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Items: 10

1.

Small-molecule inhibition of TNF-alpha.

He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC.

Science. 2005 Nov 11;310(5750):1022-5.

2.

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR.

J Med Chem. 2004 Jun 3;47(12):3111-30.

PMID:
15163192
3.

Tethering: fragment-based drug discovery.

Erlanson DA, Wells JA, Braisted AC.

Annu Rev Biophys Biomol Struct. 2004;33:199-223. Review.

PMID:
15139811
4.

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2.

Hyde J, Braisted AC, Randal M, Arkin MR.

Biochemistry. 2003 Jun 3;42(21):6475-83.

PMID:
12767230
5.

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.

Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC.

J Am Chem Soc. 2003 Apr 2;125(13):3714-5.

PMID:
12656598
6.

Binding of small molecules to an adaptive protein-protein interface.

Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8. Epub 2003 Feb 11.

7.

Site-directed ligand discovery.

Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9367-72.

8.

Structural mimicry of a native protein by a minimized binding domain.

Starovasnik MA, Braisted AC, Wells JA.

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10080-5.

9.

Synthesis of proteins by subtiligase.

Braisted AC, Judice JK, Wells JA.

Methods Enzymol. 1997;289:298-313. Review.

PMID:
9353727
10.

Minimizing a binding domain from protein A.

Braisted AC, Wells JA.

Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5688-92.

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