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GDF-15 in Pulmonary and Critical Care Medicine.

Verhamme FM, Freeman CM, Brusselle GG, Bracke KR, Curtis JL.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):621-628. doi: 10.1165/rcmb.2018-0379TR.


Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation.

Verhamme FM, De Smet EG, Van Hooste W, Delanghe J, Verleden SE, Joos GF, Brusselle GG, Bracke KR.

Mucosal Immunol. 2019 Mar;12(2):340-351. doi: 10.1038/s41385-018-0116-2. Epub 2018 Dec 12.


Heritability and genome-wide association study of diffusing capacity of the lung.

Terzikhan N, Sun F, Verhamme FM, Adams HHH, Loth D, Bracke KR, Stricker BHC, Lahousse L, Dupuis J, Brusselle GG, O'Connor GT.

Eur Respir J. 2018 Sep 15;52(3). pii: 1800647. doi: 10.1183/13993003.00647-2018. Print 2018 Sep.


Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.

De Smet EG, Seys LJ, Verhamme FM, Vanaudenaerde BM, Brusselle GG, Bingle CD, Bracke KR.

Int J Chron Obstruct Pulmon Dis. 2017 Dec 19;13:11-27. doi: 10.2147/COPD.S144136. eCollection 2018.


Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice.

Raevens S, Geerts A, Paridaens A, Lefere S, Verhelst X, Hoorens A, Van Dorpe J, Maes T, Bracke KR, Casteleyn C, Jonckx B, Horvatits T, Fuhrmann V, Van Vlierberghe H, Van Steenkiste C, Devisscher L, Colle I.

Hepatology. 2018 Aug;68(2):634-651. doi: 10.1002/hep.29579. Epub 2018 May 11.


DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients.

Seys LJM, Widagdo W, Verhamme FM, Kleinjan A, Janssens W, Joos GF, Bracke KR, Haagmans BL, Brusselle GG.

Clin Infect Dis. 2018 Jan 6;66(1):45-53. doi: 10.1093/cid/cix741.


microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Conickx G, Avila Cobos F, van den Berge M, Faiz A, Timens W, Hiemstra PS, Joos GF, Brusselle GG, Mestdagh P, Bracke KR.

Sci Rep. 2017 Oct 9;7(1):12871. doi: 10.1038/s41598-017-13265-8.


MicroRNAs as future therapeutic targets in COPD?

Bracke KR, Mestdagh P.

Eur Respir J. 2017 May 25;49(5). pii: 1700431. doi: 10.1183/13993003.00431-2017. Print 2017 May. No abstract available.


Reply: Direct Detection of Circulating MicroRNAs Unveiled the Absence of MicroRNA-218-5p in Smoker Subjects.

Conickx G, Mestdagh P, Vandesompele J, Brusselle GG, Bracke KR.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):533. doi: 10.1164/rccm.201701-0224LE. No abstract available.


Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):172-185. doi: 10.1164/rccm.201605-0904OC.


Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure.

Verhamme FM, Seys LJM, De Smet EG, Provoost S, Janssens W, Elewaut D, Joos GF, Brusselle GG, Bracke KR.

Mucosal Immunol. 2017 Nov;10(6):1400-1411. doi: 10.1038/mi.2017.3. Epub 2017 Feb 1.


Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Feb;214(2):565. doi: 10.1084/jem.2016067501052017c. Epub 2017 Jan 9. No abstract available.


End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis.

Lammertyn EJ, Vandermeulen E, Bellon H, Everaerts S, Verleden SE, Van Den Eynde K, Bracke KR, Brusselle GG, Goeminne PC, Verbeken EK, Vanaudenaerde BM, Dupont LJ.

Respir Res. 2017 Jan 10;18(1):10. doi: 10.1186/s12931-016-0489-2.


Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Jan;214(1):143-163. doi: 10.1084/jem.20160675. Epub 2016 Dec 15. Erratum in: J Exp Med. 2017 Feb;214(2):565.


Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease.

Konings GFJ, Reynaert NL, Delvoux B, Verhamme FM, Bracke KR, Brusselle GG, Romano A, Vernooy JHJ.

Mol Cell Endocrinol. 2017 Mar 5;443:23-31. doi: 10.1016/j.mce.2016.12.001. Epub 2016 Dec 8.


Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis.

Vandermeulen E, Lammertyn E, Verleden SE, Ruttens D, Bellon H, Ricciardi M, Somers J, Bracke KR, Van Den Eynde K, Tousseyn T, Brusselle GG, Verbeken EK, Verschakelen J, Emonds MP, Van Raemdonck DE, Verleden GM, Vos R, Vanaudenaerde BM.

Transpl Int. 2017 Feb;30(2):134-143. doi: 10.1111/tri.12882. Epub 2016 Dec 8.


B cells in chronic obstructive pulmonary disease: moving to center stage.

Polverino F, Seys LJ, Bracke KR, Owen CA.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. doi: 10.1152/ajplung.00304.2016. Epub 2016 Aug 19. Review.


MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Conickx G, Mestdagh P, Avila Cobos F, Verhamme FM, Maes T, Vanaudenaerde BM, Seys LJ, Lahousse L, Kim RY, Hsu AC, Wark PA, Hansbro PM, Joos GF, Vandesompele J, Bracke KR, Brusselle GG.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):43-56. doi: 10.1164/rccm.201506-1182OC.


Asthma inflammatory phenotypes show differential microRNA expression in sputum.

Maes T, Cobos FA, Schleich F, Sorbello V, Henket M, De Preter K, Bracke KR, Conickx G, Mesnil C, Vandesompele J, Lahousse L, Bureau F, Mestdagh P, Joos GF, Ricciardolo FL, Brusselle GG, Louis R.

J Allergy Clin Immunol. 2016 May;137(5):1433-46. doi: 10.1016/j.jaci.2016.02.018.


Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.

De Grove KC, Provoost S, Verhamme FM, Bracke KR, Joos GF, Maes T, Brusselle GG.

PLoS One. 2016 Jan 4;11(1):e0145961. doi: 10.1371/journal.pone.0145961. eCollection 2016.


The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice.

Allais L, Kumar S, Debusschere K, Verschuere S, Maes T, De Smet R, Conickx G, De Vos M, Laukens D, Joos GF, Brusselle GG, Elewaut D, Cuvelier CA, Bracke KR.

PLoS One. 2015 Nov 2;10(11):e0141570. doi: 10.1371/journal.pone.0141570. eCollection 2015.


MicroRNA miR-22 drives T(H)17 responses in emphysema.

Brusselle GG, Bracke KR.

Nat Immunol. 2015 Nov;16(11):1109-10. doi: 10.1038/ni.3295. No abstract available.


Elucidating COPD pathogenesis by large-scale genetic analyses.

Brusselle GG, Bracke KR.

Lancet Respir Med. 2015 Oct;3(10):737-9. doi: 10.1016/S2213-2600(15)00360-4. Epub 2015 Sep 27. No abstract available.


Role of B Cell-Activating Factor in Chronic Obstructive Pulmonary Disease.

Seys LJ, Verhamme FM, Schinwald A, Hammad H, Cunoosamy DM, Bantsimba-Malanda C, Sabirsh A, McCall E, Flavell L, Herbst R, Provoost S, Lambrecht BN, Joos GF, Brusselle GG, Bracke KR.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):706-18. doi: 10.1164/rccm.201501-0103OC.


Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice.

Seys LJ, Verhamme FM, Dupont LL, Desauter E, Duerr J, Seyhan Agircan A, Conickx G, Joos GF, Brusselle GG, Mall MA, Bracke KR.

PLoS One. 2015 Jun 12;10(6):e0129897. doi: 10.1371/journal.pone.0129897. eCollection 2015.


Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

Allais L, Kerckhof FM, Verschuere S, Bracke KR, De Smet R, Laukens D, Van den Abbeele P, De Vos M, Boon N, Brusselle GG, Cuvelier CA, Van de Wiele T.

Environ Microbiol. 2016 May;18(5):1352-63. doi: 10.1111/1462-2920.12934. Epub 2015 Jul 22.


Non-coding RNAs in the pathogenesis of COPD.

De Smet EG, Mestdagh P, Vandesompele J, Brusselle GG, Bracke KR.

Thorax. 2015 Aug;70(8):782-91. doi: 10.1136/thoraxjnl-2014-206560. Epub 2015 May 20. Review.


Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis.

Lugli EB, Correia RE, Fischer R, Lundberg K, Bracke KR, Montgomery AB, Kessler BM, Brusselle GG, Venables PJ.

Arthritis Res Ther. 2015 Jan 20;17:9. doi: 10.1186/s13075-015-0520-x.


Transforming growth factor-β superfamily in obstructive lung diseases. more suspects than TGF-β alone.

Verhamme FM, Bracke KR, Joos GF, Brusselle GG.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):653-62. doi: 10.1165/rcmb.2014-0282RT. Review.


Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.

Eurlings IM, Reynaert NL, van den Beucken T, Gosker HR, de Theije CC, Verhamme FM, Bracke KR, Wouters EF, Dentener MA.

PLoS One. 2014 Oct 16;9(10):e107757. doi: 10.1371/journal.pone.0107757. eCollection 2014.


A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.

Eurlings IM, Dentener MA, Mercken EM, de Cabo R, Bracke KR, Vernooy JH, Wouters EF, Reynaert NL.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L557-65. doi: 10.1152/ajplung.00116.2014. Epub 2014 Aug 8.


Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases.

Dupont LL, Glynos C, Bracke KR, Brouckaert P, Brusselle GG.

Pulm Pharmacol Ther. 2014 Oct;29(1):1-6. doi: 10.1016/j.pupt.2014.07.004. Epub 2014 Jul 17. Review.


Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Loth DW, Soler Artigas M, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q, Oldmeadow C, Lee MK, Strachan DP, James AL, Huffman JE, Vitart V, Ramasamy A, Wareham NJ, Kaprio J, Wang XQ, Trochet H, Kähönen M, Flexeder C, Albrecht E, Lopez LM, de Jong K, Thyagarajan B, Alves AC, Enroth S, Omenaas E, Joshi PK, Fall T, Viñuela A, Launer LJ, Loehr LR, Fornage M, Li G, Wilk JB, Tang W, Manichaikul A, Lahousse L, Harris TB, North KE, Rudnicka AR, Hui J, Gu X, Lumley T, Wright AF, Hastie ND, Campbell S, Kumar R, Pin I, Scott RA, Pietiläinen KH, Surakka I, Liu Y, Holliday EG, Schulz H, Heinrich J, Davies G, Vonk JM, Wojczynski M, Pouta A, Johansson A, Wild SH, Ingelsson E, Rivadeneira F, Völzke H, Hysi PG, Eiriksdottir G, Morrison AC, Rotter JI, Gao W, Postma DS, White WB, Rich SS, Hofman A, Aspelund T, Couper D, Smith LJ, Psaty BM, Lohman K, Burchard EG, Uitterlinden AG, Garcia M, Joubert BR, McArdle WL, Musk AB, Hansel N, Heckbert SR, Zgaga L, van Meurs JB, Navarro P, Rudan I, Oh YM, Redline S, Jarvis DL, Zhao JH, Rantanen T, O'Connor GT, Ripatti S, Scott RJ, Karrasch S, Grallert H, Gaddis NC, Starr JM, Wijmenga C, Minster RL, Lederer DJ, Pekkanen J, Gyllensten U, Campbell H, Morris AP, Gläser S, Hammond CJ, Burkart KM, Beilby J, Kritchevsky SB, Gudnason V, Hancock DB, Williams OD, Polasek O, Zemunik T, Kolcic I, Petrini MF, Wjst M, Kim WJ, Porteous DJ, Scotland G, Smith BH, Viljanen A, Heliövaara M, Attia JR, Sayers I, Hampel R, Gieger C, Deary IJ, Boezen HM, Newman A, Jarvelin MR, Wilson JF, Lind L, Stricker BH, Teumer A, Spector TD, Melén E, Peters MJ, Lange LA, Barr RG, Bracke KR, Verhamme FM, Sung J, Hiemstra PS, Cassano PA, Sood A, Hayward C, Dupuis J, Hall IP, Brusselle GG, Tobin MD, London SJ.

Nat Genet. 2014 Jul;46(7):669-77. doi: 10.1038/ng.3011. Epub 2014 Jun 15.


Inflammasomes in respiratory disease: from bench to bedside.

Brusselle GG, Provoost S, Bracke KR, Kuchmiy A, Lamkanfi M.

Chest. 2014 May;145(5):1121-1133. doi: 10.1378/chest.13-1885. Review.


Role of activin-A in cigarette smoke-induced inflammation and COPD.

Verhamme FM, Bracke KR, Amatngalim GD, Verleden GM, Van Pottelberge GR, Hiemstra PS, Joos GF, Brusselle GG.

Eur Respir J. 2014 Apr;43(4):1028-41. doi: 10.1183/09031936.00082413. Epub 2013 Nov 14.


Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice.

Dupont LL, Bracke KR, De Maeyer JH, Compan V, Joos GF, Lefebvre RA, Brusselle GG.

Pulm Pharmacol Ther. 2014 Jun;28(1):60-7. doi: 10.1016/j.pupt.2013.10.003. Epub 2013 Oct 31.


Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma.

Brusselle GG, Maes T, Bracke KR.

Nat Med. 2013 Aug;19(8):977-9. doi: 10.1038/nm.3300. No abstract available.


The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease.

Glynos C, Dupont LL, Vassilakopoulos T, Papapetropoulos A, Brouckaert P, Giannis A, Joos GF, Bracke KR, Brusselle GG.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):789-99. doi: 10.1164/rccm.201210-1884OC.


Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease.

Bracke KR, Verhamme FM, Seys LJ, Bantsimba-Malanda C, Cunoosamy DM, Herbst R, Hammad H, Lambrecht BN, Joos GF, Brusselle GG.

Am J Respir Crit Care Med. 2013 Aug 1;188(3):343-55. doi: 10.1164/rccm.201211-2055OC.


Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.

Vernooy JH, Ubags ND, Brusselle GG, Tavernier J, Suratt BT, Joos GF, Wouters EF, Bracke KR.

Pulm Pharmacol Ther. 2013 Aug;26(4):464-72. doi: 10.1016/j.pupt.2013.03.016. Epub 2013 Mar 27. Review.


Altered cigarette smoke-induced lung inflammation due to ablation of Grx1.

Kuipers I, Bracke KR, Brusselle GG, Aesif SW, Krijgsman R, Arts IC, Wouters EF, Reynaert NL.

PLoS One. 2012;7(6):e38984. doi: 10.1371/journal.pone.0038984. Epub 2012 Jun 18.


Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches.

Verschuere S, Allais L, Bracke KR, Lippens S, De Smet R, Vandenabeele P, Brusselle GG, Cuvelier CA.

Histochem Cell Biol. 2012 Mar;137(3):293-301. doi: 10.1007/s00418-011-0902-3. Epub 2011 Dec 24.


Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice.

Kuipers I, Bracke KR, Brusselle GG, Wouters EF, Reynaert NL.

Free Radic Res. 2012 Feb;46(2):164-73. doi: 10.3109/10715762.2011.647011. Epub 2012 Jan 23.


COPD is associated with reduced pulmonary interstitial expression of pentraxin-3.

Van Pottelberge GR, Bracke KR, Pauwels NS, Vermassen FE, Joos GF, Brusselle GG.

Eur Respir J. 2012 Apr;39(4):830-8. doi: 10.1183/09031936.00138110. Epub 2011 Sep 15.


New insights into the immunology of chronic obstructive pulmonary disease.

Brusselle GG, Joos GF, Bracke KR.

Lancet. 2011 Sep 10;378(9795):1015-26. doi: 10.1016/S0140-6736(11)60988-4. Review.


Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG.

Eur Respir J. 2011 Nov;38(5):1019-28. doi: 10.1183/09031936.00158110. Epub 2011 May 26.


Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice.

Huvenne W, Lanckacker EA, Krysko O, Bracke KR, Demoor T, Hellings PW, Brusselle GG, Joos GF, Bachert C, Maes T.

Respir Res. 2011 May 27;12:69. doi: 10.1186/1465-9921-12-69.


Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT.

Verschuere S, Bracke KR, Demoor T, Plantinga M, Verbrugghe P, Ferdinande L, Lambrecht BN, Brusselle GG, Cuvelier CA.

Lab Invest. 2011 Jul;91(7):1056-67. doi: 10.1038/labinvest.2011.74. Epub 2011 May 2.


The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation.

Demoor T, Bracke KR, Dupont LL, Plantinga M, Bondue B, Roy MO, Lannoy V, Lambrecht BN, Brusselle GG, Joos GF.

J Immunol. 2011 May 1;186(9):5457-67. doi: 10.4049/jimmunol.1003862. Epub 2011 Mar 23.


MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease.

Van Pottelberge GR, Mestdagh P, Bracke KR, Thas O, van Durme YM, Joos GF, Vandesompele J, Brusselle GG.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):898-906. doi: 10.1164/rccm.201002-0304OC. Epub 2010 Oct 29.


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