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Items: 1 to 50 of 73


Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency.

Rätsep MT, Moore SD, Jafri S, Mitchell M, Brady HJM, Mandelboim O, Southwood M, Morrell NW, Colucci F, Ormiston ML.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L977-L990. doi: 10.1152/ajplung.00477.2017. Epub 2018 Sep 20.


Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs.

Rollings CM, Sinclair LV, Brady HJM, Cantrell DA, Ross SH.

Sci Signal. 2018 Apr 17;11(526). pii: eaap8112. doi: 10.1126/scisignal.aap8112.


Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.

Kostrzewski T, Borg AJ, Meng Y, Filipovic I, Male V, Wack A, DiMaggio PA, Brady HJM.

J Immunol. 2018 Feb 15;200(4):1370-1381. doi: 10.4049/jimmunol.1700981. Epub 2018 Jan 8.


Murine thymic NK cells: A case of identity.

Male V, Brady HJM.

Eur J Immunol. 2017 May;47(5):797-799. doi: 10.1002/eji.201747038.


Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance.

Smyth LA, Meader L, Xiao F, Woodward M, Brady HJ, Lechler R, Lombardi G.

Clin Exp Immunol. 2017 May;188(2):219-225. doi: 10.1111/cei.12931. Epub 2017 Mar 2.


Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity.

Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J.

Cell Metab. 2016 Apr 12;23(4):685-98. doi: 10.1016/j.cmet.2016.03.002. Epub 2016 Mar 31.


The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.

Boulenouar S, Doisne JM, Sferruzzi-Perri A, Gaynor LM, Kieckbusch J, Balmas E, Yung HW, Javadzadeh S, Volmer L, Hawkes DA, Phillips K, Brady HJ, Fowden AL, Burton GJ, Moffett A, Colucci F.

Front Immunol. 2016 Feb 19;7:43. doi: 10.3389/fimmu.2016.00043. eCollection 2016.


Composition, Development, and Function of Uterine Innate Lymphoid Cells.

Doisne JM, Balmas E, Boulenouar S, Gaynor LM, Kieckbusch J, Gardner L, Hawkes DA, Barbara CF, Sharkey AM, Brady HJ, Brosens JJ, Moffett A, Colucci F.

J Immunol. 2015 Oct 15;195(8):3937-45. doi: 10.4049/jimmunol.1500689. Epub 2015 Sep 14.


ILC Lineage Specification: To Be or Not 11b, That Is the Question.

Kostrzewski T, Brady HJ.

Immunity. 2015 Aug 18;43(2):220-2. doi: 10.1016/j.immuni.2015.08.005.


Transcriptional control of NK cell differentiation and function.

Male V, Brady HJ.

Curr Top Microbiol Immunol. 2014;381:173-87. doi: 10.1007/82_2014_376. Review.


The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

Male V, Nisoli I, Kostrzewski T, Allan DS, Carlyle JR, Lord GM, Wack A, Brady HJ.

J Exp Med. 2014 Apr 7;211(4):635-42. doi: 10.1084/jem.20132398. Epub 2014 Mar 24.


The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development.

Crotta S, Gkioka A, Male V, Duarte JH, Davidson S, Nisoli I, Brady HJ, Wack A.

J Immunol. 2014 Mar 15;192(6):2677-88. doi: 10.4049/jimmunol.1302765. Epub 2014 Feb 17.


Differential requirement for Nfil3 during NK cell development.

Seillet C, Huntington ND, Gangatirkar P, Axelsson E, Minnich M, Brady HJ, Busslinger M, Smyth MJ, Belz GT, Carotta S.

J Immunol. 2014 Mar 15;192(6):2667-76. doi: 10.4049/jimmunol.1302605. Epub 2014 Feb 14.


CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.

Seillet C, Jackson JT, Markey KA, Brady HJ, Hill GR, Macdonald KP, Nutt SL, Belz GT.

Blood. 2013 Feb 28;121(9):1574-83. doi: 10.1182/blood-2012-07-445650. Epub 2013 Jan 7.


Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.

Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJ, Yin L.

J Biol Chem. 2013 Feb 22;288(8):5417-25. doi: 10.1074/jbc.M112.433482. Epub 2013 Jan 2.


NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity.

Lee WH, Salek-Ardakani S, Pandolfi PP, Brady HJ, de Boer J, Williams O.

Leukemia. 2012 May;26(5):1110-2. doi: 10.1038/leu.2011.365. Epub 2011 Dec 23. No abstract available.


E4BP4: an unexpected player in the immune response.

Male V, Nisoli I, Gascoyne DM, Brady HJ.

Trends Immunol. 2012 Feb;33(2):98-102. doi: 10.1016/ Epub 2011 Nov 8. Review.


Relation between childhood maltreatment and severe intrafamilial male-perpetrated physical violence in Chinese community: the mediating role of borderline and antisocial personality disorder features.

Liu N, Zhang Y, Brady HJ, Cao Y, He Y, Zhang Y.

Aggress Behav. 2012 Jan-Feb;38(1):64-76. doi: 10.1002/ab.20417. Epub 2011 Oct 25.


Transcriptional control of natural killer cell differentiation and function.

Martín-Fontecha A, Lord GM, Brady HJ.

Cell Mol Life Sci. 2011 Nov;68(21):3495-503. doi: 10.1007/s00018-011-0800-9. Epub 2011 Aug 24. Review.


The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors.

de Boer J, Yeung J, Ellu J, Ramanujachar R, Bornhauser B, Solarska O, Hubank M, Williams O, Brady HJ.

Leukemia. 2011 Feb;25(2):321-30. doi: 10.1038/leu.2010.253. Epub 2010 Nov 12.


AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.

Dunne J, Gascoyne DM, Lister TA, Brady HJ, Heidenreich O, Young BD.

Cancer Res. 2010 May 15;70(10):3985-95. doi: 10.1158/0008-5472.CAN-09-3604. Epub 2010 May 11.


Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.

Stam RW, Den Boer ML, Schneider P, de Boer J, Hagelstein J, Valsecchi MG, de Lorenzo P, Sallan SE, Brady HJ, Armstrong SA, Pieters R.

Blood. 2010 Feb 4;115(5):1018-25. doi: 10.1182/blood-2009-02-205963. Epub 2009 Dec 4.


The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.

Gascoyne DM, Long E, Veiga-Fernandes H, de Boer J, Williams O, Seddon B, Coles M, Kioussis D, Brady HJ.

Nat Immunol. 2009 Oct;10(10):1118-24. doi: 10.1038/ni.1787. Epub 2009 Sep 13. Erratum in: Nat Immunol. 2010 Jun;11(6):543.


Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.

Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O, Brady HJ.

Cell Death Differ. 2010 Feb;17(2):316-23. doi: 10.1038/cdd.2009.125. Epub 2009 Sep 4.


The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, Alessandri AL, Martin MC, Brady HJ, Teixeira MM, Dransfield I, Haslett C, Rossi AG.

FEBS Lett. 2009 Aug 6;583(15):2540-6. doi: 10.1016/j.febslet.2009.07.017. Epub 2009 Jul 18.


ERG is a megakaryocytic oncogene.

Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ.

Cancer Res. 2009 Jun 1;69(11):4665-73. doi: 10.1158/0008-5472.CAN-09-0075.


Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells.

Roig MB, Roset R, Ortet L, Balsiger NA, Anfosso A, Cabellos L, Garrido M, Alameda F, Brady HJ, Gil-Gómez G.

Cell Death Differ. 2009 Feb;16(2):230-43. doi: 10.1038/cdd.2008.145. Epub 2008 Oct 17.


The Ikaros splice isoform, Ikaros 6, immortalizes murine haematopoietic progenitor cells.

Ruiz A, Williams O, Brady HJ.

Int J Cancer. 2008 Sep 15;123(6):1240-5. doi: 10.1002/ijc.23706.


Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ, Kioussis D, Williams O, Brady HJ.

Cell Stem Cell. 2007 Sep 13;1(3):338-45. doi: 10.1016/j.stem.2007.07.002.


Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.

Crescenzi E, Palumbo G, de Boer J, Brady HJ.

Clin Cancer Res. 2008 Mar 15;14(6):1877-87. doi: 10.1158/1078-0432.CCR-07-4298.


Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia.

Chowdhury T, Brady HJ.

Blood Cells Mol Dis. 2008 Mar-Apr;40(2):192-9. Epub 2007 Oct 1. Review.


HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.

Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ.

Genes Funct. 1997 Dec;1(5-6):321-35.


TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.

Morrow M, Samanta A, Kioussis D, Brady HJ, Williams O.

Oncogene. 2007 Jun 28;26(30):4404-14. Epub 2007 Jan 22.


Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.

Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, Caldicott A, Martinez-Losa M, Walker TR, Duffin R, Gray M, Crescenzi E, Martin MC, Brady HJ, Savill JS, Dransfield I, Haslett C.

Nat Med. 2006 Sep;12(9):1056-64. Epub 2006 Sep 3. Erratum in: Nat Med. 2006 Dec;12(12):1434. Dosage error in article text.


Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis.

Zhuang J, Brady HJ.

Cell Death Differ. 2006 Aug;13(8):1263-7. Epub 2006 May 5. No abstract available.


The MLL recombinome of acute leukemias.

Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, Schoch C, Jansen MW, van Dongen JJ, den Boer ML, Pieters R, Ennas MG, Angelucci E, Koehl U, Greil J, Griesinger F, Zur Stadt U, Eckert C, Szczepański T, Niggli FK, Schäfer BW, Kempski H, Brady HJ, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E, Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T, Klingebiel T, Marschalek R.

Leukemia. 2006 May;20(5):777-84.


Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.

Clohessy JG, Zhuang J, de Boer J, Gil-Gómez G, Brady HJ.

J Biol Chem. 2006 Mar 3;281(9):5750-9. Epub 2005 Dec 27.


Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.

Crescenzi E, Palumbo G, Brady HJ.

Clin Cancer Res. 2005 Nov 15;11(22):8158-71.


Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ, Williams O.

Cancer Res. 2005 Oct 15;65(20):9245-52.


cMet and Fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells.

Smyth LA, Brady HJ.

Hypertension. 2005 Jul;46(1):100-6. Epub 2005 May 23.


Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA.

Hughes TA, Brady HJ.

J Biol Chem. 2005 Mar 4;280(9):8581-8. Epub 2004 Dec 16.


Cdk2 activation acts upstream of the mitochondrion during glucocorticoid induced thymocyte apoptosis.

Granés F, Roig MB, Brady HJ, Gil-Gómez G.

Eur J Immunol. 2004 Oct;34(10):2781-90.


Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells.

Clohessy JG, Zhuang J, Brady HJ.

Br J Haematol. 2004 Jun;125(5):655-65.


E4BP4 expression is regulated by the t(17;19)-associated oncoprotein E2A-HLF in pro-B cells.

Yeung J, O'Sullivan E, Hubank M, Brady HJ.

Br J Haematol. 2004 Jun;125(5):560-7.


TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity.

Morrow M, Horton S, Kioussis D, Brady HJ, Williams O.

Blood. 2004 May 15;103(10):3890-6. Epub 2004 Jan 15.

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