucose Concentration in Clonal Pancreatic Beta Cells.

Gerencser AA, Mookerjee SA, Jastroch M, Brand MD.

Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1054-1065. doi: 10.1016/j.bbadis.2016.10.015. Epub 2016 Oct 20.


Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK.

Cell Metab. 2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22.


In vitro effects of cysteine protease inhibitors on Trichomonas foetus-induced cytopathic changes in porcine intestinal epithelial cells.

Tolbert MK, Brand MD, Gould EN.

Am J Vet Res. 2016 Aug;77(8):890-7. doi: 10.2460/ajvr.77.8.890.


Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells.

Gerencser AA, Mookerjee SA, Jastroch M, Brand MD.

PLoS One. 2016 Jul 12;11(7):e0159199. doi: 10.1371/journal.pone.0159199. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0160395.


Water Temperature Affects Susceptibility to Ranavirus.

Brand MD, Hill RD, Brenes R, Chaney JC, Wilkes RP, Grayfer L, Miller DL, Gray MJ.

Ecohealth. 2016 Jun;13(2):350-9. doi: 10.1007/s10393-016-1120-1. Epub 2016 Jun 9.


Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling.

Brand MD.

Free Radic Biol Med. 2016 Nov;100:14-31. doi: 10.1016/j.freeradbiomed.2016.04.001. Epub 2016 Apr 13. Review.


Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements.

Mookerjee SA, Nicholls DG, Brand MD.

PLoS One. 2016 Mar 31;11(3):e0152016. doi: 10.1371/journal.pone.0152016. eCollection 2016.


Exploiting Mitochondria In Vivo as Chemical Reaction Chambers Dependent on Membrane Potential.

Gerencser AA, Brand MD.

Mol Cell. 2016 Mar 3;61(5):642-643. doi: 10.1016/j.molcel.2016.02.026.


Measurement and Analysis of Extracellular Acid Production to Determine Glycolytic Rate.

Mookerjee SA, Brand MD.

J Vis Exp. 2015 Dec 12;(106):e53464. doi: 10.3791/53464.


Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex.

Goncalves RL, Bunik VI, Brand MD.

Free Radic Biol Med. 2016 Feb;91:247-55. doi: 10.1016/j.freeradbiomed.2015.12.020. Epub 2015 Dec 18.


Suppressors of superoxide production from mitochondrial complex III.

Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD.

Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14.


The role of mitochondrially derived ATP in synaptic vesicle recycling.

Pathak D, Shields LY, Mendelsohn BA, Haddad D, Lin W, Gerencser AA, Kim H, Brand MD, Edwards RH, Nakamura K.

J Biol Chem. 2015 Sep 11;290(37):22325-36. doi: 10.1074/jbc.M115.656405. Epub 2015 Jun 30.


Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake.

Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RL, Quinlan CL, Ng R, Jastroch M, Benjamin DI, Nie B, Herber C, Van AA, Park MJ, Yun D, Chan K, Yu A, Vuong P, Febbraio M, Nomura DK, Napoli JL, Brand MD, Stahl A.

Cell Rep. 2015 Feb 3;10(4):505-15. doi: 10.1016/j.celrep.2014.12.048. Epub 2015 Jan 22.


The contributions of respiration and glycolysis to extracellular acid production.

Mookerjee SA, Goncalves RLS, Gerencser AA, Nicholls DG, Brand MD.

Biochim Biophys Acta. 2015 Feb;1847(2):171-181. doi: 10.1016/j.bbabio.2014.10.005. Epub 2014 Oct 27.


Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise.

Goncalves RL, Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Brand MD.

J Biol Chem. 2015 Jan 2;290(1):209-27. doi: 10.1074/jbc.M114.619072. Epub 2014 Nov 11.


Sources of superoxide/H2O2 during mitochondrial proline oxidation.

Goncalves RL, Rothschild DE, Quinlan CL, Scott GK, Benz CC, Brand MD.

Redox Biol. 2014 Jul 18;2:901-9. doi: 10.1016/j.redox.2014.07.003. eCollection 2014.


Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals.

Nicholls DG, Brand MD, Gerencser AA.

J Bioenerg Biomembr. 2015 Apr;47(1-2):63-74. doi: 10.1007/s10863-014-9573-9. Epub 2014 Aug 30. Review.


Susceptibility of fish and turtles to three ranaviruses isolated from different ectothermic vertebrate classes.

Brenes R, Miller DL, Waltzek TB, Wilkes RP, Tucker JL, Chaney JC, Hardman RH, Brand MD, Huether RR, Gray MJ.

J Aquat Anim Health. 2014 Jun;26(2):118-26. doi: 10.1080/08997659.2014.886637.


The role of mitochondria in longevity and healthspan.

Brand MD.

Longev Healthspan. 2014 May 22;3:7. doi: 10.1186/2046-2395-3-7. eCollection 2014.


Cysteine protease activity of feline Tritrichomonas foetus promotes adhesion-dependent cytotoxicity to intestinal epithelial cells.

Tolbert MK, Stauffer SH, Brand MD, Gookin JL.

Infect Immun. 2014 Jul;82(7):2851-9. doi: 10.1128/IAI.01671-14. Epub 2014 Apr 21.


Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.

Hey-Mogensen M, Goncalves RL, Orr AL, Brand MD.

Free Radic Biol Med. 2014 Jul;72:149-55. doi: 10.1016/j.freeradbiomed.2014.04.007. Epub 2014 Apr 16.


Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.

Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.

PLoS One. 2014 Feb 24;9(2):e89938. doi: 10.1371/journal.pone.0089938. eCollection 2014.


The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I.

Quinlan CL, Goncalves RL, Hey-Mogensen M, Yadava N, Bunik VI, Brand MD.

J Biol Chem. 2014 Mar 21;289(12):8312-25. doi: 10.1074/jbc.M113.545301. Epub 2014 Feb 10.


Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.

Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD.

Redox Biol. 2013 May 23;1:304-12. doi: 10.1016/j.redox.2013.04.005. eCollection 2013.


Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.

Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD.

Free Radic Biol Med. 2013 Dec;65:1047-1059. doi: 10.1016/j.freeradbiomed.2013.08.170. Epub 2013 Aug 27.


Measuring mitochondrial uncoupling protein-2 level and activity in insulinoma cells.

Barlow J, Hirschberg V, Brand MD, Affourtit C.

Methods Enzymol. 2013;528:257-67. doi: 10.1016/B978-0-12-405881-1.00015-X.


The role of mitochondrial function and cellular bioenergetics in ageing and disease.

Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL.

Br J Dermatol. 2013 Jul;169 Suppl 2:1-8. doi: 10.1111/bjd.12208. Review.


The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production.

Quinlan CL, Perevoschikova IV, Goncalves RL, Hey-Mogensen M, Brand MD.

Methods Enzymol. 2013;526:189-217. doi: 10.1016/B978-0-12-405883-5.00012-0.


A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production.

McQuaker SJ, Quinlan CL, Caldwell ST, Brand MD, Hartley RC.

Chembiochem. 2013 May 27;14(8):993-1000. doi: 10.1002/cbic.201300115. Epub 2013 May 2.


Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.

Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD.

Free Radic Biol Med. 2013 Aug;61:298-309. doi: 10.1016/j.freeradbiomed.2013.04.006. Epub 2013 Apr 11.


Metabolic downregulation and inhibition of carbohydrate catabolism during diapause in embryos of Artemia franciscana.

Patil YN, Marden B, Brand MD, Hand SC.

Physiol Biochem Zool. 2013 Jan-Feb;86(1):106-18. doi: 10.1086/667808. Epub 2012 Oct 30.


No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.

Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD.

J Neurosci. 2012 Nov 21;32(47):16775-84. doi: 10.1523/JNEUROSCI.2414-12.2012.


A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.

Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD.

J Biol Chem. 2012 Dec 14;287(51):42921-35. doi: 10.1074/jbc.M112.397828. Epub 2012 Nov 2.


Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.

Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S.

PLoS One. 2012;7(10):e47196. doi: 10.1371/journal.pone.0047196. Epub 2012 Oct 15.


Fatty acids change the conformation of uncoupling protein 1 (UCP1).

Divakaruni AS, Humphrey DM, Brand MD.

J Biol Chem. 2012 Oct 26;287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5.


Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.

Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD.

Free Radic Biol Med. 2012 Nov 1;53(9):1807-17. doi: 10.1016/j.freeradbiomed.2012.08.015. Epub 2012 Aug 17.


Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.

Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD.

J Biol Chem. 2012 Aug 3;287(32):27255-64. doi: 10.1074/jbc.M112.374629. Epub 2012 Jun 11.


Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria.

Gerencser AA, Chinopoulos C, Birket MJ, Jastroch M, Vitelli C, Nicholls DG, Brand MD.

J Physiol. 2012 Jun 15;590(12):2845-71. doi: 10.1113/jphysiol.2012.228387. Epub 2012 Apr 10.

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