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Items: 33

1.

A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system.

Ruan C, Sun L, Kroshilina A, Beckers L, De Jager P, Bradshaw EM, Hasson SA, Yang G, Elyaman W.

Brain Behav Immun. 2019 Oct 8. pii: S0889-1591(19)30814-1. doi: 10.1016/j.bbi.2019.10.009. [Epub ahead of print]

PMID:
31604143
2.

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.

Felsky D, Roostaei T, Nho K, Risacher SL, Bradshaw EM, Petyuk V, Schneider JA, Saykin A, Bennett DA, De Jager PL.

Nat Commun. 2019 Jan 24;10(1):409. doi: 10.1038/s41467-018-08279-3.

3.

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.

Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL.

Nat Neurosci. 2018 Jun;21(6):811-819. doi: 10.1038/s41593-018-0154-9. Epub 2018 May 25.

4.

A transcriptomic atlas of aged human microglia.

Olah M, Patrick E, Villani AC, Xu J, White CC, Ryan KJ, Piehowski P, Kapasi A, Nejad P, Cimpean M, Connor S, Yung CJ, Frangieh M, McHenry A, Elyaman W, Petyuk V, Schneider JA, Bennett DA, De Jager PL, Bradshaw EM.

Nat Commun. 2018 Feb 7;9(1):539. doi: 10.1038/s41467-018-02926-5.

5.

MS AHI1 genetic risk promotes IFNγ+ CD4+ T cells.

Kaskow BJ, Buttrick TS, Klein HU, White C, Bourgeois JR, Ferland RJ, Patsopoulos N, Bradshaw EM, De Jager PL, Elyaman W.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 8;5(1):e414. doi: 10.1212/NXI.0000000000000414. eCollection 2018 Jan.

6.

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

Ryan KJ, White CC, Patel K, Xu J, Olah M, Replogle JM, Frangieh M, Cimpean M, Winn P, McHenry A, Kaskow BJ, Chan G, Cuerdon N, Bennett DA, Boyd JD, Imitola J, Elyaman W, De Jager PL, Bradshaw EM.

Sci Transl Med. 2017 Dec 20;9(421). pii: eaai7635. doi: 10.1126/scitranslmed.aai7635.

7.

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.

Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ, Gupta V.

J Clin Invest. 2017 Apr 3;127(4):1271-1283. doi: 10.1172/JCI88442. Epub 2017 Mar 6.

8.

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.

Kurdi AT, Bassil R, Olah M, Wu C, Xiao S, Taga M, Frangieh M, Buttrick T, Orent W, Bradshaw EM, Khoury SJ, Elyaman W.

Nat Commun. 2016 Oct 11;7:13048. doi: 10.1038/ncomms13048.

9.

Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM.

Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug.

10.

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.

Orent W, Mchenry AR, Rao DA, White C, Klein HU, Bassil R, Srivastava G, Replogle JM, Raj T, Frangieh M, Cimpean M, Cuerdon N, Chibnik L, Khoury SJ, Karlson EW, Brenner MB, De Jager P, Bradshaw EM, Elyaman W.

Hum Mol Genet. 2016 Jan 15;25(2):404-17. doi: 10.1093/hmg/ddv474. Epub 2015 Nov 24.

11.

CD33 modulates TREM2: convergence of Alzheimer loci.

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, De Jager PL.

Nat Neurosci. 2015 Nov;18(11):1556-8. doi: 10.1038/nn.4126. Epub 2015 Sep 28.

12.

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.

Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S.

Oncotarget. 2015 Mar 10;6(7):4704-16.

13.

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.

Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL.

Ann Neurol. 2015 Mar;77(3):469-77. doi: 10.1002/ana.24337.

14.

Monoallelic expression of the human FOXP2 speech gene.

Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6848-54. doi: 10.1073/pnas.1411270111. Epub 2014 Nov 24.

15.

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility.

Raj T, Ryan KJ, Replogle JM, Chibnik LB, Rosenkrantz L, Tang A, Rothamel K, Stranger BE, Bennett DA, Evans DA, De Jager PL, Bradshaw EM.

Hum Mol Genet. 2014 May 15;23(10):2729-36. doi: 10.1093/hmg/ddt666. Epub 2013 Dec 30.

16.

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, Tang A, Rosenkrantz LL, Imboywa S, Lee M, Von Korff A; Alzheimer Disease Neuroimaging Initiative, Morris MC, Evans DA, Johnson K, Sperling RA, Schneider JA, Bennett DA, De Jager PL.

Nat Neurosci. 2013 Jul;16(7):848-50. doi: 10.1038/nn.3435. Epub 2013 May 23.

17.

Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis.

Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC.

PLoS One. 2012;7(10):e46709. doi: 10.1371/journal.pone.0046709. Epub 2012 Oct 5.

18.

Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells.

Elyaman W, Bassil R, Bradshaw EM, Orent W, Lahoud Y, Zhu B, Radtke F, Yagita H, Khoury SJ.

Immunity. 2012 Apr 20;36(4):623-34. doi: 10.1016/j.immuni.2012.01.020. Epub 2012 Apr 12.

19.

Polyfunctional responses by human T cells result from sequential release of cytokines.

Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1607-12. doi: 10.1073/pnas.1117194109. Epub 2011 Dec 12.

20.

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.

Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA.

J Immunol. 2011 Jul 15;187(2):1039-46. doi: 10.4049/jimmunol.1001543. Epub 2011 Jun 8.

21.

TGF-beta induces IL-9 production from human Th17 cells.

Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA.

J Immunol. 2010 Jul 1;185(1):46-54. doi: 10.4049/jimmunol.1000356. Epub 2010 May 24.

22.

Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving.

Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC.

Lab Chip. 2010 Jun 7;10(11):1391-400. doi: 10.1039/b926849a. Epub 2010 Apr 8.

23.

On-chip activation and subsequent detection of individual antigen-specific T cells.

Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC.

Anal Chem. 2010 Jan 15;82(2):473-7. doi: 10.1021/ac9024363.

24.

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.

Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA.

J Immunol. 2009 Oct 1;183(7):4432-9. doi: 10.4049/jimmunol.0900576. Epub 2009 Sep 11.

25.

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90. doi: 10.1073/pnas.0812530106. Epub 2009 May 11.

26.

Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.

Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC.

Clin Immunol. 2008 Oct;129(1):10-8. doi: 10.1016/j.clim.2008.06.009.

27.

JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis.

Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisäkk P, Chiba S, Yagita H, Khoury SJ.

J Immunol. 2007 Nov 1;179(9):5990-8.

28.

A local antigen-driven humoral response is present in the inflammatory myopathies.

Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC.

J Immunol. 2007 Jan 1;178(1):547-56.

29.

Plasma cells in muscle in inclusion body myositis and polymyositis.

Greenberg SA, Bradshaw EM, Pinkus JL, Pinkus GS, Burleson T, Due B, Bregoli L, O'Connor KC, Amato AA.

Neurology. 2005 Dec 13;65(11):1782-7. Erratum in: Neurology. 2006 Feb 28;66(4):493. Bregoli, L S [corrected to Bregoli, L].

PMID:
16344523
30.

T antigen origin-binding domain of simian virus 40: determinants of specific DNA binding.

Bradshaw EM, Sanford DG, Luo X, Sudmeier JL, Gurard-Levin ZA, Bullock PA, Bachovchin WW.

Biochemistry. 2004 Jun 8;43(22):6928-36.

PMID:
15170330
31.

Identification of histidine tautomers in proteins by 2D 1H/13C(delta2) one-bond correlated NMR.

Sudmeier JL, Bradshaw EM, Haddad KE, Day RM, Thalhauser CJ, Bullock PA, Bachovchin WW.

J Am Chem Soc. 2003 Jul 16;125(28):8430-1.

PMID:
12848537
32.

Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.

Ash EL, Sudmeier JL, Day RM, Vincent M, Torchilin EV, Haddad KC, Bradshaw EM, Sanford DG, Bachovchin WW.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10371-6.

33.

Changes in primary liver and esophageal cancer rates among black goldminers, 1964-1981.

Harington JS, Bradshaw EM, McGlashan ND.

S Afr Med J. 1983 Oct 15;64(17):650. No abstract available.

PMID:
6623262

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