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Items: 1 to 50 of 79

1.

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

Edin ML, Hamedani BG, Gruzdev A, Graves JP, Lih FB, Arbes SJ 3rd, Singh R, Orjuela Leon AC, Bradbury JA, DeGraff LM, Hoopes SL, Arand M, Zeldin DC.

J Biol Chem. 2018 Mar 2;293(9):3281-3292. doi: 10.1074/jbc.RA117.000298. Epub 2018 Jan 3.

PMID:
29298899
2.

Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC.

Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27.

3.

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

Hoopes SL, Gruzdev A, Edin ML, Graves JP, Bradbury JA, Flake GP, Lih FB, DeGraff LM, Zeldin DC.

PLoS One. 2017 Apr 6;12(4):e0175348. doi: 10.1371/journal.pone.0175348. eCollection 2017.

4.

Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease.

Jerschow E, Edin ML, Pelletier T, Abuzeid WM, Akbar NA, Gibber M, Fried M, Lih FB, Gruzdev A, Bradbury JA, Han W, Hudes G, Keskin T, Schuster VL, Spivack S, Zeldin DC, Rosenstreich D.

J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):998-1007.e2. doi: 10.1016/j.jaip.2016.11.021. Epub 2017 Jan 31.

5.

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Jia J, Davis CM, Zhang W, Edin ML, Jouihan S, Jia T, Bradbury JA, Graves JP, DeGraff LM, Lee CR, Ronnekleiv O, Wang R, Xu Y, Zeldin DC, Alkayed NJ.

Exp Neurol. 2016 May;279:75-85. doi: 10.1016/j.expneurol.2016.02.016. Epub 2016 Feb 20.

6.

Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.

Cheng J, Dackor RT, Bradbury JA, Li H, DeGraff LM, Hong LK, King D, Lih FB, Gruzdev A, Edin ML, Travlos GS, Flake GP, Tomer KB, Zeldin DC.

FASEB J. 2016 Jan;30(1):160-73. doi: 10.1096/fj.14-268458. Epub 2015 Sep 22.

7.

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Li H, House JS, Hoopes SL, Edin ML, Zeldin DC.

Drug Metab Dispos. 2015 Aug;43(8):1169-80. doi: 10.1124/dmd.115.064139. Epub 2015 May 20.

8.

What information can we give to the patient about the risks of strabismus surgery.

Bradbury JA.

Eye (Lond). 2015 Feb;29(2):252-7. doi: 10.1038/eye.2014.316. Epub 2015 Jan 9. Review.

9.

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity.

Zha W, Edin ML, Vendrov KC, Schuck RN, Lih FB, Jat JL, Bradbury JA, DeGraff LM, Hua K, Tomer KB, Falck JR, Zeldin DC, Lee CR.

J Lipid Res. 2014 Oct;55(10):2124-36. doi: 10.1194/jlr.M053199. Epub 2014 Aug 11.

10.

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Cheng J, Edin ML, Hoopes SL, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JS, Tomer KB, Flake GP, Falck JR, Lee CR, Poloyac SM, Schwartzman ML, Zeldin DC.

FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25.

11.

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

Westphal C, Spallek B, Konkel A, Marko L, Qadri F, DeGraff LM, Schubert C, Bradbury JA, Regitz-Zagrosek V, Falck JR, Zeldin DC, Müller DN, Schunck WH, Fischer R.

PLoS One. 2013 Aug 30;8(8):e73490. doi: 10.1371/journal.pone.0073490. eCollection 2013.

12.

NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response.

Kim JM, Kosak JP, Kim JK, Kissling G, Germolec DR, Zeldin DC, Bradbury JA, Baek SJ, Eling TE.

Mediators Inflamm. 2013;2013:641851. doi: 10.1155/2013/641851. Epub 2013 May 13.

13.

Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB.

Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, Garantziotis S, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):812-22. doi: 10.1164/rccm.201211-2073OC.

14.

Severe complications of strabismus surgery.

Bradbury JA, Taylor RH.

J AAPOS. 2013 Feb;17(1):59-63. doi: 10.1016/j.jaapos.2012.10.016. Epub 2013 Jan 23.

PMID:
23352718
15.

Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily.

Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Masinde TA, Qu W, Clayton NP, Morrison JP, Tomer KB, Zeldin DC.

Drug Metab Dispos. 2013 Apr;41(4):763-73. doi: 10.1124/dmd.112.049429. Epub 2013 Jan 11.

16.

Regulation of T helper cell subsets by cyclooxygenases and their metabolites.

Li H, Edin ML, Gruzdev A, Cheng J, Bradbury JA, Graves JP, DeGraff LM, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:74-83. doi: 10.1016/j.prostaglandins.2012.11.002. Epub 2012 Nov 28. Review.

17.

Bilateral changes in foveal structure in individuals with amblyopia.

Bruce A, Pacey IE, Bradbury JA, Scally AJ, Barrett BT.

Ophthalmology. 2013 Feb;120(2):395-403. doi: 10.1016/j.ophtha.2012.07.088. Epub 2012 Sep 29.

PMID:
23031668
18.

Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.

Yildirim E, Carey MA, Card JW, Dietrich A, Flake GP, Zhang Y, Bradbury JA, Rebolloso Y, Germolec DR, Morgan DL, Zeldin DC, Birnbaumer L.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L539-49. doi: 10.1152/ajplung.00389.2011. Epub 2012 Jul 13.

19.

Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction.

Dackor RT, Cheng J, Voltz JW, Card JW, Ferguson CD, Garrett RC, Bradbury JA, DeGraff LM, Lih FB, Tomer KB, Flake GP, Travlos GS, Ramsey RW Jr, Edin ML, Morgan DL, Zeldin DC.

Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L645-55. doi: 10.1152/ajplung.00176.2011. Epub 2011 Aug 19.

20.

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.

Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, Lee CR, Zeldin DC.

FASEB J. 2011 Oct;25(10):3436-47. doi: 10.1096/fj.11-188300. Epub 2011 Jun 22.

21.

Visual impairment in children.

Kliner M, Fell G, Pilling RF, Bradbury JA.

Eye (Lond). 2011 Aug;25(8):1097. doi: 10.1038/eye.2011.85. Epub 2011 Apr 15. No abstract available.

22.

Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation.

Li H, Bradbury JA, Dackor RT, Edin ML, Graves JP, DeGraff LM, Wang PM, Bortner CD, Maruoka S, Lih FB, Cook DN, Tomer KB, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2011 Jul 1;184(1):37-49. doi: 10.1164/rccm.201010-1637OC. Epub 2011 Apr 7.

23.

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.

Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, DeGraff LM, Lih FB, Foley J, Bradbury JA, Graves JP, Tomer KB, Falck JR, Zeldin DC, Lee CR.

FASEB J. 2011 Feb;25(2):703-13. doi: 10.1096/fj.10-171488. Epub 2010 Nov 8.

24.

Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

Carey MA, Bradbury JA, Rebolloso YD, Graves JP, Zeldin DC, Germolec DR.

PLoS One. 2010 Jul 15;5(7):e11610. doi: 10.1371/journal.pone.0011610.

25.

Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.

Thomas AC, Nouls JC, Driehuys B, Voltz JW, Fubara B, Foley J, Bradbury JA, Zeldin DC.

Am J Respir Cell Mol Biol. 2011 May;44(5):648-54. doi: 10.1165/rcmb.2009-0287OC. Epub 2010 Jul 1.

26.

Strabismus surgical skills assessment tool: development of a surgical assessment tool for strabismus surgery training.

Pilling RF, Bradbury JA, Reddy AR.

Am J Ophthalmol. 2010 Aug;150(2):275-278.e2. doi: 10.1016/j.ajo.2010.03.007. Epub 2010 Jun 11.

PMID:
20541739
27.

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC.

FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.

28.

Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis.

Card JW, Carey MA, Voltz JW, Bradbury JA, Ferguson CD, Cohen EA, Schwartz S, Flake GP, Morgan DL, Arbes SJ Jr, Barrow DA, Barros SP, Offenbacher S, Zeldin DC.

Infect Immun. 2010 Jun;78(6):2488-96. doi: 10.1128/IAI.01270-09. Epub 2010 Mar 22.

29.

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.

Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D.

PLoS One. 2009 Oct 12;4(10):e7421. doi: 10.1371/journal.pone.0007421.

30.

Nurse specialist treatment of eye emergencies: five year follow up study of quality and effectiveness.

Buchan JC, Ashiq A, Kitson N, Dixon J, Cassels-Brown A, Bradbury JA.

Int Emerg Nurs. 2009 Jul;17(3):149-54. doi: 10.1016/j.ienj.2008.12.002. Epub 2009 Jan 29.

PMID:
19577201
31.

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity.

Zhang Y, El-Sikhry H, Chaudhary KR, Batchu SN, Shayeganpour A, Jukar TO, Bradbury JA, Graves JP, DeGraff LM, Myers P, Rouse DC, Foley J, Nyska A, Zeldin DC, Seubert JM.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H37-46. doi: 10.1152/ajpheart.00983.2008. Epub 2009 May 8.

32.

Increased blood pressure in mice lacking cytochrome P450 2J5.

Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Coffman TM, Zeldin DC.

FASEB J. 2008 Dec;22(12):4096-108. doi: 10.1096/fj.08-114413. Epub 2008 Aug 20.

33.

Is this really a capillary haemangioma?

Reddy AR, Chang BY, Bradbury JA.

Orbit. 2007 Dec;26(4):327-9.

PMID:
18097979
34.

Myectomy versus anterior transposition for inferior oblique overaction.

Ghazawy S, Reddy AR, Kipioti A, McShane P, Arora S, Bradbury JA.

J AAPOS. 2007 Dec;11(6):601-5. Epub 2007 Aug 27.

PMID:
17720575
35.

Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice.

Ke Q, Xiao YF, Bradbury JA, Graves JP, Degraff LM, Seubert JM, Zeldin DC.

Mol Pharmacol. 2007 Oct;72(4):1063-73. Epub 2007 Jul 24.

36.

Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis.

Card JW, Voltz JW, Carey MA, Bradbury JA, Degraff LM, Lih FB, Bonner JC, Morgan DL, Flake GP, Zeldin DC.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):300-8. Epub 2007 May 11.

37.

Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues.

Delozier TC, Kissling GE, Coulter SJ, Dai D, Foley JF, Bradbury JA, Murphy E, Steenbergen C, Zeldin DC, Goldstein JA.

Drug Metab Dispos. 2007 Apr;35(4):682-8. Epub 2007 Jan 12.

38.

Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.

Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, Zeldin DC.

Am J Respir Crit Care Med. 2007 Jan 15;175(2):126-35. Epub 2006 Nov 9.

39.

Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation.

Card JW, Carey MA, Bradbury JA, Graves JP, Lih FB, Moorman MP, Morgan DL, DeGraff LM, Zhao Y, Foley JF, Zeldin DC.

J Immunol. 2006 Oct 1;177(7):4785-93.

40.

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC.

Circ Res. 2006 Aug 18;99(4):442-50. Epub 2006 Jul 20.

41.

Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms.

Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC.

J Physiol. 2006 Sep 1;575(Pt 2):627-44. Epub 2006 Jun 22.

42.

Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation.

Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC.

J Immunol. 2006 Jul 1;177(1):621-30.

43.

Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection.

Carey MA, Bradbury JA, Seubert JM, Langenbach R, Zeldin DC, Germolec DR.

J Immunol. 2005 Nov 15;175(10):6878-84.

44.
45.

A new phenotype of recessively inherited foveal hypoplasia and anterior segment dysgenesis maps to a locus on chromosome 16q23.2-24.2.

Pal B, Mohamed MD, Keen TJ, Williams GA, Bradbury JA, Sheridan E, Inglehearn CF.

J Med Genet. 2004 Oct;41(10):772-7. No abstract available.

46.

Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2.

Xiao YF, Ke Q, Seubert JM, Bradbury JA, Graves J, Degraff LM, Falck JR, Krausz K, Gelboin HV, Morgan JP, Zeldin DC.

Mol Pharmacol. 2004 Dec;66(6):1607-16. Epub 2004 Sep 10.

47.

Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.

Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman J, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC.

Circ Res. 2004 Sep 3;95(5):506-14. Epub 2004 Jul 15.

48.

Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.

Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC.

Mol Pharmacol. 2004 May;65(5):1148-58.

49.

CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products.

DeLozier TC, Tsao CC, Coulter SJ, Foley J, Bradbury JA, Zeldin DC, Goldstein JA.

J Pharmacol Exp Ther. 2004 Sep;310(3):845-54. Epub 2004 Apr 14.

50.

Regulation of mouse renal CYP2J5 expression by sex hormones.

Ma J, Graves J, Bradbury JA, Zhao Y, Swope DL, King L, Qu W, Clark J, Myers P, Walker V, Lindzey J, Korach KS, Zeldin DC.

Mol Pharmacol. 2004 Mar;65(3):730-43.

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