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Items: 1 to 50 of 157

1.

Increased expression of cathepsin D is required for L1-mediated colon cancer progression.

Basu S, Cheriyamundath S, Gavert N, Brabletz T, Haase G, Ben-Ze'ev A.

Oncotarget. 2019 Aug 27;10(50):5217-5228. doi: 10.18632/oncotarget.27155. eCollection 2019 Aug 27.

2.

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.

Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, Borenstein-Auerbach N, Kim M, Lesner NP, Mishra P, Brabletz T, Shay JW, DeBerardinis RJ, Williams NS, Yilmaz OH, Conacci-Sorrell M.

Genes Dev. 2019 Sep 1;33(17-18):1236-1251. doi: 10.1101/gad.327056.119. Epub 2019 Aug 15.

3.

Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli.

Musa G, Cazorla-Vázquez S, van Amerongen MJ, Stemmler MP, Eckstein M, Hartmann A, Braun T, Brabletz T, Engel FB.

Ann N Y Acad Sci. 2019 Jun 19. doi: 10.1111/nyas.14135. [Epub ahead of print]

PMID:
31215653
4.

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer.

Jolly MK, Preca BT, Tripathi SC, Jia D, George JT, Hanash SM, Brabletz T, Stemmler MP, Maurer J, Levine H.

APL Bioeng. 2018 Aug 22;2(3):031908. doi: 10.1063/1.5024874. eCollection 2018 Sep.

5.

Non-redundant functions of EMT transcription factors.

Stemmler MP, Eccles RL, Brabletz S, Brabletz T.

Nat Cell Biol. 2019 Jan;21(1):102-112. doi: 10.1038/s41556-018-0196-y. Epub 2019 Jan 2. Review.

PMID:
30602760
6.

An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.

Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X.

EMBO Rep. 2019 Jan;20(1). pii: e46273. doi: 10.15252/embr.201846273. Epub 2018 Nov 9.

PMID:
30413481
7.

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells.

Lafita-Navarro MC, Kim M, Borenstein-Auerbach N, Venkateswaran N, Hao YH, Ray R, Brabletz T, Scaglioni PP, Shay JW, Conacci-Sorrell M.

Genes Dev. 2018 Oct 1;32(19-20):1303-1308. doi: 10.1101/gad.313007.118. Epub 2018 Sep 25.

8.

The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.

Basu S, Gavert N, Brabletz T, Ben-Ze'ev A.

Cancer Lett. 2018 Jun 28;424:9-18. doi: 10.1016/j.canlet.2018.03.022. Epub 2018 Mar 15.

PMID:
29551399
9.

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells.

Schwab A, Siddiqui A, Vazakidou ME, Napoli F, Böttcher M, Menchicchi B, Raza U, Saatci Ö, Krebs AM, Ferrazzi F, Rapa I, Dettmer-Wilde K, Waldner MJ, Ekici AB, Rasheed SAK, Mougiakakos D, Oefner PJ, Sahin O, Volante M, Greten FR, Brabletz T, Ceppi P.

Cancer Res. 2018 Apr 1;78(7):1604-1618. doi: 10.1158/0008-5472.CAN-17-2834. Epub 2018 Jan 17.

10.

EMT in cancer.

Brabletz T, Kalluri R, Nieto MA, Weinberg RA.

Nat Rev Cancer. 2018 Feb;18(2):128-134. doi: 10.1038/nrc.2017.118. Epub 2018 Jan 12.

PMID:
29326430
11.

Road to perdition: Zeb1-dependent and -independent ways to metastasis.

Brabletz S, Brabletz T, Stemmler MP.

Cell Cycle. 2017 Oct 2;16(19):1729-1730. doi: 10.1080/15384101.2017.1360648. Epub 2017 Aug 18. No abstract available.

12.

Upholding a role for EMT in pancreatic cancer metastasis.

Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ.

Nature. 2017 Jul 5;547(7661):E7-E8. doi: 10.1038/nature22963. No abstract available.

13.

Upholding a role for EMT in breast cancer metastasis.

Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA.

Nature. 2017 Jul 5;547(7661):E1-E3. doi: 10.1038/nature22816. No abstract available.

14.

Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds.

Enderle-Ammour K, Bader M, Ahrens TD, Franke K, Timme S, Csanadi A, Hoeppner J, Kulemann B, Maurer J, Reiss P, Schilling O, Keck T, Brabletz T, Stickeler E, Werner M, Wellner UF, Bronsert P.

Tumour Biol. 2017 May;39(5):1010428317705501. doi: 10.1177/1010428317705501.

PMID:
28475002
15.

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.

Krebs AM, Mitschke J, Lasierra Losada M, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton VG, Pilarsky C, Winkler TH, Brabletz S, Stemmler MP, Brabletz T.

Nat Cell Biol. 2017 May;19(5):518-529. doi: 10.1038/ncb3513. Epub 2017 Apr 17.

PMID:
28414315
16.

Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells.

Siddiqui A, Vazakidou ME, Schwab A, Napoli F, Fernandez-Molina C, Rapa I, Stemmler MP, Volante M, Brabletz T, Ceppi P.

J Pathol. 2017 Jun;242(2):221-233. doi: 10.1002/path.4897.

17.

Generation and characterization of mice for conditional inactivation of Zeb1.

Brabletz S, Lasierra Losada M, Schmalhofer O, Mitschke J, Krebs A, Brabletz T, Stemmler MP.

Genesis. 2017 Apr;55(4). doi: 10.1002/dvg.23024. Epub 2017 Feb 23.

PMID:
28176446
18.

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.

Preca BT, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, Matzge-Ogi A, Orian-Rousseau V, Brabletz S, Brabletz T, Maurer J, Stemmler MP.

Oncotarget. 2017 Feb 14;8(7):11530-11543. doi: 10.18632/oncotarget.14563.

19.

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.

Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J.

Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.

20.

A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10.

Haase G, Gavert N, Brabletz T, Ben-Ze'ev A.

Oncogene. 2017 Mar;36(11):1597-1606. doi: 10.1038/onc.2016.329. Epub 2016 Sep 19.

PMID:
27641335
21.

MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.

Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5481-90. doi: 10.1073/pnas.1610994113. Epub 2016 Aug 26.

22.

Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation.

Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP.

Sci Rep. 2016 May 24;6:26562. doi: 10.1038/srep26562.

23.

The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis.

Haase G, Gavert N, Brabletz T, Ben-Ze'ev A.

Cancers (Basel). 2016 May 11;8(5). pii: E48. doi: 10.3390/cancers8050048. Review.

24.

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.

Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, Herr R, Brabletz S, Stemmler MP, Brabletz T.

Nat Commun. 2016 Feb 15;7:10498. doi: 10.1038/ncomms10498.

25.

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.

Sundararajan V, Gengenbacher N, Stemmler MP, Kleemann JA, Brabletz T, Brabletz S.

Oncotarget. 2015 Sep 29;6(29):27083-96. doi: 10.18632/oncotarget.4807.

26.

miR-200c dampens cancer cell migration via regulation of protein kinase A subunits.

Sigloch FC, Burk UC, Biniossek ML, Brabletz T, Schilling O.

Oncotarget. 2015 Sep 15;6(27):23874-89.

27.

A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.

Preca BT, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, Wellner U, Hopt UT, Brummer T, Brabletz S, Brabletz T, Stemmler MP.

Int J Cancer. 2015 Dec 1;137(11):2566-77. doi: 10.1002/ijc.29642. Epub 2015 Jun 30.

28.

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors.

Mock K, Preca BT, Brummer T, Brabletz S, Stemmler MP, Brabletz T.

Oncotarget. 2015 Jun 10;6(16):14399-412.

29.

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Shvab A, Haase G, Ben-Shmuel A, Gavert N, Brabletz T, Dedhar S, Ben-Ze'ev A.

Oncogene. 2016 Feb 4;35(5):549-57. doi: 10.1038/onc.2015.127. Epub 2015 Apr 27.

PMID:
25915847
30.

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat.

Meidhof S, Brabletz S, Lehmann W, Preca BT, Mock K, Ruh M, Schüler J, Berthold M, Weber A, Burk U, Lübbert M, Puhr M, Culig Z, Wellner U, Keck T, Bronsert P, Küsters S, Hopt UT, Stemmler MP, Brabletz T.

EMBO Mol Med. 2015 Jun;7(6):831-47. doi: 10.15252/emmm.201404396.

31.

Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.

Kohler I, Bronsert P, Timme S, Werner M, Brabletz T, Hopt UT, Schilling O, Bausch D, Keck T, Wellner UF.

J Gastroenterol Hepatol. 2015 Mar;30 Suppl 1:78-84. doi: 10.1111/jgh.12752.

PMID:
25827809
32.

Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition.

Alotaibi H, Basilicata MF, Shehwana H, Kosowan T, Schreck I, Braeutigam C, Konu O, Brabletz T, Stemmler MP.

Biochim Biophys Acta. 2015 Jun;1849(6):731-42. doi: 10.1016/j.bbagrm.2015.01.005. Epub 2015 Jan 31.

PMID:
25652130
33.

Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface.

Bronsert P, Enderle-Ammour K, Bader M, Timme S, Kuehs M, Csanadi A, Kayser G, Kohler I, Bausch D, Hoeppner J, Hopt UT, Keck T, Stickeler E, Passlick B, Schilling O, Reiss CP, Vashist Y, Brabletz T, Berger J, Lotz J, Olesch J, Werner M, Wellner UF.

J Pathol. 2014 Nov;234(3):410-22. doi: 10.1002/path.4416.

PMID:
25081610
34.

Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes.

Krohn A, Ahrens T, Yalcin A, Plönes T, Wehrle J, Taromi S, Wollner S, Follo M, Brabletz T, Mani SA, Claus R, Hackanson B, Burger M.

PLoS One. 2014 Jun 24;9(6):e100249. doi: 10.1371/journal.pone.0100249. eCollection 2014.

35.

Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer.

Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF.

Surgery. 2014 Jul;156(1):97-108. doi: 10.1016/j.surg.2014.02.018. Epub 2014 Feb 28.

PMID:
24929761
36.

Oncogenic roles of EMT-inducing transcription factors.

Puisieux A, Brabletz T, Caramel J.

Nat Cell Biol. 2014 Jun;16(6):488-94. doi: 10.1038/ncb2976. Review.

PMID:
24875735
37.

Stress-induced cleavage of Myc promotes cancer cell survival.

Conacci-Sorrell M, Ngouenet C, Anderson S, Brabletz T, Eisenman RN.

Genes Dev. 2014 Apr 1;28(7):689-707. doi: 10.1101/gad.231894.113.

38.

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells.

Zeindl-Eberhart E, Brandl L, Liebmann S, Ormanns S, Scheel SK, Brabletz T, Kirchner T, Jung A.

PLoS One. 2014 Jan 31;9(1):e87386. doi: 10.1371/journal.pone.0087386. eCollection 2014.

39.

A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster.

Li XL, Hara T, Choi Y, Subramanian M, Francis P, Bilke S, Walker RL, Pineda M, Zhu Y, Yang Y, Luo J, Wakefield LM, Brabletz T, Park BH, Sharma S, Chowdhury D, Meltzer PS, Lal A.

Mol Cell Biol. 2014 Feb;34(3):533-50. doi: 10.1128/MCB.01043-13. Epub 2013 Nov 25.

40.

Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency.

Bedzhov I, Alotaibi H, Basilicata MF, Ahlborn K, Liszewska E, Brabletz T, Stemmler MP.

Stem Cell Res. 2013 Nov;11(3):1250-63. doi: 10.1016/j.scr.2013.08.009. Epub 2013 Aug 26.

41.

Roadblocks to translational advances on metastasis research.

Brabletz T, Lyden D, Steeg PS, Werb Z.

Nat Med. 2013 Sep;19(9):1104-9. doi: 10.1038/nm.3327.

42.

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance.

Siebzehnrubl FA, Silver DJ, Tugertimur B, Deleyrolle LP, Siebzehnrubl D, Sarkisian MR, Devers KG, Yachnis AT, Kupper MD, Neal D, Nabilsi NH, Kladde MP, Suslov O, Brabletz S, Brabletz T, Reynolds BA, Steindler DA.

EMBO Mol Med. 2013 Aug;5(8):1196-212. doi: 10.1002/emmm.201302827. Epub 2013 Jul 1.

43.

Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development.

Vannier C, Mock K, Brabletz T, Driever W.

J Biol Chem. 2013 Jun 28;288(26):18643-59. doi: 10.1074/jbc.M113.467787. Epub 2013 May 10.

44.

EMT and MET in metastasis: where are the cancer stem cells?

Brabletz T.

Cancer Cell. 2012 Dec 11;22(6):699-701. doi: 10.1016/j.ccr.2012.11.009.

45.

A transcription factor-based mechanism for mouse heterochromatin formation.

Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T.

Nat Struct Mol Biol. 2012 Oct;19(10):1023-30. doi: 10.1038/nsmb.2382. Epub 2012 Sep 16. Erratum in: Nat Struct Mol Biol. 2013 Feb;20(2):244.

PMID:
22983563
46.

Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.

Jaitner S, Reiche JA, Schäffauer AJ, Hiendlmeyer E, Herbst H, Brabletz T, Kirchner T, Jung A.

Cell Cycle. 2012 Sep 1;11(17):3331-8. doi: 10.4161/cc.21790. Epub 2012 Aug 16.

47.

Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-κB signaling that promotes colon cancer progression.

Ben-Shmuel A, Shvab A, Gavert N, Brabletz T, Ben-Ze'ev A.

Oncogene. 2013 Jul 4;32(27):3220-30. doi: 10.1038/onc.2012.340. Epub 2012 Aug 6.

PMID:
22869145
48.

Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity.

Wu ZQ, Brabletz T, Fearon E, Willis AL, Hu CY, Li XY, Weiss SJ.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11312-7. doi: 10.1073/pnas.1203015109. Epub 2012 Jun 27.

49.

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.

Kahlert UD, Maciaczyk D, Doostkam S, Orr BA, Simons B, Bogiel T, Reithmeier T, Prinz M, Schubert J, Niedermann G, Brabletz T, Eberhart CG, Nikkhah G, Maciaczyk J.

Cancer Lett. 2012 Dec 1;325(1):42-53. doi: 10.1016/j.canlet.2012.05.024. Epub 2012 May 28.

PMID:
22652173
50.

To differentiate or not--routes towards metastasis.

Brabletz T.

Nat Rev Cancer. 2012 May 11;12(6):425-36. doi: 10.1038/nrc3265. Review.

PMID:
22576165

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