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Items: 1 to 50 of 128

1.

Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice.

Schultrich K, Henderson CJ, Braeuning A, Buhrke T.

Food Chem Toxicol. 2019 Nov 8:110957. doi: 10.1016/j.fct.2019.110957. [Epub ahead of print]

PMID:
31712104
2.

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS).

Behr AC, Plinsch C, Braeuning A, Buhrke T.

Toxicol In Vitro. 2020 Feb;62:104700. doi: 10.1016/j.tiv.2019.104700. Epub 2019 Oct 30.

PMID:
31676336
3.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

ALTEX. 2019;36(4):682-699. doi: 10.14573/altex.1909271.

4.

The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.

Hessel-Pras S, Braeuning A, Guenther G, Adawy A, Enge AM, Ebmeyer J, Henderson CJ, Hengstler JG, Lampen A, Reif R.

Arch Toxicol. 2019 Oct 12. doi: 10.1007/s00204-019-02582-8. [Epub ahead of print]

PMID:
31606820
5.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.

PMID:
31250071
6.

Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.

Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P.

Toxicol Lett. 2019 Oct 1;313:1-10. doi: 10.1016/j.toxlet.2019.05.024. Epub 2019 Jun 4.

PMID:
31170421
7.

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo.

Stock V, Böhmert L, Lisicki E, Block R, Cara-Carmona J, Pack LK, Selb R, Lichtenstein D, Voss L, Henderson CJ, Zabinsky E, Sieg H, Braeuning A, Lampen A.

Arch Toxicol. 2019 Jul;93(7):1817-1833. doi: 10.1007/s00204-019-02478-7. Epub 2019 May 28.

PMID:
31139862
8.

Okadaic acid activates Wnt/β-catenin-signaling in human HepaRG cells.

Dietrich J, Sommersdorf C, Gohlke S, Poetz O, Traenkle B, Rothbauer U, Hessel-Pras S, Lampen A, Braeuning A.

Arch Toxicol. 2019 Jul;93(7):1927-1939. doi: 10.1007/s00204-019-02489-4. Epub 2019 May 21.

PMID:
31115591
9.

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine.

Ebmeyer J, Braeuning A, Glatt H, These A, Hessel-Pras S, Lampen A.

Food Chem Toxicol. 2019 Aug;130:79-88. doi: 10.1016/j.fct.2019.05.019. Epub 2019 May 16.

PMID:
31103741
10.

Combined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cells.

Alarcan J, Barbé S, Kopp B, Hessel-Pras S, Braeuning A, Lampen A, Le Hégarat L, Fessard V.

Chemosphere. 2019 Aug;228:139-148. doi: 10.1016/j.chemosphere.2019.04.018. Epub 2019 Apr 5.

PMID:
31029959
11.

Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines.

Knebel C, Buhrke T, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.

Arch Toxicol. 2019 May;93(5):1311-1322. doi: 10.1007/s00204-019-02445-2. Epub 2019 Apr 15.

PMID:
30989312
12.

The use of 3D cultures of MCF-10A and MCF-12A cells by high content screening for effect-based analysis of non-genotoxic carcinogens.

Engel A, Frenzel F, Niemann B, Braeuning A, Lampen A, Buhrke T.

Toxicol In Vitro. 2019 Sep;59:55-63. doi: 10.1016/j.tiv.2019.04.008. Epub 2019 Apr 8.

PMID:
30974152
13.

Aluminum in liver cells - the element species matters.

Sieg H, Ellermann AL, Maria Kunz B, Jalili P, Burel A, Hogeveen K, Böhmert L, Chevance S, Braeuning A, Gauffre F, Fessard V, Lampen A.

Nanotoxicology. 2019 Sep;13(7):909-922. doi: 10.1080/17435390.2019.1593542. Epub 2019 Apr 2.

14.

The marine biotoxin okadaic acid affects intestinal tight junction proteins in human intestinal cells.

Dietrich J, Grass I, Günzel D, Herek S, Braeuning A, Lampen A, Hessel-Pras S.

Toxicol In Vitro. 2019 Aug;58:150-160. doi: 10.1016/j.tiv.2019.03.033. Epub 2019 Mar 26.

PMID:
30926360
15.

Sensitization of Human Liver Cells Toward Fas-Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine.

Ebmeyer J, Franz L, Lim R, Niemann B, Glatt H, Braeuning A, Lampen A, Hessel-Pras S.

Mol Nutr Food Res. 2019 Jun;63(12):e1801206. doi: 10.1002/mnfr.201801206. Epub 2019 Apr 1.

PMID:
30900802
16.

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Alarcan J, Dubreil E, Huguet A, Aráoz R, Brée F, Bouaita B, Hurtaud-Pessel D, Braeuning A, Hessel-Pras S, Lampen A, Le Hégarat L, Fessard V.

Toxicol Lett. 2019 Jun 1;307:17-25. doi: 10.1016/j.toxlet.2019.02.012. Epub 2019 Feb 27.

PMID:
30825503
17.

Application of Mass Spectrometry-Based Immunoassays for the Species- and Tissue-Specific Quantification of Banned Processed Animal Proteins in Feeds.

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O.

Anal Chem. 2019 Mar 19;91(6):3902-3911. doi: 10.1021/acs.analchem.8b04652. Epub 2019 Feb 27.

PMID:
30768891
18.

Plausibility of microplastic uptake in a paper by Deng et al., Scientific reports 7:46687, 2017.

Böhmert L, Stock V, Braeuning A.

Arch Toxicol. 2019 Jan;93(1):217-218. doi: 10.1007/s00204-018-2383-9. Epub 2019 Jan 2. No abstract available.

PMID:
30604141
19.

In vitro characterization of hepatic toxicity of Alternaria toxins.

Hessel-Pras S, Kieshauer J, Roenn G, Luckert C, Braeuning A, Lampen A.

Mycotoxin Res. 2019 May;35(2):157-168. doi: 10.1007/s12550-018-0339-9. Epub 2018 Dec 14.

PMID:
30552586
20.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.

PMID:
30511339
21.

Uptake of microplastics and related health effects: a critical discussion of Deng et al., Scientific reports 7:46687, 2017.

Braeuning A.

Arch Toxicol. 2019 Jan;93(1):219-220. doi: 10.1007/s00204-018-2367-9. Epub 2018 Nov 23. No abstract available.

PMID:
30470843
22.

In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism.

Braeuning A, Oberemm A, Heise T, Gundert-Remy U, Hengstler JG, Lampen A.

Arch Toxicol. 2019 Feb;93(2):369-383. doi: 10.1007/s00204-018-2360-3. Epub 2018 Nov 22.

PMID:
30467583
23.

Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells.

Ebmeyer J, Behrend J, Lorenz M, Günther G, Reif R, Hengstler JG, Braeuning A, Lampen A, Hessel-Pras S.

Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.

PMID:
30465738
24.

The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway.

Knebel C, Heise T, Zanger UM, Lampen A, Marx-Stoelting P, Braeuning A.

Food Chem Toxicol. 2019 Jan;123:481-491. doi: 10.1016/j.fct.2018.11.039. Epub 2018 Nov 17.

PMID:
30458266
25.

In vitro nanoparticle dosimetry for adherent growing cell monolayers covering bottom and lateral walls.

Böhmert L, König L, Sieg H, Lichtenstein D, Paul N, Braeuning A, Voigt A, Lampen A.

Part Fibre Toxicol. 2018 Oct 30;15(1):42. doi: 10.1186/s12989-018-0278-9.

26.

Uptake and molecular impact of aluminum-containing nanomaterials on human intestinal caco-2 cells.

Sieg H, Braeuning C, Kunz BM, Daher H, Kästner C, Krause BC, Meyer T, Jalili P, Hogeveen K, Böhmert L, Lichtenstein D, Burel A, Chevance S, Jungnickel H, Tentschert J, Laux P, Braeuning A, Gauffre F, Fessard V, Meijer J, Estrela-Lopis I, Thünemann AF, Luch A, Lampen A.

Nanotoxicology. 2018 Nov;12(9):992-1013. doi: 10.1080/17435390.2018.1504999. Epub 2018 Oct 14.

27.

Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand.

Knebel C, Kebben J, Eberini I, Palazzolo L, Hammer HS, Süssmuth RD, Heise T, Hessel-Pras S, Lampen A, Braeuning A, Marx-Stoelting P.

Arch Toxicol. 2018 Dec;92(12):3471-3486. doi: 10.1007/s00204-018-2321-x. Epub 2018 Oct 6.

28.

Evaluation and improvement of QSAR predictions of skin sensitization for pesticides.

Braeuning C, Braeuning A, Mielke H, Holzwarth A, Peiser M.

SAR QSAR Environ Res. 2018 Oct;29(10):823-846. doi: 10.1080/1062936X.2018.1518261. Epub 2018 Sep 25.

PMID:
30251555
29.

Species Differentiation and Quantification of Processed Animal Proteins and Blood Products in Fish Feed Using an 8-Plex Mass Spectrometry-Based Immunoassay.

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O.

J Agric Food Chem. 2018 Oct 3;66(39):10327-10335. doi: 10.1021/acs.jafc.8b03934. Epub 2018 Sep 24.

PMID:
30222351
30.

Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation.

Braeuning A, Kollotzek F, Zeller E, Knorpp T, Templin MF, Schwarz M.

Drug Metab Dispos. 2018 Nov;46(11):1462-1465. doi: 10.1124/dmd.118.083014. Epub 2018 Aug 16.

PMID:
30115646
31.

Proteomic analysis of 2-monochloropropanediol (2-MCPD) and 2-MCPD dipalmitate toxicity in rat kidney and liver in a 28-days study.

Frenzel F, Oberemm A, Braeuning A, Lampen A.

Food Chem Toxicol. 2018 Nov;121:1-10. doi: 10.1016/j.fct.2018.08.013. Epub 2018 Aug 10.

PMID:
30102926
32.

Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole.

Luckert C, Braeuning A, de Sousa G, Durinck S, Katsanou ES, Konstantinidou P, Machera K, Milani ES, Peijnenburg AACM, Rahmani R, Rajkovic A, Rijkers D, Spyropoulou A, Stamou M, Stoopen G, Sturla S, Wollscheid B, Zucchini-Pascal N, Lampen A.

Chem Res Toxicol. 2018 Aug 20;31(8):784-798. doi: 10.1021/acs.chemrestox.8b00112. Epub 2018 Jul 11.

PMID:
29995386
33.

On the necessity of careful interpretation of omics data.

Braeuning A, Frenzel F, Lampen A.

Arch Toxicol. 2018 Aug;92(8):2701-2702. doi: 10.1007/s00204-018-2245-5. Epub 2018 Jun 25. No abstract available.

PMID:
29943111
34.

Fate of Fluorescence Labels-Their Adsorption and Desorption Kinetics to Silver Nanoparticles.

Kästner C, Böhmert L, Braeuning A, Lampen A, Thünemann AF.

Langmuir. 2018 Jun 19;34(24):7153-7160. doi: 10.1021/acs.langmuir.8b01305. Epub 2018 Jun 7.

35.

The aryl hydrocarbon receptor and retinoid receptors cross-talk at the CYP1A1 promoter in vitro.

Hessel-Pras S, Ehlers A, Braeuning A, Lampen A.

EXCLI J. 2018 Mar 15;17:246-256. doi: 10.17179/excli2018-1147. eCollection 2018.

36.

Proteomic effects of repeated-dose oral exposure to 2-monochloropropanediol and its dipalmitate in rat testes.

Frenzel F, Oberemm A, Lampen A, Braeuning A.

Food Chem Toxicol. 2018 Jun;116(Pt B):354-359. doi: 10.1016/j.fct.2018.04.055. Epub 2018 Apr 26.

PMID:
29705614
37.

PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids.

Luckert C, Braeuning A, Lampen A, Hessel-Pras S.

Chem Biol Interact. 2018 May 25;288:38-48. doi: 10.1016/j.cbi.2018.04.017. Epub 2018 Apr 14.

PMID:
29665350
38.

In silico genotoxicity and carcinogenicity prediction for food-relevant secondary plant metabolites.

Glück J, Buhrke T, Frenzel F, Braeuning A, Lampen A.

Food Chem Toxicol. 2018 Jun;116(Pt B):298-306. doi: 10.1016/j.fct.2018.04.024. Epub 2018 Apr 13.

PMID:
29660365
39.

Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro.

Behr AC, Lichtenstein D, Braeuning A, Lampen A, Buhrke T.

Toxicol Lett. 2018 Jul;291:51-60. doi: 10.1016/j.toxlet.2018.03.029. Epub 2018 Mar 27.

PMID:
29601859
40.

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies.

Piersma AH, Burgdorf T, Louekari K, Desprez B, Taalman R, Landsiedel R, Barroso J, Rogiers V, Eskes C, Oelgeschläger M, Whelan M, Braeuning A, Vinggaard AM, Kienhuis A, van Benthem J, Ezendam J.

Toxicol In Vitro. 2018 Aug;50:62-74. doi: 10.1016/j.tiv.2018.02.018. Epub 2018 Mar 2.

PMID:
29501630
41.

Mass Spectrometry-Based Immunoassay for the Quantification of Banned Ruminant Processed Animal Proteins in Vegetal Feeds.

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O.

Anal Chem. 2018 Mar 20;90(6):4135-4143. doi: 10.1021/acs.analchem.8b00120. Epub 2018 Mar 7.

PMID:
29470057
42.

Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure.

Waizenegger J, Braeuning A, Templin M, Lampen A, Hessel-Pras S.

Food Chem Toxicol. 2018 Apr;114:215-226. doi: 10.1016/j.fct.2018.02.036. Epub 2018 Feb 16.

PMID:
29458164
43.

The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.

Engel A, Buhrke T, Kasper S, Behr AC, Braeuning A, Jessel S, Seidel A, Völkel W, Lampen A.

Toxicol Lett. 2018 May 1;287:83-91. doi: 10.1016/j.toxlet.2018.02.006. Epub 2018 Feb 5.

PMID:
29421333
44.

Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells.

Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.

Toxicol Sci. 2018 May 1;163(1):170-181. doi: 10.1093/toxsci/kfy026.

PMID:
29420809
45.

Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats.

Juling S, Böhmert L, Lichtenstein D, Oberemm A, Creutzenberg O, Thünemann AF, Braeuning A, Lampen A.

Food Chem Toxicol. 2018 Mar;113:255-266. doi: 10.1016/j.fct.2018.01.056. Epub 2018 Feb 3.

PMID:
29408364
46.

Detection of aflatoxin-producing fungi isolated from Nile tilapia and fish feed.

Mohamed HMA, Emeish WFA, Braeuning A, Hammad S.

EXCLI J. 2017 Dec 13;16:1308-1318. doi: 10.17179/excli2017-960. eCollection 2017.

47.

Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells.

Tanner N, Kubik L, Luckert C, Thomas M, Hofmann U, Zanger UM, Böhmert L, Lampen A, Braeuning A.

Drug Metab Dispos. 2018 Apr;46(4):326-335. doi: 10.1124/dmd.117.078675. Epub 2018 Jan 12.

PMID:
29330220
48.

Nanomaterials: certain aspects of application, risk assessment and risk communication.

Laux P, Tentschert J, Riebeling C, Braeuning A, Creutzenberg O, Epp A, Fessard V, Haas KH, Haase A, Hund-Rinke K, Jakubowski N, Kearns P, Lampen A, Rauscher H, Schoonjans R, Störmer A, Thielmann A, Mühle U, Luch A.

Arch Toxicol. 2018 Jan;92(1):121-141. doi: 10.1007/s00204-017-2144-1. Epub 2017 Dec 22. Review.

49.

Comparative proteomic analysis of silver nanoparticle effects in human liver and intestinal cells.

Braeuning A, Oberemm A, Görte J, Böhmert L, Juling S, Lampen A.

J Appl Toxicol. 2018 May;38(5):638-648. doi: 10.1002/jat.3568. Epub 2017 Dec 7.

PMID:
29218775
50.

Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.

PMID:
29051992

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