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Items: 1 to 50 of 156

1.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Bagal SK, Andrews M, Bechle BM, Bian J, Bilsland J, Blakemore DC, Braganza JF, Bungay PJ, Corbett MS, Cronin CN, Cui JJ, Dias R, Flanagan NJ, Greasley SE, Grimley R, James K, Johnson E, Kitching L, Kraus ML, McAlpine I, Nagata A, Ninkovic S, Omoto K, Scales S, Skerratt SE, Sun J, Tran-Dubé M, Waldron GJ, Wang F, Warmus JS.

J Med Chem. 2018 Aug 9;61(15):6779-6800. doi: 10.1021/acs.jmedchem.8b00633. Epub 2018 Jul 27.

PMID:
29944371
2.

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

Kung PP, Rui E, Bergqvist S, Bingham P, Braganza J, Collins M, Cui M, Diehl W, Dinh D, Fan C, Fantin VR, Gukasyan HJ, Hu W, Huang B, Kephart S, Krivacic C, Kumpf RA, Li G, Maegley KA, McAlpine I, Nguyen L, Ninkovic S, Ornelas M, Ryskin M, Scales S, Sutton S, Tatlock J, Verhelle D, Wang F, Wells P, Wythes M, Yamazaki S, Yip B, Yu X, Zehnder L, Zhang WG, Rollins RA, Edwards M.

J Med Chem. 2016 Dec 22;59(24):11196. doi: 10.1021/acs.jmedchem.6b01747. Epub 2016 Dec 12. No abstract available.

PMID:
27936698
3.

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.

Kung PP, Rui E, Bergqvist S, Bingham P, Braganza J, Collins M, Cui M, Diehl W, Dinh D, Fan C, Fantin VR, Gukasyan HJ, Hu W, Huang B, Kephart S, Krivacic C, Kumpf RA, Li G, Maegley KA, McAlpine I, Nguyen L, Ninkovic S, Ornelas M, Ryskin M, Scales S, Sutton S, Tatlock J, Verhelle D, Wang F, Wells P, Wythes M, Yamazaki S, Yip B, Yu X, Zehnder L, Zhang WG, Rollins RA, Edwards M.

J Med Chem. 2016 Sep 22;59(18):8306-25. doi: 10.1021/acs.jmedchem.6b00515. Epub 2016 Sep 6. Erratum in: J Med Chem. 2016 Dec 22;59(24):11196.

PMID:
27512831
4.

Pancreatic extracts for painful chronic pancreatitis: micronutrient antioxidant therapy by proxy.

Braganza JM.

JOP. 2014 Nov 28;15(6):541-3. doi: 10.6092/1590-8577/2851. No abstract available.

5.

Micronutrient therapy for chronic pancreatitis: premises and pitfalls.

Braganza JM.

JOP. 2013 Jul 10;14(4):304-8. doi: 10.6092/1590-8577/1580. No abstract available.

6.

Studies on the regioselective nucleophilic aromatic substitution (S(N)Ar) reaction of 2-substituted 3,5-dichloropyrazines.

Scales S, Johnson S, Hu Q, Do QQ, Richardson P, Wang F, Braganza J, Ren S, Wan Y, Zheng B, Faizi D, McAlpine I.

Org Lett. 2013 May 3;15(9):2156-9. doi: 10.1021/ol4006695. Epub 2013 Apr 19.

PMID:
23600718
7.

Limitations of patient selection and other issues in chronic pancreatitis antioxidant trial.

Braganza JM.

Gastroenterology. 2013 Mar;144(3):e17-8. doi: 10.1053/j.gastro.2012.12.034. Epub 2013 Jan 25. No abstract available.

PMID:
23357060
8.

Mast cell control: likely modus operandi of panhaematin in experimental pancreatitis.

Braganza JM.

Gut. 2012 Apr;61(4):632; author reply 632-3. doi: 10.1136/gutjnl-2011-300415. Epub 2011 Jul 13. No abstract available.

PMID:
21757450
9.

Insights into the development of alcoholic chronic pancreatitis at Soweto, South Africa: a controlled cross-sectional study.

Segal I, Ally R, Hunt LP, Sandle LN, Ubbink JB, Braganza JM.

Pancreas. 2011 May;40(4):508-16. doi: 10.1097/MPA.0b013e318214f94a.

PMID:
21499204
10.

Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.

Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP.

J Med Chem. 2011 May 12;54(9):3368-85. doi: 10.1021/jm200128m. Epub 2011 Apr 20.

PMID:
21438541
11.

Chronic pancreatitis.

Braganza JM, Lee SH, McCloy RF, McMahon MJ.

Lancet. 2011 Apr 2;377(9772):1184-97. doi: 10.1016/S0140-6736(10)61852-1. Review.

PMID:
21397320
12.

Homocysteine and chronic pancreatitis.

Braganza JM, Odom N, McCloy RF, Ubbink JB.

Pancreas. 2010 Nov;39(8):1303; author reply 1304. doi: 10.1097/MPA.0b013e3181e2d567. No abstract available.

PMID:
20944492
13.

Micronutrient therapy for chronic pancreatitis: rationale and impact.

Braganza JM, Dormandy TL.

JOP. 2010 Mar 5;11(2):99-112. Review.

14.

Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.

Jerome KD, Rucker PV, Xing L, Shieh HS, Baldus JE, Selness SR, Letavic MA, Braganza JF, McClure KF.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):469-73. doi: 10.1016/j.bmcl.2009.11.114. Epub 2009 Nov 26.

PMID:
19969459
16.

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

McClure KF, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4339-44. Epub 2006 Jun 12.

PMID:
16759861
17.

Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstones.

Worthington HV, Hunt LP, McCloy RF, Ubbink JB, Braganza JM.

Clin Chim Acta. 2004 Nov;349(1-2):157-65.

PMID:
15469869
18.

Attempted suicide by Bangladeshi adolescent girls.

Braganza J.

Paediatr Nurs. 2001 Mar;13(2):26-9. Review. No abstract available.

PMID:
12025162
19.

Acute pancreatitis in Soweto, South Africa: relationship between trypsinogen load, trypsinogen activation, and fibrinolysis.

Segal I, Chaloner C, Douglas J, John KD, Zaidi A, Cotter L, Appelros S, Borgström A, Braganza JM.

Am J Gastroenterol. 2002 Apr;97(4):883-92.

PMID:
12003423
20.
21.
22.

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

Deb S, Braganza J, Norton N, Williams H, Kehoe PG, Williams J, Owen MJ.

Br J Psychiatry. 2000 May;176:468-72.

PMID:
10912224
23.

A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis.

Herrick AL, Hollis S, Schofield D, Rieley F, Blann A, Griffin K, Moore T, Braganza JM, Jayson MI.

Clin Exp Rheumatol. 2000 May-Jun;18(3):349-56.

PMID:
10895372
24.

Mast cell: pivotal player in lethal acute pancreatitis.

Braganza JM.

QJM. 2000 Jul;93(7):469-76. Review. No abstract available.

PMID:
10874056
25.

Comparison of rating scales for the diagnosis of dementia in adults with Down's syndrome.

Deb S, Braganza J.

J Intellect Disabil Res. 1999 Oct;43 ( Pt 5):400-7.

PMID:
10546964
26.

Prevention of recurrent pancreatitis in familial lipoprotein lipase deficiency with high-dose antioxidant therapy.

Heaney AP, Sharer N, Rameh B, Braganza JM, Durrington PN.

J Clin Endocrinol Metab. 1999 Apr;84(4):1203-5.

PMID:
10199753
27.

A framework for the aetiogenesis of chronic pancreatitis.

Braganza JM.

Digestion. 1998;59 Suppl 4:1-12. Review.

PMID:
9832631
28.

Mutations of the cystic fibrosis gene in patients with chronic pancreatitis.

Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J.

N Engl J Med. 1998 Sep 3;339(10):645-52.

29.

Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.

Quesnel LB, Jaran AS, Braganza JM.

J Antimicrob Chemother. 1998 Feb;41(2):215-21.

PMID:
9533463
30.
31.

Indirect evidence for hepatic induction in patients with cholesterol gallstones.

Sandle LN, Worthington HV, Rameh B, Braganza JM.

Biochem Soc Trans. 1997 Aug;25(3):412S. No abstract available.

PMID:
9388642
32.

A pilot study of antioxidant intake in patients with cholesterol gallstones.

Worthington HV, Hunt LP, McCloy RF, Maclennan I, Braganza JM.

Nutrition. 1997 Feb;13(2):118-27.

PMID:
9106789
33.

Shortcomings of an automated assay for total antioxidant status in biological fluids.

Schofield D, Braganza JM.

Clin Chem. 1996 Oct;42(10):1712-4. No abstract available.

34.

A pilot study of blood antioxidant and free radical marker profiles in patients awaiting coronary artery bypass grafting.

Gu M, Love H, Schofield D, Turkie W, Odom N, Braganza JM.

Clin Chim Acta. 1996 Aug 30;252(2):181-95.

PMID:
8853565
35.

Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans.

Chaloner C, Mackness MI, Durrington PN, Braganza JM.

Biochem Soc Trans. 1996 May;24(2):191S. No abstract available.

PMID:
8736849
36.

The pathogenesis of chronic pancreatitis.

Braganza JM.

QJM. 1996 Apr;89(4):243-50. Review. No abstract available.

PMID:
8733510
37.

Dietary intake of micronutrient antioxidants in relation to blood levels in patients with systemic sclerosis.

Herrick AL, Worthington H, Rieley F, Clarke D, Schofield D, Braganza JM, Jayson MI.

J Rheumatol. 1996 Apr;23(4):650-3.

PMID:
8730121
38.

Iron, ascorbate and copper status of Sowetan Blacks with calcific chronic pancreatitis.

Segal I, Sharer NM, Kay PM, Gutteridge JM, Braganza JM.

QJM. 1996 Jan;89(1):45-53.

PMID:
8730342
39.

A radical view of gallstone aetiogenesis.

Braganza JM, Worthington H.

Med Hypotheses. 1995 Nov;45(5):510-6.

PMID:
8748097
40.
41.

Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis.

Sharer NM, Scott PD, Deardon DJ, Lee SH, Taylor PM, Braganza JM.

Clin Drug Investig. 1995 Sep;10(3):147-57. doi: 10.2165/00044011-199510030-00003.

PMID:
27519198
42.

Micronutrient antioxidant status in black South Africans with chronic pancreatitis: opportunity for prophylaxis.

Segal I, Gut A, Schofield D, Shiel N, Braganza JM.

Clin Chim Acta. 1995 Jul 31;239(1):71-9.

PMID:
7586589
43.

Fecal short chain fatty acids in South African urban Africans and whites.

Segal I, Hassan H, Walker AR, Becker P, Braganza J.

Dis Colon Rectum. 1995 Jul;38(7):732-4.

PMID:
7607034
44.

Evidence of toxic metabolite stress in black South Africans with chronic pancreatitis.

Gut A, Chaloner C, Schofield D, Sandle LR, Purmasir M, Segal I, Braganza JM.

Clin Chim Acta. 1995 May 15;236(2):145-53.

PMID:
7554281
45.

Evidence for early oxidative stress in acute pancreatitis. Clues for correction.

Braganza JM, Scott P, Bilton D, Schofield D, Chaloner C, Shiel N, Hunt LP, Bottiglieri T.

Int J Pancreatol. 1995 Feb;17(1):69-81.

PMID:
8568337
46.

Difficulty in detecting reperfusion injury increment in oxidative stress among patients with primary Raynaud's phenomenon and systemic sclerosis.

Herrick AL, Rieley F, Braganza JM, Jayson MI.

J Rheumatol. 1995 Feb;22(2):374-5. No abstract available.

PMID:
7738971
47.

A preliminary report on urinary BT-PABA/PAS excretion index, serum pancreatic isoamylase and faecal chymotrypsin tests of pancreatic dysfunction in Sowetan Africans.

Chaloner C, Segal I, Hassan H, McIntosh J, Gut A, Rahme M, Braganza JM.

Clin Chim Acta. 1995 Jan 16;233(1-2):89-99.

PMID:
7758206
48.

Heightened free radical activity in blacks with chronic pancreatitis at Johannesburg, South Africa.

Gut A, Shiel N, Kay PM, Segal I, Braganza JM.

Clin Chim Acta. 1994 Oct 31;230(2):189-99.

PMID:
7834869
49.

Endothelial cell harbingers of adult respiratory distress syndrome in acute pancreatitis.

Chaloner C, Blann A, Braganza JM.

Lancet. 1994 Oct 22;344(8930):1167. No abstract available.

PMID:
7523814
50.

Occupational exposure to hydrocarbons and chronic pancreatitis: a case-referent study.

McNamee R, Braganza JM, Hogg J, Leck I, Rose P, Cherry NM.

Occup Environ Med. 1994 Sep;51(9):631-7.

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