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Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining.

de Boer DV, Brink A, Buijze M, Stigter-van Walsum M, Hunter KD, Ylstra B, Bloemena E, Leemans CR, Brakenhoff RH.

Mol Cancer Res. 2018 Sep 17. doi: 10.1158/1541-7786.MCR-18-0445. [Epub ahead of print]


Publisher Correction: The molecular landscape of head and neck cancer.

Leemans CR, Snijders PJF, Brakenhoff RH.

Nat Rev Cancer. 2018 Sep 12. doi: 10.1038/s41568-018-0057-9. [Epub ahead of print]


A review of the most promising biomarkers for early diagnosis and prognosis prediction of tongue squamous cell carcinoma.

Hussein AA, Forouzanfar T, Bloemena E, de Visscher J, Brakenhoff RH, Leemans CR, Helder MN.

Br J Cancer. 2018 Sep;119(6):724-736. doi: 10.1038/s41416-018-0233-4. Epub 2018 Aug 21.


Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection.

Bachas C, Hodzic J, van der Mijn JC, Stoepker C, Verheul HMW, Wolthuis RMF, Felley-Bosco E, van Wieringen WN, van Beusechem VW, Brakenhoff RH, de Menezes RX.

BMC Bioinformatics. 2018 Aug 20;19(1):301. doi: 10.1186/s12859-018-2306-z.


The molecular landscape of head and neck cancer.

Leemans CR, Snijders PJF, Brakenhoff RH.

Nat Rev Cancer. 2018 May;18(5):269-282. doi: 10.1038/nrc.2018.11. Epub 2018 Mar 2. Review. Erratum in: Nat Rev Cancer. 2018 Sep 12;:.


Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study.

Leijenaar RT, Bogowicz M, Jochems A, Hoebers FJ, Wesseling FW, Huang SH, Chan B, Waldron JN, O'Sullivan B, Rietveld D, Leemans CR, Brakenhoff RH, Riesterer O, Tanadini-Lang S, Guckenberger M, Ikenberg K, Lambin P.

Br J Radiol. 2018 Jun;91(1086):20170498. doi: 10.1259/bjr.20170498. Epub 2018 Mar 22.


Epidemiologic associations of HPV-positive oropharyngeal cancer and (pre)cancerous cervical lesions.

Rietbergen MM, van Bokhoven AAJD, Lissenberg-Witte BI, Heideman DAM, Leemans CR, Brakenhoff RH, Bloemena E.

Int J Cancer. 2018 Jul 15;143(2):283-288. doi: 10.1002/ijc.31315. Epub 2018 Mar 2.


Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing.

Nauta IH, Rietbergen MM, van Bokhoven AAJD, Bloemena E, Lissenberg-Witte BI, Heideman DAM, Baatenburg de Jong RJ, Brakenhoff RH, Leemans CR.

Ann Oncol. 2018 May 1;29(5):1273-1279. doi: 10.1093/annonc/mdy060.


Improved high-dimensional prediction with Random Forests by the use of co-data.

Te Beest DE, Mes SW, Wilting SM, Brakenhoff RH, van de Wiel MA.

BMC Bioinformatics. 2017 Dec 28;18(1):584. doi: 10.1186/s12859-017-1993-1.


Targeting PLK1 as a novel chemopreventive approach to eradicate preneoplastic mucosal changes in the head and neck.

de Boer DV, Martens-de Kemp SR, Buijze M, Stigter-van Walsum M, Bloemena E, Dietrich R, Leemans CR, van Beusechem VW, Braakhuis BJM, Brakenhoff RH.

Oncotarget. 2017 May 16;8(58):97928-97940. doi: 10.18632/oncotarget.17880. eCollection 2017 Nov 17.


Prognostic modeling of oral cancer by gene profiles and clinicopathological co-variables.

Mes SW, Te Beest D, Poli T, Rossi S, Scheckenbach K, van Wieringen WN, Brink A, Bertani N, Lanfranco D, Silini EM, van Diest PJ, Bloemena E, Leemans CR, van de Wiel MA, Brakenhoff RH.

Oncotarget. 2017 Jul 26;8(35):59312-59323. doi: 10.18632/oncotarget.19576. eCollection 2017 Aug 29.


Corrigendum to "Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging" [Radiother Oncol 113 (2014) 324-30].

Velazquez ER, Hoebers F, Aerts HJWL, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJ, Straetmans J, Kremer B, Lambin P.

Radiother Oncol. 2017 Aug;124(2):337-338. doi: 10.1016/j.radonc.2017.06.017. Epub 2017 Jul 11. No abstract available.


The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics.

Martens-de Kemp SR, Brink A, van der Meulen IH, de Menezes RX, Te Beest DE, Leemans CR, van Beusechem VW, Braakhuis BJ, Brakenhoff RH.

Mol Cancer Ther. 2017 Mar;16(3):540-550. doi: 10.1158/1535-7163.MCT-16-0457. Epub 2016 Dec 15.


Risk Groups for Survival in HPV-Positive and HPV-Negative OPSCC.

Rietbergen MM, Brakenhoff RH, René Leemans C.

Recent Results Cancer Res. 2017;206:221-231. Review.


Molecular Patterns and Biology of HPV-Associated HNSCC.

Brakenhoff RH, Wagner S, Klussmann JP.

Recent Results Cancer Res. 2017;206:37-56. Review.


Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.

Giefing M, Wierzbicka M, Szyfter K, Brenner JC, Braakhuis BJ, Brakenhoff RH, Bradford CR, Sorensen JA, Rinaldo A, Rodrigo JP, Takes RP, Ferlito A.

Eur J Cancer. 2016 Mar;55:147-57. doi: 10.1016/j.ejca.2015.10.070. Epub 2016 Feb 4. Review.


Applications of molecular diagnostics for personalized treatment of head and neck cancer: state of the art.

Mes SW, Leemans CR, Brakenhoff RH.

Expert Rev Mol Diagn. 2016;16(2):205-21. doi: 10.1586/14737159.2016.1126512. Epub 2016 Jan 4. Review.


HPV vaccination to prevent oropharyngeal carcinoma: What can be learned from anogenital vaccination programs?

Takes RP, Wierzbicka M, D'Souza G, Jackowska J, Silver CE, Rodrigo JP, Dikkers FG, Olsen KD, Rinaldo A, Brakenhoff RH, Ferlito A.

Oral Oncol. 2015 Dec;51(12):1057-60. doi: 10.1016/j.oraloncology.2015.10.011. Epub 2015 Oct 29. Review.


Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.

de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RM.

Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399.


Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.

Braakhuis BJ, Nieuwint AW, Oostra AB, Joenje H, Flach GB, Graveland AP, Brakenhoff RH, Leemans CR.

J Oral Pathol Med. 2016 Mar;45(3):189-92. doi: 10.1111/jop.12349. Epub 2015 Aug 26.


Noninvasive molecular screening for oral precancer in Fanconi anemia patients.

Smetsers SE, Velleuer E, Dietrich R, Wu T, Brink A, Buijze M, Deeg DJ, Soulier J, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Cancer Prev Res (Phila). 2015 Nov;8(11):1102-11. doi: 10.1158/1940-6207.CAPR-15-0220. Epub 2015 Aug 14.


Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.

Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH.

Cancer Res. 2015 Sep 1;75(17):3543-53. doi: 10.1158/0008-5472.CAN-15-0528. Epub 2015 Jun 29.


Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs. secondary primary tumor.

Gleber-Netto FO, Braakhuis BJ, Triantafyllou A, Takes RP, Kelner N, Rodrigo JP, Strojan P, Vander Poorten V, Rapidis AD, Rinaldo A, Brakenhoff RH, Ferlito A, Kowalski LP.

Oral Oncol. 2015 Aug;51(8):738-44. doi: 10.1016/j.oraloncology.2015.04.016. Epub 2015 May 16. Review.


Direct benefit of vaccinating boys along with girls against oncogenic human papillomavirus: bayesian evidence synthesis.

Bogaards JA, Wallinga J, Brakenhoff RH, Meijer CJ, Berkhof J.

BMJ. 2015 May 12;350:h2016. doi: 10.1136/bmj.h2016.


Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe.

Rietbergen MM, Witte BI, Velazquez ER, Snijders PJ, Bloemena E, Speel EJ, Brakenhoff RH, Kremer B, Lambin P, Leemans CR.

Br J Cancer. 2015 May 26;112(11):1733-6. doi: 10.1038/bjc.2015.139. Epub 2015 May 7.


Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC.

Nagel R, Stigter-van Walsum M, Buijze M, van den Berg J, van der Meulen IH, Hodzic J, Piersma SR, Pham TV, Jiménez CR, van Beusechem VW, Brakenhoff RH.

Mol Cancer Ther. 2015 Jun;14(6):1434-44. doi: 10.1158/1535-7163.MCT-14-0846. Epub 2015 Mar 25.


Quantitative diffusion-weighted MRI parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.

Schouten CS, de Graaf P, Bloemena E, Witte BI, Braakhuis BJ, Brakenhoff RH, Leemans CR, Castelijns JA, de Bree R.

AJNR Am J Neuroradiol. 2015 Apr;36(4):763-7. doi: 10.3174/ajnr.A4271. Epub 2015 Feb 26.


Prevalence of human papillomavirus in laryngeal and hypopharyngeal squamous cell carcinomas in northern Spain.

Rodrigo JP, Hermsen MA, Fresno MF, Brakenhoff RH, García-Velasco F, Snijders PJ, Heideman DA, García-Pedrero JM.

Cancer Epidemiol. 2015 Feb;39(1):37-41. doi: 10.1016/j.canep.2014.11.003. Epub 2014 Nov 29.


Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging.

Rios Velazquez E, Hoebers F, Aerts HJ, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJ, Straetmans J, Kremer B, Lambin P.

Radiother Oncol. 2014 Dec;113(3):324-30. doi: 10.1016/j.radonc.2014.09.005. Epub 2014 Oct 24. Erratum in: Radiother Oncol. 2017 Aug;124(2):337-338.


Interaction of quantitative (18)F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.

Schouten CS, Hakim S, Boellaard R, Bloemena E, Doornaert PA, Witte BI, Braakhuis BJ, Brakenhoff RH, Leemans CR, Hoekstra OS, de Bree R.

Head Neck. 2016 Apr;38(4):529-35. doi: 10.1002/hed.23920. Epub 2015 May 26.


tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities.

Miok V, Wilting SM, van de Wiel MA, Jaspers A, van Noort PI, Brakenhoff RH, Snijders PJ, Steenbergen RD, van Wieringen WN.

BMC Bioinformatics. 2014 Oct 2;15:327. doi: 10.1186/1471-2105-15-327.


A comprehensive assessment protocol including patient reported outcomes, physical tests, and biological sampling in newly diagnosed patients with head and neck cancer: is it feasible?

van Nieuwenhuizen AJ, Buffart LM, Smit JH, Brakenhoff RH, Braakhuis BJ, de Bree R, Leemans CR, Verdonck-de Leeuw IM.

Support Care Cancer. 2014 Dec;22(12):3321-30. doi: 10.1007/s00520-014-2359-0. Epub 2014 Aug 12.


Cancer stem cell enrichment marker CD98: a prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer.

Rietbergen MM, Martens-de Kemp SR, Bloemena E, Witte BI, Brink A, Baatenburg de Jong RJ, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Eur J Cancer. 2014 Mar;50(4):765-73. doi: 10.1016/j.ejca.2013.11.010. Epub 2013 Dec 4.


Molecular characterization of p16-immunopositive but HPV DNA-negative oropharyngeal carcinomas.

Rietbergen MM, Snijders PJ, Beekzada D, Braakhuis BJ, Brink A, Heideman DA, Hesselink AT, Witte BI, Bloemena E, Baatenburg-De Jong RJ, Leemans CR, Brakenhoff RH.

Int J Cancer. 2014 May 15;134(10):2366-72. doi: 10.1002/ijc.28580. Epub 2013 Nov 19.


Molecular screening of oral precancer.

Graveland AP, Bremmer JF, de Maaker M, Brink A, Cobussen P, Zwart M, Braakhuis BJ, Bloemena E, van der Waal I, Leemans CR, Brakenhoff RH.

Oral Oncol. 2013 Dec;49(12):1129-35. doi: 10.1016/j.oraloncology.2013.09.005. Epub 2013 Oct 9.


No evidence for active human papillomavirus (HPV) in fields surrounding HPV-positive oropharyngeal tumors.

Rietbergen MM, Braakhuis BJ, Moukhtari N, Bloemena E, Brink A, Sie D, Ylstra B, Baatenburg de Jong RJ, Snijders PJ, Brakenhoff RH, Leemans CR.

J Oral Pathol Med. 2014 Feb;43(2):137-42. doi: 10.1111/jop.12123. Epub 2013 Oct 11.


TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients.

Braakhuis BJ, Rietbergen MM, Buijze M, Snijders PJ, Bloemena E, Brakenhoff RH, Leemans CR.

Oral Dis. 2014 Sep;20(6):602-8. doi: 10.1111/odi.12178. Epub 2013 Sep 23.


Human papillomavirus detection and comorbidity: critical issues in selection of patients with oropharyngeal cancer for treatment De-escalation trials.

Rietbergen MM, Brakenhoff RH, Bloemena E, Witte BI, Snijders PJ, Heideman DA, Boon D, Koljenovic S, Baatenburg-de Jong RJ, Leemans CR.

Ann Oncol. 2013 Nov;24(11):2740-5. doi: 10.1093/annonc/mdt319. Epub 2013 Aug 14.


Identification of lethal microRNAs specific for head and neck cancer.

Lindenbergh-van der Plas M, Martens-de Kemp SR, de Maaker M, van Wieringen WN, Ylstra B, Agami R, Cerisoli F, Leemans CR, Braakhuis BJ, Brakenhoff RH.

Clin Cancer Res. 2013 Oct 15;19(20):5647-57. doi: 10.1158/1078-0432.CCR-12-2295. Epub 2013 Aug 13.


Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009).

Rodrigo JP, Heideman DA, García-Pedrero JM, Fresno MF, Brakenhoff RH, Díaz Molina JP, Snijders PJ, Hermsen MA.

Int J Cancer. 2014 Jan 15;134(2):487-92. doi: 10.1002/ijc.28355. Epub 2013 Jul 27.


DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.

Martens-de Kemp SR, Dalm SU, Wijnolts FM, Brink A, Honeywell RJ, Peters GJ, Braakhuis BJ, Brakenhoff RH.

PLoS One. 2013 Apr 17;8(4):e61555. doi: 10.1371/journal.pone.0061555. Print 2013.


Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines.

Nagel R, Martens-de Kemp SR, Buijze M, Jacobs G, Braakhuis BJ, Brakenhoff RH.

Oral Oncol. 2013 Jun;49(6):560-6. doi: 10.1016/j.oraloncology.2013.03.446. Epub 2013 Apr 8.


High-risk human papillomavirus-positive lung cancer: molecular evidence for a pattern of pulmonary metastasis.

van Boerdonk RA, Daniels JM, Bloemena E, Krijgsman O, Steenbergen RD, Brakenhoff RH, Grünberg K, Ylstra B, Meijer CJ, Smit EF, Snijders PJ, Heideman DA.

J Thorac Oncol. 2013 Jun;8(6):711-8. doi: 10.1097/JTO.0b013e3182897c14.


CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties.

Martens-de Kemp SR, Brink A, Stigter-van Walsum M, Damen JM, Rustenburg F, Wu T, van Wieringen WN, Schuurhuis GJ, Braakhuis BJ, Slijper M, Brakenhoff RH.

Stem Cell Res. 2013 May;10(3):477-88. doi: 10.1016/j.scr.2013.02.004. Epub 2013 Feb 18.


Potentially novel options for treatment of HPV-attributable head and neck cancer.

Brakenhoff RH.

Cell Cycle. 2013 Apr 1;12(7):1020-1. doi: 10.4161/cc.24308. Epub 2013 Mar 19. No abstract available.


Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.

Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH.

Clin Cancer Res. 2013 Apr 15;19(8):1994-2003. doi: 10.1158/1078-0432.CCR-12-2539. Epub 2013 Feb 26.


Novel diagnostic modalities for assessment of the clinically node-negative neck in oral squamous-cell carcinoma.

Leusink FK, van Es RJ, de Bree R, Baatenburg de Jong RJ, van Hooff SR, Holstege FC, Slootweg PJ, Brakenhoff RH, Takes RP.

Lancet Oncol. 2012 Dec;13(12):e554-61. doi: 10.1016/S1470-2045(12)70395-9.


Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma.

van Hooff SR, Leusink FK, Roepman P, Baatenburg de Jong RJ, Speel EJ, van den Brekel MW, van Velthuysen ML, van Diest PJ, van Es RJ, Merkx MA, Kummer JA, Leemans CR, Schuuring E, Langendijk JA, Lacko M, De Herdt MJ, Jansen JC, Brakenhoff RH, Slootweg PJ, Takes RP, Holstege FC.

J Clin Oncol. 2012 Nov 20;30(33):4104-10. doi: 10.1200/JCO.2011.40.4509. Epub 2012 Oct 8.


Expression signature in peripheral blood cells for molecular diagnosis of head and neck squamous cell carcinoma.

Braakhuis BJ, Graveland AP, Dijk F, Ylstra B, van Wieringen WN, Leemans CR, Brakenhoff RH.

Oral Dis. 2013 Jul;19(5):452-5. doi: 10.1111/odi.12019. Epub 2012 Oct 3.


Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors.

Braakhuis BJ, Brakenhoff RH, Leemans CR.

Ann Oncol. 2012 Sep;23 Suppl 10:x173-7.


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