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Items: 1 to 50 of 128

1.

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10.

PMID:
30571096
2.

The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Groups.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Grimmecke HD, Brade H, Evans SV.

J Biol Chem. 2016 May 6;291(19):10104-18. doi: 10.1074/jbc.M115.712448. Epub 2016 Mar 1.

3.

Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Kosma P, Brade H, Evans SV.

J Biol Chem. 2015 Aug 7;290(32):19629-40. doi: 10.1074/jbc.M115.657874. Epub 2015 Jun 17.

4.

Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

Haji-Ghassemi O, Müller-Loennies S, Saldova R, Muniyappa M, Brade L, Rudd PM, Harvey DJ, Kosma P, Brade H, Evans SV.

J Biol Chem. 2014 Jun 13;289(24):16644-61. doi: 10.1074/jbc.M113.528224. Epub 2014 Mar 28.

5.

Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling.

Richter W, Heinbockel L, Kaconis Y, Steiniger F, Gutsmann T, Brade L, Brandenburg K.

Innate Immun. 2013 Dec;19(6):588-95. doi: 10.1177/1753425912473851. Epub 2013 Feb 12.

PMID:
23405031
6.

Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide.

Brooks CL, Wimmer K, Kosma P, Müller-Loennies S, Brade L, Brade H, Evans SV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):2-5. doi: 10.1107/S1744309112047422. Epub 2012 Dec 25.

7.

Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.

Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi: 10.1073/pnas.1209253109. Epub 2012 Nov 26.

8.
9.

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

Brade L, Heine H, Raina S, Klein G, Di Padova F, Brade H, Müller-Loennies S.

Innate Immun. 2012 Apr;18(2):279-93. doi: 10.1177/1753425911401055. Epub 2011 Aug 15.

PMID:
21844130
10.

Structural insights into parallel strategies for germline antibody recognition of lipopolysaccharide from Chlamydia.

Evans DW, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Brade H, Evans SV.

Glycobiology. 2011 Aug;21(8):1049-59. doi: 10.1093/glycob/cwr041. Epub 2011 May 4.

PMID:
21543444
11.

A common NH53K mutation in the combining site of antibodies raised against chlamydial LPS glycoconjugates significantly increases avidity.

Blackler RJ, Müller-Loennies S, Brooks CL, Evans DW, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2011 Apr 26;50(16):3357-68. doi: 10.1021/bi101886v. Epub 2011 Apr 1.

PMID:
21405106
12.

Analysis of cross-reactive and specific anti-carbohydrate antibodies against lipopolysaccharide from Chlamydophila psittaci.

Gerstenbruch S, Brooks CL, Kosma P, Brade L, Mackenzie CR, Evans SV, Brade H, Müller-Loennies S.

Glycobiology. 2010 Jan;20(4):461-72. doi: 10.1093/glycob/cwp198. Epub 2009 Dec 18.

13.

Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients.

Schmengler K, Goldmann T, Brade L, Sánchez Carballo PM, Albrecht S, Brade H, Kosma P, Sahly H, Hauber HP, Länger F, Meyer R, Welte T, Zähringer U.

Eur J Cell Biol. 2010 Jan;89(1):25-33. doi: 10.1016/j.ejcb.2009.10.010.

PMID:
20022136
14.

Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition.

Brooks CL, Müller-Loennies S, Borisova SN, Brade L, Kosma P, Hirama T, Mackenzie CR, Brade H, Evans SV.

Biochemistry. 2010 Jan 26;49(3):570-81. doi: 10.1021/bi9011308.

15.

The role of CDR H3 in antibody recognition of a synthetic analog of a lipopolysaccharide antigen.

Brooks CL, Blackler RJ, Sixta G, Kosma P, Müller-Loennies S, Brade L, Hirama T, MacKenzie CR, Brade H, Evans SV.

Glycobiology. 2010 Feb;20(2):138-47. doi: 10.1093/glycob/cwp150. Epub 2009 Sep 18.

PMID:
19767317
16.

Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.

Hanuszkiewicz A, Hübner G, Vinogradov E, Lindner B, Brade L, Brade H, Debarry J, Heine H, Holst O.

Chemistry. 2008;14(33):10251-8. doi: 10.1002/chem.200800958.

PMID:
18850609
17.

Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes.

Brooks CL, Müller-Loennies S, Brade L, Kosma P, Hirama T, MacKenzie CR, Brade H, Evans SV.

J Mol Biol. 2008 Mar 21;377(2):450-68. doi: 10.1016/j.jmb.2008.01.018. Epub 2008 Jan 16.

PMID:
18272175
18.

Neutralizing and cross-reactive antibodies against enterobacterial lipopolysaccharide.

Müller-Loennies S, Brade L, Brade H.

Int J Med Microbiol. 2007 Sep;297(5):321-40. Epub 2007 Jun 1. Review.

PMID:
17544324
19.

A novel 40-kDa protein containing six repeats of an epidermal growth factor-like domain functions as a pattern recognition protein for lipopolysaccharide.

Ju JS, Cho MH, Brade L, Kim JH, Park JW, Ha NC, Söderhäll I, Söderhäll K, Brade H, Lee BL.

J Immunol. 2006 Aug 1;177(3):1838-45.

20.

Diuretic-induced hypokalaemia in patients with hypertension.

Okosieme OE, Suruliram P, Brade L, Campbell A, Evans LM.

Int J Clin Pract. 2006 Dec;60(12):1673-4. Epub 2006 May 2.

PMID:
16669823
21.
22.

Cell membrane array fabrication and assay technology.

Yamazaki V, Sirenko O, Schafer RJ, Nguyen L, Gutsmann T, Brade L, Groves JT.

BMC Biotechnol. 2005 Jun 16;5:18.

23.

Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity.

Seydel U, Schromm AB, Brade L, Gronow S, Andrä J, Müller M, Koch MH, Fukase K, Kataoka M, Hashimoto M, Kusumoto S, Brandenburg K.

FEBS J. 2005 Jan;272(2):327-40.

24.

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.

Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schütze S, Gulbins E, Uhlig S.

Nat Med. 2004 Feb;10(2):155-60. Epub 2004 Jan 4.

PMID:
14704790
25.
26.

Germline antibody recognition of distinct carbohydrate epitopes.

Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV.

Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16.

PMID:
14625588
27.

ECA-antibodies in antisera against R mutants of Yersinia enterocolitica O:3.

Radziejewska-Lebrecht J, Kasperkiewicz K, Skurnik M, Brade L, Steinmetz I, Swierzko AS, Muszyński A.

Adv Exp Med Biol. 2003;529:215-8. No abstract available.

PMID:
12756760
28.

Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.

Muller-Loennies S, Brade L, MacKenzie CR, Di Padova FE, Brade H.

J Biol Chem. 2003 Jul 11;278(28):25618-27. Epub 2003 Apr 25.

29.
30.
31.

A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917.

Grozdanov L, Zähringer U, Blum-Oehler G, Brade L, Henne A, Knirel YA, Schombel U, Schulze J, Sonnenborn U, Gottschalk G, Hacker J, Rietschel ET, Dobrindt U.

J Bacteriol. 2002 Nov;184(21):5912-25.

32.

A novel strategy for the synthesis of neoglycoconjugates from deacylated deep rough lipopolysaccharides.

Müller-Loennies S, Grimmecke D, Brade L, Lindner B, Kosma P, Brade H.

J Endotoxin Res. 2002;8(4):295-305.

PMID:
12230919
33.

Anti-Chlamydophila immunoglobulin prevalence in sarcoidosis and usual interstitial pneumoniae.

Gaede KI, Wilke G, Brade L, Brade H, Schlaak M, Müller-Quernheim J.

Eur Respir J. 2002 Feb;19(2):267-74.

34.
36.

Crystallization and preliminary X-ray diffraction analysis of two homologous antigen-binding fragments in complex with different carbohydrate antigens.

Nguyen HP, Seto NO, Brade L, Kosma P, Brade H, Evans SV.

Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1872-6. Epub 2001 Nov 21.

PMID:
11717502
37.

Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy.

Vielhaber G, Pfeiffer S, Brade L, Lindner B, Goldmann T, Vollmer E, Hintze U, Wittern KP, Wepf R.

J Invest Dermatol. 2001 Nov;117(5):1126-36.

38.
40.
41.

Mouse anti-ceramide antiserum: a specific tool for the detection of endogenous ceramide.

Vielhaber G, Brade L, Lindner B, Pfeiffer S, Wepf R, Hintze U, Wittern KP, Brade H.

Glycobiology. 2001 Jun;11(6):451-7.

PMID:
11445550
43.
44.

Identification of a novel dendritic cell-like subset of CD64(+) / CD16(+) blood monocytes.

Grage-Griebenow E, Zawatzky R, Kahlert H, Brade L, Flad H, Ernst M.

Eur J Immunol. 2001 Jan;31(1):48-56.

45.

Synthesis of neoglycoproteins containing Kdo epitopes specific for Chlamydophila psittaci lipopolysaccharide.

Kosma P, Reiter A, Hofinger A, Brade L, Brade H.

J Endotoxin Res. 2000;6(1):57-69.

PMID:
11061033
46.

Mapping the binding of synthetic disaccharides representing epitopes of chlamydial lipopolysaccharide to antibodies with NMR.

Maaheimo H, Kosma P, Brade L, Brade H, Peters T.

Biochemistry. 2000 Oct 24;39(42):12778-88.

PMID:
11041842
47.

In vitro characterization of anti-glucosylceramide rabbit antisera.

Brade L, Vielhaber G, Heinz E, Brade H.

Glycobiology. 2000 Jun;10(6):629-36.

PMID:
10814705
49.

Characterization of high affinity monoclonal antibodies specific for chlamydial lipopolysaccharide.

Müller-Loennies S, MacKenzie CR, Patenaude SI, Evans SV, Kosma P, Brade H, Brade L, Narang S.

Glycobiology. 2000 Feb;10(2):121-30.

PMID:
10642603
50.

Assay of anti-endotoxin antibodies.

Brade L.

Methods Mol Med. 2000;36:27-35. doi: 10.1385/1-59259-216-3:27.

PMID:
21340961

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