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Tensin1 expression and function in chronic obstructive pulmonary disease.

Stylianou P, Clark K, Gooptu B, Smallwood D, Brightling CE, Amrani Y, Roach KM, Bradding P.

Sci Rep. 2019 Dec 12;9(1):18942. doi: 10.1038/s41598-019-55405-2.


Validation of antibodies for the specific detection of human TRPA1.

Virk HS, Rekas MZ, Biddle MS, Wright AKA, Sousa J, Weston CA, Chachi L, Roach KM, Bradding P.

Sci Rep. 2019 Dec 6;9(1):18500. doi: 10.1038/s41598-019-55133-7.


Ca2+ signalling in fibroblasts and the therapeutic potential of KCa 3.1 channel blockers in fibrotic diseases.

Roach KM, Bradding P.

Br J Pharmacol. 2020 Mar;177(5):1003-1024. doi: 10.1111/bph.14939. Epub 2020 Feb 3. Review.


Nocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.

Kapoor M, Storrar W, Balls L, Brown TP, Mansur A, Hedley E, Jones T, Roberts C, Shirkey B, Dutton S, Luengo-Fernandez R, Little M, Dewey A, Marshall S, Fogg C, Boughton K, Rahman N, Yu LM, Bradding P, Howarth P, Chauhan AJ.

Health Technol Assess. 2019 Jun;23(29):1-140. doi: 10.3310/hta23290.


Patient Perceptions of Living with Severe Asthma: Challenges to Effective Management.

Apps LD, Chantrell S, Majd S, Eglinton E, Singh SJ, Murphy AC, Bradding P, Green RH, Hudson N, Evans RA.

J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2613-2621.e1. doi: 10.1016/j.jaip.2019.04.026. Epub 2019 Jun 6.


Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study.

Busby J, Holweg CTJ, Chai A, Bradding P, Cai F, Chaudhuri R, Mansur AH, Lordan JL, Matthews JG, Menzies-Gow A, Niven R, Staton T, Heaney LG.

Thorax. 2019 Aug;74(8):806-809. doi: 10.1136/thoraxjnl-2018-212709. Epub 2019 Apr 2.


Understanding the measurement properties of the incremental shuttle walk test in patients with severe asthma.

Majd S, Hewitt SM, Apps LD, Murphy AC, Bradding P, Singh SJ, Green RH, Evans RA.

Respirology. 2019 Aug;24(8):752-757. doi: 10.1111/resp.13519. Epub 2019 Mar 18.


Exacerbations of severe asthma in patients treated with mepolizumab.

Shrimanker R, Pavord ID, Yancey S, Heaney LG, Green RH, Bradding P, Hargadon B, Brightling CE, Wardlaw AJ, Haldar P.

Eur Respir J. 2018 Dec 13;52(6). pii: 1801127. doi: 10.1183/13993003.01127-2018. Print 2018 Dec. No abstract available.


Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.

Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord ID, Lindsay JT, Costello RW; Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

Am J Respir Crit Care Med. 2019 Feb 15;199(4):454-464. doi: 10.1164/rccm.201806-1182OC.


Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors.

Chachi L, Alzahrani A, Koziol-White C, Biddle M, Bagadood R, Panettieri RA Jr, Bradding P, Amrani Y.

Clin Exp Immunol. 2018 Nov;194(2):253-258. doi: 10.1111/cei.13191. Epub 2018 Sep 30.


Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham-Anderson J, Hargadon B, Arron JR, Wardlaw A, Brightling CE, Heaney LG, Bradding P.

J Allergy Clin Immunol. 2018 Nov;142(5):1457-1468. doi: 10.1016/j.jaci.2017.12.982. Epub 2018 Mar 14.


The controversial role of mast cells in fibrosis.

Bradding P, Pejler G.

Immunol Rev. 2018 Mar;282(1):198-231. doi: 10.1111/imr.12626. Review.


A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis.

Roach KM, Sutcliffe A, Matthews L, Elliott G, Newby C, Amrani Y, Bradding P.

Sci Rep. 2018 Jan 10;8(1):342. doi: 10.1038/s41598-017-18555-9.


A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, Howarth PH, Lordan J, Mansur AH, Menzies-Gow A, Mosesova S, Niven RM, Robinson DS, Shaw DE, Walker S, Woodcock A, Heaney LG; RASP-UK (Refractory Asthma Stratification Programme) Consortium.

Trials. 2018 Jan 4;19(1):5. doi: 10.1186/s13063-017-2384-7.


β2-Adrenoceptor Function in Asthma.

Amrani Y, Bradding P.

Adv Immunol. 2017;136:1-28. doi: 10.1016/ Epub 2017 Jul 27. Review.


Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q.

Lal N, Willcox CR, Beggs A, Taniere P, Shikotra A, Bradding P, Adams R, Fisher D, Middleton G, Tselepis C, Willcox BE.

J Pathol Clin Res. 2017 Jul 14;3(3):155-170. doi: 10.1002/cjp2.70. eCollection 2017 Jul.


MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Welsh KG, Rousseau K, Fisher G, Bonser LR, Bradding P, Brightling CE, Thornton DJ, Gaillard EA.

Chest. 2017 Oct;152(4):771-779. doi: 10.1016/j.chest.2017.07.001. Epub 2017 Jul 14.


The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma.

Bilocca D, Hargadon B, Pavord ID, Green RH, Brightling CE, Bradding P, Wardlaw AJ, Martin N, Murphy AC, Siddiqui S.

Chron Respir Dis. 2018 Feb;15(1):85-87. doi: 10.1177/1479972317709650. Epub 2017 Jun 1.


Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.

Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE.

Eur Respir J. 2017 May 1;49(5). pii: 1601507. doi: 10.1183/13993003.01507-2016. Print 2017 May.


Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma.

Hart KM, Choy DF, Bradding P, Wynn TA, Arron JR.

Ann Transl Med. 2017 Feb;5(4):91. doi: 10.21037/atm.2017.02.07. No abstract available.


A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.

Shikotra A, Choy DF, Siddiqui S, Arthur G, Nagarkar DR, Jia G, Wright AK, Ohri CM, Doran E, Butler CA, Hargadon B, Abbas AR, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P.

J Immunol. 2017 Apr 15;198(8):3307-3317. doi: 10.4049/jimmunol.1600606. Epub 2017 Mar 8.


The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma.

Natarajan S, Free RC, Bradding P, McGarvey L, Siddiqui S.

Respir Res. 2017 Mar 4;18(1):44. doi: 10.1186/s12931-017-0520-2.


Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model.

Organ L, Bacci B, Koumoundouros E, Kimpton WG, Samuel CS, Nowell CJ, Bradding P, Roach KM, Westall G, Jaffar J, Snibson KJ.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):539-550. doi: 10.1165/rcmb.2016-0092OC.


Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer.

Shikotra A, Ohri CM, Green RH, Waller DA, Bradding P.

Sci Rep. 2016 Dec 6;6:38352. doi: 10.1038/srep38352.


CD48 on blood leukocytes and in serum of asthma patients varies with severity.

Gangwar RS, Minai-Fleminger Y, Seaf M, Gutgold A, Shikotra A, Barber C, Chauhan A, Holgate S, Bradding P, Howarth P, Eliashar R, Berkman N, Levi-Schaffer F.

Allergy. 2017 Jun;72(6):888-895. doi: 10.1111/all.13082. Epub 2016 Dec 1. Erratum in: Allergy. 2017 Oct;72 (10 ):1591.


The relationship between biomarkers of fungal allergy and lung damage in asthma.

Woolnough KF, Richardson M, Newby C, Craner M, Bourne M, Monteiro W, Siddiqui S, Bradding P, Pashley CH, Wardlaw AJ.

Clin Exp Allergy. 2017 Jan;47(1):48-56. doi: 10.1111/cea.12848. Epub 2016 Dec 2.


Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

Chachi L, Abbasian M, Gavrila A, Alzahrani A, Tliba O, Bradding P, Wardlaw AJ, Brightling C, Amrani Y.

Allergy. 2017 Jan;72(1):126-136. doi: 10.1111/all.13003. Epub 2016 Sep 15.


Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

Doran E, Choy DF, Shikotra A, Butler CA, O'Rourke DM, Johnston JA, Kissenpfennig A, Bradding P, Arron JR, Heaney LG.

Eur Respir J. 2016 Sep;48(3):715-25. doi: 10.1183/13993003.00400-2015. Epub 2016 Jun 23.


New Developments in Mast Cell Biology: Clinical Implications.

Arthur G, Bradding P.

Chest. 2016 Sep;150(3):680-93. doi: 10.1016/j.chest.2016.06.009. Epub 2016 Jun 15. Review.


Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients.

Wright A, Mahaut-Smith M, Symon F, Sylvius N, Ran S, Bafadhel M, Muessel M, Bradding P, Wardlaw A, Vial C.

J Immunol. 2016 Jun 15;196(12):4877-84. doi: 10.4049/jimmunol.1501585. Epub 2016 May 9.


Protocol for a feasibility study to inform the development of a multicentre randomised controlled trial of asthma-tailored pulmonary rehabilitation versus usual care for individuals with severe asthma.

Majd S, Apps LD, Hudson N, Hewitt S, Eglinton E, Murphy A, Bradding P, Singh S, Green R, Evans R.

BMJ Open. 2016 Mar 23;6(3):e010574. doi: 10.1136/bmjopen-2015-010574.


Mast cells and their activation in lung disease.

Virk H, Arthur G, Bradding P.

Transl Res. 2016 Aug;174:60-76. doi: 10.1016/j.trsl.2016.01.005. Epub 2016 Jan 20. Review.


Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial.

Storrar W, Fogg C, Brown T, Dennison P, Yu LM, Dewey A, Luengo-Fernandez R, Dean T, Rahman N, Mansur A, Howarth PH, Bradding P, Chauhan AJ.

Trials. 2016 Jan 8;17:15. doi: 10.1186/s13063-015-1134-y.


KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells.

Arthur GK, Duffy SM, Roach KM, Hirst RA, Shikotra A, Gaillard EA, Bradding P.

PLoS One. 2015 Dec 21;10(12):e0145259. doi: 10.1371/journal.pone.0145259. eCollection 2015.


Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors.

Lewis RJ, Chachi L, Newby C, Amrani Y, Bradding P.

J Immunol. 2016 Jan 1;196(1):55-63. doi: 10.4049/jimmunol.1402232. Epub 2015 Nov 25.


Mast cells in asthma--state of the art.

Bradding P, Arthur G.

Clin Exp Allergy. 2016 Feb;46(2):194-263. doi: 10.1111/cea.12675. Review.


TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.


Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts.

Roach KM, Feghali-Bostwick CA, Amrani Y, Bradding P.

J Immunol. 2015 Sep 15;195(6):2852-60. doi: 10.4049/jimmunol.1500936. Epub 2015 Aug 14.


Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T.

Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Review.


Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane.

Duffy SM, Ashmole I, Smallwood DT, Leyland ML, Bradding P.

Cell Commun Signal. 2015 Jul 16;13:32. doi: 10.1186/s12964-015-0112-z.


Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells.

Gough KC, Maddison BC, Shikotra A, Moiseeva EP, Yang W, Jarvis S, Bradding P.

Respir Res. 2015 Jul 15;16:86. doi: 10.1186/s12931-015-0245-z.


Mast cells in airway diseases and interstitial lung disease.

Cruse G, Bradding P.

Eur J Pharmacol. 2016 May 5;778:125-38. doi: 10.1016/j.ejphar.2015.04.046. Epub 2015 May 8. Review.


Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by KCa3.1 K(+) channels.

Roach KM, Feghali-Bostwick C, Wulff H, Amrani Y, Bradding P.

Fibrogenesis Tissue Repair. 2015 Mar 26;8:5. doi: 10.1186/s13069-015-0022-0. eCollection 2015.


The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling.

Cruse G, Beaven MA, Music SC, Bradding P, Gilfillan AM, Metcalfe DD.

Mol Biol Cell. 2015 May 1;26(9):1711-27. doi: 10.1091/mbc.E14-07-1221. Epub 2015 Feb 25.


Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.

Roach KM, Wulff H, Feghali-Bostwick C, Amrani Y, Bradding P.

Respir Res. 2014 Dec 5;15:155. doi: 10.1186/s12931-014-0155-5.


CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells.

Moiseeva EP, Straatman KR, Leyland ML, Bradding P.

PLoS One. 2014 Jan 22;9(1):e85980. doi: 10.1371/journal.pone.0085980. eCollection 2014. Erratum in: PLoS One. 2014;9(2):e91600.


Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis.

Haldar P, Brightling CE, Singapuri A, Hargadon B, Gupta S, Monteiro W, Bradding P, Green RH, Wardlaw AJ, Ortega H, Pavord ID.

J Allergy Clin Immunol. 2014 Mar;133(3):921-3. doi: 10.1016/j.jaci.2013.11.026. Epub 2014 Jan 10. No abstract available.


The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis.

Roach KM, Duffy SM, Coward W, Feghali-Bostwick C, Wulff H, Bradding P.

PLoS One. 2013 Dec 31;8(12):e85244. doi: 10.1371/journal.pone.0085244. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/790e86f8-3506-49d6-b7d0-7dbbc580d808. Roach, Katy Morgan [corrected to Roach, Katy M].


Clinical significance of small airway obstruction markers in patients with asthma.

Gonem S, Natarajan S, Desai D, Corkill S, Singapuri A, Bradding P, Gustafsson P, Costanza R, Kajekar R, Parmar H, Brightling CE, Siddiqui S.

Clin Exp Allergy. 2014 Apr;44(4):499-507. doi: 10.1111/cea.12257.


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