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Items: 23


Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study.

Shah MA, Starodub A, Sharma S, Berlin J, Patel M, Wainberg ZA, Chaves J, Gordon M, Windsor K, Brachmann CB, Huang X, Vosganian G, Maltzman JD, Smith V, Silverman JA, Lenz HJ, Bendell JC.

Clin Cancer Res. 2018 Aug 15;24(16):3829-3837. doi: 10.1158/1078-0432.CCR-17-2469. Epub 2018 Apr 24.


A phase 2 study of momelotinib, a potent JAK1 and JAK2 inhibitor, in patients with polycythemia vera or essential thrombocythemia.

Verstovsek S, Courby S, Griesshammer M, Mesa RA, Brachmann CB, Kawashima J, Maltzman JD, Shao L, Xin Y, Huang D, Bajel A.

Leuk Res. 2017 Sep;60:11-17. doi: 10.1016/j.leukres.2017.05.002. Epub 2017 May 30.


A phase 1/2, open-label study evaluating twice-daily administration of momelotinib in myelofibrosis.

Gupta V, Mesa RA, Deininger MW, Rivera CE, Sirhan S, Brachmann CB, Collins H, Kawashima J, Xin Y, Verstovsek S.

Haematologica. 2017 Jan;102(1):94-102. doi: 10.3324/haematol.2016.148924. Epub 2016 Sep 15.


SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.

Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann CB, Heise C, Pierce D, Lopez-Casas PP, Menendez C, Tabernero J, Romano A, Wei X, Lopez-Rios F, Von Hoff DD.

Clin Cancer Res. 2015 Nov 1;21(21):4811-8. doi: 10.1158/1078-0432.CCR-14-3222. Epub 2015 Jul 13. Erratum in: Clin Cancer Res. 2016 Dec 15;22(24):6302.


The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin.

Rovani MK, Brachmann CB, Ramsay G, Katzen AL.

Dev Biol. 2012 Dec 1;372(1):88-102. doi: 10.1016/j.ydbio.2012.08.022. Epub 2012 Aug 29.


Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary.

Tanner EA, Blute TA, Brachmann CB, McCall K.

Development. 2011 Jan;138(2):327-38. doi: 10.1242/dev.057943.


grim promotes programmed cell death of Drosophila microchaete glial cells.

Wu JN, Nguyen N, Aghazarian M, Tan Y, Sevrioukov EA, Mabuchi M, Tang W, Monserrate JP, White K, Brachmann CB.

Mech Dev. 2010 Sep-Dec;127(9-12):407-17. doi: 10.1016/j.mod.2010.06.001. Epub 2010 Jun 15.


The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.

Yarosh W, Monserrate J, Tong JJ, Tse S, Le PK, Nguyen K, Brachmann CB, Wallace DC, Huang T.

PLoS Genet. 2008 Jan;4(1):e6. doi: 10.1371/journal.pgen.0040006.


Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development.

Sevrioukov EA, Burr J, Huang EW, Assi HH, Monserrate JP, Purves DC, Wu JN, Song EJ, Brachmann CB.

Genesis. 2007 Apr;45(4):184-93.


Identification of the death zone: a spatially restricted region for programmed cell death that sculpts the fly eye.

Monserrate JP, Brachmann CB.

Cell Death Differ. 2007 Feb;14(2):209-17. Epub 2006 May 19.


Patterning the fly eye: the role of apoptosis.

Brachmann CB, Cagan RL.

Trends Genet. 2003 Feb;19(2):91-6. Review.


Delta and notch promote correct localization of irreC-rst.

Gorski SM, Brachmann CB, Tanenbaum SB, Cagan RL.

Cell Death Differ. 2000 Oct;7(10):1011-3. No abstract available.


A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante-Semerena JC, Grubmeyer C, Wolberger C, Boeke JD.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6658-63.


The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation.

Brachmann CB, Jassim OW, Wachsmuth BD, Cagan RL.

Curr Biol. 2000 May 4;10(9):547-50.


The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.

Freeman-Cook LL, Sherman JM, Brachmann CB, Allshire RC, Boeke JD, Pillus L.

Mol Biol Cell. 1999 Oct;10(10):3171-86.


The conserved core of a human SIR2 homologue functions in yeast silencing.

Sherman JM, Stone EM, Freeman-Cook LL, Brachmann CB, Boeke JD, Pillus L.

Mol Biol Cell. 1999 Sep;10(9):3045-59.


A critical proteolytic cleavage site near the C terminus of the yeast retrotransposon Ty1 Gag protein.

Merkulov GV, Swiderek KM, Brachmann CB, Boeke JD.

J Virol. 1996 Aug;70(8):5548-56.


The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD.

Genes Dev. 1995 Dec 1;9(23):2888-902.

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