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Items: 1 to 50 of 57

1.

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.

Khan KH, Cunningham D, Werner B, Vlachogiannis G, Spiteri I, Heide T, Mateos JF, Vatsiou A, Lampis A, Darvish Damavandi M, Lote H, Huntingford IS, Hedayat S, Chau I, Tunariu N, Mentrasti G, Trevisani F, Rao S, Anandappa G, Watkins D, Starling N, Thomas J, Peckitt C, Khan N, Rugge M, Begum R, Hezelova B, Bryant A, Jones T, Proszek P, Fassan M, Hahne JC, Hubank M, Braconi C, Sottoriva A, Valeri N.

Cancer Discov. 2018 Aug 30. doi: 10.1158/2159-8290.CD-17-0891. [Epub ahead of print]

PMID:
30166348
2.

NS1 codon usage adaptation to humans in pandemic Zika virus.

Freire CCM, Palmisano G, Braconi CT, Cugola FR, Russo FB, Beltrão-Braga PC, Iamarino A, Lima Neto DF, Sall AA, Rosa-Fernandes L, Larsen MR, Zanotto PMA.

Mem Inst Oswaldo Cruz. 2018 May 10;113(5):e170385. doi: 10.1590/0074-02760170385.

3.

MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions.

Saraggi D, Galuppini F, Fanelli GN, Remo A, Urso EDL, Bao RQ, Bacchin D, Guzzardo V, Luchini C, Braconi C, Farinati F, Rugge M, Fassan M.

Pathol Res Pract. 2018 Jun;214(6):835-839. doi: 10.1016/j.prp.2018.04.018. Epub 2018 May 1.

PMID:
29731265
4.

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández-Mateos J, Khan K, Lampis A, Eason K, Huntingford I, Burke R, Rata M, Koh DM, Tunariu N, Collins D, Hulkki-Wilson S, Ragulan C, Spiteri I, Moorcraft SY, Chau I, Rao S, Watkins D, Fotiadis N, Bali M, Darvish-Damavandi M, Lote H, Eltahir Z, Smyth EC, Begum R, Clarke PA, Hahne JC, Dowsett M, de Bono J, Workman P, Sadanandam A, Fassan M, Sansom OJ, Eccles S, Starling N, Braconi C, Sottoriva A, Robinson SP, Cunningham D, Valeri N.

Science. 2018 Feb 23;359(6378):920-926. doi: 10.1126/science.aao2774.

5.

Characterisation of Zika virus infection in primary human astrocytes.

Stefanik M, Formanova P, Bily T, Vancova M, Eyer L, Palus M, Salat J, Braconi CT, Zanotto PMA, Gould EA, Ruzek D.

BMC Neurosci. 2018 Feb 20;19(1):5. doi: 10.1186/s12868-018-0407-2.

6.

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.

Sclafani F, Chau I, Cunningham D, Hahne JC, Vlachogiannis G, Eltahir Z, Lampis A, Braconi C, Kalaitzaki E, De Castro DG, Wotherspoon A, Capdevila J, Glimelius B, Tarazona N, Begum R, Lote H, Hulkki Wilson S, Mentrasti G, Brown G, Tait D, Oates J, Valeri N.

Sci Rep. 2018 Jan 23;8(1):1445. doi: 10.1038/s41598-018-19212-5.

7.

Investigating the feasibility of tumour molecular profiling in gastrointestinal malignancies in routine clinical practice.

Moorcraft SY, Gonzalez de Castro D, Cunningham D, Jones T, Walker BA, Peckitt C, Yuan LC, Frampton M, Begum R, Eltahir Z, Wotherspoon A, Teixeira Mendes LS, Hulkki Wilson S, Gillbanks A, Baratelli C, Fotiadis N, Patel A, Braconi C, Valeri N, Gerlinger M, Rao S, Watkins D, Chau I, Starling N.

Ann Oncol. 2018 Jan 1;29(1):230-236. doi: 10.1093/annonc/mdx631.

PMID:
29361134
8.

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, Clarke P, Bosma E, Simbolo M, Scarpa A, Yu S, Cole R, Smyth E, Mateos JF, Begum R, Hezelova B, Eltahir Z, Wotherspoon A, Fotiadis N, Bali MA, Nepal C, Khan K, Stubbs M, Hahne JC, Gasparini P, Guzzardo V, Croce CM, Eccles S, Fassan M, Cunningham D, Andersen JB, Workman P, Valeri N, Braconi C.

Gastroenterology. 2018 Mar;154(4):1066-1079.e5. doi: 10.1053/j.gastro.2017.10.043. Epub 2017 Nov 4.

9.

Characterisation of the immune-related transcriptome in resected biliary tract cancers.

Ghidini M, Cascione L, Carotenuto P, Lampis A, Trevisani F, Previdi MC, Hahne JC, Said-Huntingford I, Raj M, Zerbi A, Mescoli C, Cillo U, Rugge M, Roncalli M, Torzilli G, Rimassa L, Santoro A, Valeri N, Fassan M, Braconi C.

Eur J Cancer. 2017 Nov;86:158-165. doi: 10.1016/j.ejca.2017.09.005. Epub 2017 Oct 6.

10.

Emerging molecular targets and therapy for cholangiocarcinoma.

Kayhanian H, Smyth EC, Braconi C.

World J Gastrointest Oncol. 2017 Jul 15;9(7):268-280. doi: 10.4251/wjgo.v9.i7.268. Review.

11.

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study.

Khan K, Rata M, Cunningham D, Koh DM, Tunariu N, Hahne JC, Vlachogiannis G, Hedayat S, Marchetti S, Lampis A, Damavandi MD, Lote H, Rana I, Williams A, Eccles SA, Fontana E, Collins D, Eltahir Z, Rao S, Watkins D, Starling N, Thomas J, Kalaitzaki E, Fotiadis N, Begum R, Bali M, Rugge M, Temple E, Fassan M, Chau I, Braconi C, Valeri N.

Gut. 2018 Aug;67(8):1484-1492. doi: 10.1136/gutjnl-2017-314178. Epub 2017 Aug 8.

12.

Adjuvant chemotherapy for resected biliary tract cancers: a systematic review and meta-analysis.

Ghidini M, Tomasello G, Botticelli A, Barni S, Zabbialini G, Seghezzi S, Passalacqua R, Braconi C, Petrelli F.

HPB (Oxford). 2017 Sep;19(9):741-748. doi: 10.1016/j.hpb.2017.05.010. Epub 2017 Jul 3. Review.

13.

Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells.

Pepe F, Pagotto S, Soliman S, Rossi C, Lanuti P, Braconi C, Mariani-Costantini R, Visone R, Veronese A.

Oncogenesis. 2017 May 8;6(5):e328. doi: 10.1038/oncsis.2017.35.

14.

Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.

Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M, Bose N, Simbolo M, Mafficini A, Lampis A, Hahne JC, Trevisani F, Eltahir Z, Mentrasti G, Findlay C, Kalkman EAJ, Punta M, Werner B, Lise S, Aktipis A, Maley C, Greaves M, Braconi C, White J, Fassan M, Scarpa A, Sottoriva A, Valeri N.

Ann Oncol. 2017 Jun 1;28(6):1243-1249. doi: 10.1093/annonc/mdx074.

15.

Sorafenib for the Treatment of Advanced Hepatocellular Cancer - a UK Audit.

King J, Palmer DH, Johnson P, Ross P, Hubner RA, Sumpter K, Darby S, Braconi C, Iwuji C, Swinson D, Collins P, Patel K, Nobes J, Muazzam I, Blesing C, Kirkwood A, Nash S, Meyer T.

Clin Oncol (R Coll Radiol). 2017 Apr;29(4):256-262. doi: 10.1016/j.clon.2016.11.012. Epub 2016 Dec 10.

PMID:
27964898
16.

Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?

Previdi MC, Carotenuto P, Zito D, Pandolfo R, Braconi C.

Future Oncol. 2017 Feb;13(5):443-453. doi: 10.2217/fon-2016-0253. Epub 2016 Nov 14. Review.

17.

MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma.

Trevisani F, Ghidini M, Larcher A, Lampis A, Lote H, Manunta P, Alibrandi MT, Zagato L, Citterio L, Dell'Antonio G, Carenzi C, Capasso G, Rugge M, Rigotti P, Bertini R, Cascione L, Briganti A, Salonia A, Benigni F, Braconi C, Fassan M, Hahne JC, Montorsi F, Valeri N.

Br J Cancer. 2016 Nov 22;115(11):1343-1350. doi: 10.1038/bjc.2016.329. Epub 2016 Nov 1.

18.

Prolonged Shedding of Zika Virus Associated with Congenital Infection.

Oliveira DB, Almeida FJ, Durigon EL, Mendes ÉA, Braconi CT, Marchetti I, Andreata-Santos R, Cunha MP, Alves RP, Pereira LR, Melo SR, Neto DF, Mesquita FS, Araujo DB, Favoretto SR, Sáfadi MA, Ferreira LC, Zanotto PM, Botosso VF, Berezin EN.

N Engl J Med. 2016 Sep 22;375(12):1202-4. doi: 10.1056/NEJMc1607583. Epub 2016 Aug 24. No abstract available.

19.

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, Hahne JC, Ridgway R, Jamieson T, Athineos D, Veronese A, Visone R, Murgia C, Ferrari G, Guzzardo V, Evans TRJ, MacLeod M, Feng GJ, Dale T, Negrini M, Forbes SJ, Terracciano L, Scarpa A, Patel T, Valeri N, Workman P, Sansom O, Braconi C.

Gut. 2017 Jul;66(7):1268-1277. doi: 10.1136/gutjnl-2016-312278. Epub 2016 Sep 12.

20.

Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.

Sclafani F, Chau I, Cunningham D, Lampis A, Hahne JC, Ghidini M, Lote H, Zito D, Tabernero J, Glimelius B, Cervantes A, Begum R, De Castro DG, Wilson SH, Peckitt C, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Braconi C, Valeri N.

Carcinogenesis. 2016 Sep;37(9):852-7. doi: 10.1093/carcin/bgw073. Epub 2016 Jul 5.

21.

Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial.

Smyth EC, Fassan M, Cunningham D, Allum WH, Okines AF, Lampis A, Hahne JC, Rugge M, Peckitt C, Nankivell M, Langley R, Ghidini M, Braconi C, Wotherspoon A, Grabsch HI, Valeri N.

J Clin Oncol. 2016 Aug 10;34(23):2721-7. doi: 10.1200/JCO.2015.65.7692. Epub 2016 Jun 13.

22.

The Brazilian Zika virus strain causes birth defects in experimental models.

Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltrão-Braga PC.

Nature. 2016 Jun 9;534(7606):267-71. doi: 10.1038/nature18296. Epub 2016 May 11.

23.

Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma.

Lupini L, Pepe F, Ferracin M, Braconi C, Callegari E, Pagotto S, Spizzo R, Zagatti B, Lanuti P, Fornari F, Ghasemi R, Mariani-Costantini R, Bolondi L, Gramantieri L, Calin GA, Sabbioni S, Visone R, Veronese A, Negrini M.

Oncotarget. 2016 May 24;7(21):31361-71. doi: 10.18632/oncotarget.8913.

24.

miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial.

Khan K, Cunningham D, Peckitt C, Barton S, Tait D, Hawkins M, Watkins D, Starling N, Rao S, Begum R, Thomas J, Oates J, Guzzardo V, Fassan M, Braconi C, Chau I.

Oncotarget. 2016 Mar 15;7(11):12672-81. doi: 10.18632/oncotarget.7208.

25.

The Pangenome of the Anticarsia gemmatalis Multiple Nucleopolyhedrovirus (AgMNPV).

Brito AF, Braconi CT, Weidmann M, Dilcher M, Alves JM, Gruber A, Zanotto PM.

Genome Biol Evol. 2015 Nov 27;8(1):94-108. doi: 10.1093/gbe/evv231.

26.

Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial.

Sclafani F, Chau I, Cunningham D, Peckitt C, Lampis A, Hahne JC, Braconi C, Tabernero J, Glimelius B, Cervantes A, Begum R, Gonzalez De Castro D, Hulkki Wilson S, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Valeri N.

Ann Oncol. 2015 Sep;26(9):1936-41. doi: 10.1093/annonc/mdv285. Epub 2015 Jul 10.

27.

Non-Coding RNAs in Primary Liver Cancer.

Ghidini M, Braconi C.

Front Med (Lausanne). 2015 Jun 4;2:36. doi: 10.3389/fmed.2015.00036. eCollection 2015. Review.

28.

KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.

Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Braconi C, Bordoni A, Magnusson MK, Sufliarsky J, Federico M, Jonasson JG, Hostein I, Bringuier PP, Emile JF.

J Clin Oncol. 2015 Feb 20;33(6):634-42. doi: 10.1200/JCO.2014.57.4970. Epub 2015 Jan 20.

PMID:
25605837
29.

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis.

Fassan M, Dall'Olmo L, Galasso M, Braconi C, Pizzi M, Realdon S, Volinia S, Valeri N, Gasparini P, Baffa R, Souza RF, Vicentini C, D'Angelo E, Bornschein J, Nuovo GJ, Zaninotto G, Croce CM, Rugge M.

Oncotarget. 2014 Aug 30;5(16):7162-71.

30.

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.

Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.

31.

Proteomic analyses of baculovirus Anticarsia gemmatalis multiple nucleopolyhedrovirus budded and occluded virus.

Braconi CT, Ardisson-Araújo DM, Paes Leme AF, Oliveira JV, Pauletti BA, Garcia-Maruniak A, Ribeiro BM, Maruniak JE, Zanotto PM.

J Gen Virol. 2014 Apr;95(Pt 4):980-9. doi: 10.1099/vir.0.061127-0. Epub 2014 Jan 17.

PMID:
24443474
32.

Modularity and evolutionary constraints in a baculovirus gene regulatory network.

Oliveira JV, de Brito AF, Braconi CT, de Melo Freire CC, Iamarino A, de Andrade Zanotto PM.

BMC Syst Biol. 2013 Sep 4;7:87. doi: 10.1186/1752-0509-7-87.

33.

Non-coding RNAs as therapeutic targets in hepatocellular cancer.

Braconi C, Patel T.

Curr Cancer Drug Targets. 2012 Nov 1;12(9):1073-80. Review.

34.

BF integrase genes of HIV-1 circulating in São Paulo, Brazil, with a recurrent recombination region.

Iamarino A, de Melo FL, Braconi CT, Zanotto PM.

PLoS One. 2012;7(4):e34324. doi: 10.1371/journal.pone.0034324. Epub 2012 Apr 2.

35.

Hepatic miR-29ab1 expression modulates chronic hepatic injury.

Kogure T, Costinean S, Yan I, Braconi C, Croce C, Patel T.

J Cell Mol Med. 2012 Nov;16(11):2647-54. doi: 10.1111/j.1582-4934.2012.01578.x.

36.

Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts.

Joensuu H, Vehtari A, Riihimäki J, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Cirilli C, Braconi C, Bordoni A, Magnusson MK, Linke Z, Sufliarsky J, Federico M, Jonasson JG, Dei Tos AP, Rutkowski P.

Lancet Oncol. 2012 Mar;13(3):265-74. doi: 10.1016/S1470-2045(11)70299-6. Epub 2011 Dec 6. Review.

PMID:
22153892
37.

The role of microRNAs in human liver cancers.

Braconi C, Henry JC, Kogure T, Schmittgen T, Patel T.

Semin Oncol. 2011 Dec;38(6):752-63. doi: 10.1053/j.seminoncol.2011.08.001. Review.

38.

Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth.

Kogure T, Lin WL, Yan IK, Braconi C, Patel T.

Hepatology. 2011 Oct;54(4):1237-48. doi: 10.1002/hep.24504. Epub 2011 Jul 29.

39.

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.

Braconi C, Kogure T, Valeri N, Huang N, Nuovo G, Costinean S, Negrini M, Miotto E, Croce CM, Patel T.

Oncogene. 2011 Nov 24;30(47):4750-6. doi: 10.1038/onc.2011.193. Epub 2011 May 30.

40.

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma.

Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM, Patel T.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):786-91. doi: 10.1073/pnas.1011098108. Epub 2010 Dec 27.

41.

Targeting the IL-6 dependent phenotype can identify novel therapies for cholangiocarcinoma.

Braconi C, Swenson E, Kogure T, Huang N, Patel T.

PLoS One. 2010 Dec 16;5(12):e15195. doi: 10.1371/journal.pone.0015195.

42.

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).

Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103. doi: 10.1073/pnas.1015541107. Epub 2010 Nov 15.

43.

Cholangiocarcinoma: new insights into disease pathogenesis and biology.

Braconi C, Patel T.

Infect Dis Clin North Am. 2010 Dec;24(4):871-84, vii. doi: 10.1016/j.idc.2010.07.006. Review.

44.

Modulation of mismatch repair and genomic stability by miR-155.

Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6982-7. doi: 10.1073/pnas.1002472107. Epub 2010 Mar 29.

45.
46.

Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes.

Braconi C, Valeri N, Gasparini P, Huang N, Taccioli C, Nuovo G, Suzuki T, Croce CM, Patel T.

Clin Cancer Res. 2010 Feb 1;16(3):957-66. doi: 10.1158/1078-0432.CCR-09-2123. Epub 2010 Jan 26.

47.

Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures.

Braconi C, Meng F, Swenson E, Khrapenko L, Huang N, Patel T.

Cancer. 2009 Aug 15;115(16):3738-48. doi: 10.1002/cncr.24417.

48.

Hantavirus pulmonary syndrome, central plateau, southeastern, and southern Brazil.

Figueiredo LT, Moreli ML, de-Sousa RL, Borges AA, de-Figueiredo GG, Machado AM, Bisordi I, Nagasse-Sugahara TK, Suzuki A, Pereira LE, de-Souza RP, de-Souza LT, Braconi CT, Harsi CM, de-Andrade-Zanotto PM; Viral Diversity Genetic Network Consortium.

Emerg Infect Dis. 2009 Apr;15(4):561-7. doi: 10.3201/eid1504.080289.

49.

Epigallocatechin-gallate modulates chemotherapy-induced apoptosis in human cholangiocarcinoma cells.

Lang M, Henson R, Braconi C, Patel T.

Liver Int. 2009 May;29(5):670-7. doi: 10.1111/j.1478-3231.2009.01984.x. Epub 2009 Feb 17.

50.

Molecular targets in Gastrointestinal Stromal Tumors (GIST) therapy.

Braconi C, Bracci R, Cellerino R.

Curr Cancer Drug Targets. 2008 Aug;8(5):359-66. Review.

PMID:
18690842

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