Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 149

1.

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.

Manresa-Arraut A, Johansen FF, Brakebusch C, Issazadeh-Navikas S, Hasseldam H.

Front Immunol. 2018 May 31;9:1235. doi: 10.3389/fimmu.2018.01235. eCollection 2018.

2.

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.

Laviña B, Castro M, Niaudet C, Cruys B, Álvarez-Aznar A, Carmeliet P, Bentley K, Brakebusch C, Betsholtz C, Gaengel K.

Development. 2018 Jul 2;145(13). pii: dev161182. doi: 10.1242/dev.161182.

PMID:
29853619
3.

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

Ge J, Burnier L, Adamopoulou M, Kwa MQ, Schaks M, Rottner K, Brakebusch C.

J Biol Chem. 2018 Jun 15;293(24):9358-9369. doi: 10.1074/jbc.RA117.001113. Epub 2018 Apr 26.

PMID:
29700112
4.

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C.

Nat Commun. 2018 Apr 12;9(1):1420. doi: 10.1038/s41467-018-03704-z.

5.

Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB.

García-Mariscal A, Li H, Pedersen E, Peyrollier K, Ryan KM, Stanley A, Quondamatteo F, Brakebusch C.

Oncogene. 2018 Feb 15;37(7):847-860. doi: 10.1038/onc.2017.333. Epub 2017 Oct 23.

PMID:
29059167
6.

Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke.

Karabiyik C, Fernandes R, Figueiredo FR, Socodato R, Brakebusch C, Lambertsen KL, Relvas JB, Santos SD.

Brain Pathol. 2017 Sep 28. doi: 10.1111/bpa.12562. [Epub ahead of print]

PMID:
28960571
7.

Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development.

Anttonen T, Belevich I, Laos M, Herranen A, Jokitalo E, Brakebusch C, Pirvola U.

eNeuro. 2017 Sep 18;4(5). pii: ENEURO.0149-17.2017. doi: 10.1523/ENEURO.0149-17.2017. eCollection 2017 Sep-Oct.

8.

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.

Kage F, Steffen A, Ellinger A, Ranftler C, Gehre C, Brakebusch C, Pavelka M, Stradal T, Rottner K.

Sci Rep. 2017 Aug 29;7(1):9791. doi: 10.1038/s41598-017-09952-1.

9.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B.

Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

10.

FMNL formins boost lamellipodial force generation.

Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K.

Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832.

11.

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.

12.

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.

Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D.

Nat Commun. 2017 Feb 22;8:14533. doi: 10.1038/ncomms14533.

13.

RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.

García-Mariscal A, Peyrollier K, Basse A, Pedersen E, Rühl R, van Hengel J, Brakebusch C.

Small GTPases. 2016 Oct 18:1-12. doi: 10.1080/21541248.2016.1248272. [Epub ahead of print]

14.

Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency.

Martin Gonzalez J, Morgani SM, Bone RA, Bonderup K, Abelchian S, Brakebusch C, Brickman JM.

Stem Cell Reports. 2016 Aug 9;7(2):177-91. doi: 10.1016/j.stemcr.2016.07.009.

15.

Changes in dermal matrix in the absence of Rac1 in keratinocytes.

Stanley A, Pedersen E, Brakebusch C, Quondamatteo F.

J Anat. 2016 May;228(5):826-37. doi: 10.1111/joa.12442. Epub 2016 Feb 18.

16.

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.

López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, Wirtz S, Thonn V, Watson AJ, Brakebusch C, Bergö M, Neurath MF, Atreya I.

J Clin Invest. 2016 Feb;126(2):611-26. doi: 10.1172/JCI80997. Epub 2016 Jan 11.

17.

Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.

Choudhari R, Minero VG, Menotti M, Pulito R, Brakebusch C, Compagno M, Voena C, Ambrogio C, Chiarle R.

Blood. 2016 Mar 10;127(10):1297-306. doi: 10.1182/blood-2015-11-683052. Epub 2016 Jan 8.

18.

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.

Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA, Brakebusch CH, Lichtenthaler SF, Brocker T.

J Cell Biol. 2015 Nov 9;211(3):553-67. doi: 10.1083/jcb.201503128.

19.

Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion.

Liu L, Li J, Zhang L, Zhang F, Zhang R, Chen X, Brakebusch C, Wang Z, Liu X.

Biofactors. 2015 Sep-Oct;41(5):352-9. doi: 10.1002/biof.1235. Epub 2015 Oct 13.

PMID:
26496994
20.

Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.

Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R.

J Cell Sci. 2015 Dec 1;128(23):4293-305. doi: 10.1242/jcs.164509. Epub 2015 Oct 21.

21.

Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

Li S, Dislich B, Brakebusch CH, Lichtenthaler SF, Brocker T.

J Immunol. 2015 Nov 1;195(9):4244-56. doi: 10.4049/jimmunol.1500676. Epub 2015 Sep 25.

22.

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.

Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T.

Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16.

23.

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B.

J Thromb Haemost. 2015 May;13(5):827-38. doi: 10.1111/jth.12861. Epub 2015 Feb 23.

24.

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.

Burbage M, Keppler SJ, Gasparrini F, Martínez-Martín N, Gaya M, Feest C, Domart MC, Brakebusch C, Collinson L, Bruckbauer A, Batista FD.

J Exp Med. 2015 Jan 12;212(1):53-72. doi: 10.1084/jem.20141143. Epub 2014 Dec 29.

25.

Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.

Königs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K, Brakebusch C, Schwab A, Bähler M, Knaus UG, Hanley PJ.

J Biol Chem. 2014 Oct 31;289(44):30772-84. doi: 10.1074/jbc.M114.563270. Epub 2014 Sep 11.

26.

How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse.

Anttonen T, Belevich I, Kirjavainen A, Laos M, Brakebusch C, Jokitalo E, Pirvola U.

J Assoc Res Otolaryngol. 2014 Dec;15(6):975-92. doi: 10.1007/s10162-014-0480-x. Epub 2014 Jul 30.

27.

Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry.

May M, Schelle I, Brakebusch C, Rottner K, Genth H.

Cell Cycle. 2014;13(14):2211-21. doi: 10.4161/cc.29279. Epub 2014 May 19.

28.

RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness.

Jennings RT, Strengert M, Hayes P, El-Benna J, Brakebusch C, Kubica M, Knaus UG.

Blood. 2014 Jun 5;123(23):3635-45. doi: 10.1182/blood-2014-02-557843. Epub 2014 Apr 29.

29.

Rho GTPases and cancer.

Li H, Peyrollier K, Kilic G, Brakebusch C.

Biofactors. 2014 Mar-Apr;40(2):226-35. doi: 10.1002/biof.1155. Epub 2013 Dec 21. Review.

PMID:
24375503
30.

The small GTPase Rac1 is required for smooth muscle contraction.

Rahman A, Davis B, Lövdahl C, Hanumaiah VT, Feil R, Brakebusch C, Arner A.

J Physiol. 2014 Mar 1;592(5):915-26. doi: 10.1113/jphysiol.2013.262998. Epub 2013 Dec 2.

31.

NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and Rho GTPases in cell migration.

Stanley A, Thompson K, Hynes A, Brakebusch C, Quondamatteo F.

Antioxid Redox Signal. 2014 May 1;20(13):2026-42. doi: 10.1089/ars.2013.5713. Epub 2014 Feb 21. Review.

PMID:
24251358
32.

Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes.

Wang ZB, Jiang ZZ, Zhang QH, Hu MW, Huang L, Ou XH, Guo L, Ouyang YC, Hou Y, Brakebusch C, Schatten H, Sun QY.

Mol Biol Cell. 2013 Dec;24(24):3832-41. doi: 10.1091/mbc.E13-03-0123. Epub 2013 Oct 16.

33.

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.

Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Margit Holleboom J, Schur F, Victor Small J, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K.

J Cell Sci. 2013 Oct 15;126(Pt 20):4572-88. doi: 10.1242/jcs.118232. Epub 2013 Jul 31.

34.

Neuronal Rac1 is required for learning-evoked neurogenesis.

Haditsch U, Anderson MP, Freewoman J, Cord B, Babu H, Brakebusch C, Palmer TD.

J Neurosci. 2013 Jul 24;33(30):12229-41. doi: 10.1523/JNEUROSCI.2939-12.2013.

35.

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B.

Blood. 2013 Oct 31;122(18):3178-87. doi: 10.1182/blood-2013-03-487942. Epub 2013 Jul 16.

36.

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H.

Int J Biochem Cell Biol. 2013 Aug;45(8):1767-75. doi: 10.1016/j.biocel.2013.05.020. Epub 2013 May 31.

PMID:
23732113
37.

Cdc42 promotes host defenses against fatal infection.

Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R.

Infect Immun. 2013 Aug;81(8):2714-23. doi: 10.1128/IAI.01114-12. Epub 2013 May 20.

38.

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.

Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, Atkins KB, Gyung Kang H, Henger A, Brakebusch C, Holzman LB, Kretzler M.

Kidney Int. 2013 Nov;84(5):920-30. doi: 10.1038/ki.2013.175. Epub 2013 May 15.

39.

p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.

Wang Z, Fu M, Wang L, Liu J, Li Y, Brakebusch C, Mei Q.

J Biol Chem. 2013 Jul 5;288(27):20093-9. doi: 10.1074/jbc.M112.426023. Epub 2013 May 7.

40.

Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.

Vadodaria KC, Brakebusch C, Suter U, Jessberger S.

J Neurosci. 2013 Jan 16;33(3):1179-89. doi: 10.1523/JNEUROSCI.2103-12.2013.

41.

Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood.

Anttonen T, Kirjavainen A, Belevich I, Laos M, Richardson WD, Jokitalo E, Brakebusch C, Pirvola U.

Sci Rep. 2012;2:978. doi: 10.1038/srep00978. Epub 2012 Dec 17.

42.

Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.

Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T.

J Immunol. 2013 Jan 1;190(1):27-35. doi: 10.4049/jimmunol.1201082. Epub 2012 Dec 3.

43.

Rho GTPases and Nox dependent ROS production in skin. Is there a connection?

Stanley A, Hynes A, Brakebusch C, Quondamatteo F.

Histol Histopathol. 2012 Nov;27(11):1395-406. doi: 10.14670/HH-27.1395. Review.

PMID:
23018239
44.

RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1.

Pedersen E, Wang Z, Stanley A, Peyrollier K, Rösner LM, Werfel T, Quondamatteo F, Brakebusch C.

J Cell Sci. 2012 Nov 15;125(Pt 22):5379-90. doi: 10.1242/jcs.107011. Epub 2012 Sep 6.

45.

Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.

Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.

Mol Cell Proteomics. 2012 Dec;11(12):1578-85. doi: 10.1074/mcp.M112.017905. Epub 2012 Jul 11.

46.

Opposing roles for RhoH GTPase during T-cell migration and activation.

Baker CM, Comrie WA, Hyun YM, Chung HL, Fedorchuk CA, Lim K, Brakebusch C, McGrath JL, Waugh RE, Meier-Schellersheim M, Kim M.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10474-9. doi: 10.1073/pnas.1114214109. Epub 2012 Jun 11.

47.

Rho GTPase function in development: how in vivo models change our view.

Pedersen E, Brakebusch C.

Exp Cell Res. 2012 Aug 15;318(14):1779-87. doi: 10.1016/j.yexcr.2012.05.004. Epub 2012 May 29. Review.

PMID:
22659168
48.

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K.

Curr Biol. 2012 Jun 5;22(11):1005-12. doi: 10.1016/j.cub.2012.03.064. Epub 2012 May 17.

49.

Podocyte-specific loss of Cdc42 leads to congenital nephropathy.

Scott RP, Hawley SP, Ruston J, Du J, Brakebusch C, Jones N, Pawson T.

J Am Soc Nephrol. 2012 Jul;23(7):1149-54. doi: 10.1681/ASN.2011121206. Epub 2012 Apr 19.

50.

A radial glia-specific role of RhoA in double cortex formation.

Cappello S, Böhringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M.

Neuron. 2012 Mar 8;73(5):911-24. doi: 10.1016/j.neuron.2011.12.030.

Supplemental Content

Loading ...
Support Center