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Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis.

McDonald LT, Zile MR, Zhang Y, Van Laer AO, Baicu CF, Stroud RE, Jones JA, LaRue AC, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H92-H100. doi: 10.1152/ajpheart.00719.2017. Epub 2018 Mar 9.


Iron overload: what's TIMP-3 got to do with it.

Bradshaw AD, DeLeon-Pennell KY.

Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1259-H1261. doi: 10.1152/ajpheart.00161.2018. Epub 2018 Mar 9. No abstract available.


Cardiac macrophages promote diastolic dysfunction.

Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M.

J Exp Med. 2018 Feb 5;215(2):423-440. doi: 10.1084/jem.20171274. Epub 2018 Jan 16.


Production and purification of recombinant human SPARC.

Workman G, Bradshaw AD.

Methods Cell Biol. 2018;143:335-345. doi: 10.1016/bs.mcb.2017.08.020. Epub 2017 Dec 1.


A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: An immunohistochemical, molecular and ultrastructural study.

Hickman RA, Bradshaw AD, Cassai N, Neto AG, Zhou D, Fu T, Lee P, Pei Z, Wieczorek R.

Papillomavirus Res. 2016 Dec;2:164-166. doi: 10.1016/j.pvr.2016.09.002. Epub 2016 Sep 28.


SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament.

Rosset EM, Trombetta-eSilva J, Hepfer G, Yao H, Bradshaw AD.

PLoS One. 2017 Feb 28;12(2):e0173209. doi: 10.1371/journal.pone.0173209. eCollection 2017.


The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance.

Ahmed S, Bradshaw AD, Gera S, Dewan MZ, Xu R.

J Clin Med. 2017 Jan 5;6(1). pii: E5. doi: 10.3390/jcm6010005. Review.


Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing.

Gehwolf R, Wagner A, Lehner C, Bradshaw AD, Scharler C, Niestrawska JA, Holzapfel GA, Bauer HC, Tempfer H, Traweger A.

Sci Rep. 2016 Sep 2;6:32635. doi: 10.1038/srep32635.


Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium.

Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1027-35. doi: 10.1152/ajpendo.00040.2016. Epub 2016 May 3.


SPARC/osteonectin in mineralized tissue.

Rosset EM, Bradshaw AD.

Matrix Biol. 2016 May-Jul;52-54:78-87. doi: 10.1016/j.matbio.2016.02.001. Epub 2016 Feb 3. Review.


The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?

Bradshaw AD.

J Mol Cell Cardiol. 2016 Apr;93:156-61. doi: 10.1016/j.yjmcc.2015.11.014. Epub 2015 Nov 12. Review.


Microbiome, a new dimension in cancer research.

Neto AG, Bradshaw AD, Pei Z.

Ann Transl Med. 2015 Sep;3(16):229. doi: 10.3978/j.issn.2305-5839.2015.08.07. No abstract available.


Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model.

Balasubramanian S, Pleasant DL, Kasiganesan H, Quinones L, Zhang Y, Sundararaj KP, Roche S, O'Connor R, Bradshaw AD, Kuppuswamy D.

PLoS One. 2015 Oct 12;10(10):e0140273. doi: 10.1371/journal.pone.0140273. eCollection 2015.


pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1.

Lindner HB, Felmly LM, Demcheva M, Seth A, Norris R, Bradshaw AD, Vournakis J, Muise-Helmericks RC.

PLoS One. 2015 May 8;10(5):e0127876. doi: 10.1371/journal.pone.0127876. eCollection 2015.


Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly.

Dupuis LE, Berger MG, Feldman S, Doucette L, Fowlkes V, Chakravarti S, Thibaudeau S, Alcala NE, Bradshaw AD, Kern CB.

J Mol Cell Cardiol. 2015 Jul;84:70-80. doi: 10.1016/j.yjmcc.2015.04.007. Epub 2015 Apr 15.


Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.

Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD.

Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C972-82. doi: 10.1152/ajpcell.00402.2014. Epub 2015 Apr 15.


Decreased Mechanical Strength and Collagen Content in SPARC-Null Periodontal Ligament Is Reversed by Inhibition of Transglutaminase Activity.

Trombetta-eSilva J, Rosset EA, Hepfer RG, Wright GJ, Baicu C, Yao H, Bradshaw AD.

J Bone Miner Res. 2015 Oct;30(10):1914-24. doi: 10.1002/jbmr.2522. Epub 2015 May 10.


Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin.

Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM.

Circulation. 2015 Apr 7;131(14):1247-59. doi: 10.1161/CIRCULATIONAHA.114.013215. Epub 2015 Jan 30.


Age and SPARC change the extracellular matrix composition of the left ventricle.

de Castro Brás LE, Toba H, Baicu CF, Zile MR, Weintraub ST, Lindsey ML, Bradshaw AD.

Biomed Res Int. 2014;2014:810562. doi: 10.1155/2014/810562. Epub 2014 Mar 24.


Myocardial fibroblast-matrix interactions and potential therapeutic targets.

Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG.

J Mol Cell Cardiol. 2014 May;70:92-9. doi: 10.1016/j.yjmcc.2014.01.008. Epub 2014 Jan 26. Review.


The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures.

Trombetta-eSilva J, Eadie EP, Zhang Y, Norris RA, Borg TK, Bradshaw AD.

PLoS One. 2013 Nov 6;8(11):e79715. doi: 10.1371/journal.pone.0079715. eCollection 2013.


Relationship between anisotropic diffusion properties and tissue morphology in porcine TMJ disc.

Shi C, Wright GJ, Ex-Lubeskie CL, Bradshaw AD, Yao H.

Osteoarthritis Cartilage. 2013 Apr;21(4):625-33. doi: 10.1016/j.joca.2013.01.010. Epub 2013 Jan 24.


Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression.

Goldsmith EC, Bradshaw AD, Spinale FG.

Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C393-402. doi: 10.1152/ajpcell.00347.2012. Epub 2012 Nov 21. Review.


β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse.

Balasubramanian S, Quinones L, Kasiganesan H, Zhang Y, Pleasant DL, Sundararaj KP, Zile MR, Bradshaw AD, Kuppuswamy D.

PLoS One. 2012;7(9):e45076. doi: 10.1371/journal.pone.0045076. Epub 2012 Sep 12.


Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing.

Baicu CF, Li J, Zhang Y, Kasiganesan H, Cooper G 4th, Zile MR, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2012 Nov 1;303(9):H1128-34. doi: 10.1152/ajpheart.00482.2012. Epub 2012 Aug 31.


The Function of SPARC as a Mediator of Fibrosis.

Trombetta-Esilva J, Bradshaw AD.

Open Rheumatol J. 2012;6:146-55. doi: 10.2174/1874312901206010146. Epub 2012 Jun 15.


Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload.

Baicu CF, Zhang Y, Van Laer AO, Renaud L, Zile MR, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H234-40. doi: 10.1152/ajpheart.00227.2012. Epub 2012 May 18.


Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA.

PLoS One. 2012;7(2):e31384. doi: 10.1371/journal.pone.0031384. Epub 2012 Feb 14.


Diverse biological functions of the SPARC family of proteins.

Bradshaw AD.

Int J Biochem Cell Biol. 2012 Mar;44(3):480-8. doi: 10.1016/j.biocel.2011.12.021. Epub 2012 Jan 9. Review.


The regulatory function of SPARC in vascular biology.

Rivera LB, Bradshaw AD, Brekken RA.

Cell Mol Life Sci. 2011 Oct;68(19):3165-73. doi: 10.1007/s00018-011-0781-8. Epub 2011 Aug 6. Review.


SPARC regulates collagen interaction with cardiac fibroblast cell surfaces.

Harris BS, Zhang Y, Card L, Rivera LB, Brekken RA, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H841-7. doi: 10.1152/ajpheart.01247.2010. Epub 2011 Jun 10.


SPARC mediates early extracellular matrix remodeling following myocardial infarction.

McCurdy SM, Dai Q, Zhang J, Zamilpa R, Ramirez TA, Dayah T, Nguyen N, Jin YF, Bradshaw AD, Lindsey ML.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H497-505. doi: 10.1152/ajpheart.01070.2010. Epub 2011 May 20.


LPS induces greater bone and PDL loss in SPARC-null mice.

Trombetta-Esilva J, Yu H, Arias DN, Rossa C Jr, Kirkwood KL, Bradshaw AD.

J Dent Res. 2011 Apr;90(4):477-82. doi: 10.1177/0022034510391800. Epub 2010 Dec 29.


Expression in SPARC-null mice of collagen type I lacking the globular domain of the α1(I) N-propeptide results in abdominal hernias and loss of dermal collagen.

Card L, Henderson N, Zhang Y, Bornstein P, Bradshaw AD.

Matrix Biol. 2010 Sep;29(7):559-64. doi: 10.1016/j.matbio.2010.08.002. Epub 2010 Aug 11.


Postoperative neuropathy in gynecologic surgery.

Bradshaw AD, Advincula AP.

Obstet Gynecol Clin North Am. 2010 Sep;37(3):451-9. doi: 10.1016/j.ogc.2010.05.008. Review.


Optimizing patient positioning and understanding radiofrequency energy in gynecologic surgery.

Bradshaw AD, Advincula AP.

Clin Obstet Gynecol. 2010 Sep;53(3):511-20. doi: 10.1097/GRF.0b013e3181ec17d3. Review.


Inactivation of SPARC enhances high-fat diet-induced obesity in mice.

Nie J, Bradshaw AD, Delany AM, Sage EH.

Connect Tissue Res. 2011 Apr;52(2):99-108. doi: 10.3109/03008207.2010.483747. Epub 2010 Jul 8. Erratum in: Connect Tissue Res. 2015 Feb;56(1):65.


SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament.

Trombetta JM, Bradshaw AD.

J Histochem Cytochem. 2010 Oct;58(10):871-9. doi: 10.1369/jhc.2010.956144. Epub 2010 Jun 21.


Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing.

Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H614-22. doi: 10.1152/ajpheart.00474.2009. Epub 2009 Dec 11.


Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.

Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA.

Dis Model Mech. 2010 Jan-Feb;3(1-2):57-72. doi: 10.1242/dmm.003228. Epub 2009 Dec 9.


Incidence and characteristics of patients with vaginal cuff dehiscence after robotic procedures.

Bradshaw AD, Advincula AP.

Obstet Gynecol. 2009 Dec;114(6):1372; author reply 1372-3. doi: 10.1097/AOG.0b013e3181c3f60f. No abstract available.


The role of SPARC in extracellular matrix assembly.

Bradshaw AD.

J Cell Commun Signal. 2009 Dec;3(3-4):239-46. doi: 10.1007/s12079-009-0062-6. Epub 2009 Oct 2.


Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus.

Grant JE, Bradshaw AD, Schwacke JH, Baicu CF, Zile MR, Schey KL.

J Proteome Res. 2009 Sep;8(9):4252-63. doi: 10.1021/pr900297f.


Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC).

McCurdy S, Baicu CF, Heymans S, Bradshaw AD.

J Mol Cell Cardiol. 2010 Mar;48(3):544-9. doi: 10.1016/j.yjmcc.2009.06.018. Epub 2009 Jul 3. Review.


Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing.

Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR.

Circulation. 2009 Jan 20;119(2):269-80. doi: 10.1161/CIRCULATIONAHA.108.773424. Epub 2008 Dec 31.


SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts.

Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD.

J Biol Chem. 2007 Jul 27;282(30):22062-71. Epub 2007 May 23.


Cardiac myofibroblasts differentiated in 3D culture exhibit distinct changes in collagen I production, processing, and matrix deposition.

Poobalarahi F, Baicu CF, Bradshaw AD.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2924-32. Epub 2006 Aug 4.


Unravelling phenotypic plasticity -- why should we bother?

Bradshaw AD.

New Phytol. 2006;170(4):644-8.


SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges.

Puolakkainen PA, Bradshaw AD, Brekken RA, Reed MJ, Kyriakides T, Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH.

J Histochem Cytochem. 2005 May;53(5):571-81.


Enhanced angiogenesis characteristic of SPARC-null mice disappears with age.

Reed MJ, Bradshaw AD, Shaw M, Sadoun E, Han N, Ferara N, Funk S, Puolakkainen P, Sage EH.

J Cell Physiol. 2005 Sep;204(3):800-7.


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