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The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee JS, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T.

Arch Toxicol. 2019 Jul;93(7):1917-1926. doi: 10.1007/s00204-019-02488-5. Epub 2019 May 20.


Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.

Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J.

Cell Metab. 2019 May 7;29(5):1078-1091.e5. doi: 10.1016/j.cmet.2019.01.023. Epub 2019 Feb 28.


Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro.

O'Driscoll CA, Gallo ME, Hoffmann EJ, Fechner JH, Schauer JJ, Bradfield CA, Mezrich JD.

PLoS One. 2018 Dec 21;13(12):e0209690. doi: 10.1371/journal.pone.0209690. eCollection 2018.


Transcriptomic analysis reveals similarities in genetic activation of detoxification mechanisms resulting from imidacloprid and chlorothalonil exposure.

Clements J, Sanchez-Sedillo B, Bradfield CA, Groves RL.

PLoS One. 2018 Oct 25;13(10):e0205881. doi: 10.1371/journal.pone.0205881. eCollection 2018.


Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE.

O'Driscoll CA, Owens LA, Hoffmann EJ, Gallo ME, Afrazi A, Han M, Fechner JH, Schauer JJ, Bradfield CA, Mezrich JD.

Environ Res. 2019 Jan;168:178-192. doi: 10.1016/j.envres.2018.09.038. Epub 2018 Oct 1.


Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease.

O'Driscoll CA, Owens LA, Gallo ME, Hoffmann EJ, Afrazi A, Han M, Fechner JH, Schauer JJ, Bradfield CA, Mezrich JD.

Part Fibre Toxicol. 2018 Aug 24;15(1):35. doi: 10.1186/s12989-018-0271-3.


Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures.

Nikodemova M, Yee J, Carney PR, Bradfield CA, Malecki KM.

Environ Int. 2018 Apr;113:249-258. doi: 10.1016/j.envint.2018.02.016. Epub 2018 Feb 16.


Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).

Seok SH, Ma ZX, Feltenberger JB, Chen H, Chen H, Scarlett C, Lin Z, Satyshur KA, Cortopassi M, Jefcoate CR, Ge Y, Tang W, Bradfield CA, Xing Y.

J Biol Chem. 2018 Feb 9;293(6):1994-2005. doi: 10.1074/jbc.RA117.000631. Epub 2017 Dec 26.


Retinal pathology in the PPCD1 mouse.

Shen AL, Moran SM, Glover EA, Teixeira LB, Bradfield CA.

PLoS One. 2017 Oct 5;12(10):e0185094. doi: 10.1371/journal.pone.0185094. eCollection 2017.


Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.

Seok SH, Lee W, Jiang L, Molugu K, Zheng A, Li Y, Park S, Bradfield CA, Xing Y.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5431-5436. doi: 10.1073/pnas.1617035114. Epub 2017 Apr 10.


The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J.

J Exp Med. 2017 Jan;214(1):197-208. doi: 10.1084/jem.20160789. Epub 2016 Dec 23.


Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis.

Pan X, Bradfield CA, Hussain MM.

Nat Commun. 2016 Oct 10;7:13011. doi: 10.1038/ncomms13011.


The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse.

Díaz-Díaz CJ, Ronnekleiv-Kelly SM, Nukaya M, Geiger PG, Balbo S, Dator R, Megna BW, Carney PR, Bradfield CA, Kennedy GD.

Ann Surg. 2016 Sep;264(3):429-36. doi: 10.1097/SLA.0000000000001874.


Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression.

Shen AL, Moran SA, Glover EA, Drinkwater NR, Swearingen RE, Teixeira LB, Bradfield CA.

PLoS One. 2016 Jun 16;11(6):e0157577. doi: 10.1371/journal.pone.0157577. eCollection 2016.


Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.

Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, Bass J.

Science. 2015 Nov 6;350(6261):aac4250. doi: 10.1126/science.aac4250.


Material Parameter Determination of an L4-L5 Motion Segment Finite Element Model Under High Loading Rates.

Pyles CO, Zhang J, Demetropoulos CK, Bradfield CA, Ott KA, Armiger RS, Merkle AC.

Biomed Sci Instrum. 2015;51:206-13.


Experimental Characterization of the Anatomical Structures of the Lumbar Spine Under Dynamic Sagittal Bending.

Bradfield CA, Demetropoulos CK, Luongo ME, Pyles CO, Armiger RS, Merkle AC.

Biomed Sci Instrum. 2015;51:151-8.


Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant.

Izumo M, Pejchal M, Schook AC, Lange RP, Walisser JA, Sato TR, Wang X, Bradfield CA, Takahashi JS.

Elife. 2014 Dec 19;3. doi: 10.7554/eLife.04617.


Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase.

Johnson BP, Walisser JA, Liu Y, Shen AL, McDearmon EL, Moran SM, McIntosh BE, Vollrath AL, Schook AC, Takahashi JS, Bradfield CA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18757-62. doi: 10.1073/pnas.1421708111. Epub 2014 Dec 15.


Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice.

Liu Y, Johnson BP, Shen AL, Wallisser JA, Krentz KJ, Moran SM, Sullivan R, Glover E, Parlow AF, Drinkwater NR, Schuler LA, Bradfield CA.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14295-300. doi: 10.1073/pnas.1209249111. Epub 2014 Sep 15.


Aggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing.

Sengupta S, Johnson BP, Swanson SA, Stewart R, Bradfield CA, Thomson JA.

Toxicol Sci. 2014 Jul;140(1):236-45. doi: 10.1093/toxsci/kfu069. Epub 2014 Apr 20.


Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.

Kennedy GD, Nukaya M, Moran SM, Glover E, Weinberg S, Balbo S, Hecht SS, Pitot HC, Drinkwater NR, Bradfield CA.

Toxicol Sci. 2014 Jul;140(1):135-43. doi: 10.1093/toxsci/kfu065. Epub 2014 Apr 9.


Obesity in mice with adipocyte-specific deletion of clock component Arntl.

Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA.

Nat Med. 2012 Dec;18(12):1768-77. doi: 10.1038/nm.2979. Epub 2012 Nov 11.


The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.

Pauly SK, Fechner JH, Zhang X, Torrealba J, Bradfield CA, Mezrich JD.

Toxicol Environ Chem. 2012;94(6):1175-1187. Epub 2012 Jun 20.


Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β.

Sievers CK, Shanle EK, Bradfield CA, Xu W.

Toxicol Sci. 2013 Apr;132(2):359-67. doi: 10.1093/toxsci/kfs287. Epub 2012 Sep 18.


SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation.

Mezrich JD, Nguyen LP, Kennedy G, Nukaya M, Fechner JH, Zhang X, Xing Y, Bradfield CA.

PLoS One. 2012;7(9):e44547. doi: 10.1371/journal.pone.0044547. Epub 2012 Sep 6.


Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse.

Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Löhr CV, Arlt VM, Phillips DH, Williams DE, Baird WM.

Toxicol Appl Pharmacol. 2012 Nov 1;264(3):377-86. doi: 10.1016/j.taap.2012.08.014. Epub 2012 Aug 23.


Identification of the Ah-receptor structural determinants for ligand preferences.

Xing Y, Nukaya M, Satyshur KA, Jiang L, Stanevich V, Korkmaz EN, Burdette L, Kennedy GD, Cui Q, Bradfield CA.

Toxicol Sci. 2012 Sep;129(1):86-97. doi: 10.1093/toxsci/kfs194. Epub 2012 Jun 2.


AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.

Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M.

Nat Immunol. 2011 Nov 20;13(2):144-51. doi: 10.1038/ni.2187.


Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin.

Chernoff N, Rogers EH, Zehr RD, Gage MI, Malarkey DE, Bradfield CA, Liu Y, Schmid JE, Jaskot RH, Richards JH, Wood CR, Rosen MB.

J Appl Toxicol. 2011 Apr;31(3):242-54. doi: 10.1002/jat.1586. Epub 2010 Oct 8.


Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver.

Nukaya M, Walisser JA, Moran SM, Kennedy GD, Bradfield CA.

Toxicol Sci. 2010 Dec;118(2):554-63. doi: 10.1093/toxsci/kfq305. Epub 2010 Oct 8.


The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.

Nukaya M, Lin BC, Glover E, Moran SM, Kennedy GD, Bradfield CA.

J Biol Chem. 2010 Nov 12;285(46):35599-605. doi: 10.1074/jbc.M110.132043. Epub 2010 Sep 9.


The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.

Shen AL, O'Leary KA, Dubielzig RR, Drinkwater N, Murphy CJ, Kasper CB, Bradfield CA.

PLoS One. 2010 Aug 16;5(8):e12213. doi: 10.1371/journal.pone.0012213.


An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells.

Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA.

J Immunol. 2010 Sep 15;185(6):3190-8. doi: 10.4049/jimmunol.0903670. Epub 2010 Aug 18.


Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.

Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.

Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253.


Mammalian Per-Arnt-Sim proteins in environmental adaptation.

McIntosh BE, Hogenesch JB, Bradfield CA.

Annu Rev Physiol. 2010;72:625-45. doi: 10.1146/annurev-physiol-021909-135922. Review.


D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan.

Nguyen LP, Hsu EL, Chowdhury G, Dostalek M, Guengerich FP, Bradfield CA.

Chem Res Toxicol. 2009 Dec;22(12):1897-904. doi: 10.1021/tx900043s.


Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid.

Chowdhury G, Dostalek M, Hsu EL, Nguyen LP, Stec DF, Bradfield CA, Guengerich FP.

Chem Res Toxicol. 2009 Dec;22(12):1905-12. doi: 10.1021/tx9000418.


EDGE(3): a web-based solution for management and analysis of Agilent two color microarray experiments.

Vollrath AL, Smith AA, Craven M, Bradfield CA.

BMC Bioinformatics. 2009 Sep 4;10:280. doi: 10.1186/1471-2105-10-280.


The aryl hydrocarbon receptor: a perspective on potential roles in the immune system.

Stevens EA, Mezrich JD, Bradfield CA.

Immunology. 2009 Jul;127(3):299-311. doi: 10.1111/j.1365-2567.2009.03054.x. Review.


Clustered alignments of gene-expression time series data.

Smith AA, Vollrath A, Bradfield CA, Craven M.

Bioinformatics. 2009 Jun 15;25(12):i119-27. doi: 10.1093/bioinformatics/btp206.


The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.

Nukaya M, Moran S, Bradfield CA.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4923-8. doi: 10.1073/pnas.0809613106. Epub 2009 Mar 4.


Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster.

Nukaya M, Bradfield CA.

Biochem Pharmacol. 2009 Feb 15;77(4):654-9. doi: 10.1016/j.bcp.2008.10.026. Epub 2008 Nov 6. Review.


A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse.

Lin BC, Nguyen LP, Walisser JA, Bradfield CA.

Mol Pharmacol. 2008 Nov;74(5):1367-71. doi: 10.1124/mol.108.047068. Epub 2008 Jul 31.


Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor.

Bunger MK, Glover E, Moran SM, Walisser JA, Lahvis GP, Hsu EL, Bradfield CA.

Toxicol Sci. 2008 Nov;106(1):83-92. doi: 10.1093/toxsci/kfn149. Epub 2008 Jul 27.


Similarity queries for temporal toxicogenomic expression profiles.

Smith AA, Vollrath A, Bradfield CA, Craven M.

PLoS Comput Biol. 2008 Jul 18;4(7):e1000116. doi: 10.1371/journal.pcbi.1000116. Erratum in: PLoS Comput Biol. 2008 Dec;4(12).


Immunology: T cells hang in the balance.

Stevens EA, Bradfield CA.

Nature. 2008 May 1;453(7191):46-7. doi: 10.1038/453046a. No abstract available.


Genetic components of the circadian clock regulate thrombogenesis in vivo.

Westgate EJ, Cheng Y, Reilly DF, Price TS, Walisser JA, Bradfield CA, FitzGerald GA.

Circulation. 2008 Apr 22;117(16):2087-95. doi: 10.1161/CIRCULATIONAHA.107.739227. Epub 2008 Apr 14.


Reduced nitric oxide causes age-associated impairment of circadian rhythmicity.

Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I.

Circ Res. 2008 Mar 14;102(5):607-14. doi: 10.1161/CIRCRESAHA.107.162230. Epub 2008 Jan 24.


The search for endogenous activators of the aryl hydrocarbon receptor.

Nguyen LP, Bradfield CA.

Chem Res Toxicol. 2008 Jan;21(1):102-16. Epub 2007 Dec 13. Review.

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