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Items: 27

1.

Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor.

Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prézeau L.

Mol Pharmacol. 2019 Aug;96(2):233-246. doi: 10.1124/mol.118.113019. Epub 2019 Jun 12.

PMID:
31189666
2.

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

Selvam C, Lemasson IA, Brabet I, Oueslati N, Karaman B, Cabaye A, Tora AS, Commare B, Courtiol T, Cesarini S, McCort-Tranchepain I, Rigault D, Mony L, Bessiron T, McLean H, Leroux FR, Colobert F, Daniel H, Goupil-Lamy A, Bertrand HO, Goudet C, Pin JP, Acher FC.

J Med Chem. 2018 Mar 8;61(5):1969-1989. doi: 10.1021/acs.jmedchem.7b01438. Epub 2018 Feb 14.

PMID:
29397723
3.

Allosteric modulation of metabotropic glutamate receptors by chloride ions.

Tora AS, Rovira X, Dione I, Bertrand HO, Brabet I, De Koninck Y, Doyon N, Pin JP, Acher F, Goudet C.

FASEB J. 2015 Oct;29(10):4174-88. doi: 10.1096/fj.14-269746. Epub 2015 Jun 26.

PMID:
26116702
4.

Determination of the absolute configuration of phosphinic analogues of glutamate.

Commare B, Rigault D, Lemasson IA, Deschamps P, Tomas A, Roussel P, Brabet I, Goudet C, Pin JP, Leroux FR, Colobert F, Acher FC.

Org Biomol Chem. 2015 Jan 28;13(4):1106-12. doi: 10.1039/c4ob01960a. Epub 2014 Nov 24.

PMID:
25417857
5.

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP.

FASEB J. 2012 Apr;26(4):1682-93. doi: 10.1096/fj.11-195941. Epub 2012 Jan 5.

PMID:
22223752
6.

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T.

Nat Chem Biol. 2010 Aug;6(8):587-94. doi: 10.1038/nchembio.396. Epub 2010 Jul 11.

7.

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Selvam C, Oueslati N, Lemasson IA, Brabet I, Rigault D, Courtiol T, Cesarini S, Triballeau N, Bertrand HO, Goudet C, Pin JP, Acher FC.

J Med Chem. 2010 Apr 8;53(7):2797-813. doi: 10.1021/jm901523t.

PMID:
20218620
8.

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

Sibille P, Lopez S, Brabet I, Valenti O, Oueslati N, Gaven F, Goudet C, Bertrand HO, Neyton J, Marino MJ, Amalric M, Pin JP, Acher FC.

J Med Chem. 2007 Jul 26;50(15):3585-95. Epub 2007 Jun 28.

PMID:
17602546
9.

Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15.

Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M.

Biochem Biophys Res Commun. 2006 Oct 20;349(2):471-9. Epub 2006 Aug 22.

PMID:
16945339
11.

Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.

Liu J, Maurel D, Etzol S, Brabet I, Ansanay H, Pin JP, Rondard P.

J Biol Chem. 2004 Apr 16;279(16):15824-30. Epub 2004 Jan 21.

12.

The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits.

Havlickova M, Blahos J, Brabet I, Liu J, Hruskova B, Prézeau L, Pin JP.

J Biol Chem. 2003 Sep 12;278(37):35063-70. Epub 2003 Jun 26.

13.

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.

Bessis AS, Rondard P, Gaven F, Brabet I, Triballeau N, Prezeau L, Acher F, Pin JP.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11097-102. Epub 2002 Jul 31.

14.

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.

Carroll FY, Stolle A, Beart PM, Voerste A, Brabet I, Mauler F, Joly C, Antonicek H, Bockaert J, Müller T, Pin JP, Prézeau L.

Mol Pharmacol. 2001 May;59(5):965-73.

15.

A novel site on the Galpha -protein that recognizes heptahelical receptors.

Blahos J, Fischer T, Brabet I, Stauffer D, Rovelli G, Bockaert J, Pin JP.

J Biol Chem. 2001 Feb 2;276(5):3262-9. Epub 2000 Oct 10.

16.

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.

Galvez T, Urwyler S, Prézeau L, Mosbacher J, Joly C, Malitschek B, Heid J, Brabet I, Froestl W, Bettler B, Kaupmann K, Pin JP.

Mol Pharmacol. 2000 Mar;57(3):419-26.

PMID:
10692480
17.

First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist.

Dauban P, de Saint-Fuscien C, Acher F, Prézeau L, Brabet I, Pin JP, Dodd RH.

Bioorg Med Chem Lett. 2000 Jan 17;10(2):129-33.

PMID:
10673095
18.
19.

Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8.

Corti C, Restituito S, Rimland JM, Brabet I, Corsi M, Pin JP, Ferraguti F.

Eur J Neurosci. 1998 Dec;10(12):3629-41.

PMID:
9875342
20.

Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.

Pellicciari R, Costantino G, Giovagnoni E, Mattoli L, Brabet I, Pin JP.

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1569-74.

PMID:
9873392
21.

Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

Brabet I, Parmentier ML, De Colle C, Bockaert J, Acher F, Pin JP.

Neuropharmacology. 1998 Aug;37(8):1043-51.

PMID:
9833633
22.

Extreme C terminus of G protein alpha-subunits contains a site that discriminates between Gi-coupled metabotropic glutamate receptors.

Blahos J 2nd, Mary S, Perroy J, de Colle C, Brabet I, Bockaert J, Pin JP.

J Biol Chem. 1998 Oct 2;273(40):25765-9.

24.
25.

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.

Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, Pin JP.

Mol Pharmacol. 1996 Oct;50(4):923-30.

PMID:
8863838
26.

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses.

Brabet I, Mary S, Bockaert J, Pin JP.

Neuropharmacology. 1995 Aug;34(8):895-903.

PMID:
8532171
27.

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