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Items: 1 to 50 of 81

1.

Navigating the Structural Landscape of De Novo α-Helical Bundles.

Rhys GG, Wood CW, Beesley JL, Zaccai NR, Burton AJ, Brady RL, Thomson AR, Woolfson DN.

J Am Chem Soc. 2019 Jun 5;141(22):8787-8797. doi: 10.1021/jacs.8b13354. Epub 2019 May 22.

PMID:
31066556
2.

Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF.

Brewer ML, Dymock D, Brady RL, Singer BB, Virji M, Hill DJ.

J Oral Microbiol. 2019 Jan 24;11(1):1565043. doi: 10.1080/20002297.2018.1565043. eCollection 2019.

3.

Maintaining and breaking symmetry in homomeric coiled-coil assemblies.

Rhys GG, Wood CW, Lang EJM, Mulholland AJ, Brady RL, Thomson AR, Woolfson DN.

Nat Commun. 2018 Oct 8;9(1):4132. doi: 10.1038/s41467-018-06391-y.

4.

Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.

Baxter D, Perry SR, Hill TA, Kok WM, Zaccai NR, Brady RL, Fairlie DP, Mason JM.

ACS Chem Biol. 2017 Aug 18;12(8):2051-2061. doi: 10.1021/acschembio.7b00303. Epub 2017 Jun 21.

PMID:
28636317
5.

ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design.

Wood CW, Heal JW, Thomson AR, Bartlett GJ, Ibarra AÁ, Brady RL, Sessions RB, Woolfson DN.

Bioinformatics. 2017 Oct 1;33(19):3043-3050. doi: 10.1093/bioinformatics/btx352.

6.

Installing hydrolytic activity into a completely de novo protein framework.

Burton AJ, Thomson AR, Dawson WM, Brady RL, Woolfson DN.

Nat Chem. 2016 Sep;8(9):837-44. doi: 10.1038/nchem.2555. Epub 2016 Jul 4.

PMID:
27554410
7.

The Validation of a Case-Based, Cumulative Assessment and Progressions Examination.

Brady RL, Coker AO, Copeland JT, Gottlieb HB, Horlen C, Smith HE, Urteaga EM, Ramsinghani S, Zertuche A, Maize D.

Am J Pharm Educ. 2016 Feb 25;80(1):9. doi: 10.5688/ajpe8019.

8.

Modular Design of Self-Assembling Peptide-Based Nanotubes.

Burgess NC, Sharp TH, Thomas F, Wood CW, Thomson AR, Zaccai NR, Brady RL, Serpell LC, Woolfson DN.

J Am Chem Soc. 2015 Aug 26;137(33):10554-62. doi: 10.1021/jacs.5b03973. Epub 2015 Aug 12.

PMID:
26219086
9.

Computational design of water-soluble α-helical barrels.

Thomson AR, Wood CW, Burton AJ, Bartlett GJ, Sessions RB, Brady RL, Woolfson DN.

Science. 2014 Oct 24;346(6208):485-8. doi: 10.1126/science.1257452.

10.

CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies.

Wood CW, Bruning M, Ibarra AÁ, Bartlett GJ, Thomson AR, Sessions RB, Brady RL, Woolfson DN.

Bioinformatics. 2014 Nov 1;30(21):3029-35. doi: 10.1093/bioinformatics/btu502. Epub 2014 Jul 26.

11.

Accessibility, reactivity, and selectivity of side chains within a channel of de novo peptide assembly.

Burton AJ, Thomas F, Agnew C, Hudson KL, Halford SE, Brady RL, Woolfson DN.

J Am Chem Soc. 2013 Aug 28;135(34):12524-7. doi: 10.1021/ja4053027. Epub 2013 Aug 13.

PMID:
23924058
12.

A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology.

Fletcher JM, Boyle AL, Bruning M, Bartlett GJ, Vincent TL, Zaccai NR, Armstrong CT, Bromley EH, Booth PJ, Brady RL, Thomson AR, Woolfson DN.

ACS Synth Biol. 2012 Jun 15;1(6):240-50. doi: 10.1021/sb300028q. Epub 2012 May 14.

PMID:
23651206
13.

Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design.

Sharp TH, Bruning M, Mantell J, Sessions RB, Thomson AR, Zaccai NR, Brady RL, Verkade P, Woolfson DN.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13266-71. doi: 10.1073/pnas.1118622109. Epub 2012 Jul 30.

14.

An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.

Agnew CR, Warrilow AG, Burton NM, Lamb DC, Kelly SL, Brady RL.

Antimicrob Agents Chemother. 2012 Jan;56(1):391-402. doi: 10.1128/AAC.05227-11. Epub 2011 Oct 28.

15.

A de novo peptide hexamer with a mutable channel.

Zaccai NR, Chi B, Thomson AR, Boyle AL, Bartlett GJ, Bruning M, Linden N, Sessions RB, Booth PJ, Brady RL, Woolfson DN.

Nat Chem Biol. 2011 Oct 30;7(12):935-41. doi: 10.1038/nchembio.692.

16.

Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.

Agnew C, Borodina E, Zaccai NR, Conners R, Burton NM, Vicary JA, Cole DK, Antognozzi M, Virji M, Brady RL.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15174-8. doi: 10.1073/pnas.1106341108. Epub 2011 Aug 29.

17.

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.

Singleton BK, Lau W, Fairweather VS, Burton NM, Wilson MC, Parsons SF, Richardson BM, Trakarnsanga K, Brady RL, Anstee DJ, Frayne J.

Blood. 2011 Sep 15;118(11):3137-45. doi: 10.1182/blood-2011-04-349985. Epub 2011 Jul 21.

18.

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.

Chaikuad A, Shafqat N, Al-Mokhtar R, Cameron G, Clarke AR, Brady RL, Oppermann U, Frayne J, Yue WW.

Biochem J. 2011 Apr 15;435(2):401-9. doi: 10.1042/BJ20101442.

PMID:
21269272
19.

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

Brown C, Campos-León K, Strickland M, Williams C, Fairweather V, Brady RL, Crump MP, Gaston K.

Nucleic Acids Res. 2011 Apr;39(7):2969-80. doi: 10.1093/nar/gkq1217. Epub 2010 Dec 3.

20.

Delayed-onset slipped capital femoral epiphysis: case report of association with pituitary tumor.

Brady RL, Price A.

Am J Orthop (Belle Mead NJ). 2010 Mar;39(3):137-40.

PMID:
20463986
21.

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases.

Chaikuad A, Brady RL.

BMC Struct Biol. 2009 Jul 3;9:42. doi: 10.1186/1472-6807-9-42.

22.

Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.

Levin-Iaina N, Dinour D, Romero L, Ron R, Brady RL, Cramer SD, Holtzman EJ.

J Urol. 2009 May;181(5):2146-51. doi: 10.1016/j.juro.2009.01.045. Epub 2009 Mar 17.

PMID:
19296982
23.

Oral ganciclovir versus valganciclovir for cytomegalovirus prophylaxis in high-risk liver transplant recipients.

Brady RL, Green K, Frei C, Maxwell P.

Transpl Infect Dis. 2009 Apr;11(2):106-11. doi: 10.1111/j.1399-3062.2008.00356.x.

PMID:
19054381
24.

The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein.

Bruce LJ, Guizouarn H, Burton NM, Gabillat N, Poole J, Flatt JF, Brady RL, Borgese F, Delaunay J, Stewart GW.

Blood. 2009 Feb 5;113(6):1350-7. doi: 10.1182/blood-2008-07-171140. Epub 2008 Oct 17.

25.

The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil.

Conners R, Hill DJ, Borodina E, Agnew C, Daniell SJ, Burton NM, Sessions RB, Clarke AR, Catto LE, Lammie D, Wess T, Brady RL, Virji M.

EMBO J. 2008 Jun 18;27(12):1779-89. doi: 10.1038/emboj.2008.101. Epub 2008 May 22.

26.

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype.

Singleton BK, Burton NM, Green C, Brady RL, Anstee DJ.

Blood. 2008 Sep 1;112(5):2081-8. doi: 10.1182/blood-2008-03-145672. Epub 2008 May 16.

27.

Molecular structure of the extracellular region of Lutheran blood group glycoprotein and location of the laminin binding site.

Burton NM, Brady RL.

Blood Cells Mol Dis. 2008 May-Jun;40(3):446-8. doi: 10.1016/j.bcmd.2008.01.004. Epub 2008 Mar 4. No abstract available.

PMID:
18302987
28.

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC.

Cell Signal. 2008 May;20(5):935-41. doi: 10.1016/j.cellsig.2008.01.012. Epub 2008 Jan 24.

PMID:
18294816
29.

An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.).

Conners R, Konarev AV, Forsyth J, Lovegrove A, Marsh J, Joseph-Horne T, Shewry P, Brady RL.

J Biol Chem. 2007 Sep 21;282(38):27760-8. Epub 2007 Jul 19.

30.

The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3.

Mankelow TJ, Burton N, Stefansdottir FO, Spring FA, Parsons SF, Pedersen JS, Oliveira CL, Lammie D, Wess T, Mohandas N, Chasis JA, Brady RL, Anstee DJ.

Blood. 2007 Nov 1;110(9):3398-406. Epub 2007 Jul 17.

31.

The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL.

Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12.

32.

Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase.

Booth MP, Conners R, Rumsby G, Brady RL.

J Mol Biol. 2006 Jun 30;360(1):178-89. Epub 2006 May 22.

PMID:
16756993
33.

A divergent external loop confers antagonistic activity on floral regulators FT and TFL1.

Ahn JH, Miller D, Winter VJ, Banfield MJ, Lee JH, Yoo SY, Henz SR, Brady RL, Weigel D.

EMBO J. 2006 Feb 8;25(3):605-14. Epub 2006 Jan 19.

34.

Recognition of oxidatively modified bases within the biotin-binding site of avidin.

Conners R, Hooley E, Clarke AR, Thomas S, Brady RL.

J Mol Biol. 2006 Mar 17;357(1):263-74. Epub 2006 Jan 6.

PMID:
16413579
35.

Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH.

Chaikuad A, Fairweather V, Conners R, Joseph-Horne T, Turgut-Balik D, Brady RL.

Biochemistry. 2005 Dec 13;44(49):16221-8.

PMID:
16331982
36.
38.

Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase.

Vivas L, Easton A, Kendrick H, Cameron A, Lavandera JL, Barros D, de las Heras FG, Brady RL, Croft SL.

Exp Parasitol. 2005 Oct;111(2):105-14.

PMID:
16098967
39.

Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.

Conners R, Schambach F, Read J, Cameron A, Sessions RB, Vivas L, Easton A, Croft SL, Brady RL.

Mol Biochem Parasitol. 2005 Aug;142(2):137-48. Epub 2005 Apr 18.

PMID:
15978953
40.

CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.

Karamatic Crew V, Burton N, Kagan A, Green CA, Levene C, Flinter F, Brady RL, Daniels G, Anstee DJ.

Blood. 2004 Oct 15;104(8):2217-23. Epub 2004 Jul 20.

41.

Cloning, sequence and expression of the lactate dehydrogenase gene from the human malaria parasite, Plasmodium vivax.

Turgut-Balik D, Akbulut E, Shoemark DK, Celik V, Moreton KM, Sessions RB, Holbrook JJ, Brady RL.

Biotechnol Lett. 2004 Jul;26(13):1051-5.

PMID:
15218378
42.

Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.

Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, García-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarró R, Mallo A, Gómez de las Heras F.

J Biol Chem. 2004 Jul 23;279(30):31429-39. Epub 2004 Apr 26.

43.

Structure-based approaches to the development of novel anti-malarials.

Brady RL, Cameron A.

Curr Drug Targets. 2004 Feb;5(2):137-49. Review.

PMID:
15011947
44.

Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to alpha V integrins.

Mankelow TJ, Spring FA, Parsons SF, Brady RL, Mohandas N, Chasis JA, Anstee DJ.

Blood. 2004 Feb 15;103(4):1503-8. Epub 2003 Oct 9.

45.
46.

The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family.

Simister PC, Banfield MJ, Brady RL.

Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub 2002 May 29.

PMID:
12037323
47.

A reassessment of the MAdCAM-1 structure and its role in integrin recognition.

Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL.

Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):233-41. Epub 2002 Jan 24.

PMID:
11807247
48.

Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5.

Banfield MJ, Naylor RL, Robertson AG, Allen SJ, Dawbarn D, Brady RL.

Structure. 2001 Dec;9(12):1191-9.

49.

Stability and folding rates of domains spanning the large A-band super-repeat of titin.

Head JG, Houmeida A, Knight PJ, Clarke AR, Trinick J, Brady RL.

Biophys J. 2001 Sep;81(3):1570-9.

50.

Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms.

Spring FA, Parsons SF, Ortlepp S, Olsson ML, Sessions R, Brady RL, Anstee DJ.

Blood. 2001 Jul 15;98(2):458-66.

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