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Items: 18

1.

Dose Optimization for Anticancer Drug Combinations: Maximizing Therapeutic Index via Clinical Exposure-Toxicity/Preclinical Exposure-Efficacy Modeling.

Bottino DC, Patel M, Kadakia E, Zhou J, Patel C, Neuwirth R, Iartchouk N, Brake R, Venkatakrishnan K, Chakravarty A.

Clin Cancer Res. 2019 Jul 18. doi: 10.1158/1078-0432.CCR-18-3882. [Epub ahead of print]

PMID:
31320596
2.

Novel Oral mTORC1/2 Inhibitor TAK-228 Has Synergistic Antitumor Effects When Combined with Paclitaxel or PI3Kα Inhibitor TAK-117 in Preclinical Bladder Cancer Models.

Hernández-Prat A, Rodriguez-Vida A, Juanpere-Rodero N, Arpi O, Menéndez S, Soria-Jiménez L, Martínez A, Iarchouk N, Rojo F, Albanell J, Brake R, Rovira A, Bellmunt J.

Mol Cancer Res. 2019 Sep;17(9):1931-1944. doi: 10.1158/1541-7786.MCR-18-0923. Epub 2019 Jun 3.

PMID:
31160383
3.

Chronic heart failure part 1: pathophysiology, signs and symptoms.

Brake R, Jones ID.

Nurs Stand. 2017 Jan 4;31(19):54-63. doi: 10.7748/ns.2017.e10349.

PMID:
28094639
4.

Chronic heart failure part 2: treatment and management.

Brake R, Jones ID.

Nurs Stand. 2017 Jan 11;31(20):53-63. doi: 10.7748/ns.2017.e10762.

PMID:
28075307
5.

Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors.

Teffera Y, Berry LM, Brake RL, Lewis RT, Saffran DC, Moore E, Liu J, Zhao Z.

Drug Metab Dispos. 2013 Jan;41(1):238-47. doi: 10.1124/dmd.112.047993. Epub 2012 Nov 1.

PMID:
23118327
6.

The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.

Lewis RT, Bode CM, Choquette DM, Potashman M, Romero K, Stellwagen JC, Teffera Y, Moore E, Whittington DA, Chen H, Epstein LF, Emkey R, Andrews PS, Yu VL, Saffran DC, Xu M, Drew A, Merkel P, Szilvassy S, Brake RL.

J Med Chem. 2012 Jul 26;55(14):6523-40. doi: 10.1021/jm3005866. Epub 2012 Jul 10.

PMID:
22734674
7.

Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.

Bryan MC, Whittington DA, Doherty EM, Falsey JR, Cheng AC, Emkey R, Brake RL, Lewis RT.

J Med Chem. 2012 Feb 23;55(4):1698-705. doi: 10.1021/jm201565s. Epub 2012 Feb 9.

PMID:
22263917
8.

Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor.

Drew AE, Al-Assaad S, Yu V, Andrews P, Merkel P, Szilvassy S, Emkey R, Lewis R, Brake RL.

J Biomol Screen. 2011 Feb;16(2):164-73. doi: 10.1177/1087057110394657.

PMID:
21297104
9.

Effects of palifermin on antitumor activity of chemotherapeutic and biological agents in human head and neck and colorectal carcinoma xenograft models.

Brake R, Starnes C, Lu J, Chen D, Yang S, Radinsky R, Borges L.

Mol Cancer Res. 2008 Aug;6(8):1337-46. doi: 10.1158/1541-7786.MCR-07-2131.

10.

NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis.

Göthert JR, Brake RL, Smeets M, Dührsen U, Begley CG, Izon DJ.

Blood. 2007 Nov 15;110(10):3753-62. Epub 2007 Aug 13.

PMID:
17698635
11.
12.

The functional mapping of long-range transcription control elements of the HOX11 proto-oncogene.

Brake RL, Chatterjee PK, Kees UR, Watt PM.

Biochem Biophys Res Commun. 2004 Jan 9;313(2):327-35.

PMID:
14684164
13.

Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia.

Watt PM, Hoffmann K, Greene WK, Brake RL, Ford J, Kees UR.

Gene. 2003 Dec 24;323:89-99.

PMID:
14659882
14.

A valid method for comparing rational and empirical heat stress indices.

Brake R, Bates G.

Ann Occup Hyg. 2002 Mar;46(2):165-74.

PMID:
12074026
15.

A complex containing PBX2 contributes to activation of the proto-oncogene HOX11.

Brake RL, Kees UR, Watt PM.

Biochem Biophys Res Commun. 2002 May 31;294(1):23-34.

PMID:
12054735
16.

Multiple negative elements contribute to repression of the HOX11 proto-oncogene.

Brake RL, Kees UR, Watt PM.

Oncogene. 1998 Oct 8;17(14):1787-95.

17.

Effect of irradiation on the viability of Toxoplasma gondii cysts in tissues of mice and pigs.

Dubey JP, Brake RJ, Murrell KD, Fayer R.

Am J Vet Res. 1986 Mar;47(3):518-22.

PMID:
3963554
18.

Photo-induced reactions of benzo(a)pyrene with DNA in vitro.

Strniste GF, Martinez E, Martinez AM, Brake RJ.

Cancer Res. 1980 Feb;40(2):245-52. No abstract available.

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