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Items: 1 to 50 of 94

1.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.

Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):32-49. doi: 10.1080/15287394.2015.958418.

2.

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.

Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I.

J Toxicol Environ Health A. 2015;78(1):15-31. doi: 10.1080/15287394.2015.958417.

3.

Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.

Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I.

Toxicol Sci. 2013 Mar;132(1):53-63. doi: 10.1093/toxsci/kfs342. Epub 2013 Jan 3.

4.

Acetaminophen-induced acute liver injury in HCV transgenic mice.

Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):224-32. doi: 10.1016/j.taap.2012.11.019. Epub 2012 Nov 29.

5.

Glycine reduces platelet aggregation.

Schemmer P, Zhong Z, Galli U, Wheeler MD, Xiangli L, Bradford BU, Conzelmann LO, Forman D, Boyer J, Thurman RG.

Amino Acids. 2013 Mar;44(3):925-31. doi: 10.1007/s00726-012-1422-8. Epub 2012 Nov 8.

6.

Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.

Jeannot E, Boorman GA, Kosyk O, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak V, Pogribny IP, Rusyn I.

Int J Cancer. 2012 Mar 15;130(6):1347-56. doi: 10.1002/ijc.26140. Epub 2011 Jun 9.

7.

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I.

Toxicol Sci. 2011 Mar;120(1):206-17. doi: 10.1093/toxsci/kfq362. Epub 2010 Dec 6.

8.

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I.

Toxicol Appl Pharmacol. 2010 Dec 15;249(3):208-16. doi: 10.1016/j.taap.2010.09.012. Epub 2010 Sep 24.

9.

Sex-specific gene expression in the BXD mouse liver.

Gatti DM, Zhao N, Chesler EJ, Bradford BU, Shabalin AA, Yordanova R, Lu L, Rusyn I.

Physiol Genomics. 2010 Aug;42(3):456-68. doi: 10.1152/physiolgenomics.00110.2009. Epub 2010 Jun 15.

10.

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.

Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I.

Toxicol Sci. 2010 May;115(1):131-9. doi: 10.1093/toxsci/kfq031. Epub 2010 Jan 29.

11.

Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I.

Toxicology. 2009 Aug 21;262(3):230-8. doi: 10.1016/j.tox.2009.06.013. Epub 2009 Jun 21.

12.

Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.

Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I.

Toxicol Appl Pharmacol. 2009 Mar 1;235(2):199-207. doi: 10.1016/j.taap.2008.12.011. Epub 2008 Dec 24.

13.

Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.

Bradford BU, O'Connell TM, Han J, Kosyk O, Shymonyak S, Ross PK, Winnike J, Kono H, Rusyn I.

Toxicol Appl Pharmacol. 2008 Oct 15;232(2):236-43. doi: 10.1016/j.taap.2008.06.022. Epub 2008 Jul 12.

14.

Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.

Woods CG, Kosyk O, Bradford BU, Ross PK, Burns AM, Cunningham ML, Qu P, Ibrahim JG, Rusyn I.

Toxicol Appl Pharmacol. 2007 Dec 15;225(3):267-77. Epub 2007 Sep 16.

15.

Role of peroxisomes in the swift increase in alcohol metabolism.

Bradford BU.

J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S28-30. Erratum in: J Gastroenterol Hepatol. 2008 Mar;23(3):501-2.

PMID:
17567460
16.

Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.

Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium.

Toxicol Sci. 2007 Sep;99(1):326-37. Epub 2007 Jun 11.

PMID:
17562736
17.

Rates of ethanol metabolism decrease in sons of alcoholics following a priming dose of ethanol.

Bradford BU, Karnitsching J, Powell LL, Garbutt JC.

Alcohol. 2007 Jun;41(4):263-70. Epub 2007 May 23.

18.

WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.

Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunningham ML, Rusyn I.

Toxicol Sci. 2007 Aug;98(2):366-74. Epub 2007 May 5.

PMID:
17483499
19.

Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.

Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I.

Free Radic Biol Med. 2007 Feb 1;42(3):335-42. Epub 2006 Nov 3.

20.

Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.

Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z, Brenner DA, Marzi I, Lemasters JJ.

Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G456-63. Epub 2006 Apr 13.

21.

Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.

Powell CL, Kosyk O, Bradford BU, Parker JS, Lobenhofer EK, Denda A, Uematsu F, Nakae D, Rusyn I.

Hepatology. 2005 Nov;42(5):1137-47.

PMID:
16250055
22.
23.

Standardizing global gene expression analysis between laboratories and across platforms.

Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li YJ, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin LX, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin JL, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl H; Members of the Toxicogenomics Research Consortium.

Nat Methods. 2005 May;2(5):351-6. Epub 2005 Apr 21. Erratum in: Nat Methods. 2005 Jun;2(6):477.

PMID:
15846362
24.

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.

Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn I.

Hepatology. 2005 Feb;41(2):336-44.

PMID:
15660387
25.

Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.

Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA.

Hepatology. 2004 Nov;40(5):1106-15.

PMID:
15389776
26.

Contribution of angiotensin II to alcohol-induced pancreatic fibrosis in rats.

Uesugi T, Froh M, Gäbele E, Isayama F, Bradford BU, Ikai I, Yamaoka Y, Arteel GE.

J Pharmacol Exp Ther. 2004 Dec;311(3):921-8. Epub 2004 Aug 17.

PMID:
15316086
27.

CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan-polysaccharide complexes of Gram-positive bacterial cell walls.

Li X, Bradford BU, Dalldorf F, Goyert SM, Stimpson SA, Thurman RG, Makarov SS.

Arthritis Res Ther. 2004;6(3):R273-81. Epub 2004 Apr 27.

28.
29.

The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice.

Isayama F, Froh M, Bradford BU, McKim SE, Kadiiska MB, Connor HD, Mason RP, Koop DR, Wheeler MD, Arteel GE.

Free Radic Biol Med. 2003 Dec 15;35(12):1568-81.

PMID:
14680680
30.

New method of delivering gene-altered Kupffer cells to rat liver: studies in an ischemia-reperfusion model.

Froh M, Wheeler MD, Smutney O, Zhong Z, Bradford BU, Thurman RG.

Gastroenterology. 2003 Jan;124(1):172-83.

PMID:
12512041
31.

Nicotine increases hepatic oxygen uptake in the isolated perfused rat liver by inhibiting glycolysis.

Dewar BJ, Bradford BU, Thurman RG.

J Pharmacol Exp Ther. 2002 Jun;301(3):930-7.

PMID:
12023521
32.

Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice.

Uesugi T, Froh M, Arteel GE, Bradford BU, Wheeler MD, Gäbele E, Isayama F, Thurman RG.

J Immunol. 2002 Mar 15;168(6):2963-9.

33.

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gäbele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, Mason RP, Goyert SM, Peters JM, Gonzalez FJ, Samulski RJ, Thurman RG.

Free Radic Biol Med. 2001 Dec 15;31(12):1544-9. Review.

PMID:
11744328
34.

Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats.

Uesugi T, Froh M, Arteel GE, Bradford BU, Gäbele E, Wheeler MD, Thurman RG.

Hepatology. 2001 Dec;34(6):1149-57.

PMID:
11732004
35.

Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?

Yin M, Gäbele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, Rusyn I, Mason R, Thurman RG.

Hepatology. 2001 Nov;34(5):935-42.

PMID:
11679964
36.

Dietary glycine prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for glycine-gated chloride channel.

Li X, Bradford BU, Wheeler MD, Stimpson SA, Pink HM, Brodie TA, Schwab JH, Thurman RG.

Infect Immun. 2001 Sep;69(9):5883-91.

37.

Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat.

Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M, Thurman RG.

J Biol Chem. 2001 Sep 28;276(39):36664-72. Epub 2001 Jul 26.

38.

Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice.

Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG.

Hepatology. 2001 Jul;34(1):101-8.

PMID:
11431739
39.

Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine.

Rivera CA, Bradford BU, Hunt KJ, Adachi Y, Schrum LW, Koop DR, Burchardt ER, Rippe RA, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G200-7.

40.

How is the liver primed or sensitized for alcoholic liver disease?

Tsukamoto H, Takei Y, McClain CJ, Joshi-Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC, Yokoyama H, Okamura Y, Nakamura Y, Ishii H, Chawla RK, Barve S, Joshi-Barve S, Watson W, Nelson W, Lin M, Ohata M, Motomura K, Enomoto N, Ikejima K, Kitamura T, Oide H, Hirose M, Bradford BU, Rivera CA, Kono H, Peter S, Yamashina S, Konno A, Ishikawa M, Shimizu H, Sato N, Thurman R.

Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):171S-181S. Review.

PMID:
11391068
41.

ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.

Kono H, Uesugi T, Froh M, Rusyn I, Bradford BU, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1289-95.

42.

Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats.

Schemmer P, Enomoto N, Bradford BU, Bunzendahl H, Raleigh JA, Lemasters JJ, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1076-82.

43.

Autonomic nervous system and gut-derived endotoxin: involvement in activation of Kupffer cells after in situ organ manipulation.

Schemmer P, Enomoto N, Bradford BU, Bunzendahl H, Raleigh JA, Thurman RG.

World J Surg. 2001 Apr;25(4):399-406.

PMID:
11344388
44.

Reduced early alcohol-induced liver injury in CD14-deficient mice.

Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, Thurman RG.

J Immunol. 2001 Apr 1;166(7):4737-42.

45.

Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology.

Kono H, Bradford BU, Rusyn I, Fujii H, Matsumoto Y, Yin M, Thurman RG.

J Hepatobiliary Pancreat Surg. 2000;7(4):395-400. Review.

PMID:
11180860
46.

Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha.

Rose ML, Bradford BU, Germolec DR, Lin M, Tsukamoto H, Thurman RG.

Toxicol Appl Pharmacol. 2001 Jan 1;170(1):39-45.

PMID:
11141354
47.

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG.

J Clin Invest. 2000 Oct;106(7):867-72.

48.

Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver.

Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T, Brenner DA, Schemmer P, Bradford BU, Rivera CA, Zhong Z, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G100-6.

49.

Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha.

Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, Bradford BU, Forman DT, Thurman RG.

Am J Physiol Gastrointest Liver Physiol. 2000 Apr;278(4):G652-61.

50.

Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury.

Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner DA, Sato N, Thurman RG.

J Gastroenterol Hepatol. 2000 Mar;15 Suppl:D20-5. Review.

PMID:
10759216

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