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In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.

Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M.

Leukemia. 2019 Oct 4. doi: 10.1038/s41375-019-0582-x. [Epub ahead of print]


A Decision-Analytic Approach to Addressing the Evidence About Football and Chronic Traumatic Encephalopathy.

Brand KP, Finkel AM.

Semin Neurol. 2019 Jul 16. doi: 10.1055/s-0039-1688484. [Epub ahead of print]


Effects of needle gauge and syringe size on small intestinal leakage at injection sites.

Brand KJ, Hess E, Risselada M.

Vet Surg. 2019 Oct;48(7):1237-1244. doi: 10.1111/vsu.13278. Epub 2019 Jul 8.


First report the findings: genuine balance when reporting CTE.

Finkel AM, Brand KP, Caplan AL, Evans JS, Wolpe PR.

Lancet Neurol. 2019 Jun;18(6):521-522. doi: 10.1016/S1474-4422(19)30159-0. No abstract available.


Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.

Jyotsana N, Sharma A, Chaturvedi A, Budida R, Scherr M, Kuchenbauer F, Lindner R, Noyan F, Sühs KW, Stangel M, Grote-Koska D, Brand K, Vornlocher HP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M.

Ann Hematol. 2019 Aug;98(8):1905-1918. doi: 10.1007/s00277-019-03713-y. Epub 2019 May 18.


Mechanisms of action of metformin with special reference to cardiovascular protection.

Zilov AV, Abdelaziz SI, AlShammary A, Al Zahrani A, Amir A, Assaad Khalil SH, Brand K, Elkafrawy N, Hassoun AAK, Jahed A, Jarrah N, Mrabeti S, Paruk I.

Diabetes Metab Res Rev. 2019 Oct;35(7):e3173. doi: 10.1002/dmrr.3173. Epub 2019 Jul 24. Review.


Cellular and Molecular Effects of High-Molecular-Weight Heparin on Matrix Metalloproteinase 9 Expression.

Huber R, Attili/Abedalkhader R, Küper D, Hauke L, Lüns B, Brand K, Weissenborn K, Lichtinghagen R.

Int J Mol Sci. 2019 Mar 30;20(7). pii: E1595. doi: 10.3390/ijms20071595.


Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study.

Huber R, Kirsten H, Näkki A, Pohlers D, Thude H, Eidner T, Heinig M, Brand K, Ahnert P, Kinne RW.

Int J Mol Sci. 2019 Mar 19;20(6). pii: E1382. doi: 10.3390/ijms20061382.


Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes.

Welz B, Bikker R, Junemann J, Christmann M, Neumann K, Weber M, Hoffmeister L, Preuß K, Pich A, Huber R, Brand K.

Int J Mol Sci. 2019 Mar 12;20(5). pii: E1241. doi: 10.3390/ijms20051241.


Radiographic and CT features of colonic entrapment due to an omental rent in a dog.

Brand KJ, Lim CK, Cichocki BN.

Vet Radiol Ultrasound. 2019 Feb 27. doi: 10.1111/vru.12725. [Epub ahead of print]


Diagnostic and Prognostic Performance of Secreted Protein Acidic and Rich in Cysteine (SPARC) Assay for Detecting Primary and Recurrent Urinary Bladder Cancer.

Critselis E, Rava M, Marquez M, Lygirou V, Chatzicharalambous D, Liapi P, Lichtinghagen R, Brand K, Cecchini L, Vlahou A, Malats N, Zoidakis J.

Proteomics Clin Appl. 2019 Mar;13(2):e1800148. doi: 10.1002/prca.201800148. Epub 2019 Jan 30.


Exploration of the spatial patterns and determinants of asthma prevalence and health services use in Ontario using a Bayesian approach.

Ouédraogo AM, Crighton EJ, Sawada M, To T, Brand K, Lavigne E.

PLoS One. 2018 Dec 10;13(12):e0208205. doi: 10.1371/journal.pone.0208205. eCollection 2018.


Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.

Neven E, Vervaet B, Brand K, Gottwald-Hostalek U, Opdebeeck B, De Maré A, Verhulst A, Lalau JD, Kamel S, De Broe ME, D'Haese PC.

Kidney Int. 2018 Jul;94(1):102-113. doi: 10.1016/j.kint.2018.01.027. Epub 2018 Apr 30.


ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.

Kumar A, Cherukumilli M, Mahmoudpour SH, Brand K, Bandapalli OR.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):731-737. doi: 10.1016/j.bbrc.2018.04.144. Epub 2018 Apr 23.


Reference measurement procedure for total bilirubin in serum re-evaluated and measurement uncertainty determined.

Klauke R, Kytzia HJ, Weber F, Grote-Koska D, Brand K, Schumann G.

Clin Chim Acta. 2018 Jun;481:115-120. doi: 10.1016/j.cca.2018.02.037. Epub 2018 Mar 1.


Surface receptor Toso controls B cell-mediated regulation of T cell immunity.

Yu J, Duong VHH, Westphal K, Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, Föger N, Lee KH.

J Clin Invest. 2018 May 1;128(5):1820-1836. doi: 10.1172/JCI97280. Epub 2018 Apr 3.


TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms.

Huber R, Bikker R, Welz B, Christmann M, Brand K.

J Immunol Res. 2017;2017:9570129. doi: 10.1155/2017/9570129. Epub 2017 Nov 8. Review.


Validity of two POCT glucose measurement devices in hypoglycaemia - how reliable is my result?

Bikker R, Grote-Koska D, Domberg P, Brand K.

Scand J Clin Lab Invest. 2018 Feb - Apr;78(1-2):157-158. doi: 10.1080/00365513.2017.1411971. Epub 2017 Dec 3. No abstract available.


Limited comparability of creatinine assays in patients with liver cirrhosis and their impact on the MELD score.

Kaiser T, Kinny-Köster B, Gnewuch C, Karailieva D, Kiehntopf M, Kessler A, Ritter-Sket C, Schmidt M, Brand K, Thiery J, Lichtinghagen R.

Pract Lab Med. 2017 Apr 14;8:41-48. doi: 10.1016/j.plabm.2017.04.002. eCollection 2017 Aug.


RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M.

Leukemia. 2018 Jan;32(1):224-226. doi: 10.1038/leu.2017.269. Epub 2017 Aug 22. No abstract available.


My week.

Brand K.

Vet Rec. 2017 Aug 12;181(7):i-ii. doi: 10.1136/vr.j3774.


Prospective observational study in two Dutch hospitals to assess the performance of inflammatory plasma markers to determine disease severity of viral respiratory tract infections in children.

Ahout IML, Brand KH, Zomer A, van den Hurk WH, Schilders G, Brouwer ML, Neeleman C, Groot R, Ferwerda G.

BMJ Open. 2017 Jun 30;7(6):e014596. doi: 10.1136/bmjopen-2016-014596.


Lung cancer incidence attributable to residential radon exposure in Alberta in 2012.

Grundy A, Brand K, Khandwala F, Poirier A, Tamminen S, Friedenreich CM, Brenner DR.

CMAJ Open. 2017 Jun 28;5(2):E529-E534. doi: 10.9778/cmajo.20160053.


TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD.

Bikker R, Christmann M, Preuß K, Welz B, Friesenhagen J, Dittrich-Breiholz O, Huber R, Brand K.

Cell Signal. 2017 Sep;37:123-135. doi: 10.1016/j.cellsig.2017.06.009. Epub 2017 Jun 16.


Collaborative writing applications in healthcare: effects on professional practice and healthcare outcomes.

Archambault PM, van de Belt TH, Kuziemsky C, Plaisance A, Dupuis A, McGinn CA, Francois R, Gagnon MP, Turgeon AF, Horsley T, Witteman W, Poitras J, Lapointe J, Brand K, Lachaine J, Légaré F.

Cochrane Database Syst Rev. 2017 May 10;5:CD011388. doi: 10.1002/14651858.CD011388.pub2. Review.


Alkaline phosphatase activity - pH impact on the measurement result.

Grote-Koska D, Klauke R, Brand K, Schumann G.

Clin Chem Lab Med. 2017 Jun 27;55(7):e146-e149. doi: 10.1515/cclm-2016-0771. No abstract available.


Oral morphine dosing predictions based on single dose in healthy children undergoing surgery.

Dawes JM, Cooke EM, Hannam JA, Brand KA, Winton P, Jimenez-Mendez R, Aleksa K, Lauder GR, Carleton BC, Koren G, Rieder MJ, Anderson BJ, Montgomery CJ.

Paediatr Anaesth. 2017 Jan;27(1):28-36. doi: 10.1111/pan.13020. Epub 2016 Oct 25.


Dynamics of the erythropoiesis stimulating agent resistance index in incident hemodiafiltration and high-flux hemodialysis patients.

Marcelli D, Bayh I, Merello JI, Ponce P, Heaton A, Kircelli F, Chazot C, Di Benedetto A, Marelli C, Ladanyi E, Kroczak M, Stuard S, Grassmann A, Scatizzi L, Brand K, Canaud B.

Kidney Int. 2016 Jul;90(1):192-202. doi: 10.1016/j.kint.2016.03.009. Epub 2016 May 10.


Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.

Halama N, Zoernig I, Berthel A, Kahlert C, Klupp F, Suarez-Carmona M, Suetterlin T, Brand K, Krauss J, Lasitschka F, Lerchl T, Luckner-Minden C, Ulrich A, Koch M, Weitz J, Schneider M, Buechler MW, Zitvogel L, Herrmann T, Benner A, Kunz C, Luecke S, Springfeld C, Grabe N, Falk CS, Jaeger D.

Cancer Cell. 2016 Apr 11;29(4):587-601. doi: 10.1016/j.ccell.2016.03.005.


Exhaled breath profiling using broadband quantum cascade laser-based spectroscopy in healthy children and children with asthma and cystic fibrosis.

van Mastrigt E, Reyes-Reyes A, Brand K, Bhattacharya N, Urbach HP, Stubbs AP, de Jongste JC, Pijnenburg MW.

J Breath Res. 2016 Apr 8;10(2):026003. doi: 10.1088/1752-7155/10/2/026003.


Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study.

Frantzi M, van Kessel KE, Zwarthoff EC, Marquez M, Rava M, Malats N, Merseburger AS, Katafigiotis I, Stravodimos K, Mullen W, Zoidakis J, Makridakis M, Pejchinovski M, Critselis E, Lichtinghagen R, Brand K, Dakna M, Roubelakis MG, Theodorescu D, Vlahou A, Mischak H, Anagnou NP.

Clin Cancer Res. 2016 Aug 15;22(16):4077-86. doi: 10.1158/1078-0432.CCR-15-2715. Epub 2016 Mar 29.


Evaluation of the LigaSure(™) Vessel Sealing System for bowel transection and intestinal anastomosis-an experimental study in a porcine model.

Gehrig T, Billeter AT, Wekerle AL, Shevchenko M, Brand K, Müller-Stich BP.

Langenbecks Arch Surg. 2016 May;401(3):381-7. doi: 10.1007/s00423-016-1406-3. Epub 2016 Mar 23.


Urinary Peptide Analysis Differentiates Pancreatic Cancer From Chronic Pancreatitis.

Schönemeier B, Metzger J, Klein J, Husi H, Bremer B, Armbrecht N, Dakna M, Schanstra JP, Rosendahl J, Wiegand J, Jäger M, Mullen W, Breuil B, Plentz RR, Lichtinghagen R, Brand K, Kühnel F, Mischak H, Manns MP, Lankisch TO.

Pancreas. 2016 Aug;45(7):1018-26. doi: 10.1097/MPA.0000000000000573.


Time-dependent impact of age and comorbidities on long-term overall survival after liver resection.

Schiergens TS, Lindenthaler A, Thomas MN, Rentsch M, Mittermeier L, Brand K, Küchenhoff H, Lee S, Guba M, Werner J, Thasler WE.

Liver Int. 2016 Sep;36(9):1340-50. doi: 10.1111/liv.13068. Epub 2016 Mar 24.


Estimated public health impacts of changes in concentrations of fine particle air pollution in Canada, 2000 to 2011.

Stieb DM, Judek S, van Donkelaar A, Martin RV, Brand K, Shin HH, Burnett RT, Smith-Doiron MH.

Can J Public Health. 2015 Jun 18;106(6):e362-8. doi: 10.17269/cjph.106.4983.


C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation.

Huber R, Panterodt T, Welz B, Christmann M, Friesenhagen J, Westphal A, Pietsch D, Brand K.

PLoS One. 2015 Dec 8;10(12):e0144338. doi: 10.1371/journal.pone.0144338. eCollection 2015.


Longitudinal Changes in Body Composition in Patients After Initiation of Hemodialysis Therapy: Results From an International Cohort.

Marcelli D, Brand K, Ponce P, Milkowski A, Marelli C, Ok E, Merello Godino JI, Gurevich K, Jirka T, Rosenberger J, Di Benedetto A, Ladányi E, Grassmann A, Scatizzi L, Bayh I, Kooman J, Canaud B.

J Ren Nutr. 2016 Mar;26(2):72-80. doi: 10.1053/j.jrn.2015.10.001. Epub 2015 Nov 28.


Analysis of polyethylene microplastics in environmental samples, using a thermal decomposition method.

Dümichen E, Barthel AK, Braun U, Bannick CG, Brand K, Jekel M, Senz R.

Water Res. 2015 Nov 15;85:451-7. doi: 10.1016/j.watres.2015.09.002. Epub 2015 Sep 7.


Thirty-day mortality leads to underestimation of postoperative death after liver resection: A novel method to define the acute postoperative period.

Schiergens TS, Dörsch M, Mittermeier L, Brand K, Küchenhoff H, Lee SM, Feng H, Jauch KW, Werner J, Thasler WE.

Surgery. 2015 Dec;158(6):1530-7. doi: 10.1016/j.surg.2015.07.019. Epub 2015 Aug 19.


Phenotypic and molecular insights into CASK-related disorders in males.

Moog U, Bierhals T, Brand K, Bautsch J, Biskup S, Brune T, Denecke J, de Die-Smulders CE, Evers C, Hempel M, Henneke M, Yntema H, Menten B, Pietz J, Pfundt R, Schmidtke J, Steinemann D, Stumpel CT, Van Maldergem L, Kutsche K.

Orphanet J Rare Dis. 2015 Apr 12;10:44. doi: 10.1186/s13023-015-0256-3.


Approximations for Estimating Change in Life Expectancy Attributable to Air Pollution in Relation to Multiple Causes of Death Using a Cause Modified Life Table.

Stieb DM, Judek S, Brand K, Burnett RT, Shin HH.

Risk Anal. 2015 Aug;35(8):1468-78. doi: 10.1111/risa.12355. Epub 2015 Mar 24.


Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome.

van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K.

Am J Hum Genet. 2015 Apr 2;96(4):640-50. doi: 10.1016/j.ajhg.2015.02.002. Epub 2015 Mar 12.


Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care: The WikiTrauma Interrupted Time Series Protocol.

Archambault PM, Turgeon AF, Witteman HO, Lauzier F, Moore L, Lamontagne F, Horsley T, Gagnon MP, Droit A, Weiss M, Tremblay S, Lachaine J, Le Sage N, Émond M, Berthelot S, Plaisance A, Lapointe J, Razek T, van de Belt TH, Brand K, Bérubé M, Clément J, Grajales Iii FJ, Eysenbach G, Kuziemsky C, Friedman D, Lang E, Muscedere J, Rizoli S, Roberts DJ, Scales DC, Sinuff T, Stelfox HT, Gagnon I, Chabot C, Grenier R, Légaré F; Canadian Critical Care Trials Group.

JMIR Res Protoc. 2015 Feb 19;4(1):e21. doi: 10.2196/resprot.4024.


Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection.

Worthmann H, Tryc AB, Dirks M, Schuppner R, Brand K, Klawonn F, Lichtinghagen R, Weissenborn K.

J Neuroinflammation. 2015 Jan 23;12:13. doi: 10.1186/s12974-014-0231-2.


Does the extracorporeal blood flow affect survival of the arteriovenous vascular access?

Ponce P, Marcelli D, Scholz C, Wehmeyer W, Gonçalves P, Grassmann A, Brand K, Canaud B.

Hemodial Int. 2015 Apr;19(2):314-22. doi: 10.1111/hdi.12240. Epub 2014 Nov 6.


Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.

van den Kieboom CH, Ahout IM, Zomer A, Brand KH, de Groot R, Ferwerda G, de Jonge MI.

Eur Respir J. 2015 Mar;45(3):718-25. doi: 10.1183/09031936.00085614. Epub 2014 Sep 26.


Performance of the New RapidFire System for Therapeutic Monitoring of Immunosuppressants.

Grote-Koska D, Czajkowski S, Brand K.

Ther Drug Monit. 2015 Jun;37(3):400-4. doi: 10.1097/FTD.0000000000000139.


RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR.

Brand K, Kentsch H, Glashoff C, Rosenberger G.

Hum Mutat. 2014 Nov;35(11):1372-81. doi: 10.1002/humu.22682.


The urinary proteome as correlate and predictor of renal function in a population study.

Gu YM, Thijs L, Liu YP, Zhang Z, Jacobs L, Koeck T, Zürbig P, Lichtinghagen R, Brand K, Kuznetsova T, Olivi L, Verhamme P, Delles C, Mischak H, Staessen JA.

Nephrol Dial Transplant. 2014 Dec;29(12):2260-8. doi: 10.1093/ndt/gfu234. Epub 2014 Jun 30.


Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy.

Siwy J, Schanstra JP, Argiles A, Bakker SJ, Beige J, Boucek P, Brand K, Delles C, Duranton F, Fernandez-Fernandez B, Jankowski ML, Al Khatib M, Kunt T, Lajer M, Lichtinghagen R, Lindhardt M, Maahs DM, Mischak H, Mullen W, Navis G, Noutsou M, Ortiz A, Persson F, Petrie JR, Roob JM, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Snell-Bergeon J, Spasovski G, Stojceva-Taneva O, Trillini M, von der Leyen H, Winklhofer-Roob BM, Zürbig P, Jankowski J.

Nephrol Dial Transplant. 2014 Aug;29(8):1563-70. doi: 10.1093/ndt/gfu039. Epub 2014 Mar 2.

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