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Items: 1 to 50 of 55

1.

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M.

EMBO Rep. 2018 Oct 2. pii: e46512. doi: 10.15252/embr.201846512. [Epub ahead of print]

PMID:
30279279
2.

Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.

Nairismägi M-, Gerritsen ME, Li ZM, Wijaya GC, Chia BKH, Laurensia Y, Lim JQ, Yeoh KW, Yao XS, Pang WL, Bisconte A, Hill RJ, Bradshaw JM, Huang D, Song TLL, Ng CCY, Rajasegaran V, Tang T, Tang QQ, Xia XJ, Kang TB, Teh BT, Lim ST, Ong CK, Tan J.

Leukemia. 2018 May;32(5):1147-1156. doi: 10.1038/s41375-017-0004-x. Epub 2018 Feb 2.

3.

PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A.

Br J Pharmacol. 2018 Feb;175(3):429-439. doi: 10.1111/bph.14090. Epub 2017 Dec 22.

PMID:
29130484
4.

ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.

Fuhriman JM, Winge MCG, Haberstock-Debic H, Funk JO, Bradshaw JM, Marinkovich MP.

J Invest Dermatol. 2018 Apr;138(4):864-871. doi: 10.1016/j.jid.2017.10.029. Epub 2017 Nov 10.

PMID:
29129599
5.

The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.

Venetsanakos E, Brameld KA, Phan VT, Verner E, Owens TD, Xing Y, Tam D, LaStant J, Leung K, Karr DE, Hill RJ, Gerritsen ME, Goldstein DM, Funk JO, Bradshaw JM.

Mol Cancer Ther. 2017 Dec;16(12):2668-2676. doi: 10.1158/1535-7163.MCT-17-0309. Epub 2017 Oct 4.

PMID:
28978721
6.

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

Brameld KA, Owens TD, Verner E, Venetsanakos E, Bradshaw JM, Phan VT, Tam D, Leung K, Shu J, LaStant J, Loughhead DG, Ton T, Karr DE, Gerritsen ME, Goldstein DM, Funk JO.

J Med Chem. 2017 Aug 10;60(15):6516-6527. doi: 10.1021/acs.jmedchem.7b00360. Epub 2017 Jul 25.

PMID:
28665128
7.

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.

Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ.

J Immunol. 2015 Nov 15;195(10):4822-31. doi: 10.4049/jimmunol.1501828. Epub 2015 Oct 14.

8.

Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J.

Nat Chem Biol. 2015 Jul;11(7):525-31. doi: 10.1038/nchembio.1817. Epub 2015 May 25.

9.

Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.

Zhong Y, Dong S, Strattan E, Ren L, Butchar JP, Thornton K, Mishra A, Porcu P, Bradshaw JM, Bisconte A, Owens TD, Verner E, Brameld KA, Funk JO, Hill RJ, Johnson AJ, Dubovsky JA.

J Biol Chem. 2015 Mar 6;290(10):5960-78. doi: 10.1074/jbc.M114.614891. Epub 2015 Jan 15.

10.

Osteopenic consequences of botulinum toxin injections in the masticatory muscles: a pilot study.

Raphael KG, Tadinada A, Bradshaw JM, Janal MN, Sirois DA, Chan KC, Lurie AG.

J Oral Rehabil. 2014 Aug;41(8):555-63. doi: 10.1111/joor.12180. Epub 2014 May 17.

PMID:
24836732
11.

Monitoring signaling by the p75(NTR) receptor utilizing a caspase-3 activation assay amenable to small-molecule screening.

Bradshaw JM, Nguyen L, Wallace W, Li C, Sauer JM, Bard F, Bova MP.

Assay Drug Dev Technol. 2012 Aug;10(4):353-64. doi: 10.1089/adt.2011.398. Epub 2012 Jun 4.

PMID:
22663019
12.

DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.

Stone JL, McMillan RE, Skaar DA, Bradshaw JM, Jirtle RL, Sikes ML.

J Immunol. 2012 Mar 1;188(5):2266-75. doi: 10.4049/jimmunol.1002931. Epub 2012 Jan 27.

13.

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.

Kuglstatter A, Wong A, Tsing S, Lee SW, Lou Y, Villaseñor AG, Bradshaw JM, Shaw D, Barnett JW, Browner MF.

Protein Sci. 2011 Feb;20(2):428-36. doi: 10.1002/pro.575.

14.

Bovine spongiform encephalopathy: investigation of phenotypic variation among passive surveillance cases.

Stack MJ, Moore SJ, Davis A, Webb PR, Bradshaw JM, Lee YH, Chaplin M, Focosi-Snyman R, Thurston L, Spencer YI, Hawkins SA, Arnold ME, Simmons MM, Wells GA.

J Comp Pathol. 2011 May;144(4):277-88. doi: 10.1016/j.jcpa.2010.10.007. Epub 2010 Dec 9.

PMID:
21145564
15.

The center of accessibility: Dβ control of V(D)J recombination.

Sikes ML, McMillan RE, Bradshaw JM.

Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):427-33. doi: 10.1007/s00005-010-0101-2. Epub 2010 Oct 2. Review.

16.

The Src, Syk, and Tec family kinases: distinct types of molecular switches.

Bradshaw JM.

Cell Signal. 2010 Aug;22(8):1175-84. doi: 10.1016/j.cellsig.2010.03.001. Epub 2010 Mar 4. Review.

PMID:
20206686
17.

A fluorescence resonance energy transfer-based binding assay for characterizing kinase inhibitors: important role for C-terminal biotin tagging of the kinase.

Kwan J, Ling A, Papp E, Shaw D, Bradshaw JM.

Anal Biochem. 2009 Dec 15;395(2):256-62. doi: 10.1016/j.ab.2009.08.032. Epub 2009 Aug 27.

PMID:
19716360
18.

Uterine endometrial carcinoma associated with dystocia in a captive scimitar-horned oryx (Oryx dammah).

Harwood DG, Griffiths WH, Bradshaw JM, Gilbert T.

Vet Rec. 2009 May 23;164(21):661-2. No abstract available.

PMID:
19465757
19.

A streamlined method for rapid and sensitive chromatin immunoprecipitation.

Sikes ML, Bradshaw JM, Ivory WT, Lunsford JL, McMillan RE, Morrison CR.

J Immunol Methods. 2009 May 15;344(1):58-63. doi: 10.1016/j.jim.2009.03.007. Epub 2009 Mar 26.

20.

Molecular mechanism of the Syk activation switch.

Tsang E, Giannetti AM, Shaw D, Dinh M, Tse JK, Gandhi S, Ho H, Wang S, Papp E, Bradshaw JM.

J Biol Chem. 2008 Nov 21;283(47):32650-9. doi: 10.1074/jbc.M806340200. Epub 2008 Sep 25.

21.

Role of the N- and C-lobes of calmodulin in the activation of Ca(2+)/calmodulin-dependent protein kinase II.

Forest A, Swulius MT, Tse JK, Bradshaw JM, Gaertner T, Waxham MN.

Biochemistry. 2008 Oct 7;47(40):10587-99. doi: 10.1021/bi8007033. Epub 2008 Sep 17.

22.

Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay.

Papp E, Tse JK, Ho H, Wang S, Shaw D, Lee S, Barnett J, Swinney DC, Bradshaw JM.

Biochemistry. 2007 Dec 25;46(51):15103-14. Epub 2007 Dec 1.

PMID:
18052078
23.
24.

Activation mechanism and steady state kinetics of Bruton's tyrosine kinase.

Dinh M, Grunberger D, Ho H, Tsing SY, Shaw D, Lee S, Barnett J, Hill RJ, Swinney DC, Bradshaw JM.

J Biol Chem. 2007 Mar 23;282(12):8768-76. Epub 2007 Jan 30.

25.

Higher cortical deficits influence attentional processing in dementia with Lewy bodies, relative to patients with dementia of the Alzheimer's type and controls.

Bradshaw JM, Saling M, Anderson V, Hopwood M, Brodtmann A.

J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1129-35. Epub 2006 Jun 13.

26.

Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.

Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ.

J Feline Med Surg. 2006 Aug;8(4):234-42. Epub 2006 Apr 17.

PMID:
16603401
27.

A retrospective study of 286 cases of neurological disorders of the cat.

Bradshaw JM, Pearson GR, Gruffydd-Jones TJ.

J Comp Pathol. 2004 Aug-Oct;131(2-3):112-20.

PMID:
15276850
28.

Feline necrotising sialometaplasia: a report of two cases.

Brown PJ, Bradshaw JM, Sozmen M, Campbell RH.

J Feline Med Surg. 2004 Aug;6(4):279-81.

PMID:
15265483
29.

An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.

Bradshaw JM, Kubota Y, Meyer T, Schulman H.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10512-7. Epub 2003 Aug 19.

30.

Molecular recognition by SH2 domains.

Bradshaw JM, Waksman G.

Adv Protein Chem. 2002;61:161-210. Review.

PMID:
12461824
31.
32.
33.

Inconsistent detection of PrP in extraneural tissues of cats with feline spongiform encephalopathy.

Ryder SJ, Wells GA, Bradshaw JM, Pearson GR.

Vet Rec. 2001 Apr 7;148(14):437-41.

PMID:
11338713
35.

Mutational investigation of the specificity determining region of the Src SH2 domain.

Bradshaw JM, Mitaxov V, Waksman G.

J Mol Biol. 2000 Jun 2;299(2):521-35.

PMID:
10860756
36.

Physician participation in research surveys. A randomized study of inducements to return mailed research questionnaires.

Donaldson GW, Moinpour CM, Bush NE, Chapko M, Jocom J, Siadak M, Nielsen-Stoeck M, Bradshaw JM, Bichindaritz I, Sullivan KM.

Eval Health Prof. 1999 Dec;22(4):427-41.

PMID:
10623399
37.

Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase.

Bradshaw JM, Mitaxov V, Waksman G.

J Mol Biol. 1999 Nov 5;293(4):971-85.

PMID:
10543978
38.

A neuropsychological-genetic profile of atypical cri du chat syndrome: implications for prognosis.

Cornish KM, Cross G, Green A, Willatt L, Bradshaw JM.

J Med Genet. 1999 Jul;36(7):567-70.

39.

SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.

Grucza RA, Bradshaw JM, Fütterer K, Waksman G.

Med Res Rev. 1999 Jul;19(4):273-93. Review. No abstract available.

PMID:
10398925
41.

CARE-PARTNER: a computerized knowledge-support system for stem-cell post-transplant long-term follow-up on the World-Wide-Web.

Bichindaritz I, Siadak MF, Jocom J, Moinpour C, Kansu E, Donaldson G, Bush N, Chapko M, Bradshaw JM, Sullivan KM.

Proc AMIA Symp. 1998:386-90.

43.

Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.

Chung E, Henriques D, Renzoni D, Zvelebil M, Bradshaw JM, Waksman G, Robinson CV, Ladbury JE.

Structure. 1998 Sep 15;6(9):1141-51.

44.
45.

Dysuria associated with urethral caruncle in the dog.

Bradshaw JM, Brown PJ, Pearson GR, Holt PE.

J Comp Pathol. 1996 Jul;115(1):77-84.

PMID:
8878753
46.

Plasma concentrations of prolactin, progesterone, relaxin and oestradiol-17 beta in sows treated with progesterone, bromocriptine or indomethacin during late pregnancy.

Taverne M, Bevers M, Bradshaw JM, Dieleman SJ, Willemse AH, Porter DG.

J Reprod Fertil. 1982 May;65(1):85-96.

PMID:
7077605
47.

The timing and possible mechanisms of cervical opening in the oestrous rat.

Foulkes A, Bradshaw JM, Porter DG.

Q J Exp Physiol. 1982 Jan;67(1):81-6.

48.

Demonstration of some of the physiological properties of rat relaxin.

Bradshaw JM, Downing SJ, Moffatt A, Hinton JC, Porter DG.

J Reprod Fertil. 1981 Sep;63(1):145-53.

PMID:
7277312
49.
50.

Relaxin inhibits myometrial activity in the ovariectomized non-pregnant ewe.

Porter DG, Lye SJ, Bradshaw JM, Kendall JZ.

J Reprod Fertil. 1981 Mar;61(2):409-14.

PMID:
7205786

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