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Items: 1 to 50 of 77

1.

Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299.

Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hökfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. Epub 2005 Nov 15. Erratum in: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5632. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14978.

2.

Use of Caenorhabditis elegans G{alpha}q chimeras to detect G-protein-coupled receptor signals.

Walker MW, Jones KA, Tamm J, Zhong H, Smith KE, Gerald C, Vaysse P, Branchek TA.

J Biomol Screen. 2005 Mar;10(2):127-36.

PMID:
15799956
3.

Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.

Mathes BM, Hudziak KJ, Schaus JM, Xu YC, Nelson DL, Wainscott DB, Nutter SE, Gough WH, Branchek TA, Zgombick JM, Filla SA.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):167-70.

PMID:
14684321
4.

Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.

Filla SA, Mathes BM, Johnson KW, Phebus LA, Cohen ML, Nelson DL, Zgombick JM, Erickson JA, Schenck KW, Wainscott DB, Branchek TA, Schaus JM.

J Med Chem. 2003 Jul 3;46(14):3060-71.

PMID:
12825944
5.

Trace amine receptors as targets for novel therapeutics: legend, myth and fact.

Branchek TA, Blackburn TP.

Curr Opin Pharmacol. 2003 Feb;3(1):90-7. Review.

PMID:
12550748
6.

Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.

Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, Blackburn TP, Branchek TA, Gerald C, Vaysse PJ, Forray C.

Nat Med. 2002 Aug;8(8):825-30. Epub 2002 Jul 15. Erratum in: Nat Med 2002 Sep;8(9):1039.

PMID:
12118247
7.

Trace amines: identification of a family of mammalian G protein-coupled receptors.

Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C.

Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71. Epub 2001 Jul 17.

8.

Identification and characterization of two G protein-coupled receptors for neuropeptide FF.

Bonini JA, Jones KA, Adham N, Forray C, Artymyshyn R, Durkin MM, Smith KE, Tamm JA, Boteju LW, Lakhlani PP, Raddatz R, Yao WJ, Ogozalek KL, Boyle N, Kouranova EV, Quan Y, Vaysse PJ, Wetzel JM, Branchek TA, Gerald C, Borowsky B.

J Biol Chem. 2000 Dec 15;275(50):39324-31.

9.

Expression of a novel neuropeptide Y receptor subtype involved in food intake: an in situ hybridization study of Y5 mRNA distribution in rat brain.

Durkin MM, Walker MW, Smith KE, Gustafson EL, Gerald C, Branchek TA.

Exp Neurol. 2000 Sep;165(1):90-100.

PMID:
10964488
10.

The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.

Rasmussen K, Calligaro DO, Czachura JF, Dreshfield-Ahmad LJ, Evans DC, Hemrick-Luecke SK, Kallman MJ, Kendrick WT, Leander JD, Nelson DL, Overshiner CD, Wainscott DB, Wolff MC, Wong DT, Branchek TA, Zgombick JM, Xu YC.

J Pharmacol Exp Ther. 2000 Aug;294(2):688-700.

PMID:
10900249
11.

Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.

Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS, Dai M, Lerman GS, Vaysse PJ, Branchek TA, Gerald C, Forray C, Adham N.

J Biol Chem. 2000 Oct 20;275(42):32452-9.

12.

5-ht6 receptors as emerging targets for drug discovery.

Branchek TA, Blackburn TP.

Annu Rev Pharmacol Toxicol. 2000;40:319-34. Review.

PMID:
10836139
13.

2-amino-2-oxazolines as subtype selective alpha(2) adrenoceptor agonists.

Wong WC, Sun W, Cui W, Chen Y, Forray C, Vaysse PJ, Branchek TA, Gluchowski C.

J Med Chem. 2000 May 4;43(9):1699-704.

PMID:
10794687
14.

Galanin receptor subtypes.

Branchek TA, Smith KE, Gerald C, Walker MW.

Trends Pharmacol Sci. 2000 Mar;21(3):109-17. Review.

PMID:
10689365
15.

An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS.

Durkin MM, Gunwaldsen CA, Borowsky B, Jones KA, Branchek TA.

Brain Res Mol Brain Res. 1999 Aug 25;71(2):185-200.

PMID:
10521573
16.

Cloning and characterization of the human galanin GALR2 receptor.

Borowsky B, Walker MW, Huang LY, Jones KA, Smith KE, Bard J, Branchek TA, Gerald C.

Peptides. 1998;19(10):1771-81.

PMID:
9880084
17.

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, Yao WJ, Johnson M, Gunwaldsen C, Huang LY, Tang C, Shen Q, Salon JA, Morse K, Laz T, Smith KE, Nagarathnam D, Noble SA, Branchek TA, Gerald C.

Nature. 1998 Dec 17;396(6712):674-9.

PMID:
9872315
18.

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C.

J Med Chem. 1998 Dec 17;41(26):5320-33.

PMID:
9857099
19.
20.

Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation.

Adham N, Zgombick JM, Bard J, Branchek TA.

J Pharmacol Exp Ther. 1998 Nov;287(2):508-14.

PMID:
9808674
21.

Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs.

Borowsky B, Walker MW, Bard J, Weinshank RL, Laz TM, Vaysse P, Branchek TA, Gerald C.

Regul Pept. 1998 Sep 25;75-76:45-53.

PMID:
9802393
22.

Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.

Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA.

J Biol Chem. 1998 Sep 4;273(36):23321-6.

23.

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

Wong WC, Chiu G, Wetzel JM, Marzabadi MR, Nagarathnam D, Wang D, Fang J, Miao SW, Hong X, Forray C, Vaysse PJ, Branchek TA, Gluchowski C, Tang R, Lepor H.

J Med Chem. 1998 Jul 2;41(14):2643-50.

PMID:
9651170
24.

Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.

Smith KE, Forray C, Walker MW, Jones KA, Tamm JA, Bard J, Branchek TA, Linemeyer DL, Gerald C.

J Biol Chem. 1997 Sep 26;272(39):24612-6.

25.

5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs.

Johnson KW, Schaus JM, Durkin MM, Audia JE, Kaldor SW, Flaugh ME, Adham N, Zgombick JM, Cohen ML, Branchek TA, Phebus LA.

Neuroreport. 1997 Jul 7;8(9-10):2237-40.

PMID:
9243618
26.

Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system.

Gustafson EL, Smith KE, Durkin MM, Walker MW, Gerald C, Weinshank R, Branchek TA.

Brain Res Mol Brain Res. 1997 Jun;46(1-2):223-35.

PMID:
9191097
27.

[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.

Bonhaus DW, Berger J, Adham N, Branchek TA, Hsu SA, Loury DN, Leung E, Wong EH, Clark RD, Eglen RM.

Neuropharmacology. 1997 Apr-May;36(4-5):671-9.

PMID:
9225293
28.

Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog.

Adham N, Bard JA, Zgombick JM, Durkin MM, Kucharewicz S, Weinshank RL, Branchek TA.

Neuropharmacology. 1997 Apr-May;36(4-5):569-76.

PMID:
9225282
29.

Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors.

Zgombick JM, Bard JA, Kucharewicz SA, Urquhart DA, Weinshank RL, Branchek TA.

Neuropharmacology. 1997 Apr-May;36(4-5):513-24.

PMID:
9225276
30.

Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites.

Du P, Salon JA, Tamm JA, Hou C, Cui W, Walker MW, Adham N, Dhanoa DS, Islam I, Vaysse PJ, Dowling B, Shifman Y, Boyle N, Rueger H, Schmidlin T, Yamaguchi Y, Branchek TA, Weinshank RL, Gluchowski C.

Protein Eng. 1997 Feb;10(2):109-17.

PMID:
9089810
31.

Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.

Phebus LA, Johnson KW, Zgombick JM, Gilbert PJ, Van Belle K, Mancuso V, Nelson DL, Calligaro DO, Kiefer AD Jr, Branchek TA, Flaugh ME.

Life Sci. 1997;61(21):2117-26.

PMID:
9395253
32.

A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide.

Walker MW, Smith KE, Bard J, Vaysse PJ, Gerald C, Daouti S, Weinshank RL, Branchek TA.

Peptides. 1997;18(4):609-12.

PMID:
9210181
33.

Localization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry.

Vilaró MT, Cortés R, Gerald C, Branchek TA, Palacios JM, Mengod G.

Brain Res Mol Brain Res. 1996 Dec 31;43(1-2):356-60.

PMID:
9037555
34.

Differences in ligand binding profiles between cloned rabbit and human 5-HT1D alpha and 5-HT1D beta receptors: ketanserin and methiothepin distinguish rabbit 5-HT1D receptor subtypes.

Bard JA, Kucharewicz SA, Zgombick JM, Weinshank RL, Branchek TA, Cohen ML.

Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):237-44.

PMID:
8878052
35.
36.

A receptor subtype involved in neuropeptide-Y-induced food intake.

Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL.

Nature. 1996 Jul 11;382(6587):168-71.

PMID:
8700207
37.

Distribution of a rat galanin receptor mRNA in rat brain.

Gustafson EL, Smith KE, Durkin MM, Gerald C, Branchek TA.

Neuroreport. 1996 Mar 22;7(4):953-7.

PMID:
8724681
38.

A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-ht7 receptor in rat brain.

Gustafson EL, Durkin MM, Bard JA, Zgombick J, Branchek TA.

Br J Pharmacol. 1996 Feb;117(4):657-66.

39.

Modeling and mutagenesis of the human alpha 1a-adrenoceptor: orientation and function of transmembrane helix V sidechains.

Wetzel JM, Salon JA, Tamm JA, Forray C, Craig D, Nakanishi H, Cui W, Vaysse PJ, Chiu G, Weinshank RL, Hartig PR, Branchek TA, Gluchowski C.

Receptors Channels. 1996;4(3):165-77.

PMID:
9014240
40.

Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.

Bard JA, Walker MW, Branchek TA, Weinshank RL.

J Biol Chem. 1995 Nov 10;270(45):26762-5.

41.

Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.

Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL.

J Biol Chem. 1995 Nov 10;270(45):26758-61.

42.

Localization of messenger RNAs encoding three GABA transporters in rat brain: an in situ hybridization study.

Durkin MM, Smith KE, Borden LA, Weinshank RL, Branchek TA, Gustafson EL.

Brain Res Mol Brain Res. 1995 Oct;33(1):7-21.

PMID:
8774941
43.

Ketanserin and ritanserin discriminate between recombinant human 5-HT1D alpha and 5-HT1D beta receptor subtypes.

Zgombick JM, Schechter LE, Kucharewicz SA, Weinshank RL, Branchek TA.

Eur J Pharmacol. 1995 Sep 15;291(1):9-15.

PMID:
8549648
44.

The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

Gerald C, Adham N, Kao HT, Olsen MA, Laz TM, Schechter LE, Bard JA, Vaysse PJ, Hartig PR, Branchek TA, et al.

EMBO J. 1995 Jun 15;14(12):2806-15.

45.

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C.

J Med Chem. 1995 May 12;38(10):1579-81. No abstract available.

PMID:
7752182
46.

Cloning and expression of a betaine/GABA transporter from human brain.

Borden LA, Smith KE, Gustafson EL, Branchek TA, Weinshank RL.

J Neurochem. 1995 Mar;64(3):977-84.

PMID:
7861179
47.

The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed.

Bard JA, Nawoschik SP, O'Dowd BF, George SR, Branchek TA, Weinshank RL.

Gene. 1995 Feb 14;153(2):295-6.

PMID:
7875610
48.

Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family.

Smith KE, Fried SG, Durkin MM, Gustafson EL, Borden LA, Branchek TA, Weinshank RL.

FEBS Lett. 1995 Jan 2;357(1):86-92.

49.

Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization.

Borden LA, Smith KE, Vaysse PJ, Gustafson EL, Weinshank RL, Branchek TA.

Receptors Channels. 1995;3(2):129-46.

PMID:
8581400
50.

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C.

Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

PMID:
7851497

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