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Items: 1 to 50 of 252

1.

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10.

PMID:
30571096
2.

The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Groups.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Grimmecke HD, Brade H, Evans SV.

J Biol Chem. 2016 May 6;291(19):10104-18. doi: 10.1074/jbc.M115.712448. Epub 2016 Mar 1.

3.

Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Kosma P, Brade H, Evans SV.

J Biol Chem. 2015 Aug 7;290(32):19629-40. doi: 10.1074/jbc.M115.657874. Epub 2015 Jun 17.

4.

Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

Haji-Ghassemi O, Müller-Loennies S, Saldova R, Muniyappa M, Brade L, Rudd PM, Harvey DJ, Kosma P, Brade H, Evans SV.

J Biol Chem. 2014 Jun 13;289(24):16644-61. doi: 10.1074/jbc.M113.528224. Epub 2014 Mar 28.

5.

Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region.

Klein G, Müller-Loennies S, Lindner B, Kobylak N, Brade H, Raina S.

J Biol Chem. 2013 Mar 22;288(12):8111-27. doi: 10.1074/jbc.M112.445981. Epub 2013 Jan 31.

6.

Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide.

Brooks CL, Wimmer K, Kosma P, Müller-Loennies S, Brade L, Brade H, Evans SV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):2-5. doi: 10.1107/S1744309112047422. Epub 2012 Dec 25.

7.
8.

Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.

Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20877-82. doi: 10.1073/pnas.1209253109. Epub 2012 Nov 26.

9.
10.
11.

Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.

Brade L, Heine H, Raina S, Klein G, Di Padova F, Brade H, Müller-Loennies S.

Innate Immun. 2012 Apr;18(2):279-93. doi: 10.1177/1753425911401055. Epub 2011 Aug 15.

PMID:
21844130
12.

Structural insights into parallel strategies for germline antibody recognition of lipopolysaccharide from Chlamydia.

Evans DW, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Brade H, Evans SV.

Glycobiology. 2011 Aug;21(8):1049-59. doi: 10.1093/glycob/cwr041. Epub 2011 May 4.

PMID:
21543444
13.

A common NH53K mutation in the combining site of antibodies raised against chlamydial LPS glycoconjugates significantly increases avidity.

Blackler RJ, Müller-Loennies S, Brooks CL, Evans DW, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2011 Apr 26;50(16):3357-68. doi: 10.1021/bi101886v. Epub 2011 Apr 1.

PMID:
21405106
14.

The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type.

Duda KA, Lindner B, Brade H, Leimbach A, Brzuszkiewicz E, Dobrindt U, Holst O.

Microbiology. 2011 Jun;157(Pt 6):1750-60. doi: 10.1099/mic.0.046912-0. Epub 2011 Mar 3.

PMID:
21372091
15.

Efficient Synthesis of 4-Amino-4-deoxy-L-arabinose and Spacer-equipped 4-Amino-4-deoxy-L-arabinopyranosides by Transglycosylation Reactions.

Müller B, Blaukopf M, Hofinger A, Zamyatina A, Brade H, Kosma P.

Synthesis (Stuttg). 2010 Sep;2010(18):3143-3151.

16.

Synthesis of a neoglycoconjugate containing a Chlamydophila psittaci-specific branched Kdo trisaccharide epitope.

Kosma P, Hofinger A, Müller-Loennies S, Brade H.

Carbohydr Res. 2010 Mar 30;345(5):704-8. doi: 10.1016/j.carres.2009.12.015. Epub 2009 Dec 21.

PMID:
20116048
17.

Analysis of cross-reactive and specific anti-carbohydrate antibodies against lipopolysaccharide from Chlamydophila psittaci.

Gerstenbruch S, Brooks CL, Kosma P, Brade L, Mackenzie CR, Evans SV, Brade H, Müller-Loennies S.

Glycobiology. 2010 Jan;20(4):461-72. doi: 10.1093/glycob/cwp198. Epub 2009 Dec 18.

18.

Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients.

Schmengler K, Goldmann T, Brade L, Sánchez Carballo PM, Albrecht S, Brade H, Kosma P, Sahly H, Hauber HP, Länger F, Meyer R, Welte T, Zähringer U.

Eur J Cell Biol. 2010 Jan;89(1):25-33. doi: 10.1016/j.ejcb.2009.10.010.

PMID:
20022136
19.

Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition.

Brooks CL, Müller-Loennies S, Borisova SN, Brade L, Kosma P, Hirama T, Mackenzie CR, Brade H, Evans SV.

Biochemistry. 2010 Jan 26;49(3):570-81. doi: 10.1021/bi9011308.

20.

Glycosyltransferases involved in the biosynthesis of the inner core region of different lipopolysaccharides.

Gronow S, Xia G, Brade H.

Eur J Cell Biol. 2010 Jan;89(1):3-10. doi: 10.1016/j.ejcb.2009.10.002. Epub 2009 Nov 8.

PMID:
19900730
21.

Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages.

Prantner D, Darville T, Sikes JD, Andrews CW Jr, Brade H, Rank RG, Nagarajan UM.

Infect Immun. 2009 Dec;77(12):5334-46. doi: 10.1128/IAI.00883-09. Epub 2009 Oct 5.

22.

The role of CDR H3 in antibody recognition of a synthetic analog of a lipopolysaccharide antigen.

Brooks CL, Blackler RJ, Sixta G, Kosma P, Müller-Loennies S, Brade L, Hirama T, MacKenzie CR, Brade H, Evans SV.

Glycobiology. 2010 Feb;20(2):138-47. doi: 10.1093/glycob/cwp150. Epub 2009 Sep 18.

PMID:
19767317
23.

Synthesis and antigenic properties of C-7-modified Kdo mono- and disaccharide ligands and Kdo disaccharide interresidue lactones.

Sixta G, Wimmer K, Hofinger A, Brade H, Kosma P.

Carbohydr Res. 2009 Sep 8;344(13):1660-9. doi: 10.1016/j.carres.2009.06.015. Epub 2009 Jun 21.

PMID:
19665108
24.

Escherichia coli K-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases: minimal lipopolysaccharide structure and induction of envelope stress response.

Klein G, Lindner B, Brabetz W, Brade H, Raina S.

J Biol Chem. 2009 Jun 5;284(23):15369-89. doi: 10.1074/jbc.M900490200. Epub 2009 Apr 3.

25.
26.

Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments.

Brooks CL, Blackler RJ, Gerstenbruch S, Kosma P, Müller-Loennies S, Brade H, Evans SV.

Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1250-8. doi: 10.1107/S0907444908033453. Epub 2008 Nov 18.

PMID:
19018101
27.

Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle.

Howe J, Richter W, Hawkins L, Rössle M, Alexander C, Fournier K, Mach JP, Waelli T, Gorczynski RM, Ulmer AJ, Brade H, Zamyatina A, Kosma P, Rietschel ET, Brandenburg K.

Med Chem. 2008 Nov;4(6):520-5.

PMID:
18991733
28.

Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.

Hanuszkiewicz A, Hübner G, Vinogradov E, Lindner B, Brade L, Brade H, Debarry J, Heine H, Holst O.

Chemistry. 2008;14(33):10251-8. doi: 10.1002/chem.200800958.

PMID:
18850609
29.

Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.

Jabs S, Quitsch A, Käkelä R, Koch B, Tyynelä J, Brade H, Glatzel M, Walkley S, Saftig P, Vanier MT, Braulke T.

J Neurochem. 2008 Aug;106(3):1415-25. doi: 10.1111/j.1471-4159.2008.05497.x. Epub 2008 May 21.

30.

Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes.

Brooks CL, Müller-Loennies S, Brade L, Kosma P, Hirama T, MacKenzie CR, Brade H, Evans SV.

J Mol Biol. 2008 Mar 21;377(2):450-68. doi: 10.1016/j.jmb.2008.01.018. Epub 2008 Jan 16.

PMID:
18272175
31.

Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.

Wang H, Head J, Kosma P, Brade H, Müller-Loennies S, Sheikh S, McDonald B, Smith K, Cafarella T, Seaton B, Crouch E.

Biochemistry. 2008 Jan 15;47(2):710-20. Epub 2007 Dec 20.

PMID:
18092821
32.
33.

Neutralizing and cross-reactive antibodies against enterobacterial lipopolysaccharide.

Müller-Loennies S, Brade L, Brade H.

Int J Med Microbiol. 2007 Sep;297(5):321-40. Epub 2007 Jun 1. Review.

PMID:
17544324
34.

Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.

Spiller S, Dreher S, Meng G, Grabiec A, Thomas W, Hartung T, Pfeffer K, Hochrein H, Brade H, Bessler W, Wagner H, Kirschning CJ.

J Biol Chem. 2007 May 4;282(18):13190-8. Epub 2007 Mar 12.

35.

A novel 40-kDa protein containing six repeats of an epidermal growth factor-like domain functions as a pattern recognition protein for lipopolysaccharide.

Ju JS, Cho MH, Brade L, Kim JH, Park JW, Ha NC, Söderhäll I, Söderhäll K, Brade H, Lee BL.

J Immunol. 2006 Aug 1;177(3):1838-45.

36.
37.
38.

Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis.

van Zandbergen G, Gieffers J, Kothe H, Rupp J, Bollinger A, Aga E, Klinger M, Brade H, Dalhoff K, Maass M, Solbach W, Laskay T.

J Immunol. 2004 Feb 1;172(3):1768-76.

39.

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.

Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schütze S, Gulbins E, Uhlig S.

Nat Med. 2004 Feb;10(2):155-60. Epub 2004 Jan 4.

PMID:
14704790
40.
41.

Germline antibody recognition of distinct carbohydrate epitopes.

Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV.

Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16.

PMID:
14625588
42.
43.

The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin.

Prebeck S, Brade H, Kirschning CJ, da Costa CP, Dürr S, Wagner H, Miethke T.

Microbes Infect. 2003 May;5(6):463-70.

PMID:
12758273
44.

Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.

Muller-Loennies S, Brade L, MacKenzie CR, Di Padova FE, Brade H.

J Biol Chem. 2003 Jul 11;278(28):25618-27. Epub 2003 Apr 25.

45.
46.
47.
48.

Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties.

Gronow S, Noah C, Blumenthal A, Lindner B, Brade H.

J Biol Chem. 2003 Jan 17;278(3):1647-55. Epub 2002 Nov 8.

49.

Sphingolipid metabolism during epidermal barrier development in mice.

Doering T, Brade H, Sandhoff K.

J Lipid Res. 2002 Oct;43(10):1727-33.

50.

A novel strategy for the synthesis of neoglycoconjugates from deacylated deep rough lipopolysaccharides.

Müller-Loennies S, Grimmecke D, Brade L, Lindner B, Kosma P, Brade H.

J Endotoxin Res. 2002;8(4):295-305.

PMID:
12230919

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