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Items: 1 to 50 of 178

1.

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, Mao X, Lee Y, Swing DA, Tessarollo L, Ko HS, Dawson VL, Dawson TM.

Brain. 2019 Jun 25. pii: awz172. doi: 10.1093/brain/awz172. [Epub ahead of print]

PMID:
31237944
2.
3.

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL.

Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.

4.

DNA Mechanics and Topology.

Brahmachari S, Marko JF.

Adv Exp Med Biol. 2018;1092:11-39. doi: 10.1007/978-3-319-95294-9_2.

PMID:
30368746
5.

Intronic miRNA mediated gene expression regulation controls protein crowding inside the cell.

Sinha P, Jaiswal P, Jainarayanan AK, Brahmachari SK.

Gene. 2018 Dec 30;679:172-178. doi: 10.1016/j.gene.2018.08.082. Epub 2018 Sep 4.

PMID:
30189267
6.

Paradigm for disease deconvolution in rare neurodegenerative disorders in Indian population: insights from studies in cerebellar ataxias.

Kumari R, Kumar D, Brahmachari SK, Srivastava AK, Faruq M, Mukerji M.

J Genet. 2018 Jul;97(3):589-609.

7.

The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study.

Mo Y, Brahmachari S, Lei J, Gilead S, Tang Y, Gazit E, Wei G.

ACS Chem Neurosci. 2018 Nov 21;9(11):2741-2752. doi: 10.1021/acschemneuro.8b00166. Epub 2018 Jul 23.

PMID:
29986579
8.

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.

Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke VV, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS.

Nat Med. 2018 Jul;24(7):931-938. doi: 10.1038/s41591-018-0051-5. Epub 2018 Jun 11.

9.

Defect-facilitated buckling in supercoiled double-helix DNA.

Brahmachari S, Dittmore A, Takagi Y, Neuman KC, Marko JF.

Phys Rev E. 2018 Feb;97(2-1):022416. doi: 10.1103/PhysRevE.97.022416.

10.

Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis.

Kaur D, Mathew S, Nair CGS, Begum A, Jainanarayan AK, Sharma M, Brahmachari SK.

J Transl Med. 2017 Dec 21;15(1):261. doi: 10.1186/s12967-017-1363-9.

11.

Nucleation of Multiple Buckled Structures in Intertwined DNA Double Helices.

Brahmachari S, Gunn KH, Giuntoli RD, Mondragón A, Marko JF.

Phys Rev Lett. 2017 Nov 3;119(18):188103. doi: 10.1103/PhysRevLett.119.188103. Epub 2017 Oct 31.

12.

iCHRCloud: Web & Mobile based Child Health Imprints for Smart Healthcare.

Singh H, Mallaiah R, Yadav G, Verma N, Sawhney A, Brahmachari SK.

J Med Syst. 2017 Nov 29;42(1):14. doi: 10.1007/s10916-017-0866-5.

PMID:
29188446
13.

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity.

Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E.

Nat Commun. 2017 Nov 8;8(1):1365. doi: 10.1038/s41467-017-01447-x.

14.

c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.

Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS.

J Parkinsons Dis. 2017;7(4):589-601. doi: 10.3233/JPD-171191.

15.

Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model.

Bram Y, Peled S, Brahmachari S, Harlev M, Gazit E.

Sci Rep. 2017 Oct 25;7(1):14031. doi: 10.1038/s41598-017-14311-1.

16.

Supercoiling DNA Locates Mismatches.

Dittmore A, Brahmachari S, Takagi Y, Marko JF, Neuman KC.

Phys Rev Lett. 2017 Oct 6;119(14):147801. doi: 10.1103/PhysRevLett.119.147801. Epub 2017 Oct 3.

17.

iNICU - Integrated Neonatal Care Unit: Capturing Neonatal Journey in an Intelligent Data Way.

Singh H, Yadav G, Mallaiah R, Joshi P, Joshi V, Kaur R, Bansal S, Brahmachari SK.

J Med Syst. 2017 Aug;41(8):132. doi: 10.1007/s10916-017-0774-8. Epub 2017 Jul 26.

18.
19.

Torque and buckling in stretched intertwined double-helix DNAs.

Brahmachari S, Marko JF.

Phys Rev E. 2017 May;95(5-1):052401. doi: 10.1103/PhysRevE.95.052401. Epub 2017 May 1.

20.

Diphenylalanine as a Reductionist Model for the Mechanistic Characterization of β-Amyloid Modulators.

Brahmachari S, Arnon ZA, Frydman-Marom A, Gazit E, Adler-Abramovich L.

ACS Nano. 2017 Jun 27;11(6):5960-5969. doi: 10.1021/acsnano.7b01662. Epub 2017 Jun 8.

PMID:
28575577
21.

Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.

Brahmachari S, Paul A, Segal D, Gazit E.

Future Med Chem. 2017 May;9(8):797-810. doi: 10.4155/fmc-2017-0026. Epub 2017 May 9. Review.

PMID:
28485623
22.
23.

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM.

Cell Rep. 2017 Jan 24;18(4):918-932. doi: 10.1016/j.celrep.2016.12.090.

24.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.

25.

The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan.

Sagner M, McNeil A, Puska P, Auffray C, Price ND, Hood L, Lavie CJ, Han ZG, Chen Z, Brahmachari SK, McEwen BS, Soares MB, Balling R, Epel E, Arena R.

Prog Cardiovasc Dis. 2017 Mar - Apr;59(5):506-521. doi: 10.1016/j.pcad.2016.08.002. Epub 2016 Aug 18. Review.

PMID:
27546358
26.

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.

Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Shin JH, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS.

J Clin Invest. 2016 Aug 1;126(8):2970-88. doi: 10.1172/JCI85456. Epub 2016 Jun 27.

27.

Anti-HIV microRNA expression in a novel Indian cohort.

Dey R, Soni K, Saravanan S, Balakrishnan P, Kumar V, Boobalan J, Solomon SS, Scaria V, Solomon S, Brahmachari SK, Pillai B.

Sci Rep. 2016 Jun 20;6:28279. doi: 10.1038/srep28279.

28.

A web-based resource for designing therapeutics against Ebola Virus.

Dhanda SK, Chaudhary K, Gupta S, Brahmachari SK, Raghava GP.

Sci Rep. 2016 Apr 26;6:24782. doi: 10.1038/srep24782.

29.

Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine.

Gupta S, Chaudhary K, Kumar R, Gautam A, Nanda JS, Dhanda SK, Brahmachari SK, Raghava GP.

Sci Rep. 2016 Mar 31;6:23857. doi: 10.1038/srep23857.

30.

Hydrophobic End-Modulated Amino-Acid-Based Neutral Hydrogelators: Structure-Specific Inclusion of Carbon Nanomaterials.

Choudhury P, Mandal D, Brahmachari S, Das PK.

Chemistry. 2016 Apr 4;22(15):5160-72. doi: 10.1002/chem.201504888. Epub 2016 Feb 24.

31.

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity.

Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL.

J Chem Neuroanat. 2016 Oct;76(Pt B):90-97. doi: 10.1016/j.jchemneu.2016.01.007. Epub 2016 Jan 22.

32.

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF.

Nam JH, Park ES, Won SY, Lee YA, Kim KI, Jeong JY, Baek JY, Cho EJ, Jin M, Chung YC, Lee BD, Kim SH, Kim EG, Byun K, Lee B, Woo DH, Lee CJ, Kim SR, Bok E, Kim YS, Ahn TB, Ko HW, Brahmachari S, Pletinkova O, Troconso JC, Dawson VL, Dawson TM, Jin BK.

Brain. 2015 Dec;138(Pt 12):3610-22. doi: 10.1093/brain/awv297. Epub 2015 Oct 21.

33.

Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp.

Asati DP, Brahmachari S, Kudligi C, Gupta C.

Indian J Dermatol. 2015 Jul-Aug;60(4):421. doi: 10.4103/0019-5154.160527.

34.

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's Disease.

Modi KK, Roy A, Brahmachari S, Rangasamy SB, Pahan K.

PLoS One. 2015 Jun 23;10(6):e0130398. doi: 10.1371/journal.pone.0130398. eCollection 2015.

35.

Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis.

Vashisht R, Brahmachari SK.

J Transl Med. 2015 Mar 7;13:83. doi: 10.1186/s12967-015-0443-y.

36.

Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets.

Vashisht R, Bhat AG, Kushwaha S, Bhardwaj A; OSDD Consortium, Brahmachari SK.

J Transl Med. 2014 Oct 11;12:263. doi: 10.1186/s12967-014-0263-5.

37.

pH-Responsive single walled carbon nanotube dispersion for target specific release of doxorubicin to cancer cells.

Ghosh M, Brahmachari S, Das PK.

Macromol Biosci. 2014 Dec;14(12):1795-806. doi: 10.1002/mabi.201400290. Epub 2014 Sep 11.

PMID:
25212998
38.

Fabrication of SWCNT-Ag nanoparticle hybrid included self-assemblies for antibacterial applications.

Brahmachari S, Mandal SK, Das PK.

PLoS One. 2014 Sep 5;9(9):e106775. doi: 10.1371/journal.pone.0106775. eCollection 2014.

39.

Genetic epidemiology of pharmacogenetic variations in CYP2C9, CYP4F2 and VKORC1 genes associated with warfarin dosage in the Indian population.

Giri AK, Khan NM, Grover S, Kaur I, Basu A, Tandon N, Scaria V; Consortium IGV; INDICO, Kukreti R, Brahmachari SK, Bharadwaj D.

Pharmacogenomics. 2014 Jul;15(10):1337-54. doi: 10.2217/pgs.14.88.

PMID:
25155935
40.

Biocompatible nanocrystalline natural bonelike carbonated hydroxyapatite synthesized by mechanical alloying in a record minimum time.

Lala S, Brahmachari S, Das PK, Das D, Kar T, Pradhan SK.

Mater Sci Eng C Mater Biol Appl. 2014 Sep;42:647-56. doi: 10.1016/j.msec.2014.06.014. Epub 2014 Jun 19.

PMID:
25063165
41.

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease.

Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS.

Sci Rep. 2014 May 2;4:4874. doi: 10.1038/srep04874.

42.

Integrating health care delivery and data collection in rural India using a rapidly deployable ehealth center.

Agrawal A, Bhattacharya J, Baranwal N, Bhatla S, Dube S, Sardana V, Gaur DR, Balazova D, Brahmachari SK.

PLoS Med. 2013;10(6):e1001468. doi: 10.1371/journal.pmed.1001468. Epub 2013 Jun 25. No abstract available.

43.

Open source software and web services for designing therapeutic molecules.

Singla D, Dhanda SK, Chauhan JS, Bhardwaj A, Brahmachari SK; Open Source Drug Discovery Consortium, Raghava GP.

Curr Top Med Chem. 2013;13(10):1172-91. Review.

PMID:
23647540
44.

Social networks to biological networks: systems biology of Mycobacterium tuberculosis.

Vashisht R, Bhardwaj A, Osdd Consortium, Brahmachari SK.

Mol Biosyst. 2013 Jul;9(7):1584-93. doi: 10.1039/c3mb25546h. Epub 2013 Apr 29. Review.

PMID:
23629487
45.
46.

Introducing the medical bioinformatics in Journal of Translational Medicine.

Brahmachari SK.

J Transl Med. 2012 Sep 26;10:202. doi: 10.1186/1479-5876-10-202. No abstract available.

47.

Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis.

Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, Priyadarshini P, Bhattacharyya K, Rohira H, Bhat AG, Passi A, Mukherjee K, Choudhary KS, Kumar V, Arora A, Munusamy P, Subramanian A, Venkatachalam A, Gayathri S, Raj S, Chitra V, Verma K, Zaheer S, Balaganesh J, Gurusamy M, Razeeth M, Raja I, Thandapani M, Mevada V, Soni R, Rana S, Ramanna GM, Raghavan S, Subramanya SN, Kholia T, Patel R, Bhavnani V, Chiranjeevi L, Sengupta S, Singh PK, Atray N, Gandhi S, Avasthi TS, Nisthar S, Anurag M, Sharma P, Hasija Y, Dash D, Sharma A, Scaria V, Thomas Z; OSDD Consortium, Chandra N, Brahmachari SK, Bhardwaj A.

PLoS One. 2012;7(7):e39808. doi: 10.1371/journal.pone.0039808. Epub 2012 Jul 11.

48.

Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease.

Roy A, Ghosh A, Jana A, Liu X, Brahmachari S, Gendelman HE, Pahan K.

PLoS One. 2012;7(6):e38113. doi: 10.1371/journal.pone.0038113. Epub 2012 Jun 18.

49.

A simple method for incorporating dynamic effects of intronic miRNA mediated regulation.

Gokhale S, Hariharan M, Brahmachari SK, Gadgil C.

Mol Biosyst. 2012 Aug;8(8):2145-52. doi: 10.1039/c2mb25046b. Epub 2012 Jun 15.

PMID:
22699750
50.

Structural annotation of Mycobacterium tuberculosis proteome.

Anand P, Sankaran S, Mukherjee S, Yeturu K, Laskowski R, Bhardwaj A, Bhagavat R; OSDD Consortium, Brahmachari SK, Chandra N.

PLoS One. 2011;6(10):e27044. doi: 10.1371/journal.pone.0027044. Epub 2011 Oct 31.

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