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Challenges in the design, planning and implementation of trials evaluating group interventions.

Biggs K, Hind D, Gossage-Worrall R, Sprange K, White D, Wright J, Chatters R, Berry K, Papaioannou D, Bradburn M, Walters SJ, Cooper C.

Trials. 2020 Jan 29;21(1):116. doi: 10.1186/s13063-019-3807-4.


Accuracy of in-utero MRI to detect fetal brain abnormalities and prognosticate developmental outcome: postnatal follow-up of the MERIDIAN cohort.

Hart AR, Embleton ND, Bradburn M, Connolly DJA, Mandefield L, Mooney C, Griffiths PD.

Lancet Child Adolesc Health. 2020 Feb;4(2):131-140. doi: 10.1016/S2352-4642(19)30349-9. Epub 2019 Nov 27.


Design, planning and implementation lessons learnt from a surgical multi-centre randomised controlled trial.

Biggs K, Hind D, Bradburn M, Swaby L, Brown S.

Trials. 2019 Nov 1;20(1):620. doi: 10.1186/s13063-019-3649-0.


Process evaluation and exploration of telehealth in motor neuron disease in a UK specialist centre.

Hobson E, Baird W, Bradburn M, Cooper C, Mawson S, Quinn A, Shaw PJ, Walsh T, McDermott CJ.

BMJ Open. 2019 Oct 22;9(10):e028526. doi: 10.1136/bmjopen-2018-028526.


Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care: a UK-based pilot and feasibility study.

Hobson EV, Baird WO, Bradburn M, Cooper C, Mawson S, Quinn A, Shaw PJ, Walsh T, McDermott CJ.

BMJ Open. 2019 Oct 22;9(10):e028525. doi: 10.1136/bmjopen-2018-028525.


MRI in the diagnosis of fetal developmental brain abnormalities: the MERIDIAN diagnostic accuracy study.

Griffiths PD, Bradburn M, Campbell MJ, Cooper CL, Embleton N, Graham R, Hart AR, Jarvis D, Kilby MD, Lie M, Mason G, Mandefield L, Mooney C, Pennington R, Robson SC, Wailoo A.

Health Technol Assess. 2019 Sep;23(49):1-144. doi: 10.3310/hta23490.


Malnutrition, nutritional interventions and clinical outcomes of patients with acute small bowel obstruction: results from a national, multicentre, prospective audit.

Lee MJ, Sayers AE, Drake TM, Singh P, Bradburn M, Wilson TR, Murugananthan A, Walsh CJ, Fearnhead NS; NASBO Steering Group and NASBO Collaborators.

BMJ Open. 2019 Jul 27;9(7):e029235. doi: 10.1136/bmjopen-2019-029235.


Needs and preferences for psychological interventions of people with motor neuron disease.

Weeks KR, Gould RL, Mcdermott C, Lynch J, Goldstein LH, Graham CD, McCracken L, Serfaty M, Howard R, Al-Chalabi A, White D, Bradburn M, Young T, Cooper C, Shaw DPJ, Lawrence V.

Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(7-8):521-531. doi: 10.1080/21678421.2019.1621344. Epub 2019 Jul 12.


Variation in prognosis given by fetomaternal units in fetuses with neurological abnormalities.

Hart A, Embleton N, Mooney C, Bradburn M, Griffiths PD.

Arch Dis Child Fetal Neonatal Ed. 2020 Jan;105(1):109-110. doi: 10.1136/archdischild-2019-317517. Epub 2019 Jul 4. No abstract available.


National prospective cohort study of the burden of acute small bowel obstruction.

Lee MJ, Sayers AE, Drake TM, Marriott PJ, Anderson ID, Bach SP, Bradburn M, Hind D, Verjee A, Fearnhead NS; NASBO steering group and NASBO collaborators.

BJS Open. 2019 Feb 22;3(3):354-366. doi: 10.1002/bjs5.50136. eCollection 2019 Jun.


The rate of brain abnormalities on in utero MRI studies in fetuses with normal ultrasound examinations of the brain and calculation of indicators of diagnostic performance.

Griffiths PD, Bradburn M, Mandefield L, Mooney C, Jarvis D.

Clin Radiol. 2019 Jul;74(7):527-533. doi: 10.1016/j.crad.2019.03.010. Epub 2019 Apr 12.


Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors.

Heywood EG, Drake TM, Bradburn M, Lee J, Wilson MJ, Lee MJ.

J Surg Res. 2019 Jun;238:23-28. doi: 10.1016/j.jss.2019.01.017. Epub 2019 Feb 5.


Structured lifestyle education to support weight loss for people with schizophrenia, schizoaffective disorder and first episode psychosis: the STEPWISE RCT.

Holt RI, Hind D, Gossage-Worrall R, Bradburn MJ, Saxon D, McCrone P, Morris TA, Etherington A, Shiers D, Barnard K, Swaby L, Edwardson C, Carey ME, Davies MJ, Dickens CM, Doherty Y, French P, Greenwood KE, Kalidindi S, Khunti K, Laugharne R, Pendlebury J, Rathod S, Siddiqi N, Wright S, Waller G, Gaughran F, Barnett J, Northern A.

Health Technol Assess. 2018 Nov;22(65):1-160. doi: 10.3310/hta22650.


Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial.

Selvarajah D, Petrie J, White D, Julious S, Bortolami O, Cooper C, Bradburn M, Loban A, Bowler H, Swaby L, Sutherland K, Tesfaye S; OPTION-DM group.

Trials. 2018 Oct 22;19(1):578. doi: 10.1186/s13063-018-2959-y.


Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial.

Holt RIG, Gossage-Worrall R, Hind D, Bradburn MJ, McCrone P, Morris T, Edwardson C, Barnard K, Carey ME, Davies MJ, Dickens CM, Doherty Y, Etherington A, French P, Gaughran F, Greenwood KE, Kalidindi S, Khunti K, Laugharne R, Pendlebury J, Rathod S, Saxon D, Shiers D, Siddiqi N, Swaby EA, Waller G, Wright S.

Br J Psychiatry. 2019 Feb;214(2):63-73. doi: 10.1192/bjp.2018.167. Epub 2018 Sep 25.


Analysis of errors made on in utero MR studies of the foetal brain in the MERIDIAN study.

Batty R, Gawne-Cain ML, Mooney C, Mandefield L, Bradburn M, Mason G, Griffiths PD.

Eur Radiol. 2019 Jan;29(1):195-201. doi: 10.1007/s00330-018-5508-x. Epub 2018 Jun 15.


The ACUTE (Ambulance CPAP: Use, Treatment effect and economics) feasibility study: a pilot randomised controlled trial of prehospital CPAP for acute respiratory failure.

Fuller GW, Goodacre S, Keating S, Perkins G, Ward M, Rosser A, Gunson I, Miller J, Bradburn M, Thokala P, Harris T, Carson A, Marsh M, Cooper C.

Pilot Feasibility Stud. 2018 Jun 18;4:86. doi: 10.1186/s40814-018-0281-9. eCollection 2018.


Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density.

Naylor KE, Bradburn M, Paggiosi MA, Gossiel F, Peel NFA, McCloskey EV, Walsh JS, Eastell R.

Osteoporos Int. 2018 Jun;29(6):1407-1417. doi: 10.1007/s00198-018-4460-6. Epub 2018 Mar 10.


Cost-Effectiveness of Haemorrhoidal Artery Ligation versus Rubber Band Ligation for the Treatment of Grade II-III Haemorrhoids: Analysis Using Evidence from the HubBLe Trial.

Alshreef A, Wailoo AJ, Brown SR, Tiernan JP, Watson AJM, Biggs K, Bradburn M, Hind D.

Pharmacoecon Open. 2017 Sep;1(3):175-184. doi: 10.1007/s41669-017-0023-6.


Imaging muscle as a potential biomarker of denervation in motor neuron disease.

Jenkins TM, Alix JJP, David C, Pearson E, Rao DG, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott CJ, Wilkinson ID, Shaw PJ.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):248-255. doi: 10.1136/jnnp-2017-316744. Epub 2017 Oct 31.


Should we perform in utero MRI on a fetus at increased risk of a brain abnormality if ultrasonography is normal or shows non-specific findings?

Griffiths PD, Mooney C, Bradburn M, Jarvis D.

Clin Radiol. 2018 Feb;73(2):123-134. doi: 10.1016/j.crad.2017.09.007. Epub 2017 Oct 16. Review.


UK-based, multisite, prospective cohort study of small bowel obstruction in acute surgical services: National Audit of Small Bowel Obstruction (NASBO) protocol.

Lee MJ, Sayers AE, Drake TM, Hollyman M, Bradburn M, Hind D, Wilson TR, Fearnhead NS; NASBO Steering Group.

BMJ Open. 2017 Oct 5;7(10):e016796. doi: 10.1136/bmjopen-2017-016796.


Smart Clothing for Falls Protection and Detection: User-Centred Co-Design and Feasibility Study.

Easton K, Burton T, Ariss S, Bradburn M, Hawley M.

Stud Health Technol Inform. 2017;242:152-159.


A randomized trial found online questionnaires supplemented by postal reminders generated a cost-effective and generalizable sample but don't forget the reminders.

Loban A, Mandefield L, Hind D, Bradburn M.

J Clin Epidemiol. 2017 Dec;92:116-125. doi: 10.1016/j.jclinepi.2017.08.003. Epub 2017 Aug 24.


Comparative costs and activity from a sample of UK clinical trials units.

Hind D, Reeves BC, Bathers S, Bray C, Corkhill A, Hayward C, Harper L, Napp V, Norrie J, Speed C, Tremain L, Keat N, Bradburn M.

Trials. 2017 May 2;18(1):203. doi: 10.1186/s13063-017-1934-3.


Anatomical subgroup analysis of the MERIDIAN cohort: failed commissuration.

Griffiths PD, Brackley K, Bradburn M, Connolly DJA, Gawne-Cain ML, Griffiths DI, Kilby MD, Mandefield L, Mooney C, Robson SC, Vollmer B, Mason G.

Ultrasound Obstet Gynecol. 2017 Dec;50(6):753-760. doi: 10.1002/uog.17502. Epub 2017 Nov 3.


Anatomical subgroup analysis of the MERIDIAN cohort: posterior fossa abnormalities.

Griffiths PD, Brackley K, Bradburn M, Connolly DJA, Gawne-Cain ML, Kilby MD, Mandefield L, Mooney C, Robson SC, Vollmer B, Mason G.

Ultrasound Obstet Gynecol. 2017 Dec;50(6):745-752. doi: 10.1002/uog.17485. Epub 2017 Nov 8.


Anatomical subgroup analysis of the MERIDIAN cohort: ventriculomegaly.

Griffiths PD, Brackley K, Bradburn M, Connolly DJA, Gawne-Cain ML, Griffiths DI, Kilby MD, Mandefield L, Mooney C, Robson SC, Vollmer B, Mason G.

Ultrasound Obstet Gynecol. 2017 Dec;50(6):736-744. doi: 10.1002/uog.17475. Epub 2017 Nov 5.


A pragmatic randomised controlled trial assessing the non-inferiority of counselling for depression versus cognitive-behaviour therapy for patients in primary care meeting a diagnosis of moderate or severe depression (PRaCTICED): Study protocol for a randomised controlled trial.

Saxon D, Ashley K, Bishop-Edwards L, Connell J, Harrison P, Ohlsen S, Hardy GE, Kellett S, Mukuria C, Mank T, Bower P, Bradburn M, Brazier J, Elliott R, Gabriel L, King M, Pilling S, Shaw S, Waller G, Barkham M.

Trials. 2017 Mar 1;18(1):93. doi: 10.1186/s13063-017-1834-6.


Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort.

Griffiths PD, Bradburn M, Campbell MJ, Connolly DJA, Cooper CL, Jarvis D, Kilby MD, Mason G, Mooney C, Robson SC, Wailoo A; MERIDIAN Collaborative Group.

Clin Radiol. 2017 Jun;72(6):451-457. doi: 10.1016/j.crad.2017.01.009. Epub 2017 Feb 24.


PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.

Julious SA, Horspool MJ, Davis S, Bradburn M, Norman P, Shephard N, Cooper CL, Smithson WH, Boote J, Elphick H, Loban A, Franklin M, Kua WS, May R, Campbell J, Williams R, Rex S, Bortolami O.

Health Technol Assess. 2016 Dec;20(93):1-154. doi: 10.3310/hta20930.


The HubBle trial: a word of caution - Authors' reply.

Brown SR, Bradburn M.

Lancet. 2016 Dec 17;388(10063):2996. doi: 10.1016/S0140-6736(16)32530-2. No abstract available.


Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study.

Griffiths PD, Bradburn M, Campbell MJ, Cooper CL, Graham R, Jarvis D, Kilby MD, Mason G, Mooney C, Robson SC, Wailoo A; MERIDIAN collaborative group.

Lancet. 2017 Feb 4;389(10068):538-546. doi: 10.1016/S0140-6736(16)31723-8. Epub 2016 Dec 15.


The Role of Ultrasound Compared to Biopsy of Temporal Arteries in the Diagnosis and Treatment of Giant Cell Arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study.

Luqmani R, Lee E, Singh S, Gillett M, Schmidt WA, Bradburn M, Dasgupta B, Diamantopoulos AP, Forrester-Barker W, Hamilton W, Masters S, McDonald B, McNally E, Pease C, Piper J, Salmon J, Wailoo A, Wolfe K, Hutchings A.

Health Technol Assess. 2016 Nov;20(90):1-238.


The HubBLe Trial: haemorrhoidal artery ligation (HAL) versus rubber band ligation (RBL) for symptomatic second- and third-degree haemorrhoids: a multicentre randomised controlled trial and health-economic evaluation.

Brown S, Tiernan J, Biggs K, Hind D, Shephard N, Bradburn M, Wailoo A, Alshreef A, Swaby L, Watson A, Radley S, Jones O, Skaife P, Agarwal A, Giordano P, Lamah M, Cartmell M, Davies J, Faiz O, Nugent K, Clarke A, MacDonald A, Conaghan P, Ziprin P, Makhija R.

Health Technol Assess. 2016 Nov;20(88):1-150.


A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero.

Jarvis D, Mooney C, Cohen J, Papaioannou D, Bradburn M, Sutton A, Griffiths PD.

Eur Radiol. 2017 Jun;27(6):2367-2380. doi: 10.1007/s00330-016-4563-4. Epub 2016 Sep 21. Review.


Academic requirements for Certificate of Completion of Training in surgical training: Consensus recommendations from the Association of Surgeons in Training/National Research Collaborative Consensus Group.

Lee MJ, Bhangu A, Blencowe NS, Nepogodiev D, Gokani VJ, Harries RL; Association of Surgeons in Training/National Research Collaborative Consensus group, Akinfala M, Ali O, Allum W, Bosanquet DC, Boyce K, Bradburn M, Chapman SJ, Christopher E, Coulter I, Dean BJ, Dickfos M, El Boghdady M, Elmasry M, Fleming S, Glasbey J, Healy C, Kasivisvanathan V, Khan KS, Kolias AG, Lee SM, Morton D, O'Beirne J, Sinclair P, Sutton PA.

Int J Surg. 2016 Nov;36 Suppl 1:S24-S30. doi: 10.1016/j.ijsu.2016.08.236. Epub 2016 Aug 23.


DiPALS: Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis - a randomised controlled trial.

McDermott CJ, Bradburn MJ, Maguire C, Cooper CL, Baird WO, Baxter SK, Cohen J, Cantrill H, Dixon S, Ackroyd R, Baudouin S, Bentley A, Berrisford R, Bianchi S, Bourke SC, Darlison R, Ealing J, Elliott M, Fitzgerald P, Galloway S, Hamdalla H, Hanemann CO, Hughes P, Imam I, Karat D, Leek R, Maynard N, Orrell RW, Sarela A, Stradling J, Talbot K, Taylor L, Turner M, Simonds AK, Williams T, Wedzicha W, Young C, Shaw PJ.

Health Technol Assess. 2016 Jun;20(45):1-186. doi: 10.3310/hta20450.


Diaphragm pacing in patients with amyotrophic lateral sclerosis - Authors' reply.

McDermott CJ, Bradburn MJ.

Lancet Neurol. 2016 May;15(6):543-4. doi: 10.1016/S1474-4422(16)30010-2. Epub 2016 Apr 11. No abstract available.


Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial.

Brown SR, Tiernan JP, Watson AJM, Biggs K, Shephard N, Wailoo AJ, Bradburn M, Alshreef A, Hind D; HubBLe Study team.

Lancet. 2016 Jul 23;388(10042):356-364. doi: 10.1016/S0140-6736(16)30584-0. Epub 2016 May 25. Erratum in: Lancet. 2016 Jul 23;388(10042):342.


Creatine kinase enzyme level correlates positively with serum creatinine and lean body mass, and is a prognostic factor for survival in amyotrophic lateral sclerosis.

Rafiq MK, Lee E, Bradburn M, McDermott CJ, Shaw PJ.

Eur J Neurol. 2016 Jun;23(6):1071-8. doi: 10.1111/ene.12995. Epub 2016 Mar 31.


Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis.

Maguire C, Cantrill H, Hind D, Bradburn M, Everard ML.

BMC Pulm Med. 2015 Nov 23;15:148. doi: 10.1186/s12890-015-0140-x. Review.


Development and validation of a score to identify in the Emergency Department patients who may benefit from a time-critical intervention: a cohort study.

Challen K, Bradburn M, Goodacre SW.

Scand J Trauma Resusc Emerg Med. 2015 Sep 17;23:67. doi: 10.1186/s13049-015-0150-y.


Saline in acute bronchiolitis RCT and economic evaluation: hypertonic saline in acute bronchiolitis - randomised controlled trial and systematic review.

Everard ML, Hind D, Ugonna K, Freeman J, Bradburn M, Dixon S, Maguire C, Cantrill H, Alexander J, Lenney W, McNamara P, Elphick H, Chetcuti PA, Moya EF, Powell C, Garside JP, Chadha LK, Kurian M, Lehal RS, MacFarlane PI, Cooper CL, Cross E.

Health Technol Assess. 2015 Aug;19(66):1-130. doi: 10.3310/hta19660.


Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial.

Rafiq MK, Lee E, Bradburn M, McDermott CJ, Shaw PJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):478-84. doi: 10.3109/21678421.2015.1062517. Epub 2015 Jul 10.


A preliminary randomized trial of the mechanical insufflator-exsufflator versus breath-stacking technique in patients with amyotrophic lateral sclerosis.

Rafiq MK, Bradburn M, Proctor AR, Billings CG, Bianchi S, McDermott CJ, Shaw PJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):448-55. doi: 10.3109/21678421.2015.1051992. Epub 2015 Jul 3.


The use of an acellular porcine dermal collagen implant in the repair of complex abdominal wall defects: a European multicentre retrospective study.

Giordano P, Pullan RD, Ystgaard B, Gossetti F, Bradburn M, McKinley AJ, Smart NJ, Daniels IR.

Tech Coloproctol. 2015 Jul;19(7):411-7. doi: 10.1007/s10151-015-1307-4. Epub 2015 Jun 17.


Secondary analysis and literature review of community rehabilitation and intermediate care: an information resource.

Ariss SM, Enderby PM, Smith T, Nancarrow SA, Bradburn MJ, Harrop D, Parker SG, McDonnell A, Dixon S, Ryan T, Hayman A, Campbell M.

Southampton (UK): NIHR Journals Library; 2015 Jan.


Antenatal diagnosis of agenesis of the corpus callosum.

Craven I, Bradburn MJ, Griffiths PD.

Clin Radiol. 2015 Mar;70(3):248-53. doi: 10.1016/j.crad.2014.11.004. Epub 2014 Dec 12.


A rapid review indicated higher recruitment rates in treatment trials than in prevention trials.

Cooper CL, Hind D, Duncan R, Walters S, Lartey A, Lee E, Bradburn M.

J Clin Epidemiol. 2015 Mar;68(3):347-54. doi: 10.1016/j.jclinepi.2014.10.007. Epub 2014 Dec 6. Review.

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