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Items: 1 to 50 of 399

1.

Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated Ir(III) complex conjugated to a far-red emitting coumarin.

Novohradsky V, Rovira A, Hally C, Galindo A, Vigueras G, Gandioso A, Svitelova M, Bresolí-Obach R, Kostrhunova H, Markova L, Kasparkova J, Nonell S, Ruiz J, Brabec V, Marchan V.

Angew Chem Int Ed Engl. 2019 Mar 19. doi: 10.1002/anie.201901268. [Epub ahead of print]

PMID:
30889300
2.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

Kostrhunova H, Petruzzella E, Gibson D, Kasparkova J, Brabec V.

Chemistry. 2019 Feb 10. doi: 10.1002/chem.201805626. [Epub ahead of print]

PMID:
30740808
3.

Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs.

Kozsup M, Farkas E, Bényei AC, Kasparkova J, Crlikova H, Brabec V, Buglyó P.

J Inorg Biochem. 2019 Apr;193:94-105. doi: 10.1016/j.jinorgbio.2019.01.005. Epub 2019 Jan 21.

PMID:
30703748
4.

New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells.

Ballester FJ, Ortega E, Porto V, Kostrhunova H, Davila-Ferreira N, Bautista D, Brabec V, Domínguez F, Santana MD, Ruiz J.

Chem Commun (Camb). 2019 Jan 25;55(8):1140-1143. doi: 10.1039/c8cc09211g. Epub 2019 Jan 11.

PMID:
30631876
5.

Substitution-Inert Polynuclear Platinum Complexes Act as Potent Inducers of Condensation/Aggregation of Short Single- and Double-Stranded DNA and RNA Oligonucleotides.

Malina J, Farrell NP, Brabec V.

Chemistry. 2019 Feb 26;25(12):2995-2999. doi: 10.1002/chem.201806276. Epub 2019 Jan 29.

PMID:
30565774
6.

N,N-Dialkylbenzimidazol-2-ylidene platinum complexes - effects of alkyl residues and ancillary cis-ligands on anticancer activity.

Rehm T, Rothemund M, Bär A, Dietel T, Kempe R, Kostrhunova H, Brabec V, Kasparkova J, Schobert R.

Dalton Trans. 2018 Dec 28;47(48):17367-17381. doi: 10.1039/c8dt03360a. Epub 2018 Nov 27.

PMID:
30480671
7.

Correction: Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.

Novohradsky V, Zajac J, Vrana O, Kasparkova J, Brabec V.

Oncotarget. 2018 Oct 30;9(85):35599. doi: 10.18632/oncotarget.26304. eCollection 2018 Oct 30.

8.

Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.

Shi H, Romero-Canelón I, Hreusova M, Novakova O, Venkatesh V, Habtemariam A, Clarkson GJ, Song JI, Brabec V, Sadler PJ.

Inorg Chem. 2018 Nov 19;57(22):14409-14420. doi: 10.1021/acs.inorgchem.8b02599. Epub 2018 Oct 26.

9.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

Pracharova J, Novohradsky V, Kostrhunova H, Štarha P, Trávníček Z, Kasparkova J, Brabec V.

Dalton Trans. 2018 Sep 11;47(35):12197-12208. doi: 10.1039/c8dt02236d.

PMID:
30112527
10.

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells.

Novohradsky V, Zajac J, Vrana O, Kasparkova J, Brabec V.

Oncotarget. 2018 Jun 19;9(47):28456-28473. doi: 10.18632/oncotarget.25466. eCollection 2018 Jun 19. Erratum in: Oncotarget. 2018 Oct 30;9(85):35599.

11.

Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.

Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ.

Organometallics. 2018 May 29;37(10):1555-1566. doi: 10.1021/acs.organomet.8b00132. Epub 2018 Apr 23.

12.

Substitution-Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex-Forming Templates.

Malina J, Farrell NP, Brabec V.

Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8535-8539. doi: 10.1002/anie.201803448. Epub 2018 Jun 7.

PMID:
29766623
13.

New (arene)ruthenium(II) complexes of 4‑aryl‑4H‑naphthopyrans with anticancer and anti-vascular activities.

Schmitt F, Kasparkova J, Brabec V, Begemann G, Schobert R, Biersack B.

J Inorg Biochem. 2018 Jul;184:69-78. doi: 10.1016/j.jinorgbio.2018.03.013. Epub 2018 Apr 5.

PMID:
29684697
14.

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

Hormann J, Malina J, Lemke O, Hülsey MJ, Wedepohl S, Potthoff J, Schmidt C, Ott I, Keller BG, Brabec V, Kulak N.

Inorg Chem. 2018 May 7;57(9):5004-5012. doi: 10.1021/acs.inorgchem.8b00027. Epub 2018 Apr 23.

PMID:
29683319
15.

Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ.

Dalton Trans. 2018 May 29;47(21):7178-7189. doi: 10.1039/c8dt00438b.

PMID:
29651471
16.

Polynuclear Platinum Complexes. Structural Diversity and DNA Binding.

Brabec V, Kasparkova J, Menon V, Farrell NP.

Met Ions Life Sci. 2018 Feb 5;18. pii: /books/9783110470734/9783110470734-007/9783110470734-008.xml. doi: 10.1515/9783110470734-008. Review.

PMID:
29394021
17.

Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents.

Pracharova J, Vigueras G, Novohradsky V, Cutillas N, Janiak C, Kostrhunova H, Kasparkova J, Ruiz J, Brabec V.

Chemistry. 2018 Mar 26;24(18):4607-4619. doi: 10.1002/chem.201705362. Epub 2018 Feb 27.

PMID:
29369444
18.
19.

Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA.

Lemmerhirt H, Behnisch S, Bodtke A, Lillig CH, Pazderova L, Kasparkova J, Brabec V, Bednarski PJ.

J Inorg Biochem. 2018 Jan;178:94-105. doi: 10.1016/j.jinorgbio.2017.10.011. Epub 2017 Oct 26.

PMID:
29125948
20.

Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA.

Kasparkova J, Kostrhunova H, Novohradsky V, Pracharova J, Curci A, Margiotta N, Natile G, Brabec V.

Dalton Trans. 2017 Oct 24;46(41):14139-14148. doi: 10.1039/c7dt02633a.

PMID:
28972623
21.

Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action.

Novohradsky V, Yellol J, Stuchlikova O, Santana MD, Kostrhunova H, Yellol G, Kasparkova J, Bautista D, Ruiz J, Brabec V.

Chemistry. 2017 Nov 2;23(61):15294-15299. doi: 10.1002/chem.201703581. Epub 2017 Oct 13.

PMID:
28922506
22.

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates.

Novohradsky V, Zanellato I, Marzano C, Pracharova J, Kasparkova J, Gibson D, Gandin V, Osella D, Brabec V.

Sci Rep. 2017 Jun 16;7(1):3751. doi: 10.1038/s41598-017-03864-w.

23.

Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents.

Novohradsky V, Zamora A, Gandioso A, Brabec V, Ruiz J, Marchán V.

Chem Commun (Camb). 2017 May 17;53(40):5523-5526. doi: 10.1039/c7cc01946g.

PMID:
28466888
24.

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex.

Hrabina O, Kasparkova J, Suchankova T, Novohradsky V, Guo Z, Brabec V.

Metallomics. 2017 May 24;9(5):494-500. doi: 10.1039/c7mt00052a.

PMID:
28436510
25.

New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry.

Pérez SA, de Haro C, Vicente C, Donaire A, Zamora A, Zajac J, Kostrhunova H, Brabec V, Bautista D, Ruiz J.

ACS Chem Biol. 2017 Jun 16;12(6):1524-1537. doi: 10.1021/acschembio.7b00090. Epub 2017 Apr 19.

PMID:
28388047
26.

3-[(E)-(acridin-9'-ylmethylidene)amino]-1-substituted thioureas and their biological activity.

Bečka M, Vilková M, Salem O, Kašpárková J, Brabec V, Kožurková M.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 5;180:234-241. doi: 10.1016/j.saa.2017.03.014. Epub 2017 Mar 8.

PMID:
28315620
27.

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects.

Intini FP, Zajac J, Novohradsky V, Saltarella T, Pacifico C, Brabec V, Natile G, Kasparkova J.

Inorg Chem. 2017 Feb 6;56(3):1483-1497. doi: 10.1021/acs.inorgchem.6b02553. Epub 2017 Jan 19.

PMID:
28102676
28.

Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization.

Yellol J, Pérez SA, Yellol G, Zajac J, Donaire A, Vigueras G, Novohradsky V, Janiak C, Brabec V, Ruiz J.

Chem Commun (Camb). 2016 Dec 1;52(98):14165-14168.

PMID:
27869279
29.

"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes.

Liu HK, Kostrhunova H, Habtemariam A, Kong Y, Deeth RJ, Brabec V, Sadler PJ.

Dalton Trans. 2016 Nov 22;45(46):18676-18688.

PMID:
27830851
30.

Effects of histidin-2-ylidene vs. imidazol-2-ylidene ligands on the anticancer and antivascular activity of complexes of ruthenium, iridium, platinum, and gold.

Schmitt F, Donnelly K, Muenzner JK, Rehm T, Novohradsky V, Brabec V, Kasparkova J, Albrecht M, Schobert R, Mueller T.

J Inorg Biochem. 2016 Oct;163:221-228. doi: 10.1016/j.jinorgbio.2016.07.021. Epub 2016 Jul 27.

PMID:
27491634
31.

Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.

Muenzner JK, Biersack B, Albrecht A, Rehm T, Lacher U, Milius W, Casini A, Zhang JJ, Ott I, Brabec V, Stuchlikova O, Andronache IC, Kaps L, Schuppan D, Schobert R.

Chemistry. 2016 Dec 23;22(52):18953-18962. doi: 10.1002/chem.201604246. Epub 2016 Nov 17.

PMID:
27761940
32.

Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.

Brabec V, Kasparkova J, Kostrhunova H, Farrell NP.

Sci Rep. 2016 Aug 30;6:28474. doi: 10.1038/srep28474.

33.

Activation of Platinum(IV) Prodrugs by Cytochrome c and Characterization of the Protein Binding Sites.

Lasorsa A, Stuchlíková O, Brabec V, Natile G, Arnesano F.

Mol Pharm. 2016 Sep 6;13(9):3216-23. doi: 10.1021/acs.molpharmaceut.6b00438. Epub 2016 Aug 9.

PMID:
27505350
34.

Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity.

Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M.

Mol Biosyst. 2016 Aug 16;12(9):2910-20. doi: 10.1039/c6mb00332j.

PMID:
27412811
35.

Iron(II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication.

Malina J, Hannon MJ, Brabec V.

Sci Rep. 2016 Jul 12;6:29674. doi: 10.1038/srep29674.

36.

Anticancer potential of a photoactivated transplatin derivative containing the methylazaindole ligand mediated by ROS generation and DNA cleavage.

Pracharova J, Radosova Muchova T, Dvorak Tomastikova E, Intini FP, Pacifico C, Natile G, Kasparkova J, Brabec V.

Dalton Trans. 2016 Aug 16;45(33):13179-86. doi: 10.1039/c6dt01467d.

PMID:
27396365
37.

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.

Medříková Z, Novohradsky V, Zajac J, Vrána O, Kasparkova J, Bakandritsos A, Petr M, Zbořil R, Brabec V.

Chemistry. 2016 Jul 4;22(28):9750-9. doi: 10.1002/chem.201600949. Epub 2016 Jun 1.

PMID:
27246144
38.

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action.

Raveendran R, Braude JP, Wexselblatt E, Novohradsky V, Stuchlikova O, Brabec V, Gandin V, Gibson D.

Chem Sci. 2016 Mar 1;7(3):2381-2391. doi: 10.1039/c5sc04205d. Epub 2016 Jan 15.

39.
40.

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds.

Salem OM, Vilková M, Janočková J, Jendželovský R, Fedoročko P, Žilecká E, Kašpárková J, Brabec V, Imrich J, Kožurková M.

Int J Biol Macromol. 2016 May;86:690-700. doi: 10.1016/j.ijbiomac.2016.02.018. Epub 2016 Feb 6.

PMID:
26861825
41.

Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario.

Šponer JE, Šponer J, Nováková O, Brabec V, Šedo O, Zdráhal Z, Costanzo G, Pino S, Saladino R, Di Mauro E.

Chemistry. 2016 Mar 7;22(11):3572-86. doi: 10.1002/chem.201503906. Epub 2016 Jan 25. Review.

PMID:
26807661
42.

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic.

Vrana O, Novohradsky V, Medrikova Z, Burdikova J, Stuchlikova O, Kasparkova J, Brabec V.

Chemistry. 2016 Feb 18;22(8):2728-35. doi: 10.1002/chem.201504671. Epub 2016 Jan 20.

PMID:
26789279
43.

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.

Zajac J, Kostrhunova H, Novohradsky V, Vrana O, Raveendran R, Gibson D, Kasparkova J, Brabec V.

J Inorg Biochem. 2016 Mar;156:89-97. doi: 10.1016/j.jinorgbio.2015.12.003. Epub 2015 Dec 31.

PMID:
26780576
44.

Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex.

Brabec V, Pracharova J, Stepankova J, Sadler PJ, Kasparkova J.

J Inorg Biochem. 2016 Jul;160:149-55. doi: 10.1016/j.jinorgbio.2015.12.029. Epub 2015 Dec 30.

PMID:
26778426
45.

Design, Preparation, and Characterization of Zn and Cu Metallopeptides Based On Tetradentate Aminopyridine Ligands Showing Enhanced DNA Cleavage Activity.

Soler M, Figueras E, Serrano-Plana J, González-Bártulos M, Massaguer A, Company A, Martínez MÁ, Malina J, Brabec V, Feliu L, Planas M, Ribas X, Costas M.

Inorg Chem. 2015 Nov 16;54(22):10542-58. doi: 10.1021/acs.inorgchem.5b01680. Epub 2015 Oct 27.

PMID:
26503063
46.

A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases.

Kasparkova J, Kostrhunova H, Novakova O, Křikavová R, Vančo J, Trávníček Z, Brabec V.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14478-82. doi: 10.1002/anie.201506533. Epub 2015 Oct 12.

PMID:
26458068
47.

Effects of antitumor derivatives of ineffective transplatin on bacterial cells: Is DNA a pharmacological target?

Kasparkova J, Brabec V.

J Inorg Biochem. 2015 Dec;153:206-210. doi: 10.1016/j.jinorgbio.2015.07.014. Epub 2015 Jul 20.

PMID:
26255233
48.

cis-Pt I2(NH3)2: a reappraisal.

Marzo T, Pillozzi S, Hrabina O, Kasparkova J, Brabec V, Arcangeli A, Bartoli G, Severi M, Lunghi A, Totti F, Gabbiani C, Quiroga AG, Messori L.

Dalton Trans. 2015 Sep 7;44(33):14896-905. doi: 10.1039/c5dt01196e.

PMID:
26226326
49.

Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices.

Malina J, Scott P, Brabec V.

Dalton Trans. 2015 Sep 7;44(33):14656-65. doi: 10.1039/c5dt02018b.

PMID:
26212708
50.

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group.

Muenzner JK, Rehm T, Biersack B, Casini A, de Graaf IA, Worawutputtapong P, Noor A, Kempe R, Brabec V, Kasparkova J, Schobert R.

J Med Chem. 2015 Aug 13;58(15):6283-92. doi: 10.1021/acs.jmedchem.5b00896. Epub 2015 Jul 29.

PMID:
26182125

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