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Items: 14


The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.

Jeong E, Brady OA, Martina JA, Pirooznia M, Tunc I, Puertollano R.

Elife. 2018 Dec 6;7. pii: e40856. doi: 10.7554/eLife.40856.


Emerging roles for TFEB in the immune response and inflammation.

Brady OA, Martina JA, Puertollano R.

Autophagy. 2018;14(2):181-189. doi: 10.1080/15548627.2017.1313943. Epub 2017 Jul 24.


Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.

Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F.

Nat Commun. 2017 May 25;8:15277. doi: 10.1038/ncomms15277.


Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.

Zhou X, Sun L, Brady OA, Murphy KA, Hu F.

Acta Neuropathol Commun. 2017 Jan 26;5(1):9. doi: 10.1186/s40478-017-0412-1.


Rags to riches: Amino acid sensing by the Rag GTPases in health and disease.

Brady OA, Diab HI, Puertollano R.

Small GTPases. 2016 Oct;7(4):197-206. Epub 2016 Aug 31. Review.


TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.

Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R.

Autophagy. 2016 Aug 2;12(8):1240-58. doi: 10.1080/15548627.2016.1179405. Epub 2016 May 12.


TFEB and TFE3 are novel components of the integrated stress response.

Martina JA, Diab HI, Brady OA, Puertollano R.

EMBO J. 2016 Mar 1;35(5):479-95. doi: 10.15252/embj.201593428. Epub 2016 Jan 25.


Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

Brady OA, Zhou X, Hu F.

J Biol Chem. 2014 Jul 11;289(28):19670-80. doi: 10.1074/jbc.M113.515700. Epub 2014 May 28.


The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.

Brady OA, Zheng Y, Murphy K, Huang M, Hu F.

Hum Mol Genet. 2013 Feb 15;22(4):685-95. doi: 10.1093/hmg/dds475. Epub 2012 Nov 6.


C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.

Zheng Y, Brady OA, Meng PS, Mao Y, Hu F.

PLoS One. 2011;6(6):e21023. doi: 10.1371/journal.pone.0021023. Epub 2011 Jun 15.


L1 stimulation of human glioma cell motility correlates with FAK activation.

Yang M, Li Y, Chilukuri K, Brady OA, Boulos MI, Kappes JC, Galileo DS.

J Neurooncol. 2011 Oct;105(1):27-44. doi: 10.1007/s11060-011-0557-x. Epub 2011 Mar 4.


Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM.

Neuron. 2010 Nov 18;68(4):654-67. doi: 10.1016/j.neuron.2010.09.034.


Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

Brady OA, Meng P, Zheng Y, Mao Y, Hu F.

J Neurochem. 2011 Jan;116(2):248-59. doi: 10.1111/j.1471-4159.2010.07098.x. Epub 2010 Dec 2.


Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule.

Yang M, Adla S, Temburni MK, Patel VP, Lagow EL, Brady OA, Tian J, Boulos MI, Galileo DS.

Cancer Cell Int. 2009 Oct 29;9:27. doi: 10.1186/1475-2867-9-27.

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