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Items: 1 to 50 of 116

1.

Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.

Wu C, Shang Z, Lemetre C, Ternei MA, Brady SF.

J Am Chem Soc. 2019 Mar 6;141(9):3910-3919. doi: 10.1021/jacs.8b12087. Epub 2019 Feb 20.

PMID:
30735616
2.

Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach.

Kim SH, Lu W, Ahmadi MK, Montiel D, Ternei MA, Brady SF.

ACS Synth Biol. 2019 Jan 18;8(1):109-118. doi: 10.1021/acssynbio.8b00361. Epub 2018 Dec 21.

3.

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.

Peek J, Lilic M, Montiel D, Milshteyn A, Woodworth I, Biggins JB, Ternei MA, Calle PY, Danziger M, Warrier T, Saito K, Braffman N, Fay A, Glickman MS, Darst SA, Campbell EA, Brady SF.

Nat Commun. 2018 Oct 8;9(1):4147. doi: 10.1038/s41467-018-06587-2.

4.

Accessing Bioactive Natural Products from the Human Microbiome.

Milshteyn A, Colosimo DA, Brady SF.

Cell Host Microbe. 2018 Jun 13;23(6):725-736. doi: 10.1016/j.chom.2018.05.013. Review.

PMID:
29902438
5.

Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules.

Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK, Brady SF.

Nature. 2018 Apr 4;556(7699):135. doi: 10.1038/nature25997.

PMID:
29620727
6.

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.

Hover BM, Kim SH, Katz M, Charlop-Powers Z, Owen JG, Ternei MA, Maniko J, Estrela AB, Molina H, Park S, Perlin DS, Brady SF.

Nat Microbiol. 2018 Apr;3(4):415-422. doi: 10.1038/s41564-018-0110-1. Epub 2018 Feb 12.

7.

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds.

Vila-Farres X, Chu J, Ternei MA, Lemetre C, Park S, Perlin DS, Brady SF.

mSphere. 2018 Jan 24;3(1). pii: e00528-17. doi: 10.1128/mSphere.00528-17. eCollection 2018 Jan-Feb.

8.

Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.

Lemetre C, Maniko J, Charlop-Powers Z, Sparrow B, Lowe AJ, Brady SF.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11615-11620. doi: 10.1073/pnas.1710262114. Epub 2017 Oct 18.

9.

Commensal bacteria make GPCR ligands that mimic human signalling molecules.

Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK, Brady SF.

Nature. 2017 Sep 7;549(7670):48-53. doi: 10.1038/nature23874. Epub 2017 Aug 30. Erratum in: Nature. 2018 Apr 4;556(7699):135.

10.

Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus.

Chu J, Vila-Farres X, Inoyama D, Gallardo-Macias R, Jaskowski M, Satish S, Freundlich JS, Brady SF.

ACS Infect Dis. 2018 Jan 12;4(1):33-38. doi: 10.1021/acsinfecdis.7b00056. Epub 2017 Sep 11.

PMID:
28845973
11.

Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host.

Bitok JK, Lemetre C, Ternei MA, Brady SF.

FEMS Microbiol Lett. 2017 Sep 1;364(16). doi: 10.1093/femsle/fnx155.

12.

Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library.

Cohen LJ, Han S, Huang YH, Brady SF.

ACS Infect Dis. 2018 Jan 12;4(1):27-32. doi: 10.1021/acsinfecdis.7b00081. Epub 2017 Aug 21.

PMID:
28810737
13.

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.

Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundlich JS, Perlin DS, Brady SF.

J Am Chem Soc. 2017 Feb 1;139(4):1404-1407. doi: 10.1021/jacs.6b11861. Epub 2017 Jan 23.

PMID:
28055186
14.

Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.

Charlop-Powers Z, Pregitzer CC, Lemetre C, Ternei MA, Maniko J, Hover BM, Calle PY, McGuire KL, Garbarino J, Forgione HM, Charlop-Powers S, Brady SF.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14811-14816. doi: 10.1073/pnas.1615581113. Epub 2016 Nov 28.

15.

Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis.

Valentic TR, Jackson DR, Brady SF, Tsai SC.

ACS Chem Biol. 2016 Dec 16;11(12):3421-3430. Epub 2016 Nov 8.

PMID:
27779377
16.

Discovery of MRSA active antibiotics using primary sequence from the human microbiome.

Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF.

Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17.

17.

Natural Product Discovery through Improved Functional Metagenomics in Streptomyces.

Iqbal HA, Low-Beinart L, Obiajulu JU, Brady SF.

J Am Chem Soc. 2016 Aug 3;138(30):9341-4. doi: 10.1021/jacs.6b02921. Epub 2016 Jul 22.

18.

Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast.

Kang HS, Charlop-Powers Z, Brady SF.

ACS Synth Biol. 2016 Sep 16;5(9):1002-10. doi: 10.1021/acssynbio.6b00080. Epub 2016 Jun 10.

19.

Culture-independent discovery of natural products from soil metagenomes.

Katz M, Hover BM, Brady SF.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):129-41. doi: 10.1007/s10295-015-1706-6. Epub 2015 Nov 19. Review.

PMID:
26586404
20.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

21.

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist.

Cohen LJ, Kang HS, Chu J, Huang YH, Gordon EA, Reddy BV, Ternei MA, Craig JW, Brady SF.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4825-34. doi: 10.1073/pnas.1508737112. Epub 2015 Aug 17.

22.

Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.

Montiel D, Kang HS, Chang FY, Charlop-Powers Z, Brady SF.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8953-8. doi: 10.1073/pnas.1507606112. Epub 2015 Jul 6.

23.

phylogeo: an R package for geographic analysis and visualization of microbiome data.

Charlop-Powers Z, Brady SF.

Bioinformatics. 2015 Sep 1;31(17):2909-11. doi: 10.1093/bioinformatics/btv269. Epub 2015 Apr 25.

24.

Targeted metagenomics: finding rare tryptophan dimer natural products in the environment.

Chang FY, Ternei MA, Calle PY, Brady SF.

J Am Chem Soc. 2015 May 13;137(18):6044-52. doi: 10.1021/jacs.5b01968. Epub 2015 May 4.

25.

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4221-6. doi: 10.1073/pnas.1501124112. Epub 2015 Mar 23.

26.

Global biogeographic sampling of bacterial secondary metabolism.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Guimarães DO, de Frias UA, Pupo MT, Seepe P, Feng Z, Brady SF.

Elife. 2015 Jan 19;4:e05048. doi: 10.7554/eLife.05048.

27.

Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.

Kang HS, Brady SF.

J Am Chem Soc. 2014 Dec 31;136(52):18111-9. doi: 10.1021/ja510606j. Epub 2014 Dec 18.

28.

Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products.

Chang FY, Kawashima SA, Brady SF.

Biochemistry. 2014 Nov 18;53(45):7123-31. doi: 10.1021/bi501078j. Epub 2014 Oct 31.

29.

Mining the metabiome: identifying novel natural products from microbial communities.

Milshteyn A, Schneider JS, Brady SF.

Chem Biol. 2014 Sep 18;21(9):1211-23. doi: 10.1016/j.chembiol.2014.08.006. Review.

30.

eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes.

Reddy BV, Milshteyn A, Charlop-Powers Z, Brady SF.

Chem Biol. 2014 Aug 14;21(8):1023-33. doi: 10.1016/j.chembiol.2014.06.007. Epub 2014 Jul 24.

31.

Metagenomic small molecule discovery methods.

Charlop-Powers Z, Milshteyn A, Brady SF.

Curr Opin Microbiol. 2014 Jun;19:70-75. doi: 10.1016/j.mib.2014.05.021. Epub 2014 Jul 5.

32.

The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.

Biggins JB, Kang HS, Ternei MA, DeShazer D, Brady SF.

J Am Chem Soc. 2014 Jul 2;136(26):9484-90. doi: 10.1021/ja504617n. Epub 2014 Jun 24.

33.

Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols.

Kang HS, Brady SF.

ACS Chem Biol. 2014 Jun 20;9(6):1267-72. doi: 10.1021/cb500141b. Epub 2014 Apr 30.

34.

Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans.

Iqbal HA, Craig JW, Brady SF.

FEMS Microbiol Lett. 2014 May;354(1):19-26. doi: 10.1111/1574-6968.12431. Epub 2014 Apr 10.

35.

Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin.

Chang FY, Brady SF.

Chembiochem. 2014 Apr 14;15(6):815-21. doi: 10.1002/cbic.201300756. Epub 2014 Mar 19.

36.

Chemical-biogeographic survey of secondary metabolism in soil.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Brady SF.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62. doi: 10.1073/pnas.1318021111. Epub 2014 Feb 18.

37.

Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment.

Chang FY, Ternei MA, Calle PY, Brady SF.

J Am Chem Soc. 2013 Nov 27;135(47):17906-12. doi: 10.1021/ja408683p. Epub 2013 Nov 14.

38.

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

Kang HS, Brady SF.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11063-7. doi: 10.1002/anie.201305109. Epub 2013 Sep 3.

39.

Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada.

Engel K, Ashby D, Brady SF, Cowan DA, Doemer J, Edwards EA, Fiebig K, Martens EC, McCormac D, Mead DA, Miyazaki K, Moreno-Hagelsieb G, O'Gara F, Reid A, Rose DR, Simonet P, Sjöling S, Smalla K, Streit WR, Tedman-Jones J, Valla S, Wellington EM, Wu CC, Liles MR, Neufeld JD, Sessitsch A, Charles TC.

Stand Genomic Sci. 2013 Apr 15;8(1):106-11. doi: 10.4056/sigs.3406845. eCollection 2013 Apr 15.

40.

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.

Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11797-802. doi: 10.1073/pnas.1222159110. Epub 2013 Jul 3.

41.

The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes.

Qaisar U, Luo L, Haley CL, Brady SF, Carty NL, Colmer-Hamood JA, Hamood AN.

PLoS One. 2013 Apr 30;8(4):e62735. doi: 10.1371/journal.pone.0062735. Print 2013.

42.

Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

Chang FY, Brady SF.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2478-83. doi: 10.1073/pnas.1218073110. Epub 2013 Jan 9.

43.

Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.

Kallifidas D, Kang HS, Brady SF.

J Am Chem Soc. 2012 Dec 5;134(48):19552-5. doi: 10.1021/ja3093828. Epub 2012 Nov 27.

44.

Reassembly of functionally intact environmental DNA-derived biosynthetic gene clusters.

Kallifidas D, Brady SF.

Methods Enzymol. 2012;517:225-39. doi: 10.1016/B978-0-12-404634-4.00011-5.

45.

Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis.

Charlop-Powers Z, Banik JJ, Owen JG, Craig JW, Brady SF.

ACS Chem Biol. 2013 Jan 18;8(1):138-43. doi: 10.1021/cb3004918. Epub 2012 Oct 26.

46.

Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.

Biggins JB, Ternei MA, Brady SF.

J Am Chem Soc. 2012 Aug 15;134(32):13192-5. doi: 10.1021/ja3052156. Epub 2012 Aug 1.

47.

Biocatalysts and small molecule products from metagenomic studies.

Iqbal HA, Feng Z, Brady SF.

Curr Opin Chem Biol. 2012 Apr;16(1-2):109-16. doi: 10.1016/j.cbpa.2012.02.015. Epub 2012 Mar 26. Review.

48.

Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF.

Appl Environ Microbiol. 2012 May;78(10):3744-52. doi: 10.1128/AEM.00102-12. Epub 2012 Mar 16.

49.

Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis.

Feng Z, Chakraborty D, Dewell SB, Reddy BV, Brady SF.

J Am Chem Soc. 2012 Feb 15;134(6):2981-7. doi: 10.1021/ja207662w. Epub 2012 Feb 2.

50.

Long-chain N-acyl amino acid synthases are linked to the putative PEP-CTERM/exosortase protein-sorting system in Gram-negative bacteria.

Craig JW, Cherry MA, Brady SF.

J Bacteriol. 2011 Oct;193(20):5707-15. doi: 10.1128/JB.05426-11. Epub 2011 Aug 12.

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