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Items: 42

1.

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities.

Carson M, Keppler JK, Brackman G, Dawood D, Vandrovcova M, Fawzy El-Sayed K, Coenye T, Schwarz K, Clarke SA, Skirtach AG, Douglas TEL.

Cells Tissues Organs. 2018;206(1-2):106-118. doi: 10.1159/000494732. Epub 2019 Jan 24.

PMID:
30677765
2.

Novel injectable gellan gum hydrogel composites incorporating Zn- and Sr-enriched bioactive glass microparticles: High-resolution X-ray microcomputed tomography, antibacterial and in vitro testing.

Douglas TEL, Dziadek M, Gorodzha S, Lišková J, Brackman G, Vanhoorne V, Vervaet C, Balcaen L, Del Rosario Florez Garcia M, Boccaccini AR, Weinhardt V, Baumbach T, Vanhaecke F, Coenye T, Bačáková L, Surmeneva MA, Surmenev RA, Cholewa-Kowalska K, Skirtach AG.

J Tissue Eng Regen Med. 2018 Jun;12(6):1313-1326. doi: 10.1002/term.2654. Epub 2018 Apr 23.

PMID:
29489058
3.

Elucidation of the mechanism behind the potentiating activity of baicalin against Burkholderia cenocepacia biofilms.

Slachmuylders L, Van Acker H, Brackman G, Sass A, Van Nieuwerburgh F, Coenye T.

PLoS One. 2018 Jan 2;13(1):e0190533. doi: 10.1371/journal.pone.0190533. eCollection 2018.

4.
5.

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.

Van den Driessche F, Vanhoutte B, Brackman G, Crabbé A, Rigole P, Vercruysse J, Verstraete G, Cappoen D, Vervaet C, Cos P, Coenye T.

PLoS One. 2017 Mar 1;12(3):e0172723. doi: 10.1371/journal.pone.0172723. eCollection 2017.

6.

Ca:Mg:Zn:CO3 and Ca:Mg:CO3-tri- and bi-elemental carbonate microparticles for novel injectable self-gelling hydrogel-microparticle composites for tissue regeneration.

Douglas TEL, Sobczyk K, Łapa A, Włodarczyk K, Brackman G, Vidiasheva I, Reczyńska K, Pietryga K, Schaubroeck D, Bliznuk V, Voort PV, Declercq HA, Bulcke JVD, Samal SK, Khalenkow D, Parakhonskiy BV, Van Acker J, Coenye T, Lewandowska-Szumieł M, Pamuła E, Skirtach AG.

Biomed Mater. 2017 Mar 24;12(2):025015. doi: 10.1088/1748-605X/aa6200.

PMID:
28223552
7.

Screening a repurposing library for potentiators of antibiotics against Staphylococcus aureus biofilms.

Van den Driessche F, Brackman G, Swimberghe R, Rigole P, Coenye T.

Int J Antimicrob Agents. 2017 Mar;49(3):315-320. doi: 10.1016/j.ijantimicag.2016.11.023. Epub 2017 Jan 31.

PMID:
28159655
8.

Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach.

Vermote A, Brackman G, Risseeuw MD, Cappoen D, Cos P, Coenye T, Van Calenbergh S.

ACS Med Chem Lett. 2016 Nov 9;8(1):38-42. doi: 10.1021/acsmedchemlett.6b00315. eCollection 2017 Jan 12.

9.

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections-A scaffold hopping approach.

Vermote A, Brackman G, Risseeuw MDP, Coenye T, Van Calenbergh S.

Eur J Med Chem. 2017 Feb 15;127:757-770. doi: 10.1016/j.ejmech.2016.10.056. Epub 2016 Oct 26.

PMID:
27823882
10.

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo.

Scoffone VC, Chiarelli LR, Makarov V, Brackman G, Israyilova A, Azzalin A, Forneris F, Riabova O, Savina S, Coenye T, Riccardi G, Buroni S.

Sci Rep. 2016 Sep 1;6:32487. doi: 10.1038/srep32487.

11.

Enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich Ecklonia cava extract Seanol(®) to endow antibacterial properties and promote mineralization.

Douglas TE, Dokupil A, Reczyńska K, Brackman G, Krok-Borkowicz M, Keppler JK, Božič M, Van Der Voort P, Pietryga K, Samal SK, Balcaen L, van den Bulcke J, Van Acker J, Vanhaecke F, Schwarz K, Coenye T, Pamuła E.

Biomed Mater. 2016 Aug 10;11(4):045015. doi: 10.1088/1748-6041/11/4/045015.

PMID:
27509486
12.

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections.

Vermote A, Brackman G, Risseeuw MDP, Coenye T, Van Calenbergh S.

Bioorg Med Chem. 2016 Oct 1;24(19):4563-4575. doi: 10.1016/j.bmc.2016.07.058. Epub 2016 Jul 28.

PMID:
27507109
13.

Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus.

Vermote A, Brackman G, Risseeuw MD, Vanhoutte B, Cos P, Van Hecke K, Breyne K, Meyer E, Coenye T, Van Calenbergh S.

Angew Chem Int Ed Engl. 2016 May 23;55(22):6551-5. doi: 10.1002/anie.201601973. Epub 2016 Apr 20.

PMID:
27095479
14.

Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities.

Brackman G, Garcia-Fernandez MJ, Lenoir J, De Meyer L, Remon JP, De Beer T, Concheiro A, Alvarez-Lorenzo C, Coenye T.

Macromol Biosci. 2016 Jun;16(6):859-69. doi: 10.1002/mabi.201500437. Epub 2016 Feb 18.

PMID:
26891369
15.

The Quorum Sensing Inhibitor Hamamelitannin Increases Antibiotic Susceptibility of Staphylococcus aureus Biofilms by Affecting Peptidoglycan Biosynthesis and eDNA Release.

Brackman G, Breyne K, De Rycke R, Vermote A, Van Nieuwerburgh F, Meyer E, Van Calenbergh S, Coenye T.

Sci Rep. 2016 Feb 1;6:20321. doi: 10.1038/srep20321.

16.

In Vitro and In Vivo Biofilm Wound Models and Their Application.

Brackman G, Coenye T.

Adv Exp Med Biol. 2016;897:15-32. doi: 10.1007/5584_2015_5002. Review.

PMID:
26563304
17.

Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains.

Cullen L, Weiser R, Olszak T, Maldonado RF, Moreira AS, Slachmuylders L, Brackman G, Paunova-Krasteva TS, Zarnowiec P, Czerwonka G, Reilly J, Drevinek P, Kaca W, Melter O, De Soyza A, Perry A, Winstanley C, Stoitsova SR, Lavigne R, Mahenthiralingam E, Sá-Correia I, Coenye T, Drulis-Kawa Z, Augustyniak D, Valvano MA, McClean S.

Microbiology. 2015 Oct;161(10):1961-77. doi: 10.1099/mic.0.000155. Epub 2015 Aug 6.

PMID:
26253522
18.

Composites of gellan gum hydrogel enzymatically mineralized with calcium-zinc phosphate for bone regeneration with antibacterial activity.

Douglas TEL, Pilarz M, Lopez-Heredia M, Brackman G, Schaubroeck D, Balcaen L, Bliznuk V, Dubruel P, Knabe-Ducheyne C, Vanhaecke F, Coenye T, Pamula E.

J Tissue Eng Regen Med. 2017 May;11(5):1610-1618. doi: 10.1002/term.2062. Epub 2015 Jul 15.

PMID:
26174042
19.

Inhibition of Quorum Sensing in Staphylococcus spp.

Brackman G, Coenye T.

Curr Pharm Des. 2015;21(16):2101-8. Review.

PMID:
25760342
20.

D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections.

de la Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, Hernández D, Brackman G, Coenye T, Hancock RE.

Chem Biol. 2015 Feb 19;22(2):196-205. doi: 10.1016/j.chembiol.2015.01.002. Erratum in: Chem Biol. 2015 Sep 17;22(9):1280-2.

21.

MomL, a novel marine-derived N-acyl homoserine lactonase from Muricauda olearia.

Tang K, Su Y, Brackman G, Cui F, Zhang Y, Shi X, Coenye T, Zhang XH.

Appl Environ Microbiol. 2015 Jan;81(2):774-82. doi: 10.1128/AEM.02805-14. Epub 2014 Nov 14.

22.

Quorum sensing inhibitors as anti-biofilm agents.

Brackman G, Coenye T.

Curr Pharm Des. 2015;21(1):5-11. Review.

PMID:
25189863
23.

Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioglasses.

Douglas TE, Piwowarczyk W, Pamula E, Liskova J, Schaubroeck D, Leeuwenburgh SC, Brackman G, Balcaen L, Detsch R, Declercq H, Cholewa-Kowalska K, Dokupil A, Cuijpers VM, Vanhaecke F, Cornelissen R, Coenye T, Boccaccini AR, Dubruel P.

Biomed Mater. 2014 Aug;9(4):045014. doi: 10.1088/1748-6041/9/4/045014. Epub 2014 Jul 25.

PMID:
25065649
24.

Materials with fungi-bioinspired surface for efficient binding and fungi-sensitive release of antifungal agents.

Segura T, Puga AM, Burillo G, Llovo J, Brackman G, Coenye T, Concheiro A, Alvarez-Lorenzo C.

Biomacromolecules. 2014 May 12;15(5):1860-70. doi: 10.1021/bm500257s. Epub 2014 Apr 21.

PMID:
24712760
25.

Optimization of resazurin-based viability staining for quantification of microbial biofilms.

Van den Driessche F, Rigole P, Brackman G, Coenye T.

J Microbiol Methods. 2014 Mar;98:31-4. doi: 10.1016/j.mimet.2013.12.011. Epub 2013 Dec 21.

PMID:
24365109
26.

Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms.

Brackman G, Forier K, Al Quntar AA, De Canck E, Enk CD, Srebnik M, Braeckmans K, Coenye T.

J Appl Microbiol. 2014 Mar;116(3):492-501. doi: 10.1111/jam.12378. Epub 2013 Nov 20.

27.

Quorum sensing inhibitors: how strong is the evidence?

Defoirdt T, Brackman G, Coenye T.

Trends Microbiol. 2013 Dec;21(12):619-24. doi: 10.1016/j.tim.2013.09.006. Epub 2013 Oct 11. Review.

PMID:
24126008
28.
29.

Biofilm inhibitory and eradicating activity of wound care products against Staphylococcus aureus and Staphylococcus epidermidis biofilms in an in vitro chronic wound model.

Brackman G, De Meyer L, Nelis HJ, Coenye T.

J Appl Microbiol. 2013 Jun;114(6):1833-42. doi: 10.1111/jam.12191. Epub 2013 Apr 4.

30.

Antiseptic cyclodextrin-functionalized hydrogels and gauzes for loading and delivery of benzalkonium chloride.

Garcia-Fernandez MJ, Brackman G, Coenye T, Concheiro A, Alvarez-Lorenzo C.

Biofouling. 2013;29(3):261-71. doi: 10.1080/08927014.2013.765947.

PMID:
23439005
31.

Phenotypic and genotypic characterisation of Burkholderia cenocepacia J2315 mutants affected in homoserine lactone and diffusible signal factor-based quorum sensing systems suggests interplay between both types of systems.

Udine C, Brackman G, Bazzini S, Buroni S, Van Acker H, Pasca MR, Riccardi G, Coenye T.

PLoS One. 2013;8(1):e55112. doi: 10.1371/journal.pone.0055112. Epub 2013 Jan 28.

32.

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi.

Brackman G, Al Quntar AA, Enk CD, Karalic I, Nelis HJ, Van Calenbergh S, Srebnik M, Coenye T.

Bioorg Med Chem. 2013 Feb 1;21(3):660-7. doi: 10.1016/j.bmc.2012.11.055. Epub 2012 Dec 11. Erratum in: Bioorg Med Chem. 2013 May 1;21(9):2671.

PMID:
23286963
33.

A quorum sensing-disrupting brominated thiophenone with a promising therapeutic potential to treat luminescent vibriosis.

Defoirdt T, Benneche T, Brackman G, Coenye T, Sorgeloos P, Scheie AA.

PLoS One. 2012;7(7):e41788. doi: 10.1371/journal.pone.0041788. Epub 2012 Jul 25.

34.

Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones.

Brackman G, Risseeuw M, Celen S, Cos P, Maes L, Nelis HJ, Van Calenbergh S, Coenye T.

Bioorg Med Chem. 2012 Aug 1;20(15):4737-43. doi: 10.1016/j.bmc.2012.06.009. Epub 2012 Jun 9.

PMID:
22748377
35.

Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds.

Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.

Phytomedicine. 2012 Mar 15;19(5):409-12. doi: 10.1016/j.phymed.2011.10.005. Epub 2012 Feb 2.

PMID:
22305279
36.

Isolation and identification of quorum quenching bacteria from environmental samples.

Christiaen SE, Brackman G, Nelis HJ, Coenye T.

J Microbiol Methods. 2011 Nov;87(2):213-9. doi: 10.1016/j.mimet.2011.08.002. Epub 2011 Aug 12.

PMID:
21856341
37.

Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.

Brackman G, Cos P, Maes L, Nelis HJ, Coenye T.

Antimicrob Agents Chemother. 2011 Jun;55(6):2655-61. doi: 10.1128/AAC.00045-11. Epub 2011 Mar 21.

38.

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp.

Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, Nelis HJ, Coenye T.

PLoS One. 2011 Jan 13;6(1):e16084. doi: 10.1371/journal.pone.0016084.

39.

Biofilm inhibition and drug-eluting properties of novel DMAEMA-modified polyethylene and silicone rubber surfaces.

Contreras-García A, Bucio E, Brackman G, Coenye T, Concheiro A, Alvarez-Lorenzo C.

Biofouling. 2011 Feb;27(2):123-35. doi: 10.1080/08927014.2010.548115.

PMID:
21213154
40.

AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ.

Brackman G, Celen S, Baruah K, Bossier P, Van Calenbergh S, Nelis HJ, Coenye T.

Microbiology. 2009 Dec;155(Pt 12):4114-22. doi: 10.1099/mic.0.032474-0. Epub 2009 Sep 24.

PMID:
19778962
41.

Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia.

Brackman G, Hillaert U, Van Calenbergh S, Nelis HJ, Coenye T.

Res Microbiol. 2009 Mar;160(2):144-51. doi: 10.1016/j.resmic.2008.12.003. Epub 2008 Dec 31.

PMID:
19146953
42.

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR.

Brackman G, Defoirdt T, Miyamoto C, Bossier P, Van Calenbergh S, Nelis H, Coenye T.

BMC Microbiol. 2008 Sep 16;8:149. doi: 10.1186/1471-2180-8-149.

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