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Items: 25


CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation.

Rasool RU, Natesan R, Deng Q, Aras S, Lal P, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA.

Cancer Discov. 2019 Aug 29. pii: CD-19-0189. doi: 10.1158/2159-8290.CD-19-0189. [Epub ahead of print]


Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism.

Chung CY, Posimo JM, Lee S, Tsang T, Davis JM, Brady DC, Chang CJ.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18285-18294. doi: 10.1073/pnas.1904610116. Epub 2019 Aug 26.


The brighter side of climate change: How local oceanography amplified a lobster boom in the Gulf of Maine.

Goode AG, Brady DC, Steneck RS, Wahle RA.

Glob Chang Biol. 2019 Jul 25. doi: 10.1111/gcb.14778. [Epub ahead of print]


Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma.

Kim YJ, Bond GJ, Tsang T, Posimo JM, Busino L, Brady DC.

Metallomics. 2019 Aug 1;11(8):1430-1440. doi: 10.1039/c9mt00042a. Epub 2019 Jul 18.


Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription.

Katona BW, Glynn RA, Paulosky KE, Feng Z, Davis CI, Ma J, Berry CT, Szigety KM, Matkar S, Liu Y, Wang H, Wu Y, He X, Freedman BD, Brady DC, Hua X.

Cancer Res. 2019 May 1;79(9):2195-2207. doi: 10.1158/0008-5472.CAN-18-2133. Epub 2019 Mar 15.


Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior.

Sadeghi RS, Kulej K, Kathayat RS, Garcia BA, Dickinson BC, Brady DC, Witze ES.

Elife. 2018 Apr 12;7. pii: e34362. doi: 10.7554/eLife.34362.


Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.

Brady DC, Crowe MS, Greenberg DN, Counter CM.

Cancer Res. 2017 Nov 15;77(22):6240-6252. doi: 10.1158/0008-5472.CAN-16-1190. Epub 2017 Oct 6.


A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.


Model-assisted measurements of suspension-feeding flow velocities.

Du Clos KT, Jones IT, Carrier TJ, Brady DC, Jumars PA.

J Exp Biol. 2017 Jun 1;220(Pt 11):2096-2107. doi: 10.1242/jeb.147934. Epub 2017 Mar 27.


Abiotic proxies for predictive mapping of nearshore benthic assemblages: implications for marine spatial planning.

McHenry J, Steneck RS, Brady DC.

Ecol Appl. 2017 Mar;27(2):603-618. doi: 10.1002/eap.1469.


Double Trouble: Kinase domain duplication as a new path to drug resistance.

Chen HY, Brady DC, Villanueva J.

Pigment Cell Melanoma Res. 2016 Sep;29(5):493-5. doi: 10.1111/pcmr.12508. No abstract available.


Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature.

Lim DC, Brady DC, Soans R, Kim EY, Valverde L, Keenan BT, Guo X, Kim WY, Park MJ, Galante R, Shackleford JA, Pack AI.

J Appl Physiol (1985). 2016 Jul 1;121(1):78-88. doi: 10.1152/japplphysiol.01040.2015. Epub 2016 Apr 28.


Simulating obstructive sleep apnea patients' oxygenation characteristics into a mouse model of cyclical intermittent hypoxia.

Lim DC, Brady DC, Po P, Chuang LP, Marcondes L, Kim EY, Keenan BT, Guo X, Maislin G, Galante RJ, Pack AI.

J Appl Physiol (1985). 2015 Mar 1;118(5):544-57. doi: 10.1152/japplphysiol.00629.2014. Epub 2014 Nov 26.


Copper is required for oncogenic BRAF signalling and tumorigenesis.

Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM.

Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9.


Long-term seasonal trends of nitrogen, phosphorus, and suspended sediment load from the non-tidal Susquehanna River Basin to Chesapeake Bay.

Zhang Q, Brady DC, Ball WP.

Sci Total Environ. 2013 May 1;452-453:208-21. doi: 10.1016/j.scitotenv.2013.02.012. Epub 2013 Mar 19.


A novel role for copper in Ras/mitogen-activated protein kinase signaling.

Turski ML, Brady DC, Kim HJ, Kim BE, Nose Y, Counter CM, Winge DR, Thiele DJ.

Mol Cell Biol. 2012 Apr;32(7):1284-95. doi: 10.1128/MCB.05722-11. Epub 2012 Jan 30.


RALA and RALBP1 regulate mitochondrial fission at mitosis.

Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM.

Nat Cell Biol. 2011 Aug 7;13(9):1108-15. doi: 10.1038/ncb2310.


Characterizing the escape response of juvenile summer flounder Paralichthys dentatus to diel-cycling hypoxia.

Brady DC, Targett TE.

J Fish Biol. 2010 Jul;77(1):137-52. doi: 10.1111/j.1095-8649.2010.02663.x.


Ral activation promotes melanomagenesis.

Zipfel PA, Brady DC, Kashatus DF, Ancrile BD, Tyler DS, Counter CM.

Oncogene. 2010 Aug 26;29(34):4859-64. doi: 10.1038/onc.2010.224. Epub 2010 Jun 21.


Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.

Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM.

Mol Cell Biol. 2010 Jan;30(2):508-23. doi: 10.1128/MCB.00916-08. Epub 2009 Nov 9.


ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.

O'Hayer KM, Brady DC, Counter CM.

Carcinogenesis. 2009 Nov;30(11):1841-7. doi: 10.1093/carcin/bgp198. Epub 2009 Oct 5.


Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD.

Biochem J. 2009 Oct 23;424(1):153-61. doi: 10.1042/BJ20082377.


The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.

Brady DC, Alan JK, Madigan JP, Fanning AS, Cox AD.

Mol Cell Biol. 2009 Feb;29(4):1035-49. doi: 10.1128/MCB.00336-08. Epub 2008 Dec 8.


Using inhibitors of prenylation to block localization and transforming activity.

Berzat AC, Brady DC, Fiordalisi JJ, Cox AD.

Methods Enzymol. 2006;407:575-97.


Unification of critical care nurses: an approach to recruitment and retention.

Brady DC, Dunn DC, Frey GM.

Nurs Adm Q. 1990 Summer;14(4):61-5. No abstract available.


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